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cd00065: FYVE (model is obsolete and has been replaced with a more recent version: 238022)
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FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1;
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BioAssay Targets and Results
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CID: 128419
AID: 1811
GI: 18158794
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Experimentally measured binding affinity data derived from PDB
Chemical Name: 1joc
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Statistics
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PSSM-Id: 28947
View PSSM: cd00065
Aligned: 88 rows
Threshold Bit Score: 39.6422
Threshold Setting Gi: 17510181
Created: 1-Nov-2000
Updated: 9-Mar-2011
Structure
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Program:
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Aligned Rows:
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Hierarchy
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Zn bindingphosphatidyli..
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding sites [ion binding site]
Evidence:
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cd00065 is part of a hierarchy of related CD models.
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cd00065:FYVE4181737493156689967093667801751018174969147493101110616229663386140426537506623174426481285428615426196749315647318671755354011641241418173729734973050551706790334224676570873599944752243674966321457164846204715220554152292447301552165506291072859575087261VFY A17238077492085729157312468231DVP A74931611522242374882171522821062270177301558795934115220569222468381010791HYI A7507640174771771004725374997046753054174343074984331676928299677001347009263205191523412115231820141653381756914966854751756940716553773100473637498095179337001521406776620487495620475852824997683123160164184397297694729944622245837511925163593581458584972431057322354181737493156689967093667801751018174969147493101110616229663386140426537506623174426481285428615426196749315647318671755354011641241418173729734973050551706790334224676570873599944752243674966321457164846204715220554152292447301552165506291072859575087261VFY A17238077492085729157312468231DVP A74931611522242374882171522821062270177301558795934115220569222468381010791HYI A750764017477177100472537499704675305417434307498433167692829967700134700926320519152341211523182014165338175691496685475175694071655377310047363749809517933700152140677662048749562047585282499768312316016418439729769472994462224583751192516359358145858497243105732235
cd00065 Sequence Cluster
cd00065 Sequence Cluster
Sub-family Hierarchy
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CD Hierarchy
Sequence Alignment?
Format: Row Display: Color Bits: Type Selection: 
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
Feature 1           #    #              #  #    #  #                       #  #   
1VFY_A       10 DSDACm--ICsKKFSL--LNRKHHCRSCGGVFCQEHSSNSIplpdl-----giyePVRVCDSCFED 66
gi 418173    74 GKSCCh--TCgRTLNN--NIGAINCRKCGKLYCRRHLPNMIklnlsaqydprngkWYNCCHDCFVT 135
gi 7493156  136 PDMVChdpMCdKLLNF--INGHIHCRKCGYIFCNFHSMYQIklsihatydsengfWCRVCRECYEG 199
gi 15426196  21 TARSCv--QCgKSFRL--FQAAGNCHGCGRVCCPSCLTEHLvlpgq-----pgsqPVPVCAICTKA 77
gi 11061622 118 NCQSCh--CChRFLMS--PSSIHHCRLCWRATCAECSNYMRmndf------mggrITRTCLTCAVP 173
gi 14042653   1 MESRCy--GCaVKFTL--FKKEYGCKNCGRAFCSGCLSFSAavpr------tgntQQKVCKQCHEV 56
gi 7506623   10 SSICCt--NCrTKYSL--LNREAGCSNCALSFCKKCLPHRAiipt------lsdlPMIVCNNCYQK 65
gi 7496914  670 ESKHCa--DCdIEFGF--LSRGSKCVKCSRRLCKKCFGRRRne----------skKHRICDTCTKN 721
gi 9366780  816 GPKMCh--WChKTFGLlsKFTTVRCSHCGHIHCSDCMETEVk-------------GKKLCRSCYSA 866
gi 12854286  43 SEPSCk--ACgVHFAS--TTRKQTCLDCKKNFCMTCSSQEGn-------------GPRLCLLCLRF 91

Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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Click on image for an interactive view with Cn3D
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D