Conserved Protein Domain Family
Tmemb_185A
?
pfam10269: Tmemb_185A (this model, PSSM-Id:287271 is obsolete and has been replaced by 402059)
Transmembrane Fragile-X-F protein
This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B.
Links
?
Statistics
?
PSSM-Id: 287271
Aligned: 26 rows
Threshold Bit Score: 113.667
Created: 21-Jul-2015
Updated: 5-Aug-2015
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q94K50        35 LKLDHVVSHSWWFVFAPLWLFHA---VIARGRF-------SLPApSMPHDRHWAPFHSVMAT----PLLVAFEILLCVHL 100 thale cress
Q9U2T2        33 LKLDGKVSFSYAFVFAPLWACNL---LVFVGAIvgicsfcSKPP-SRNEIVMRVDFSAMLITatehIFLCTFVSLVFIKL 108 Caenorhabditis ...
Q05AZ1        30 LRLDNIIQWSYWAVFAPIWLWKL---MVIVGASvgtgvwaRNPQ-YRAEGETCVEFKAMLIAvgihLLLLMFEVLVCDRI 105 western clawed ...
Q86KX9       120 VKTKGAVDWSWAKVFSPAWIIMS---LVIVFTAflailskKLTF---------------FIWaahnLFIMTFMGLLVSKL 181 Dictyostelium d...
Q4D9L8       117 VRLDYNKGWPWAAVFAPVWVALVpllLIGGLLVfhgvtrrEIAS-----------------------TLLGLMCFLVTFA 173 Trypanosoma cruzi
XP_782890     30 LRLDETIQCSFWLVFLPLWFWKG---VVIVGAIvagvvwwKHPE-YRVEGEGYIDMKAIIIClalnSLLLIFEILACDQL 105 purple sea urchin
XP_001850518  30 LRLDDYIDWPYWVIFIPLWVWKS---IATLGAIvgaivwcRYPH-YRVEGDSYAHFKAMLISlslhLILLMFELLACDRL 105 southern house ...
XP_001892744  37 LRFDGTIELNYALVFLPLWICEF---IVFLGAIvaaisfvISPP-SLTESSLRSDFYGMILCtgehGLLILFEVLCCHKL 112 Brugia malayi
XP_003294112 121 ktksGGVSWSWAKVFSPMWILVG---ISTLLFGiiairikKLGT---------------TVIfiqhICVLLFMAFLTANL 182 Dictyostelium p...
XP_004358117 121 VKINHRVDWSWAKVFSPFWIIWG---LVVLAMIivaavsrRMRS---------------TVLmsksVAILVFGALIVANL 182 Dictyostelium f...

Q94K50       101 EDKYV------VDLKIVFLPLLAFEVAILIDNVRMCRTL--M-----PGDEETMSdeaiwet-------------lphfw 154 thale cress
Q9U2T2       109 EFDYLfepgypLPWTIVFCPLFSLSILSIGIAIWSLRHD--K-----PFEFEFFY------------------------- 156 Caenorhabditis ...
Q05AZ1       106 ERGNh------YFWLLVFMPLFFVSPVSVAACVWGFRHD--R-----SLELEILC------------------------- 147 western clawed ...
Q86KX9       182 DATTYta--ssMLWSEVFIPIYALIVTSILQ--KYEIFS--R-----EHYEKRFSspehldtctnfglghpgfilrkllr 250 Dictyostelium d...
Q4D9L8       174 VAMFVvglsgaLTWTIALAPSAAIYVFQSCFILRYLLPFqfR-----NGFAEFIPpgssvcl-------------srmyw 235 Trypanosoma cruzi
XP_782890    106 ESSNAakp-wrHPWLIVFMPLFLTSPVSIAACVWGFKHD--R-----GLELEAMC------------------------- 152 purple sea urchin
XP_001850518 106 TSGRH-------LWVLVFIPLIFGSVASVGACVWAVKHD--R-----SFELELFC------------------------- 146 southern house ...
XP_001892744 113 QANATvd---eLPWLLVFVPIFALSLLSVVVAIWAIRND--K-----SFELELFF------------------------- 157 Brugia malayi
XP_003294112 183 DGRTH------LMWAKVFIPIYILIAANMGK--KYEVFK--K-----DAYEKRFTdpeylrpvtnfglgrlgfwirsfyt 247 Dictyostelium p...
XP_004358117 183 DHAIH------IDWTVVFIPVYFLLAVNICSIIPNTIYS--RylkrlQGEKEYFNaatdyglgya------gwlyrryif 248 Dictyostelium f...

Q94K50       155 vSISMVFFIaattFTLLKL----------CGDVAalgwWDLFINF------------GIAECFAFLVCTKWSNQSIHRYs 212 thale cress
Q9U2T2       157 -AINIVQLV----FIAFKL----------DKQVD----WTWAVVFiplwvvlslaavGVLYALVLSVVLIRSRHFIPAH- 216 Caenorhabditis ...
Q05AZ1       148 -SVNILQFI----FIALRL----------DRIIT----WPWLVVCvplwilmsflclVVLYYIVWSVLFLRSMDVIAEQ- 207 western clawed ...
Q86KX9       251 dLVASWFFV----FLMLKL----------DHVVE----WNWWINSipvf----------fyiIFYLVLMALDNS--SKMn 300 Dictyostelium d...
Q4D9L8       236 gFLLETVFEklccFSFISLallraaqtggEDTSKlisfW---IVFtplily-fgcmtLVSAARRFFAGTVEGQSCLLSR- 310 Trypanosoma cruzi
XP_782890    153 -SINILQFI----FIALKL----------DEIIT----WRWGVVFiplwiltclmclIVLYYVIWSLLILRATELMAEQ- 212 purple sea urchin
XP_001850518 147 -AVNALQFV----FLPLKL----------DGFVS----WSWEVVFvplwivlclslvAVLYSIIFCGILLRTPEVSHQQ- 206 southern house ...
XP_001892744 158 -SINIVQFV----FVAFKL----------DGILD----WHWTIVFiplwvvlslsvvGVLYAFVLAVVLARSVHMLASQ- 217 Brugia malayi
XP_003294112 248 dLHACWFFV----FLILKI----------DRAVG----WTWYINSipl----------fvYIGTYFIIMFLDNSAKSKNl 299 Dictyostelium p...
XP_004358117 249 eAMEVWFIV----FLVIRL----------DRIVT----WSWWINAi----------pILVSMLIRLITIVADSKYLAKHt 300 Dictyostelium f...

Q94K50       213 hip-----epssSSMVVRYLDWNRglvvtaddehqqsnricglqdigghVMKIPFVTFQIILFMRLE------GTP---- 277 thale cress
Q9U2T2       217 ------------RRQHVYSAILHT-------------------------FFVIPALVCLVLLTGKLD------SMNwpdk 253 Caenorhabditis ...
Q05AZ1       208 ------------RRTHITMAVSWM-------------------------AIVVPLLTFEILLVHRLD------GHN---- 240 western clawed ...
Q86KX9       301 nlsmdederasnESVNSFLYCIFI-------------------------FLMIPVILFISLLAAHIS------ADR---- 345 Dictyostelium d...
Q4D9L8       311 ------------LCRALAAAMGYA-----------------------------SLLFMACMLAAKCEaeqnhkAVSlhps 349 Trypanosoma cruzi
XP_782890    213 ------------RRANFMTAVTAV-------------------------SLVAPLLTFEILLVNRLD------GIN---- 245 purple sea urchin
XP_001850518 207 ------------KKSAINSAIGNC-------------------------ATVLPILVFQVLLADKLD------NEN---- 239 southern house ...
XP_001892744 218 ------------RRQHLYSALCHT-------------------------LLVIPILVFLLLLTGKLD------AISwsdd 254 Brugia malayi
XP_003294112 300 dqi-----deedEGGHKFFVSIFC-------------------------CIMIPVIIFIGLLAAHLT------SDK---- 339 Dictyostelium p...
XP_004358117 301 qgse----seeeSSFNTFLICCYI-------------------------ILIIPIVIFLGLLVSYLN------GKG---- 341 Dictyostelium f...

Q94K50       278 ASAKNIPILVLFVPLFLL 295 thale cress
Q9U2T2       254 GSVSELSYTLAMAPLQVS 271 Caenorhabditis elegans
Q05AZ1       241 ----YFAYIPIFVPLWLS 254 western clawed frog
Q86KX9       346 -----FAIANVFIPIFIV 358 Dictyostelium discoideum
Q4D9L8       350 AAVALLPLEVTLA--LAV 365 Trypanosoma cruzi
XP_782890    246 ----DYPVSAVFCPLYIS 259 purple sea urchin
XP_001850518 240 ---LDWPFIGVAGPllls 254 southern house mosquito
XP_001892744 255 EPVSQIAFIIVCAPldla 272 Brugia malayi
XP_003294112 340 -----FLIAKIFAPIFIL 352 Dictyostelium purpureum
XP_004358117 342 -----FAIASVFIPIFIi 354 Dictyostelium fasciculatum
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap