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cd00060: FHA (model is obsolete and has been replaced with a more recent version: 238017)
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Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).
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BioAssay Targets and Results
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CID: 10133199
AID: 241478
GI: 6685284
IC50: 0.0023µM
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Inhibition of recombinant human Chk2 kinase
Target Name: Serine/threonine-protein kinase Chk2
Chemical Name: SureCN3918732
IC50: 0.0023µM
CID: 10177646
AID: 241478
GI: 6685284
IC50: 0.0044µM
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Inhibition of recombinant human Chk2 kinase
Target Name: Serine/threonine-protein kinase Chk2
Chemical Name: SureCN3919556
IC50: 0.0044µM
CID: 10115542
AID: 241478
GI: 6685284
IC50: 0.0034µM
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Inhibition of recombinant human Chk2 kinase
Target Name: Serine/threonine-protein kinase Chk2
Chemical Name: SureCN3926044
IC50: 0.0034µM
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Statistics
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PSSM-Id: 28942
View PSSM: cd00060
Aligned: 141 rows
Threshold Bit Score: 41.9696
Threshold Setting Gi: 15837873
Created: 1-Nov-2000
Updated: 9-Jan-2008
Structure
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Program:
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Aligned Rows:
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Hierarchy
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phosphopeptide
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:phosphopeptide binding site
Evidence:
  • Comment:conserved residues are involved in binding directly to the ligand backbone and phosphate group
  • Comment: non-conserved residues may determine binding specificity
  • Structure:1FHR_A; FHA2 binds a phosphotyrosyl peptide
    - View structure with Cn3D
  • Structure:1G6G_A; FHA binds a phosphothreonine peptide
    - View structure with Cn3D
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cd00060 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00060:FHA1FHR A1G6G A126443961753174113472157158906481632645913472144155952791722804413994667293751272991264445473028841938721354914376618781520936517944883131941971176161117137322255510512644018136260444265931857955762757714028593668529412584930320449613124323729486191151841523142573187311696921911355610728000117097872924247949080152222877288013197441777430355632070963232121206047574692591723076115893337172292201825572174303581561049616199171723087158429207430358127184261969903372888971523229674968511343201915241559118629731855048846614915238804929702117505372168832213994661740259715240169590270859027075902706590270598572941522657518087867450533972948851754644748954125072221523290274850411592106315897954747604368553931723482731703163318661169734191125541072950417541530107736763204061694461415614340158933341589369719551297747616557131262496539766196611706547513614499610177160037480073754666515837873172324461722867074485551632935374703582829614746960117231268744273674303557295157465488156053971561862212718426172315761561862215605397158346601FHR A1G6G A12644396175317411347215715890648163264591347214415595279172280441399466729375127299126444547302884193872135491437661878152093651794488313194197117616111713732225551051264401813626044426593185795576275771402859366852941258493032044961312432372948619115184152314257318731169692191135561072800011709787292424794908015222287728801319744177743035563207096323212120604757469259172307611589333717229220182557217430358156104961619917172308715842920743035812718426196990337288897152322967496851134320191524155911862973185504884661491523880492970211750537216883221399466174025971524016959027085902707590270659027059857294152265751808786745053397294885175464474895412507222152329027485041159210631589795474760436855393172348273170316331866116973419112554107295041754153010773676320406169446141561434015893334158936971955129774761655713126249653976619661170654751361449961017716003748007375466651583787317232446172286707448555163293537470358282961474696011723126874427367430355729515746548815605397156186221271842617231576156186221560539715834660
cd00060 Sequence Cluster
cd00060 Sequence Cluster
Sub-family Hierarchy
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CD Hierarchy
Sequence Alignment?
Format: Row Display: Color Bits: Type Selection: 
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                #                         # ##          
1FHR_A         5 FLTLKPLpds-------iiqESLEIQqg-----vnPFFIGRSEDc------------NCKIE--DNRLSRVHCFIFKKrh 58
gi 2555105   633 QACLVNLtadp-----ilsgTLFYLLpq------gLVRIGRGRLpggss----ssqpDIVLD--GPLVALQHCSIEHEr- 694
gi 4426593   354 LPVLIVMnndg-----hlstHRITLHe-------gVTGVGSDSQmsnf------sqhNIYLD--GPDIRGRHAAIAFMe- 412
gi 1399466   312 TYPILRIlsdrihrveskiyDLGALRsp------lPWDLGRHSKs------------TIQVS--HSSVSTNHLLIVNIke 371
gi 465488      1 MWVVRYQntled---gsisfISCCLQaf------kTYSIGRSSKn-----------pLIIKN--DKSISRQHITFKWE-- 56
gi 7430355     8 RPYIIVTnqg-------qslPPFELTk-------sKHILGRDSQf-----------aDLIVPtdWSIISRCQATLVEDqg 62
gi 19744177   13 VTCLQMTiyhpgq--qsgifKSIRFCskekfpsieVVKFGRNSNm-----------cQYTFQ--DKQVSRIQFVLQPFkq 77
gi 15837873   94 MLVIGIQaeppdd-aiatldRNCLVLrg-----vgGRHYGRSFTletprivgqeagvDIWID--DPFFAARHAVFERHg- 164
gi 6320709    73 KSALSSPskqek---vlagpIEIELDasd----psRLAIGRKKSv-----------cNIILPc-RKNISRQHAFISYAad 133
gi 6323212    93 SSKLSSPsrh-------trvINAELDpsk----isTITVGRNSSqc----------dVALCK--NKFISRVHASITYLpq 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                             ## #                                       
1FHR_A        59 avgksm--------------yespaqglDDIWYCHTGTN-VSYLNNNRMIq-------------gTKFLLQd-gDEIKII 109
gi 2555105   695 ---------------------------gGKLYVIPGSEDfETYVNGELLKd--------------RRQLFHg--DRLVIG 731
gi 4426593   413 ----------------------------GVVTLTPSTRDaYLEVNGHQLM---------------QTEILRd-gDHIRIG 448
gi 1399466   372 hdqvaqelkyksntshkfdesspiekdwGIGVIDLGSSI-GTMLKIQPKHrla----------tdEVIHLA---DRVEII 437
gi 465488     57 ----------------------------INNSSDLKHSS-LCLVNKGKLTslnkkfmkvgetftiNASDVLk-sTIIELG 106
gi 7430355    63 n------------------------yfiYDGDRLNPSSN-KLFINHHLITh-------------dIGYPLQn-gDVIKIG 103
gi 19744177   78 fn-----------------------ssvLSFEIKNMSKKtSLMVDNQELGy-------------lNKMDLPy-kCMLRFG 120
gi 15837873  165 ---------------------------nRVLLRDLGSEE-GSVVNGCKVRdawlqagdqivldgqHRFVLEs-pLFLLLP 215
gi 6320709   134 ---------------------------rNEIKLECNGTN-GLSVHLPYSMql------------hLVKPFPt-rNFYKLV 172
gi 6323212   150 ---------------------------tNEVKIHCFSMN-GLIVTYRKQFdc-----------yqLKDTMNnnnRAYRLV 190

                        170       180       190
                 ....*....|....*....|....*....|.
Feature 1                                       
1FHR_A       110 wdkn----------------nkfVIGFKVEI 124
gi 2555105   732 g----------------------SHYFRISN 740
gi 4426593   449 a----------------------DHSFKFST 457
gi 1399466   438 vkirkieei------tnednlngDSRILINE 462
gi 465488    107 t---------------------tPIRIEFEW 116
gi 7430355   104 qni------------------niLITIKYFT 116
gi 19744177  121 -----------------------EYQFLLQK 128
gi 15837873  216 lscs----------------mseDVAVPLPP 230
gi 6320709   173 aeepltsqntkqshgktlqknqnFISFVLAK 203
gi 6323212   191 prfsnekcv------keiqdeggFINFTLEE 215

Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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Click on image for an interactive view with Cn3D
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D