Conserved Protein Domain Family
Med23

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pfam11573: Med23 
Mediator complex subunit 23
Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.
Statistics
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PSSM-Id: 288430
View PSSM: pfam11573
Aligned: 16 rows
Threshold Bit Score: 1575.82
Threshold Setting Gi: 2498975
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam11573 is a member of the superfamily cl18592.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121987747    1 METQIIDTVNDFlkvdsIDEAFGSVIVFKPNge----edKAKNFSNDLVTAFGNVAQEHREHVLRLYLLRAASASSY-HM 75
gi 121954381    3 TDTQIIKLVEEI-----LCEKTNDYDYEGPMpdeaelqkRAEDGMKKFATVFAGMSQEVKENALRSCLIHVAGINHRnKV 77
gi 347595793   27 EVNRVKSQIKSLienntTLRFFKPLTSNLGD--------VTAILRISFNNMMSKMEEKEKQSLVKELIKLVHHVAEKnTQ 98
gi 158706146    1 METQLQSIFEEVvkteiIEEAFPGMFMDTPEde----ktKLISCLAAFRQFWNGLSQESHEQCVQWIVKFIHGQHSPkRI 76
gi 242019825    4 TETQITNIVNEIlkvegMEEAFSCFLVHRPDfe----neKMEQFRSELQIALNNVVPEQQEAGVRQFLLLAANMTNPsRL 79
gi 645035686    3 NESQIVNILNDIlkveaIEEAFSCIIVHNTNne----kaKITGWQTEMTNAMMGLTTEQQENAIRKFLYTSAEITNYrRM 78
gi 357616355    2 TDSQVANIVNEIlrveaVEEAFSCFLVYKPEqe----seRLSIYQKKLCSIMSSPSAEVQESAIRQYLTLTAVLTNRyKM 77
gi 158295231    3 aDLRIVKLFEEVvedknIVPNF------DEEeq----rkKTEEGYKKIGTLFGAMAPESKEAAIRNYLGYVASVNHQnRV 72
gi 321478574    4 dgSKVQALVSEAlkvdaIEEAFNDFLIQRKDeg-----iKYSALEKDLIAMMNDSQAESQDAILPQFIAVISGVSSDsHS 78
gi 699241523    3 vESQLEAVFGKAlntdiIVEVFTGFVSLANLdh----tkRLKTCIKDFRTLYNSQSTEEHVTSITLLIKFIHKQQHPrRI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121987747   76 RVMM----------AALVKLVDAHVITAWMLCDKVLMCEKLDYEHKtFWIESFRLIKKVIMQVDYKGVREIMKVCRD-KA 144
gi 121954381   78 RKHM----------QVLKDLVGKGIIPARLLCEQIMSSEKLVYQNQsFWIECFQVVRRVIGGVDYKGVREIMKCCKE-KA 146
gi 347595793   99 DKVFiaasyervvdELLRYANQKEVISTTLCVEGLIMTSDFRMCSR-IDQEKWKFIKECIPKIDYKGIRTIIRYILEsQL 177
gi 158706146   77 SFLY----------DCLAMAVETGLLPPRMVCESLINSDTLEWERTqLWALTFKLVRKIIGGVDYKGVRDLLKVILE-KI 145
gi 242019825   80 QFLL----------QLLEGAVQSNIVSARLVCECILSCDKLSLNNQdFWVQCFQLMRKIIVGVDYKGVREIMKGCRE-KA 148
gi 645035686   79 HLIL----------TLLEKLVSNNVLPARLVCECILSCDKLKYQNEeFWIKCFTLVRHIIGGVDYKGVRDVLKACRE-KA 147
gi 357616355   78 KQLL----------GLLENLVNTNILQARMLCDCILTSEKLVYKNSdYWIECFNLVRRVIGGVDYKGVREIMKGCRE-KA 146
gi 158295231   73 HNYL----------QVMNRMVALNIIPAKLLCDQLMCSEKLVYKNPcFWIEAFRLIRKVIGGVDYKGVREIMKCCKE-KA 141
gi 321478574   79 KILF----------KLLESVVNTNIATSRKVCDSLLGNEKLTPANPlLWQGSFSLIRKIVCHVDYKGVREIMKTCLE-KA 147
gi 699241523   79 SFMF----------DFLETCIQDGFLLPRPVLDQLQGAE-LVHTNRlHWCRTYEVIRKFVHMVDYKGCRNLLHSMVL-KM 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121987747  145 QWFPLNVNVTYMPQLLAVEEILRFLFDRNNCLLPAYFVANEIMRP-FPYh-----wKLNKLMTDFVEEFRTTAQMVSIIG 218
gi 121954381  147 LSFPSGISSSILPQMLELTEVIEHIFNRNACLLPAYFIINEIQKAdYQDth----wRIANLIANFIEEFVIVAQMLSIIG 222
gi 347595793  178 RRLPYQLSPEKVNELRRVEDVLLKIVDRDLNLMPPLITLSEVMRGtPKQahm--fpRLTEKLANLSSHFRPIADLTHVCG 255
gi 158706146  146 LTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKL-YPEgkl-phwLLGNLVSDFVDTFRPTARINSICG 223
gi 242019825  149 AVIPAKLNAAQMPQITALESVMEFIFDRNACLLPAYFIVNEIQKA-YPEnknwphwKLANLLSGFVESFRPCAQMVSIVG 227
gi 645035686  148 HSLPTRLDASVQPQMKALENLVEYIFDRNACLIPSYLIIDELEKN--AEnkiw-phwLAKLISNFVTSFRNVVQIVSIIG 224
gi 357616355  147 QTLPVRLNSSTMPQMRALCNVIEYIFDRNASLLPAYFIVTEIQKD-YPDnnhwphwQLAKLLTTFVESFKPCAQMVSIIG 225
gi 158295231  142 LSFPASVSVNILPQLLELVELIEHIFNRNACLLPAYFIINEIKKT-DYQnm---hwRVSNLTANFIEEFVSVAQMLSIIG 217
gi 321478574  148 QLLPSRFSTSEYPNVTALEHTLKHILDRQVCLLPAYFIVNEIRKM-YPEnkdwphwKLAGLLSEVVDSFRPLVQMLSPIG 226
gi 699241523  147 TQIPQSVWIEEKQQVDAICSTIQLLLDPEACLLPGYLAVNEIRQN-MQDdlldapwPLLGKLTEFIDRFRATATMVSTTA 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121987747  219 HANMLPIVEHFGYAdHMMNSWR---LDHNTLKFNFKGSLPYEPELL-EEQRPLLRYVLEQPYSREmvsqmlNLQKHQKQR 294
gi 121954381  223 HSSMLPIVEHSSYAdNLINPWK---LDPTTLKLALRGNLPYEPELL-QPQIKLLRFVLEQPYSRDmvcsmlNLQKTQKQK 298
gi 347595793  256 RPFIYPIPFHPAFH-PPTSYWEdfgMNAQSPYTQSHHMLPYRPQHKaASCLYTFYMILRQPLGKD------SLNPTNRNK 328
gi 158706146  224 RCSLLPVVNNSG---AICNSWK---LDPATLRFPLKGLLPYDKDLF-EPQTALLRYVLEQPYSRDmvcnmlGLNKQHKQR 296
gi 242019825  228 HSKLLPVVEHSGYAdHL-SPWK---LDPTTLKFTLKGILPYDRELS-EPQTGLLRYVLEQPYSRDmvccmlGLVKQHKQR 302
gi 645035686  225 HSKMLPVVEHTGYGdHSVTPWV---LDRNTLQFTLKGNLPYDPELL-KPQTDLLRYVLEQPYSRDmvcsmlGLQNKQNTR 300
gi 357616355  226 HSQMLPVVEFSGYAdHLVNPWR---LDPTTLKFSLKGNLPYDDELL-KPQISLLRHVLQQPYSRDmmcsmlGLQKQHKQR 301
gi 158295231  218 HSAMLPIVEHSSYAdNLIIPWK---LDPDTLKLSLRGNLPYDEELL-QPQARLLRFVLQQPYSRDmvcsmlNFQKQQKQK 293
gi 321478574  227 RPLMFPVVDPSAHGvH--HSWK---LEQGTLKLALKGNLPYEKEYT-EPQTRLIRYVLEQPYSREvlcgmlGLQKQHKQR 300
gi 699241523  226 RWMLLPVVDHAFY--QLPSTWK---LEADTLRFQLKKQLPYRPEMY-QRQHRLLNYILDQTYSRDmvlqvlGMQKHQKQR 299
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121987747  295 YNALEEQLVNLIIH-AMEMTEsndttags------gfnssdeqITSNEWVWLHLSSQLIYFV---LFQFVSFMHIVLSLH 364
gi 121954381  299 CMALEEQLVWLVMC-AMECSEkepvht-----------vdgeiSSHTQWVWLHLSSQLIYFV---LFQFATFQNIVNTLH 363
gi 347595793  329 TKSHWEPLLSVMIVeAMAETEalp-----------------egKQIPRYQWDNITNLVMYGMshlLVNPKNFFHYLKGLI 391
gi 158706146  297 CPVLEDQLVDLVVY-AMERSEteek---------------fddGGTSQLLWQHLSSQLIFFV---LFQFASFPHMVLSLH 357
gi 242019825  303 CVALEEQLVALVVV-AMERSEte-------------------tGDSSHWLWLHLSSQLIYFV---LFQFASFPNIVMALH 359
gi 645035686  301 CAALEEQLVDLVIR-TMEKSEneptpv-----------egvdgVTTNHWPWLHLSSQIICHV---LSQFASFPSFVTAIH 365
gi 357616355  302 CIALEDQLVELMIL-PMERSEqene---------------ddeMPSTHWCWLHLSSQVIYLI---LIGFASFPSIVMGLH 362
gi 158295231  294 CAALEEQLVWLVLN-AMECSEkeaaqggqgaaggtgmnehegdQSHTQWIWLHLSSQLIYFV---LFQFATFQNIVNTLH 369
gi 321478574  301 HAVLEEQLVELLVQ-AMERAEiapeqd----------sdaadeLGVSHWLWHHLSSQIIYFV---LFQFASFSHLVTLLH 366
gi 699241523  300 CEALEMGLVDLMFS-TVKKCstf-----------------edkSNIQHLMWQHVACQVIYFV---LYQLASFPHIVEDLH 358
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121987747  365 EKLSkl------eLRKGRDQLMWILLQFISGSIQKNPITNFLP-VFRLFDLLYPEQE-PLKLPDiNKSSMVRQMAPICVW 436
gi 121954381  364 DKLAvs------nLRRGRDHLMWVLLQYISGSIQRNSITNFLP-ILKLYDSLYPEKE-PLPVPDyNNPLCTHQMAPTCIW 435
gi 347595793  392 NQCK---------YTRARDEVMWIVFQVVSSLHKMIKIEDAVQeIVDLYNELFDGEFsWHGASD-HPARMARFLAAASTW 461
gi 158706146  358 QKLAgr------gLIKGRDHLMWVLLQFISGSIQKNALADFLP-VMKLFDLLYPEKE-CIPVPDiNKPQSTHAFAMTCIW 429
gi 242019825  360 DKLSgr------dLKKGRDHLMWVLLQFISGSIQRNPLSNFLP-VLKLYDLLYPEKE-PLPVPDvNKAVCTHQMAMTCIW 431
gi 645035686  366 EKLAgr------eWKKSRDHLMWVLLQFISGSIQRKPIAVFFP-IFKLYDLLYPEKD-PLPVPDlTQSICAHQMACVSIW 437
gi 357616355  363 NKLVgc------dLKKGRDHLMWVLLQFISGSIQRNPLSNFLP-IIKLHELLYPEKE-ALPMPDyTKAHCTHQMAVVCIW 434
gi 158295231  370 EKLAvr------nLRRGRDHLMWVFLQYISGSIQKHSILNFLP-ILKLYDILYPEKE-PLPVPDnNNPNCTHQMAPTCIW 441
gi 321478574  367 EKLAer------kLRKGRDQLMWVLLQYISGSIQKNPLAEFLP-LLRLYDLLYPERE-PLPVPDyTRPICVHQMAVACIW 438
gi 699241523  359 TKLAaseelrdqcIQGGRDYIMWVLLQFISGSIQKNPLSDFLS-VIKLVNLLYPEKQ-PLELPEmKSHSCTISFAAVCNL 436
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121987747  437 IHLMKKARVEnm-------niTRPLPIALKNHHDFLQHLVSPNTMMNMTLgndfrIILVCNAYSTNQEYFGRPMGLLLEA 509
gi 121954381  436 IHLLKRAQSEhy-------niNRSIPTALKLHHEFLQHLVMPNNNATLCMgsdyrLALLCNAYSTNPDYFSRPMAALIET 508
gi 347595793  462 MLLEKNKAHKqn-------------tDTIKSHIKVIHEAALNFDPKNMGM-----LAVLANAFKSDTRIGAQIVPAMSEA 523
gi 158706146  430 IHLNRKAQNDns-------klQIPIPHSLKLHHEFLQQ-SLRNKS--LQMnd-ykIALLCNAYSTNSECFTLPMGALVET 498
gi 242019825  432 IHLLKKAQADhl-------niQRPIPLTLKIHHEFLQHLVQPNNSLGLCMgadyrIALLCNAYSTNQEYFTRPMAALVET 504
gi 645035686  438 LHLVKKIHPDht-------nfHKLIPYNLKTHHEFLQHMAVQNTP--LSMgsdykIALLCNAYSTSNELFSRPMSVLVES 508
gi 357616355  435 MHLLKKAESEhk-------tmI--MPQNLKVQYEFLQHLMTSNNTPTL-MgadyrIALLCNAYSTNQEYYARPMGIIIET 504
gi 158295231  442 IHLMKRAQTEny-------niNRPVPIALRLHFEYLQHLAMPSNNPTLFMgseyrFALLCNAYSTQTDYFSRPMQALIDT 514
gi 321478574  439 IHIVKKAQTEqq-------klQRHFPQALKNHQEFLQHNALNPPSS--APsgdyrVALLCNAFSTTLDCLARPMGSLMES 509
gi 699241523  437 VHLNRKAQAKppsdgnqdrnqQWNIPVALHNQHECIKQ-CLKTTSINLKds---qVALISNACSSNTEMFNMAVSVLVES 512
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121987747  510 LNGTSKspng------------aqiPAVNF----------------SVAVLDSLTVHSKMSLIHSFVTQMLKQAQTKGqv 561
gi 121954381  509 ILGNCKnpsagggs----tsatqplPTVPL----------------SMSVLDSLTIHSKMSLIHSIVTHMIKQAQSKTtv 568
gi 347595793  524 LNTPPD-------------------PSQPTfdlsyqrkavnqfdafPKEFLDALTSRAKRSLLGQILSVFRSFGTDKLp- 583
gi 158706146  499 IYGNGImrvplpg-----tsclasaSVTPL----------------PMNLLDSLTVHAKMSLIHSIATRVIKLAHTKSsv 557
gi 242019825  505 ILGAQKsssl------------ppgPTTPL----------------SMAILDSLTVHSKMSLIHSIVTHVVKQAQSKSil 556
gi 645035686  509 VLGTQKnqqqqplqnlqnnsalsnsPTAPL----------------PMSILDSLTVHVKMSLIHSILTHVAKSASTKSnl 572
gi 357616355  505 LFGNQKpmpngn--------paaplPTVPL----------------SMCILDSLTLHCKMSLIHSIVTHVAKLAQNKTti 560
gi 158295231  515 ILGNSKnpqanmv------gggqplPTAPL----------------SMRVLDSLTIHSKMSLIHSIVMHMIKQAQNKSsi 572
gi 321478574  510 LHGNLSqkgsgnagg-saggmpntgPISPI----------------PLAFLDALTVHAKMSLIHSIVTHVIKCAQTKMnv 572
gi 699241523  513 VFGDTSstspmpg-----nncvafnKTVPC----------------SMDLLDTLTVHTKMSMLHSISTKIQKFAQAKSsv 571
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121987747  562 -----pAAALLETYARL-------LVYTEIESLGVKGF----LSQLMPTVFKNHAWAMLHTLMEMFSYRLHHVPTHYRvq 625
gi 121954381  569 pntnnmAPALVETYSRL-------LVYTEIESLGIKGF----LGQLLPQVFKSAAWGILYTLLEMFSYRMHHIQPHYRvq 637
gi 347595793  584 ------SPAAFETLARIcqsedyeMAVKDLESLASRSLhistQERAADIATNNQAKDQCHFLFDFLAYRLPHVHSYGK-- 655
gi 158706146  558 ----alAPALVETYSRL-------LVYMEIESLGIKGF----ISQLLPTVFKSHAWGILHTLLEMFSHRMHHIQPHYRvq 622
gi 242019825  557 ----alAPALVETYSRL-------LVYTEIESLGIKGF----ISHLLPTVFKHHAWGILYTLLEMFSYRMHHIQPHYRvq 621
gi 645035686  573 ----plPPALVETYSRL-------LVYTEIENIGIKKF----ISHLLPTVFKAHAWGILYTLLDMFSYRMHHIQPTYRvq 637
gi 357616355  561 pgsnmmAPALVETYSRL-------LVYTEIESLGIKGF----INQLLPNVFKSHAWGILHNLLDMFSYRIHHIQPHYRvt 629
gi 158295231  573 pngnnmAPALVETYSRL-------LVYTEIESLGIKGF----LGQLLPQVFKSQAWGILYTLLEMFSYRMHHIHSHYRvq 641
gi 321478574  573 ----plAPALVETYSRL-------LVYTEIESLGIKGF----ITQVMTSVSKSQAWGIFHTLVEMFTFRVHHMQPQYRiq 637
gi 699241523  572 ----glAPALVETYSRL-------LIYYEIETLGIKIL----VSQVVPKVYEYRAWGILNTLLELMSYRMHHIQPNYRiq 636
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121987747  626 LLSLLHSL---------SSVPQTNkmQLNLCFESTGLRLI-------------TSIGSAEFQPQ---FSRYFND-KSPgA 679
gi 121954381  638 LLSHLHSL---------ASVPHTNqmQLHSCVESTALRLI-------------TGLGSVEVQAQ---MSRYVTEqKAPgN 692
gi 347595793  656 YTSTTGSLllyftasvaPNTPQNH--QVYRLLEQALLRRMywrtfhesvinhsQLFGSSYKENSnnvMLRHLKNpKTFsT 733
gi 158706146  623 LLSHLHTL---------AAVAQTNqnQLHLCVESTALRLI-------------TALGSSEVQPQ---FTRFLNDpKT--- 674
gi 242019825  622 LLSHLHSL---------AAVPQTNqtQLHLCVESTALRLI-------------TGLGSAEVQPQ---LSRFLNEpKT--- 673
gi 645035686  638 ILSHLHSL---------ASVPQTNqtQLHLCVESTALRLI-------------TGLGSAEVQPH---LSKFLSEpKT--- 689
gi 357616355  630 LLSNINSL---------AAYPQANqtQLQLCFESTALRLI-------------TSLGSSGVQLQ---MSRVVSEpKSc-V 683
gi 158295231  642 LLTHLHSL---------ASVPHTNqmQLHSCVESTALRLI-------------IGLGSVEVQAQ---LSRYVSEpKPpgN 696
gi 321478574  638 LLTLLHSC---------A-VPQQHqtQLILCVENAALRLI-------------GLLGAAEMQPC---YSRSAADiKP--- 688
gi 699241523  637 LLTHLHTL---------ANSPHANqrQLHLRLESTALKLI-------------MGFDNFGIKPQ---LVRMFNEqKQ--S 689
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121987747  680 VASNESEELN----RVLILTLARSMHVHGggdemq-----swckdfLANIMQHTPH-------SWSLQSLACFPPALNEY 743
gi 121954381  693 IVSAESEELN----RALILTLARSMQITGtgndpqs---ttwckelLNSIMQNTPH-------TWSQHTLQCFPPVLNDL 758
gi 347595793  734 PVDQWQFPLNpeifKMTIYAFMRALKITG-----------------QEIPLDGTMHpihvagyGWPEKSTTFFPKWALEE 796
gi 158706146  675 VLSAESEELN----RALILTLARATHVTDfftgsdsi-qgtwckdiLQTIMTFTPH-------NWASHTLSCFPAPLQAF 742
gi 242019825  674 LVSAESEELN----RALVLTLARSMHVTGtgsdsis---gtwckelLSTIMQNTPH-------SWANHTLQCFPLALHDF 739
gi 645035686  690 LVSADSEELN----RALVLTIARSMHITGtggdtnrdvnsiwckdlLNTIMQNTPH-------SWAEHTLRCFPPALSEF 758
gi 357616355  684 VVSSESEELN----RVLVLTLARGIYMTGtgndga------avkeiLTTIMTNTPH-------MWSQHTLQCFPPVLVEF 746
gi 158295231  697 IVSGESEELN----RALILTLARSMHITGtgndpqs---sawckdlLQNIMVNTPH-------AWPQHTLYCFPPVLNEF 762
gi 321478574  689 LFSSDSEELN----RALILTLARVISVAGcetqhs-----swykdlLTLIQQQTPH-------SWSSNTRDCFPPPLAEF 752
gi 699241523  690 IVSQKSEELN----RVLVLTLARSIHITGaesisg-----swctdiLKAVMSATPH-------RWPQQTLACFPQSIQDF 753
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121987747  744 FTQ--NAQPPE--NKQQLKKSVEEEYRTWTSMTs---------------ENDIIAHF---LRP-TTNPLFLCLL---FKI 797
gi 121954381  759 VVQ--HNVPKE--NKQLLKKSVDEEYRNWTSMSn---------------ENDIIGHFgtaGTP-GTPPLFLCLL---FKM 815
gi 347595793  797 IKK--TDVKKLapNYAEILSTTDEAFRMNTLLT----------------GGQYVIRY---ADD-PNPITYHCMLaviFKQ 854
gi 158706146  743 FKQ--NNVPQE--SRFNLKKNVEEEYRKWKSMTd---------------ENEIITQF---SMQ-GFPPLFLCLL---WKM 796
gi 242019825  740 FQH--SPVQKE--NKPQLKKAVEEEYRNWASMNn---------------ENDIIAHF---SVA-GTPPLFICLL---WKM 793
gi 645035686  759 FQQ--NSIPKE--EKQQIKKAVEEEYRNWASMSn---------------ENDIIAHF---SVP-NSAPLFLCLI---WKM 812
gi 357616355  747 FSQ--NPAPKE--NKQLLKKSVEEEYRKWTSMAn---------------DNDIISHF---SVP-GTP-LFLCLL---WKM 799
gi 158295231  763 FMQ--HNIPKE--SKQLLKKTVDEEYRNWASMTn---------------ENDIIAHF---GMT-VNPPLFLCLV---FKM 816
gi 321478574  753 FGQaaNQPVKE--SKQQLKQNIEEEHRKVLTMn----------------PDDWPAHF---APQsNNPPFFLCLL---WKQ 808
gi 699241523  754 FNH--SNVEPL--NKKQLKTNVEQEYIKWAPLLsadgmdsssssgssltEADALNHF---SQP-GTPPYYLCLL---WKV 822
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121987747  798 IWET--ESISPVAYKILEGISARALTTHLRKFCDYLVAEVa-S-SSDGRDFIHKCVDTINNMIWKFNVVTIDRVVLCLAL 873
gi 121954381  816 IVET--DTISPVAYKILERIGARALSAHLRKLCDYLVFEV--S-NSGDGAHVNKCVDTINDMIWKYNIITIDRLVLCLSL 890
gi 347595793  855 LCSKpeQDLTSEYYQVMEKKSPKDIVVMGNYLVDFIIADVknN-QDCNEQTFKTIAKTAALMCFHFNIHRADRFLLSLIM 933
gi 158706146  797 LLET--DHISQIGYKVLERIGARALVAHVRTFADFLVYEF--S-TSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAM 871
gi 242019825  794 ILET--DRITSIAYKILERIGARALSAHLRKFCDYLVFEF--A-NSRGEQHVNKCVDALNDMIWKYNIVTIDRLVLCLAL 868
gi 645035686  813 ILET--DRVNPIVYKILERIGARALSAHVRKFCDYIVFEV--SsTAADGIYVNKSVDAINHMIWKYNIVTFDRLVLCLAL 888
gi 357616355  800 IFET--NRINPIAFKILERIGARALSAHLRKFCDYLVFEV--T-NPAGGPHINKCVDAINDIIWKYNIVTIDRLVLCLVL 874
gi 158295231  817 IIET--DGISPVAYKILERIGARALSTHLRKMCDYLLFEV--A-NSGGGAHVNKCVDTINDMIWKYNIITIDRLVLCLIL 891
gi 321478574  809 LLET--ERINPVAYKCIERIGARGLGSHLRTFCDFLVYEF--A-NSGKGQHVNKCIDVLNEMVWQYNVVTIERLVLCLAL 883
gi 699241523  823 LFEE--KKLSSTSYKVLERIGASQLSQHVRKFSDFLVYEF--S-VLEGGSDVKICANVLQDMVWKYNIVFLDRLILCLAL 897
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121987747  874 RTH-EGNEAQVCFLIIQLLLLkASELRNRVQEFCKd-NNPDHWKQSNWQDKHLS-FHQKYPEKFA-LDE----------- 938
gi 121954381  891 RTL-EGNEAQVSFCIIQLLLLkTSEFRNRLQEFVSi-NSPEHWKQNNWHERHLA-FHQKFPEKFT-PDE----------- 955
gi 347595793  934 HPS-TDEDAQICIQIANEFLL-TPKFQERIKWFYEn-DVPRKEKDPYEYIKAIVkYHDAFPEFEA-CQLvpk-------- 1001
gi 158706146  872 RSH-EGNEAQVCYFIIQLLLLkPNDFRNRVSDFVKe-NSPEHWLQSDWHTKHMS-YHKKYPEKLY-FEGlaeqv------ 941
gi 242019825  869 RTQ-EGSEAQVCFFIIQLLLLkAAELRNRVQDFVKe-NSPEHWKQSNWHEKHLA-FHRKYPEKFA-PEGileq------- 937
gi 645035686  889 RTL-EGNEAQVCFFIIQLLLLkATEFRNRVVEFVKe-NSPDHWKQSNWHEKHLA-FHKKFPEKFA-PEGmmdq------- 957
gi 357616355  875 RPNpDGNESQVCLYIIQLLLLkGSELRNRAQDFVKe-NSPEHWKQNNWYERHSA-FHRKYPEKFA-PEEtsg-------- 943
gi 158295231  892 RTL-DGNEAQVSFYIIQLLLLkTTEFRNRVQEFITi-NSPEHWKQNNWHERHLA-FHQKFPEKFA-PDE----------- 956
gi 321478574  884 RPL-EGNEAQVCCFIIQLLLLkTPQFRSRVQDFVKd-NSSEHWRQNNWHEKHLA-FQRKFPERFGpPESvles------- 953
gi 699241523  898 RSS-EANDVQVAFFIIQYLLIkPDDFLNRVRSFDHdvENLDHWMQDDWHAKHMA-YHQKFPEHYF-FEGlvahcsspeqp 974
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121987747  939 -----SASHLALPVYFSNVCLRFLPVLDVVVHRFIEltipNVHQILGFILDHLSILYKFHDRPITYLYNTLhYYERILRE 1013
gi 121954381  956 -----SVSHPSLPVYFGNVCLRFLPVLDITIHRYLEvp-aAMSKTLDVLLDHLGPLYKFHDRPITYLYNTLhYYERMLRD 1029
gi 347595793 1002 --nddTGTNVHMPTYYGCLIERLLPILDQYVYVALEq---QGYKMSNALLQLVSMFYRYHPMPIHFMYSVL-FVSHGKMA 1075
gi 158706146  942 -dppvPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLEl--lPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLhYYEMCLRN 1018
gi 242019825  938 -sggaSSPYHSLPVYFGNVCLRFLPVFDIVIHRYLEl--pPVTKSLETLLEHLGCLYKFHDRPVTYLYNTLhYYDRNLRD 1014
gi 645035686  958 -ssgsPNQYQSFPAYFGNVCLRFLPVLDIVMHRYLEv--pQVTKSLEVLLDHLGCLYRFHDRPVTYLYNTLhYYERKLRD 1034
gi 357616355  944 --aygG----PIPVYLSNVCLRFIPVLDIVVHRHLEi--pQVSKNLEQLLEHLGYLYKFHDRPVTFLYNTLhYYESKLRD 1015
gi 158295231  957 -----SVSHPSLPVYFGNVCLRFLPVLDIIVHRYLEvp-tQLSKTLDVILDHLGSLYKFHDRPITYLYNTLhYYERKLRD 1030
gi 321478574  954 --igqGGSYQSLPTYFGNVCLRFLPVFDITIHRFTEi--pPVTKSLETILEHLGCLYKFHDRPVTYLYTTLhYYERKLRD 1029
gi 699241523  975 natgeKPQPTYLPTYFCNITLRFLPVLDIVIHRCLEl--pPSSKSLETLLEHLGLLYKFHDQPVTYLFNTLhYYESKLRG 1052
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121987747 1014 RPPLKkKLVSTITGAFSDIRppnwsVSEPYKVFl-Q-NQDLLwnpe---lsyyMNLIKRLSETISG-K--N--VFYTTDW 1083
gi 121954381 1030 RPQLKkRLVGTVIGSLKDVRpdnwaVTEQYQSY--M-SKKDDavnwmpdlnyyIYLVRRMQDTIDG-T--N--IFPGTDW 1101
gi 347595793 1076 GPDAK-SFVSAFASQIEECH-----LTEEFEKYnhQ-KSSCEel--------iMELLDRMAASLDF-Vl-TppTFVAKDW 1138
gi 158706146 1019 RDHLKrKLVHAIIGSLKDNRpqgwcLSDTYLKHa-M-NAREDnpwvp-edsyyCKLIGRLVDTMAG-K--SpgPFPNCDW 1092
gi 242019825 1015 RPVLKrRLVAAILGALKDIRppgwsLSEAYINYm-S-GSGDEvswlp-dldyyIKLIRRIVETMNGsK--A--HFPSTDW 1087
gi 645035686 1035 QHFLKrRLVTAILGSLKEIRapgwaLSEAYQRYt-A-RSTDDvkwqp-eldyyVRLVQRLVETISG-R--A--QFPSTDW 1106
gi 357616355 1016 KPLLKrKLVTAVLGSLKEVRapgwaTTEAFQTFl-G-SETEawspd---lnyyLSLINRMVDTMMG-S--S--HFPNTDW 1085
gi 158295231 1031 RPQLKkRLVGTVVGSLKDVRpenwaLTEAYQAYm-MtKESDNvnwvp-elsyyINLVRRMQDTMDG-K--N--IFAGTDW 1103
gi 321478574 1030 RPLLKrKLVSSIMGSLKDVRppgwaLSESYLNYs-T-RQADDlnwlp-eldyyVKLVGRLVDTTAG-R--SpfPFPAMDW 1103
gi 699241523 1053 RHLLKkKLVSTIIGAITKNKppgwiLSETFMDYl-Q-QPNDQqwqpd--svyyCQLIQRLANTVGG-KmtS--SFSSRDW 1125
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121987747 1084 RFNEFPnAPAHALYVTCVELLGLPVAPALVANNLIDVIVSGYAVIPQKEih---syINAVGIVMAALPEPYWTGIYDRLK 1160
gi 121954381 1102 RFNEFPnPPAHALYVTCVELLGLPVGPQGVANSLIDVVVKGYPVIPSQSvh---nwINTIGLIMAALPESYWGVIYERLR 1178
gi 347595793 1139 RTAEMS-PGAQALYLACIELMASPHSPEKLVNAMINVMQMRPHLRPFNV-------FNLIALLLTALPSTYADALHEEFI 1210
gi 158706146 1093 RFNEFPnPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENit---awMNAIGLIITALPEPYWIVLHDRIV 1169
gi 242019825 1088 RFNEFPnPAAHALYVTCVELMAVPVSPSVVANNLLDVVTKGYSVIPWDQih---lwINSIGLVLAALPESYWSIVDDRLI 1164
gi 645035686 1107 RFNEFPnPTAHTLYVTCVELMALPVAPNVVANNLLDVVAKGYTIIPSDEih---vwINCIGIIMTALPECYWSTLHDRLV 1183
gi 357616355 1086 RFNEYPnPSAHCLYVTCVELMSLPVPPNTVGNNLLDVVTKGFVVIPANKiq---lwINAIGIIMAALPDPYWTVVHDRLL 1162
gi 158295231 1104 RFNEFPnPPAHALYVTCVELLGLPVGPSVVANSIIDVLVKGYPVVPNGVih---nwANTIGLIMAALPEAYWSVIYERMQ 1180
gi 321478574 1104 RFNEFPnASCHALYVTAVELLALPASPAIVANALMDVVLQGYNLLPVSEetpleswVNAVGLLLTYLPESYWSVLYDRIV 1183
gi 699241523 1126 RFNEFPnASSHALHVTCVEALALPLPGEQVGQALMDVVLKTQSFVEREQsl---pwLNAVALVLTALPEIYWKPLHQNIL 1202
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121987747 1161 EMLNTPNMLNWtyr--fnAFELFNFKTVREAM---LEKSYAVVLAVAHSVFHHMGVFKLAAMTRNIKEKLKPCVHTEQQL 1235
gi 121954381 1179 EVISCPQMTDWlhr--qsPFELFNFKIVREAM---LEKNYVVILAIAQSILHHSGIGQISTVTEHIKENFKPIIKTEYQL 1253
gi 347595793 1211 GVFKNGETANL-------KFEEIVFDNYDSSLllhLPNRARSINMIAQIYWTQCNMALLNPFANDQVPKLLEHVKTEKDL 1283
gi 158706146 1170 SVISSSSLTSEtew-vgyPFRLFDFTACHQSY---SEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPVVKTEFQL 1245
gi 242019825 1165 EVMTCSRMTNWpyh--nsAFQIFNFSVTHESL---LENKFSYILALAHAMWYHAGVGQISTLPVFVKEKAKTVIKTEEQF 1239
gi 645035686 1184 ETITSPGLTSWqyd-nlsPFQLFNFNLTHNSF---LENKYSYMLALAHSIWHHAGVGQITAMTRFVKERIQPVVNNEEQL 1259
gi 357616355 1163 ELITGTEMVEWtyq--htPFQLFNLTKTNECM---LENKYSLTLALAHAVWYHAGPGQIMQVPTFVKEKMSPEIRTEVQL 1237
gi 158295231 1181 EALGSKAMKEWtyr--qsPFDMFNFKIVKEAM---LDRSYVTVLAIVHSIFHHFGIGQLATITDSIKEKLKPLVHTEYQL 1255
gi 321478574 1184 ELLSGPQLSTYtyp--csPLHLFHFSTVVGQG---LDAPFVLLLAVSHAFFTHANIGQMGGLPQFVKDRLHPLIRTEEQY 1258
gi 699241523 1203 KMLQCPTLTADiepgssyPYHILSYSNQQLSF---TDMPCTRLLALTHVVWHHMSIGQLSLVSQFLKEEAKPLIETELQL 1279
                        1450      1460      1470      1480      1490      1500      1510
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 121987747 1236 LYLCHVFGPFMKRI----------ELETPN-AVAGIAILLYEILEVVDKHSgsRPLQYVDQICDFLYHIKYIHVG 1299
gi 121954381 1254 IYLCHLVGPFLNRL----------CAERSR-AVSDITLILYELLEQVDKAQpsLALKYMDPICDLLYHIKYMFIG 1317
gi 347595793 1284 WYTLRLVMPIIRRFwdswdfaktmRALRERfGPLVIMKLIIEKLGSMAESG--VEIVHEAPFCDLFYNCKYVFVG 1356
gi 158706146 1246 LYVYHLVGPFLQRF----------QQERTR-CMIEIGVAFYDMLLNVDQCS--THLNYMDPICDFLYHMKYMFTG 1307
gi 242019825 1240 LFLCHLVGPFLQRL----------NAERPR-CVLELTIELYELLEQVDKSV--LQLKYMDPICDLLYHIKYMFVG 1301
gi 645035686 1260 IFVCHLIGPTLTRM----------NIERPR-CVNDLTEILYEMLEQVNRLQ--THLKQMDPVCDLFYHIKYMFVG 1321
gi 357616355 1238 IFLCHLMGPYLQRF----------NTDLSR-AVMDITIVLYELLAHIDKSQ--THLQYIDPICDLLYHIKYMFVG 1299
gi 158295231 1256 IYLCHVVGPFLHRL----------SIERAR-AVADITLMLYELLEQVDKAQpaQPLRYMDPICDLLYHIKYMFVG 1319
gi 321478574 1259 LWLCHLIGPTLQRF----------SVDKPK-CVFDLTVELYELLEQVDKNV--AEIRMIDPICDLLYHIKYMFTG 1320
gi 699241523 1280 LYIFHLIGPYFPRF----------QLERTR-CMMDVAQLLYNILLRVSKHS--SEIHFADEIADFLYHVKYMHIG 1341
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