Conserved Protein Domain Family
MYSc_type_V

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cd01380: MYSc_type_V 
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Myosin motor domain, type V myosins. Myosins V transport a variety of intracellular cargo processively along actin filaments, such as membraneous organelles and mRNA. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle.
BioAssay Targets and Results
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CID: 324093
AID: 600880
GI: 547967
IC50: 1.2µM
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Inhibition of chicken myosin 5a assessed as ATP hydrolysis
Target Name: Unconventional myosin-Va
Chemical Name: Pentabromopseudilin
IC50: 1.2µM
Statistics
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PSSM-Id: 30102
View PSSM: cd01380
Aligned: 22 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 1-Nov-2000
Updated: 9-Mar-2011
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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Display:
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Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP-binding site [chemical binding site]
Evidence:
  • Comment:the residues of the P-loop wrap around the triphosphate region of the nucleotide and the N-terminal region forms the binding pocket for the nucleotide

cd01380 is part of a hierarchy of related CD models.
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cd00106:KISccd00124:MYSccd01363:Motor_domaincd01364:KISc_BimC_Eg5cd01365:KISc_KIF1A_KIF1Bcd01366:KISc_C_terminalcd01367:KISc_KIF2_likecd01368:KISc_KIF23_likecd01369:KISc_KHC_KIF5cd01370:KISc_KIP3_likecd01371:KISc_KIF3cd01372:KISc_KIF4cd01373:KISc_KLP2_likecd01374:KISc_CENP_Ecd01375:KISc_KIF9_likecd01376:KISc_KID_likecd01377:MYSc_class_IIcd01378:MYSc_Myo1cd01379:MYSc_Myo3cd01380:MYSc_Myo5cd01381:MYSc_Myo7cd01382:MYSc_Myo6cd01383:MYSc_Myo8cd01384:MYSc_Myo11cd01385:MYSc_Myo9cd01386:MYSc_Myo18cd01387:MYSc_Myo151OE9 A13431722399327368745416667217424586270335894102458627374414107498293378592213256704531076787191130254639614212773641733525573172257778013287953932414799289503521OE9 A1343172239932736874541666721742458627033589410245862737441410749829337859221325670453107678719113025463961421277364173352557317225777801328795393241479928950352
cd01380 Sequence Cluster
cd01380 Sequence Cluster
Sub-family Hierarchy
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 cd01380 Branch
 Whole Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                       #### ##                          
1OE9_A        70 GENDLTALSy------lHEPAVLHNLKVRFidsklIYTYCGIVLVAINPYEQLPi-YGEDIINAYsgqnmgdmdPHIFAV 142
gi 127736     71 ATEDLTSLSy------lNEPAVLHAIKQRYsq-lnIYTYSGIVLIATNPFDRVDqlYTQDMIQAYagkrrgelePHLFAI 143
gi 417335     72 STDDLTTLSy------lNEPAVLHAIKKRYmn-gqIYTYSGIVLIAANPFDKVDhlYSREMIQNYsskrkdelePHLFAI 144
gi 32879539   86 ATDDLTNLSy------lNEPSVLHTILNRYsq-riIYTYSGIVLIAVNPFYGLSl-YSPEIIQAYsgrrkgelePHLFAI 157
gi 31076787   74 DADDLTDLSy------lNEPSVLDALSTRYnq-lqIYTYSGIVLIAVNPFQRLPnlYTHEIVRAYseksrdeldPHLYAI 146
gi 32414799   75 ASDDLTNLSh------lNEPAVLQAIRLRYaq-keIYTYSGIVLIATNPFARVDslYVPGMVQVYagkqratqaPHLFAI 147
gi 28950352   75 ASDDLTNLSh------lNEPAVLQAIRLRYaq-keIYTYSGIVLIATNPFARVDslYVPGMVQVYagkqratqaPHLFAI 147
gi 25573172   94 NVEDLANLSnlnepsgkFSHALLHAIATRYmq-hlPYTYSGIVLLSVNPFTPLNi-YDNAFVKLYsgqkkgqqdPHVFAI 171
gi 25777801   94 NVEDLANLSnlnepsgkFTRVLLHAIATRYmq-hlPYTYSGIVLLSVNPFTPLNi-YDNAFVKLYsgqkkgqqdPHVFAI 171
gi 19113025   66 SPSDLTNLPy------lNEPSVLHALHNRYnn-kqIYTYSGIVLVSINPYQNLPefYNDNLIKHFhkdpeaakvPHLYSI 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                        ########                                        
1OE9_A       143 AEEAYKQMArd----------eRNQSIIVSGESGAGKTVSAKYAMRYFATVsgsa-----------------seanVEEK 195
gi 127736    144 AEEAYRLMKnd----------kQNQTIVVSGESGAGKTVSAKYIMRYFASVeeensatv---------qhqvemseTEQK 204
gi 417335    145 AEEAYRFMVhe----------kANQTVVVSGESGAGKTVSAKYIMRYFASVqesnnre-----------gevemsqIESQ 203
gi 32879539  158 AEDAYRCMIrd----------eKDQTIVVSGESGAGKTVSAKYIMRYFATVedpdrpgsrkag--sagkdtsgmseTEQQ 225
gi 31076787  147 AEDSYKCMNqe----------hKNQTIIISGESGAGKTVSARYIMRYFASVqaliqstdsn------fheapqltaVENE 210
gi 32414799  148 AEEAFMDMLrd----------gKNQTIVVSGESGAGKTVSAKYIMRYFATRespdspgsrv-----kkgghesmsqTEEA 212
gi 28950352  148 AEEAFMDMLrd----------gKNQTIVVSGESGAGKTVSAKYIMRYFATRespdspgsrv-----kkgghesmsqTEEA 212
gi 25573172  172 AEEALDALRrgkgvkgvdpagaGDQTIVVSGESGAGKTVAAKYILRYFASAthvplvasefetlrkntadeesmseVEGQ 251
gi 25777801  172 AEEALDALRrgkgvkgvdpagaGDQTIIVSGESGAGKTVAAKYILRYFASAthvppvasefetlrkntadeesmseVEGQ 251
gi 19113025  139 ASSCYHALTtd----------sKNQTIIVSGESGAGKTVAAKYIMRYLTSVqgvdhn-------------gvvkrsVENQ 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1OE9_A       196 VLASNPIMESIGNAKTTRNDNSSRFGKYIEIgFDKRYrIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCAsaaLPEFK 275
gi 127736    205 ILATNPIMEAFGNAKTTRNDNSSRFGKYLEIlFDKDTsIIGARIRTYLLERSRLVYQPPIERNYHIFYQLMAglpAQTKE 284
gi 417335    204 ILATNPIMEAFGNAKTTRNDNSSRFGKYLQIlFDENTtIRGSKIRTYLLEKSRLVYQPETERNYHIFYQILEglpEPVKQ 283
gi 32879539  226 ILATNPIMEAFGNAKTTRNDNSSRFGKYLEIlFDKSHeIVGAKMRTYLLERSRLVYQPETERNYHIFYQLCAgapSSEKK 305
gi 31076787  211 ILATNPIMEAFGNSKTSRNDNSSRFGKYIQIlFDGNAtIIGAKIQTYLLERSRLVFQPNQERNYHIFYQILAgssSEQLE 290
gi 32414799  213 ILATNPIMEAFGNAKTTRNDNSSRFGKYIEImFDKATnIIGAKIRTYLLERSRLVFQPLKERNYHIFYQLVAgvtDKERQ 292
gi 28950352  213 ILATNPIMEAFGNAKTTRNDNSSRFGKYIEImFDKATnIIGAKIRTYLLERSRLVFQPLKERNYHIFYQLVAgvtDKERQ 292
gi 25573172  252 ILASNPIMEAFGNAKTTRNDNSSRFGKYIQVlFNDGNeIVGAHVRTYLLERSRLVYQPALERNYHIFYQLLAgapSQERK 331
gi 25777801  252 ILASNPIMEAFGNAKTTRNDNSSRFGKYIQVlFNDRNeIVGARVRTYLLERSRLVYQPAFERNYHIFYQLLAgapSQERK 331
gi 19113025  196 VLATNPIMEAFGNAKTIRNDNSSRFGKYVTIsFDENLlITGANVNTYLLERSRVVSLLKGERNYHIFYQLITgctEEQRD 275
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1OE9_A       276 TLRLGna-nyFHYTKQGgs--pvIDGIDDAKEMVNTRQACTLLGISDSYQMGIFRILAGILHLGNVEFasrdsdscaipp 352
gi 127736    285 ELHLTda-sdYFYMNQGgd--tkINGIDDAKEYKITVDALTLVGITKETQHQIFKILAALLHIGNIEIkktrnda-slsa 360
gi 417335    284 ELHLSsp-kdYHYTNQGgq--pnIAGIDEAREYKITTDALSLVGINHETQLGIFKILAGLLHIGNIEMkmtrnda-slss 359
gi 32879539  306 DLGLEda-skFFYLNQGgagshiINGVNDAEDFKATQKALSTVGLTIERQWNIFRLLAALLHLGNVNItaarnda-vlad 383
gi 31076787  291 KWKLVensqeFNYLKQGnc--stIEGVNDKEEFKATVDALKTVGIDNDTCECIFSLLAALLHIGNIEVkhsrnda-yids 367
gi 32414799  293 ELGLLpv-eqFEYLNQGnt--ptIDGVDDKAEFNATKASLKTIGVDEGKQTEIFKLLAGLLHLGNVKIgamrnds-sldp 368
gi 28950352  293 ELGLLpv-eqFEYLNQGnt--ptIDGVDDKAEFNATKASLKTIGVDEGKQTEIFKLLAGLLHLGNVKIgamrnds-sldp 368
gi 25573172  332 DLALSgspgdFAYLSGGgpssitIAGVDDAKDFTATQQALSTVGISVERQWRVFKLLAALLHLGNAEIiqtrtda-llde 410
gi 25777801  332 DLALSsspcdFAYLSGGgpssitIGGVDDAKDFTATQQALSTVGISVERQWRVFKLLAALLHLGNAEItqtrtda-ilde 410
gi 19113025  276 KWFLEsa-ssFNYLSQGnc--deISGVDDSNDFTITCRALSTIGISESRQEDVFCLLAALLHLGNIEVcatrnea-qiqp 351
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1OE9_A       353 khdPLTIFCDLMGVDYEEMAHWLCHRKLATATETYIKPISKLHAINARDALAKHIYANLFNWIVDHVNKALhst-----v 427
gi 127736    361 depNLKLACELLGIDAYNFAKWVTKKQIITRSEKIVSNLNYSQALVAKDSVAKFIYSALFDWLVENINTVLcnpa--vnd 438
gi 417335    360 eeqNLQIACELLGIDPFNFAKWIVKKQIVTRSEKIVTNLNYNQALIARDSVAKFIYSTLFDWLVDNINKTLydpeldqqd 439
gi 32879539  384 ddpSLFMATRMLGIDSSEFRKWTVKKQLQTRGEKVVSNLTQAQAIVVRDSVSKYVYTCLFDWLVDQMNRSLalgs---sk 460
gi 31076787  368 kneNLINATSLLGVDPSSLVKWLTKRKIKMASEGILKPLNEFQAVVARDSVAKFLYASLFDWLVATINKALmysadksnq 447
gi 32414799  369 sepSLVKACEILGIDAPEFAKWIVKKQLVTRGEKIVSNLTQAQAIVVRDSVAKYIYSSLFDWLVEIINHSLasee--vlt 446
gi 28950352  369 sepSLVKACEILGIDAPEFAKWIVKKQLVTRGEKIVSNLTQAQAIVVRDSVAKYIYSSLFDWLVEIINHSLasee--vlt 446
gi 25573172  411 tdvNLIRAAELLGLPLSDFRRWIIKKQLVTRNEKIITSLAGPQAIVVRDSVAKFIYSCLFQWLVNVINESLsgegirkkf 490
gi 25777801  411 sdvNLIRAAELLGLPLSDFRRWIIKKQLVTRSEKIVTSLAGPQAIVVRDSVAKFIYSCLFQWLVNVINESLsgegsrkki 490
gi 19113025  352 gdgYLQKAALLLGVDSSTLAKWIVKRQLKTRSETIITSSTLEHAISIRDSVAKYLYSALFLWIVHMINASLdhnk--vkr 429
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1OE9_A       428 kQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIEAKMGVLD 507
gi 127736    439 qISSFIGVLDIYGFEHFEKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFNDNQPCIDLIENKLGILS 518
gi 417335    440 hVFSFIGILDIYGFEHFEKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFSDNQPCIDLIENKLGILS 519
gi 32879539  461 sRESMIGVLDIYGFERFKVNSYEQFCINYANERLQHEFNHHVFKLEQEEYLQEQISWTFIDFSDNQPCIDMIEGKLGILS 540
gi 31076787  448 tAKSFIGVLDIYGFEHFKKNSFEQFCINYANEKLQQEFYRHVFKLEQEEYAAEGLNWSYIDYQDNQQCISMIESRLGILS 527
gi 32414799  447 rVTSFIGVLDIYGFEHFAKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYLREQIDWTFIDFADNQPCIDLIEGKLGILS 526
gi 28950352  447 rVTSFIGVLDIYGFEHFAKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYLREQIDWTFIDFADNQPCIDLIEGKLGILS 526
gi 25573172  491 tATNFIGVLDIYGFEHFAKNSFEQFCINWANEKLQQEFYARVFRLEQDEYLREKIDWAFISFTDNQACIDVIEGKMGILS 570
gi 25777801  491 tATNFIGVLDIYGFEHFAKNSFEQFCINWANEKLQQEFYARVFRLEQDEYLREKIDWAFISFTDNQACIDVIEGKMGILA 570
gi 19113025  430 aAYKYIGVVDIYGFEHFEKNSMEQFCINYANEKLQQEFNKHVFKLEQEEYVKEGLDWRLIEYSDNQGCISLIEDKLGILS 509
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1OE9_A       508 LLDEECKMPKGSDDTWAQKLYnthln---kcalFEKPRLSNKAFIIKHFADKVEYQCEGFLEKNKDTVYEEQIKVLKSSk 584
gi 127736    519 LLDEESRLPAGSDESWTQKLYqtldks-ptnkvFSKPRFGQTKFIVSHYALDVAYDVEGFIEKNRDTVSDGHLEVLKASt 597
gi 417335    520 LLDEESRLPSGSDESWASKLYsafnkp-psnevFSKPRFGQTKFIVSHYAVDVEYEVEGFIEKNRDSVSLGHLDVFKATt 598
gi 32879539  541 LLDEESRLPSGSDESFVQKLYtqmdrrpefknaFKKPRFGTTGFTVCHYALDVEYSSAGFVEKNKDTVPDEHLNLLNNTt 620
gi 31076787  528 LLDEECRMPTNSDENWVSKLNdafskp-efknsYQKSRFGNKEFTIKHYALDVVYCAEGFIDKNRDTISDELLELFTNSd 606
gi 32414799  527 LLDEESRLPMGSDEQFVTKLHhnyaa--dkhkfYKKPRFGKSSFTVCHYAIDVTYESDGFIEKNRDTVPDEHMAVLRASt 604
gi 28950352  527 LLDEESRLPMGSDEQFVTKLHhnyaa--dkhkfYKKPRFGKSSFTVCHYAIDVTYESDGFIEKNRDTVPDEHMAVLRASt 604
gi 25573172  571 LLDEESRLPAGSDVSFATKLHqqlpra-anrdvFKKPRFNERAFTVAHYAHDVTYDVDGFVEKNRDTVPDQHLDLLQNSd 649
gi 25777801  571 LLDEESRLPAGSDVSFATKLHqqlprp-anrdfFRKPRFNERAFTVVHYAHDVTYDVDGFVEKNRDTVPDQHLDLLQNSd 649
gi 19113025  510 LLDEECRLPSGNHQSFLQKLNnqlpt--khsqfYKKSRFNDGSFMVKHYALDVSYQVHDFLAKNSDAIPDEFISLLQNSk 587
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1OE9_A       585 kfkLLPELFQdeekaisptsatpsgrvplsrtpvkpakarpgqtskehKKTVGHQFRNSLHLLMETLNATTPHYVRCIKP 664
gi 127736    598 n-eTLINILEglekaakkleeakklel-----eqagskkpgpirtvnrKPTLGSMFKQSLIELMNTINSTNVHYIRCIKP 671
gi 417335    599 n-pIFKQILDnrelrsddapeeqn----------tekkimiparlsqkKPTLGSMFKKSLGELMAIINSTNVHYIRCIKP 667
gi 32879539  621 n-vFLKEVLDtavnlhkpddsndasad----saavkpaprklpgasikKPTLGSQFKTSLISLMNTIDSTNVHYIRCIKP 695
gi 31076787  607 v-pFVKDLVLfrleqtappa------------------dtkkiktkpkSNTLGSMFKSSLVSLMSTINETNAHYIRCIKP 667
gi 32414799  605 n-qFLVSVLDaasavrekdlasassn------avkpaagrrigvavnrKPTLGGIFKSSLIELMNTINGTDVHYIRCIKP 677
gi 28950352  605 n-qFLVSVLDaasavrekdlasassn------avkpaagrrigvavnrKPTLGGIFKSSLIELMNTINGTDVHYIRCIKP 677
gi 25573172  650 n-eFLREVVNaamdsssakqvgqq----------datatslsrrtnprKPTLGSIFKSSLVELMTTIYSTNVHYIRCIKP 718
gi 25777801  650 n-gFLREVVNaamdsssakqvgqq----------datatsmprrtnprKPTLGSIFKSSLVELMATIYSTNVHYIRCIKP 718
gi 19113025  588 n-eFITYLLDfymqlvssqn------------------knprktaisrKPTLSSMFKSSLSQLMTTVSSTNVHYIRCIKP 648
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1OE9_A       665 NDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMkqkd----------vlsDRKQTCKNVLEK 734
gi 127736    672 NADKEAWQFDNLMVLSQLRACGVLETIRISCAGFPSRWTFEEFVLRYYILIpheqwdlifkkketteeDIISVVKMILDA 751
gi 417335    668 NSEKKPWEFDNLMVLSQLRACGVLETIRISCAGFPSRWTFDEFVQRYFLLTdyslwsgilynpdlpkeAIVNFCQSILDA 747
gi 32879539  696 NEAKKAWEVEPQNVLGQLRACGVLETIRISCAGYPSRWTFADFAERYYMLVpsdrwn------msdmdKVKALATHILTT 769
gi 31076787  668 NEEKEAWKFDNQMVVSQLRACGVLETIKISCAGFPSRWTFDEFVSRYYMLVpsav----------rttESLTFSKAILEK 737
gi 32414799  678 NEAKEPWKFEGPMVLSQLRACGVLETVRISCAGYPTRWTYEEFALRYYMLVpstq----------wtsEIREMANAILTK 747
gi 28950352  678 NEAKEPWKFEGPMVLSQLRACGVLETVRISCAGYPTRWTYEEFALRYYMLVpstq----------wtsEIREMANAILTK 747
gi 25573172  719 NEAKKAWELDSIQVLAQLRACGVLETIRISCAGYPSRWEFNQFAQRYLIMLhsqew--------rpdmDVKQLCSAILTK 790
gi 25777801  719 NEAKKAWELDSNQVLAQLRACGVLETIRISCAGYPSRWEFSQFAQRYLIMLhsqew--------rpdmDVKQLCSAILTK 790
gi 19113025  649 NEEKLPWTFSPPMVLSQLRACGVFETIRISSLGFPARFSYEEFAHRFRILLsske----------weeDNKKLTLNIVNS 718
                        730       740       750
                 ....*....|....*....|....*....|....
Feature 1                                          
1OE9_A       735 LIld-----kDKYQFGKTKIFFRAGQVAYLEKIR 763
gi 127736    752 TVkd-----kSKYQIGNTKIFFKAGMLAYLEKLR 780
gi 417335    748 TIsd-----sAKYQIGNTKIFFKAGMLAFLEKLR 776
gi 32879539  770 TIte-----kDKYQIGLTKIFFRAGMLAQFEQRR 798
gi 31076787  738 HAd------pTKYQIGKTKIFFRSGVTPLLESAR 765
gi 32414799  748 AFgastgkglDKYQLGLTKIFFRAGMLAFLENLR 781
gi 28950352  748 AFgastgkglDKYQLGLTKIFFRAGMLAFLENLR 781
gi 25573172  791 VLdd-----eNQYQLGLTKIFFRPGVLALLESLR 819
gi 25777801  791 VLdd-----eKQYQLGLTKIFFRPGVLALLESLR 819
gi 19113025  719 VIph----dnLNFQVGRSKIFFRSNVIGNFEEAH 748

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Click on image for an interactive view with Cn3D
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D