Conserved Protein Domain Family
TcpQ

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pfam10671: TcpQ 
Toxin co-regulated pilus biosynthesis protein Q
The toxin-coregulated pilus (TCP) of Vibrio cholerae and the soluble TcpF protein that is secreted via the TCP biogenesis apparatus are essential for intestinal colonization in the disease of cholera. TcpQ is part of an outer membrane complex of the TCP biogenesis apparatus, comprised of TcpC and TcpQ, and the TcpQ is required for proper localization of TcpC to the outer membrane. The domain is found in other Proteobacterial species apart from Vibrio.
Statistics
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PSSM-Id: 287623
View PSSM: pfam10671
Aligned: 48 rows
Threshold Bit Score: 67.2582
Threshold Setting Gi: 123164038
Created: 14-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam10671 is a member of the superfamily cl11272.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75352587   90 LTAQEGESLKNRLLDFLSNN------G--------YKMIWNSQYDVLFDNDIIYEGDEALdVVKNISDD-LSVMGIDIHM 154
gi 123587662  98 FE--NGSTLKKALSQYASNE------G--------IELYWYLSKDYVVKDHFRVDSNFTS-TLYQVGRAiNDDFENEVYT 160
gi 122971597 116 FK--AGSTLRDSIITYAQSE------G--------MQVIWELNRDFIIKHPFQIDNSIVG-SLDEIGRAiDSNFDGTVKT 178
gi 81420102  262 WRAETGTTLRGTLERWANTTdcpvggH--------WVVVWSSPTDYRIDAPLMFKGNFES-LLVQVFDL-YRQAEKPLFA 331
gi 502860180 339 WRAEPGSTLKETLTGWASKAtcsnggN--------WVVIWPVSLDYRIDAPLVFHGNFES-VLVQVFDL-YRKAEKPLFA 408
gi 740918553  83 WSATVGATLRESVTHWAQEApcqgsgQ--------WVVIWPTRLDYRIDAQLTFHGPFED-VLSQLFEL-YRQADKPLFV 152
gi 229466285  12 WRAQKGSTLKETLYLWVEQE------KclpdkkrtWSLIWDTDTNYRIDAPLSFSGTFRD-ALNGIFRL-YAKATVPLFA 83
gi 494914844  97 rifKAGSTLRSAITEYAQSE------G--------MQVIWELDQDFIVKHPFQLDDSLLA-SLKIIGNAiDANFDGEVKA 161
gi 522831352 113 rTFKEGNTLREAISQYAQAE------G--------MQVIWNLEQDFVIKHQFQLDNTVSG-SLAKIASAiDSSFEGEVKA 177
gi 503875553 111 rsfaQGTTIRTEAMKYAEQE------G--------MQLIWDLNQDFIIRQRFLSENSLVA-TLDEIAGAiDANFIPQVNV 175
                         90
                 ....*....|...
gi 75352587  155 NVYIKNNVVLVYS 167
gi 123587662 161 YLCHKQRAAVITE 173
gi 122971597 179 YVCPKQRSLVITA 191
gi 81420102  332 EVSRLQCLISVSD 344
gi 502860180 409 EANRIQCLISVSD 421
gi 740918553 153 AANRLQCLVHVDD 165
gi 229466285  84 GINTTQCLLKVDD 96
gi 494914844 162 YMCPLQRSLVITS 174
gi 522831352 178 YLCAGQRSLVVTA 190
gi 503875553 176 YFCNKKRAIVIAE 188
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