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cd00992: PDZ_signaling 
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PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this subfamily of PDZ domains an N-terminal beta-strand forms the peptide-binding groove base, a circular permutation with respect to PDZ domains found in proteases.
BioAssay Targets and Results
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CID: 24207752
AID: 602267
GI: 62868213
IC50: 2.03µM
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Fluorescence Polarization with CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-02_Inhibitor_Dose_CherryPick_Activity
Chemical Name: MLS001360432
IC50: 2.03µM
CID: 774975
AID: 602267
GI: 62868213
IC50: 1.78µM
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Fluorescence Polarization with CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-02_Inhibitor_Dose_CherryPick_Activity
Chemical Name: AC1LGORW
IC50: 1.78µM
CID: 24207752
AID: 504773
GI: 62868213
IC50: 3.597µM
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Fluorescence Polarization with Cer CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-01_Inhibitor_Dose_CherryPick_Activity
Chemical Name: MLS001360432
IC50: 3.597µM
Statistics
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PSSM-Id: 29049
View PSSM: cd00992
Aligned: 291 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 1-Nov-2000
Updated: 9-Mar-2011
Structure
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Program:
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Aligned Rows:
Hierarchy
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Display:
 
protein binding
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:protein binding site [polypeptide binding site]
Evidence:
  • Comment:contains the GLGF loop, a carboxylate-binding motif
  • Comment:PDZ binds to either the terminal COOH group of a peptide ligand (1KWA) or an internal peptide sequence that mimics the PDZ binding motif (1QAV)
  • Structure:1KWA; CasLIN-2 PDZ and C-terminal polypeptide ligand complex
    View structure with Cn3D
  • Citation:PMID 8674113
  • Structure:1QAV; Syntrophin PDZ - Nnos complex
    View structure with Cn3D

cd00992 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00136:PDZcd00986:PDZ_LON_proteasecd00987:PDZ_serine_proteasecd00988:PDZ_CTP_proteasecd00989:PDZ_metalloproteasecd00990:PDZ_glycyl_aminopeptidasecd00991:PDZ_archaeal_metalloproteasecd00992:PDZ_signaling6691801186447362464917592571952309734027436957301481953122587692571951754116220304109175524841807175321355851282796981I92 A7495107282784117302804251501572331224104392652331224843954921750453631508277693983217122124659028766208617506801246399361501047617532255220019881935433024649087246469702752970825151090246473472466044224643532255358662984130413153062268909229928223161732465474222832296232729152458153263071416550758246543933120473123312241136032324664679175414481N99 A2885623289279672464106817564818205210791754042020455510249486476624162833291303144873PDZ A17532531925719520304109175411623122161392571951754116220304109298407811754315212643716312037611PDR  26238362773543216304505311982054521241710684417564516301522847512000104403532826101530061507925719517541162203041097512038248175811223084827882453282797121350676192571951754116213376286134362301I16  2139209830061509824793930061509246641751N7T A28261019752264324640023889601631198205175325311753253116665387144483205218322781731844265932464412517532531298407811666538751181330913163541032029029546541032029029546749781117532531298407811L6O A170652827882087710647917065277496570251530611QAV A17507009246541822827974869812187522643147352722466392775126622466393820137583165515272081050720137583246400361M5Z A24640023276675881176780290295487899272208105071754042019922294277342716755692750783276572612415842975034642421207624656228750756124647797199099707512038278824532481758127734271199211441992114431225876277342712148338829336037246400363006150717564396277174032013745620137932301522841B8Q A588195628912522889601675226432464002395069011283995716665382464002324969311750912524641457325659551IHJ A17543152246641791N99 A28856232312321861754377828574146297894031NF3 C175084871886009975327977500501246517782257461246415617522643246400231751110375120382481758127882453135067617522643246400231992114431225876277342711KWA A170883259218031346574287038161952847927735218282776671755744017646233218867362776485617538778892796724641068312304572465772124642734309131638896016311982059506901175325312984078188960163119820512643716249814720870591274774672017831227735405285028052886695728574408246619363123048228573805751156524817533246542243123046460942887512645201375836691801186447362464917592571952309734027436957301481953122587692571951754116220304109175524841807175321355851282796981I92 A7495107282784117302804251501572331224104392652331224843954921750453631508277693983217122124659028766208617506801246399361501047617532255220019881935433024649087246469702752970825151090246473472466044224643532255358662984130413153062268909229928223161732465474222832296232729152458153263071416550758246543933120473123312241136032324664679175414481N99 A2885623289279672464106817564818205210791754042020455510249486476624162833291303144873PDZ A17532531925719520304109175411623122161392571951754116220304109298407811754315212643716312037611PDR  26238362773543216304505311982054521241710684417564516301522847512000104403532826101530061507925719517541162203041097512038248175811223084827882453282797121350676192571951754116213376286134362301I16  2139209830061509824793930061509246641751N7T A28261019752264324640023889601631198205175325311753253116665387144483205218322781731844265932464412517532531298407811666538751181330913163541032029029546541032029029546749781117532531298407811L6O A170652827882087710647917065277496570251530611QAV A17507009246541822827974869812187522643147352722466392775126622466393820137583165515272081050720137583246400361M5Z A24640023276675881176780290295487899272208105071754042019922294277342716755692750783276572612415842975034642421207624656228750756124647797199099707512038278824532481758127734271199211441992114431225876277342712148338829336037246400363006150717564396277174032013745620137932301522841B8Q A588195628912522889601675226432464002395069011283995716665382464002324969311750912524641457325659551IHJ A17543152246641791N99 A28856232312321861754377828574146297894031NF3 C175084871886009975327977500501246517782257461246415617522643246400231751110375120382481758127882453135067617522643246400231992114431225876277342711KWA A17088325921803134657428703816195284792773521828277667175574401764623321886736277648561753877889279672464106831230457246577212464273430913163889601631198205950690117532531298407818896016311982051264371624981472087059127477467201783122773540528502805288669572857440824661936312304822857380575115652481753324654224312304646094288751264520137583
cd00992 Sequence Cluster
cd00992 Sequence Cluster
Sub-family Hierarchy
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 cd00992 Branch
 Whole Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                        #### #                                                          
3PDZ_A         6 IFEVELAKn-----dNSLGISVTGgvnts---------vrhggIYVKAVIp-QGAAesdgrIHKGDRVLAVNGVSLeg-- 68
1KWA_A         2 SRLVQFQKnt----dEPMGITLKMnel--------------nhCIVARIMh-GGMIhrqgtLHVGDEIREINGISVan-- 60
gi 1666538   383 TFPPIPEKse---neKQLGIEVNAvfdesselpgtseptklssVQIMKIEdgGRIAkd-grIRVGDCIVAIDGKPVdqms 458
gi 17540420  273 ISDVCLPLn------YGVGLELSNg------------------VFINSCEp-NGAAsr-sgLAPGQRVVHVMHTPVy--- 323
gi 20455510  680 TRELALPRdg----qGRLGFEVDAe-----------------gFITHVER--FTFAet-tgLRPGARLLRVCGQTLpk-- 733
gi 24817533    5 TISVRMNRsd---rnIRWGFSVRQqa---------------dgLIIDRVEa-ESLSdk-agVKHNDKVDQINGRSTrg-- 62
gi 30913163  201 TRTVEISGe-----gGPLGIHVVPffssls--------grilgLFIRGIEd-NSRSkreglFHENECIVKINNVDLvd-- 264
gi 31225876  239 VEMVEIDTspllsnsSDWGLTISGdldhsygsd-hsntknlcgPYVAAVEh-DSIFag--kLKPNDIICQINNHDCst-- 312
gi 31230457  107 YKRPKFKRniipfdtEDLSVRVIRer----------------fLIPNQVSe-GSPAqk-agLQLGDQILKINGADAsa-- 166
gi 31232186    1 LLIRKGED-------GKIGITVRYiee--------------gkILICAVLr-RSPAyl-agLRYGDEVLSLEDEPLvg-- 55
                         90       100
                 ....*....|....*....|....*....
Feature 1                  ##  ##             
3PDZ_A        69 -----atHKQAVETLRNTgq--vVHLLLE 90
1KWA_A        61 -----qtVEQLQKMLREMrg--sITFKIV 82
gi 1666538   459 iirvrasISDLAAVTSRPv----TLIINR 483
gi 17540420  324 ------dAKHAEMLIKNSre--pLVIGIL 344
gi 20455510  734 -----lgPETAAQMLRSAp---kVCVTVL 754
gi 24817533   63 -----ldAASANRLIDDSfn--eVRLSLQ 84
gi 30913163  265 -----ktFAQAQDVFRQAmkspsVLLHVL 288
gi 31225876  313 -----fsRRMIYRTIRNSvp--qCIITVK 334
gi 31230457  167 -----mrLATAQSVIKQAge--qLQMIVA 188
gi 31232186   56 -----qtVDRVRELVRKNtr-nsIKLRTK 78

Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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Click on image for an interactive view with Cn3D
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D