NCBI CDD Logo
?
cd00079: HELICc 
Click on image for an interactive view with Cn3D
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may not be an autonomously folding unit, but an integral part of the helicase; 4 helicase superfamilies at present according to the organization of their signature motifs; all helicases share the ability to unwind nucleic acid duplexes with a distinct directional polarity; they utilize the free energy from nucleoside triphosphate hydrolysis to fuel their translocation along DNA, unwinding the duplex in the process
BioAssay Targets and Results
?
CID: 16757839
AID: 2549
GI: 282403581
IC50: 0.0316µM
more
qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)
Chemical Name: NCGC00095101-02
IC50: 0.0316µM
CID: 16745534
AID: 2528
GI: 4557365
IC50: 0.1µM
more
qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM)
Chemical Name: Chebulinic acid
IC50: 0.1µM
CID: 16757839
AID: 2528
GI: 4557365
IC50: 0.0708µM
more
qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM)
Chemical Name: NCGC00095101-02
IC50: 0.0708µM
Statistics
?
PSSM-Id: 28960
View PSSM: cd00079
Aligned: 130 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 1-Nov-2000
Updated: 9-Mar-2011
Structure
?
Program:
Drawing:
Aligned Rows:
Hierarchy
?
 
nucleotideATP-binding
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleotide binding region [chemical binding site]
Evidence:
  • Structure:1A1V; Hepatitis C virus NS3 RNA helicase domain complexed with ssDNA oligonucleotide
    View structure with Cn3D
  • Citation:PMID 9493270

cd00079 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00079:HELICc1D2M A1D9Z A312300313513873122998249909861361571GM5 A391463839146141827928539146123914611391461339146351322521343222039140142507063391401358548139140153914012391461073108713760673217439134453913437130830548590117261613080413638202250733239134342506501173095424951541A1V A1CU1 B173774167313801723776117702224951523219961285148825001125921178464912117548411728981710074250011340092017234975486694175874624952493353117008331232625865104014381723929117346666475601176015417373417308416959730465249335417310402506239135423213915469130806466042173067812644178135312125005371170186312198112732454959713478725005391723162250053817231471175447731740586550731667465975170652113516561FUU B1242172500524135243825005147293292500533250053417081521HV8 A892855311692611706338117701072953141264415111828411692281708151312218925005251706311117259654873017310061325301175401250053513487811744401D2M A1D9Z A312300313513873122998249909861361571GM5 A391463839146141827928539146123914611391461339146351322521343222039140142507063391401358548139140153914012391461073108713760673217439134453913437130830548590117261613080413638202250733239134342506501173095424951541A1V A1CU1 B173774167313801723776117702224951523219961285148825001125921178464912117548411728981710074250011340092017234975486694175874624952493353117008331232625865104014381723929117346666475601176015417373417308416959730465249335417310402506239135423213915469130806466042173067812644178135312125005371170186312198112732454959713478725005391723162250053817231471175447731740586550731667465975170652113516561FUU B1242172500524135243825005147293292500533250053417081521HV8 A89285531169261170633811770107295314126441511182841169228170815131221892500525170631111725965487301731006132530117540125005351348781174440
cd00079 Sequence Cluster
cd00079 Sequence Cluster
Sub-family Hierarchy
Click to see CD Hierarchy help
CD Hierarchy
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                   ##       ##                         #
1D2M_A       414 DPLVRVKPTe-------nQILDL-MEGIReraa-rgeRTLVTVLT-------VRMAEELTSFLVe------hGIRARYLH 471
1A1V_A       170 NIEEVALSTtge---ipfYGKAIpLEVIKg------gRHLIFCHS-------KKKCDELAAKLVa------lGINAVAYY 227
gi 1172616   276 QIHYTYTPEpd------yLDACL-RTIFQlhtklppgDILVFLTGqdeiealEALIKSYSKQLPsn----lpQIQACPLF 344
gi 3913445   580 DIFYTKAPEad------yLEACV-VSVLQihvtqppgDILVFLTGqeeieaaCEMLQDPCRRLGsk----irELLVLPIY 648
gi 3913437   648 EILYTKQPEtd------yLDAAL-ITVLQihltepegDILVFLTGqeeidsaCQSLYERMKGLGkn----vpELIILPVY 716
gi 130830    663 EVLYSQTPQmd------yIEAAL-DCVIDihinegpgDILVFLTGqeeidscCEILYDRVKTLGds----igELLILPVY 731
gi 3913434   628 QLNEKETPFeli----eaLLKYI-ETLNVp------gAVLVFLPG-------WNLIYTMQKHLEnnshfgshRYQILPLH 689
gi 13638202  262 PIVEEADDTerdq--lqaIFDAV-DELSQes----hgDILIFMSG-------EREIRDTADALNkln---lrHTEILPLY 324
gi 2507332   182 PVERRYLPLpahqrfddaVAVAT-AEMLRqe----sgSLLLFLPG-------VGEIQRVQEQLAsri---gsDVLLCPLY 246
gi 2506501   372 KLTINEYERl-------gKLSVE-EKPIKdgikglrkGDCVVAFS-------KKKILDLKLKIEk-------DTNLKVAV 429
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #                                      ###                                      
1D2M_A       472 Held--afKRQAlirdLRLGh------------yDCLVGINLLREGLDIPeVSLVAILDadke----------------g 521
1A1V_A       228 Rg-----lDVSVi---PTSGd-------------VVVVATDALMTGFTGD-FDSVIDCNtxvtqtvdfsldptftiettt 285
gi 1172616   345 As-----lPQEQqlqvFLPAlanhrkvvlstniaETSVTISGIRYVIDTGlAKIKQFNSklgles------------ltv 407
gi 3913445   649 An-----lPSDMqariFQPTppgarkvvvatniaETSPTIEGIIYVLDPGfCKQKSYNPrtgmes------------ltv 711
gi 3913437   717 Sa-----lPSEMqsriFDPPppgkrkvvvatniaEASLTIDGIYYVVDPGfAKQNVYNPkqgles------------lvi 779
gi 130830    732 Sa-----lPSEIqskiFEPTpkgsrkvvfatniaETSITIDGIYYVVDPGfAKINIYNAragieq------------liv 794
gi 3913434   690 Sq-----iPREEqrkvFDPVpdgvtkvilstniaETSITINDVVYVIDSCkQKVKLFTAhnnmtn------------yat 752
gi 13638202  325 Ar-----lSNSEqnrvFQSHsgrriv--latnvaETSLTVPGIKYVIDPGtARISRYSYrtkvqr------------lpi 385
gi 2507332   247 Gal----sLNDQrk-aILPApqgmrkvvlatniaETSLTIEGIRLVVDCAqERVARFDPrtgltr------------lit 309
gi 2506501   430 IygslppeTRVQqaalFNNGe------------yDIMVASDAIGMGLNLS-IDRVVFTTnmkyng------------eel 484
                        170       180
                 ....*....|....*....|....*.
Feature 1                                  
1D2M_A       522 flRSERSLIQTIGRAARNARGEVWLY 547
1A1V_A       286 lpQDAVSRTQRRGRTGRGKPGIYRFV 311
gi 1172616   408 qpISQSAAMQRSGRAGREAAGQCYRI 433
gi 3913445   712 tpCSKASANQRAGRAGRVAAGKCFRL 737
gi 3913437   780 tpISQASAKQRAGRAGRTGPGKCYRL 805
gi 130830    795 spISQAQANQRKGRAGRTGPGKCYRL 820
gi 3913434   753 vwASKTNLEQRKGRAGRVRPGFCFHL 778
gi 13638202  386 epISQASANQRKGRCGRVSEGICIRL 411
gi 2507332   310 qrVSQASMTQRAGRAGRLEPGISLHL 335
gi 2506501   485 meMTSSQIKQIGGRAGRFKSRSASGG 510

Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap
Click on image for an interactive view with Cn3D
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D