Conserved Protein Domain Family
Nha1_C
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pfam08619: Nha1_C (this model, PSSM-Id:285783 is obsolete and has been replaced by 400785)
Alkali metal cation/H+ antiporter Nha1 C terminus
The C terminus of the plasma membrane Nha1 antiporter plays an important role in the immediate cell response to hypo-osmotic shock which prevents an execessive loss of ions and water. This domain is found with pfam00999.
Links
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Statistics
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PSSM-Id: 285783
Aligned: 56 rows
Threshold Bit Score: 195.643
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q7RXS9        460 WMNRLPRITSVSRSQ---ARN-M-S--DTEddmkmp---------efppgTL-PPTGLPGTF---------------LR- 506  Neurospora cr...
Q6BMF1        463 WMSRLQKLDKASTSFslhRID-TqA--PSTekghklq-------qsntveTSgIKVRPAGGA---------------KR- 516  Debaryomyces ...
XP_004200051  463 WMSRLQKLDKASTSFslhRVD-TqV--NKDqdnekla-------qynsieTSgVKVRPAGGAkrrkhkkkkhdssyrLRh 532  Pichia farino...
EDK37276      370 WMNRLQKLDKASTSFslhRID-T-A--VPgdeeme---------rsntieTSgVKVRPAGGAkrkrhkkkrrgaasnLK- 435  Meyerozyma gu...
XP_003684661  463 WMSRLPQLENSGRSFslqRVD-T-DapEKSgkmsems-------rsstveTSgIPVRHAGGM---------------RR- 517  Tetrapisispor...
EMG47527      464 WMQRLQKLDRANTSFslhRVDtM-A--PPDdkekvqeef---esppegpeTSgIKVRPAGGA---------------KR- 521  Candida malto...
XP_011275006  462 WMSRLPELKSNGRSFslhRIDtM-A--PSThsasasgaeagqlsqaptveTSgIPARPAGGM---------------DR- 522  Wickerhamomyc...
XP_007376714  462 WMQRLQKLDKTSTTFslhRVD-TiA--VTEkekptdeq-----gvatgveTSgIKVRPAGGA---------------KR- 517  Spathaspora p...
CCE44430      468 WMQRLQKLDRANTSFslhRVD-TmA--PDEkeeqpdeq-----eqtqlpeTSgVKVRPAGGA---------------KR- 523  Candida parap...
XP_001524316  465 WIQRLQKLDRTSSSFslqRVD-TmA--PEElqnlknka-----eqmnvpeTSgLKVRPAGGA---------------KR- 520  Lodderomyces ...

Q7RXS9        507 -----Rqkee---------dkgtG------------RHAG-SRS---SS------------------------------A 526  Neurospora cr...
Q6BMF1        517 -----R--------------------------------KH-KKK---RDprsrlkkslsra------sadseadeivpsQ 549  Debaryomyces ...
XP_004200051  533 tlsksRdqe------------esP------------V-----------S------------------------------H 547  Pichia farino...
EDK37276      436 -----Ktls------------maN------------SESD-AAS---MN------------------------------Q 452  Meyerozyma gu...
XP_003684661  518 -----Lnkd------------qrKhkhikkkrenffSKHH-KHF---PDdel------------------------ndlG 552  Tetrapisispor...
EMG47527      522 -----Rkkk------------srRskqp-----gliKKTL-SRA---TS------------------------------R 545  Candida malto...
XP_011275006  523 -----RkkkskkskkrrshlhkiH------------SHHGdSNAdttAA------------------------------D 555  Wickerhamomyc...
XP_007376714  518 -----Raq--------------lK------------KKKK-KKK---KKpahiikktlskvttggmsdeeeeeeyehktD 562  Spathaspora p...
CCE44430      524 -----R--------------------------------KK-KRR---SQkpgliqktlsr--------vtsgddekthqP 554  Candida parap...
XP_001524316  521 -----R--------------------------------TK-KKK---KHnhglllrtls----------rvrtgddqreE 549  Lodderomyces ...

Q7RXS9        527 NGRRR--RKRWDDGIGPGGPISQSAIfpqrrsqseq--------------aiasphdemSLE--------------PSDT 576  Neurospora cr...
Q6BMF1        550 RHKPQa------eFLQLGRTPSTAIRtpsdeesepesa---------vgidnskedfddSPG--------------SSNS 600  Debaryomyces ...
XP_004200051  548 RQRPQt------EILQLGKVPSAETSqqveesp-------------------ttavsgiSQE--------------SSNE 588  Pichia farino...
EDK37276      453 RQRPHt------EFLQLGRSTSNAPpdesipv---------------------seeslnSPE--------------TESP 491  Meyerozyma gu...
XP_003684661  553 RERLQleKEAAAGTFALGGIRNHAPPspvkgetvestpsee---neksyesqidngdksSHT--------------NSYQ 615  Tetrapisispor...
EMG47527      546 DEDEKr-ARPEAQFLQLGNRNANTEDeksmsefepertttneikgssssseeggaaissTTA--------------EQGE 610  Candida malto...
XP_011275006  556 IEKLQreREAKAAAFALGGPRREESQqqntnsssp----------------ddsfvqqgITPattfnekvpwptggNDEE 619  Wickerhamomyc...
XP_007376714  563 RQRPQt------eFLQLGRSNNLAPse-------------------------------tSED--------------TVEE 591  Spathaspora p...
CCE44430      555 RHRPHq------eVLQLGGGSQQQQQqqnsptk-------------------stistssEPE--------------VTAE 595  Candida parap...
XP_001524316  550 RHRPVt------eSLQLGGLGTGAGVgagaksnfssepdt------stnevkassssstESD--------------QQEK 603  Lodderomyces ...

Q7RXS9        577 AR----LSPSD-----ALTTrrrsvr---------ksekerSSDETASPyep----------sptSEQRDQELEYYDEGD 628  Neurospora cr...
Q6BMF1        601 IE----VVANE-----DQGRmvfa-------------vppyDSHGRVEQdedqdngkvsfarnamEGRKSVPSTAFQEGE 658  Debaryomyces ...
XP_004200051  589 KA----SDYSE-----ARSEkn-----------------snDIKEDESNvihdni-----ednksEYDNPVPTTAYQEGE 637  Pichia farino...
EDK37276      492 QT----GIDEK-----DNDSvpsleventgekiaiavphgsQQDAEADKvdh----------rttERKQSVATVAYQEGN 552  Meyerozyma gu...
XP_003684661  616 NS----SSVRD-----YEEKfdqdedyqi---kpiriegidDQTSQSTDerv----------aqlSQVECKPVTAYVDED 673  Tetrapisispor...
EMG47527      611 VApqvfVSPPS-----PTSDki-----------------qlSSSPPTTPkktsglseygqkqptkLEKAPVPTVAYQDGD 668  Candida malto...
XP_011275006  620 AQ----LNGSDlynetTESDek-----------------qqSSETSENNdgag---------gedYERNRRPSAAYTEGD 669  Wickerhamomyc...
XP_007376714  592 KP----SSPKE-----DTSVet------------------eETMQGGVPdktsgmkkygqrppteEEKRSIPTVAYQDGD 644  Spathaspora p...
CCE44430      596 VK----NSSSS-----TEGE-----------------------HLLDPNektsgks---qygqrsRPEVPVPTSAYQEGD 640  Candida parap...
XP_001524316  604 RA----GTTNE-----DSEEngdg--------------gdeFITSPGILekqsgkskyglhpsrtKDRERIPTAAYQEGD 660  Lodderomyces ...

Q7RXS9        629 HVIVEDREGNVL-----Av-----eSPAT--GEGQNpvealk------------------------ekleaeAGPSGWSY 672  Neurospora cr...
Q6BMF1        659 KIIIEDQAGEIIetlplKs-----lQGQP--ENE--------------------------------------DDLSIHSM 693  Debaryomyces ...
XP_004200051  638 QIIVEDQNGEIY-----Et-----lPLKG--AKKEKpkes-----------------------------anpDTMSIHSM 676  Pichia farino...
EDK37276      553 KIVIEDENGEVV-----Et-----lP---------Mkgnkaia-----------------------kaargeDNMSIHSA 590  Meyerozyma gu...
XP_003684661  674 NVIIENREGEVL-----Dhis--laRSPD--DEEAIknyhgneqtsiy------------snqnlnkltrivSNASSKSF 732  Tetrapisispor...
EMG47527      669 QVIIEDQYGEIM-----EtlkltskPDRQ--KLEEMtgeaprp-----------------------prrhsaDSGSIHSM 718  Candida malto...
XP_011275006  670 KLIIEDQHGEIL-----Dqa---nmDVPDrlKKNDSsrssrsk-----------------------ksstkrSKSPSSSI 718  Wickerhamomyc...
XP_007376714  645 QIIIEDQYGEIMdslklQq-----rAKPA--PVEPVesftn---------------------------inddDDASVHSE 690  Spathaspora p...
CCE44430      641 NIIIEDQFGEIMdnltlGk-----rGEAV--EKRRKsqssnapvsspgvasvaaaaaaddaqhegddegaegDDESIHSM 713  Candida parap...
XP_001524316  661 NLIVEDQHGEILdnlklNt-----lPVGQ--RKPVGkae------------------------------sknDDDSIHSM 703  Lodderomyces ...

Q7RXS9        673 DALKKKIQNWrdeeaakr----------------------------------------------kekekstrRSEPARAY 706  Neurospora cr...
Q6BMF1        694 NSLSRQLSKYstaqsdrtstetslntkekpnsplg------------klarssslslgrkgkrkgyykkndpKHRKVFAH 761  Debaryomyces ...
XP_004200051  677 NSLRRKLSQYskvsepfsdtedkakanvpk-----------------------kkekqkansktayhkkddpNSRLVYAH 733  Pichia farino...
EDK37276      591 ESLRRQMTQYstasnssnqsrtqtleer---------------------------lskvpsrrrafykkgdpGQRKVYAH 643  Meyerozyma gu...
XP_003684661  733 GAIKTAFSPPppdek-----------------------------------------------------rndnNKSRYYAY 759  Tetrapisispor...
EMG47527      719 ESLERHLTQYstvssgtvdsevdekdhhlgls-------------------plqkklsrtlsrrsyykkgdpNKHKVYAH 779  Candida malto...
XP_011275006  719 NSLTRKTSSIlervn-----------------------------------------------------sgnrDRPKYTAY 745  Wickerhamomyc...
XP_007376714  691 ASLQRRLSQYasadseysfndekqeqddtdlsp-----------------irkrisrsiskktkvlyrkddpHRKKVYAH 753  Spathaspora p...
CCE44430      714 GSLERQLSQYsngstiksgpsdsdttqdttggk----------------ksplhkrisrsasrrsyyrkddpHRRKVYAH 777  Candida parap...
XP_001524316  704 ESLQRRLSQYsiasdksresmkqdemragatsgatsgpekrkpsiaqsaashilpkikrtesrrtyykkddpKRRKVYAH 783  Lodderomyces ...

Q7RXS9        707 QFGTTIIVENEDGEVLKKYELpSE-KP----------------------------ENDFVSQSLKYMGIKAGDKA---Qv 754  Neurospora cr...
Q6BMF1        762 QVDNFIVIENADGDIIRRYKV-NR-HTanra--------------------rsntGNSMVGKALNFVGLK---------- 809  Debaryomyces ...
XP_004200051  734 RVDNFIFIENADGEIIRRYRV-NP-HTkaked------------------ksnqgINSVFNKAISLVGIKNKPKA---D- 789  Pichia farino...
EDK37276      644 QVDNLIIIENEDGDIVRRYRV-NK-HStnr-----------------------erSGSLMNRALSKVGIRSRQGS---T- 694  Meyerozyma gu...
XP_003684661  760 KVGDIVMIENADGEVLRRYRI-KT-KTdss-----------------------gqNENVLHKTLSKLGLKNRREAisdQ- 813  Tetrapisispor...
EMG47527      780 RIDDLIVIENEDGDIMRRYKV-NR-HTgnptttpqqqqqqadpnqptsgnktrsrSGTLMGMMKSIVGLKPSDKT---K- 853  Candida malto...
XP_011275006  746 KLDNQLIIENEDGEILRRYKI-NH-HKtvqqk------------------trsgsIAGGFGKALSAVGIK---------- 795  Wickerhamomyc...
XP_007376714  754 QVDDLIVIENEEGEIIRRYKV-NRhHSkfrnppqe------------qeggtrprSTTLVGKMKSILGFN---------- 810  Spathaspora p...
CCE44430      778 RIDNIITIENEDGDIIRRYKV-NR-HVsnppnp----------------tpnrsrSSTLVGKMKSLVGM----------- 828  Candida parap...
XP_001524316  784 RIDNLILIENEDGDIIRRYKV-NR-HAsnipk------------------pnrsrSSTLVGKMKSFVGMKDKEQQ---Q- 839  Lodderomyces ...

Q7RXS9        755 aggtaggegsatrpskptkrptwasavvgggdaSK---------KKN----AV--------EEQeeddrhirftiggvgq 813  Neurospora cr...
Q6BMF1        810 ---------------------------------KNn-------pKNN----VD--------ANDlekndienilipehdd 837  Debaryomyces ...
XP_004200051  790 ---------------------------------ENknntqqdleKNNqnvlVP--------EHD---------------- 812  Pichia farino...
EDK37276      695 ---------------------------------SAp-------ePVL----TQ--------VHD---------------- 706  Meyerozyma gu...
XP_003684661  814 ---------------------------------NLn-------kEQN----DI--------AHS---------------- 825  Tetrapisispor...
EMG47527      854 ---------------------------------SAs-------pETS----VPistlnsdlEQG---------------- 873  Candida malto...
XP_011275006  796 ----------------------------------Sn-------iGAN----KD--------ESP---------------- 806  Wickerhamomyc...
XP_007376714  811 ---------------------------------ESe-------pTSP----TT--------PTIqvsnydleqgnsnmii 838  Spathaspora p...
CCE44430      829 ---------------------------------KPn-------tTAT----AT--------ATTttntshtgastnqtpt 856  Candida parap...
XP_001524316  840 ---------------------------------QAl-------aSSL----AG--------ANGelqqqhqqqqqqqptv 867  Lodderomyces ...

Q7RXS9        814 rmnkedfiremqkldkstrkeivdqsnassa--------vkslakadltpkqlqqpqqqqpqpvqrrgspagsvksshsk 885  Neurospora cr...
Q6BMF1        838 tnnpnhplknpkfenaie-----------------------------------skltkillddrskssnflsvgnkseti 882  Debaryomyces ...
XP_004200051      --------------------------------------------------------------------------------      Pichia farino...
EDK37276          --------------------------------------------------------------------------------      Meyerozyma gu...
XP_003684661      --------------------------------------------------------------------------------      Tetrapisispor...
EMG47527          --------------------------------------------------------------------------------      Candida malto...
XP_011275006      --------------------------------------------------------------------------------      Wickerhamomyc...
XP_007376714  839 phegdegdtkl-------------------------------------------------ehklsnmlskkksppprvls 869  Spathaspora p...
CCE44430      857 npdevsqvhvtdlekgthhnilipeavrdphp-------dsakldkiedkiatiletkhqtghhsairkasppppppnrl 929  Candida parap...
XP_001524316  868 hvtdlekgthhtilvpqddeknqhsphladgldkvedkiagilesrhqhgghelvrrasppppihgdineegededgdvv 947  Lodderomyces ...

Q7RXS9        886 dsltrqGRPEK----S-------------E-------------------------MM----------------SGGS--- 904  Neurospora cr...
Q6BMF1        883 qedserGVSDD----D-------------Y-------------------------DT----------------SSGS--- 901  Debaryomyces ...
XP_004200051  813 ----------E----E-------------DnnnhplkdpkieskienkltnlilnSS----------------NREKivk 849  Pichia farino...
EDK37276      707 ----------StkpnS-------------P-------------------------LR----------------DSKL--- 719  Meyerozyma gu...
XP_003684661  826 ----------E----D-------------Pftkkm----------------rrnlTP----------------APKN--- 843  Tetrapisispor...
EMG47527      874 ----------N----SnpvlvadvgnqplD-------------------------SRteqkledklanmltqkSETG--- 911  Candida malto...
XP_011275006  807 ----------L----D-------------N--------------------------S----------------NTEI--- 814  Wickerhamomyc...
XP_007376714  870 dedeedSNESQ----D-------------S-------------------------EE----------------DVSE--- 888  Spathaspora p...
CCE44430      930 gddavdEYDDE----D-------------S-------------------------TA----------------DEEE--- 948  Candida parap...
XP_001524316  948 ddddenGEDSE----E-------------Y-------------------------DT----------------DSDE--- 966  Lodderomyces ...

Q7RXS9        905 --NA-------------ERSESPSIsrsrsrsrsrspspltaeggsaapsrdvpetaaerrrrLA--------------- 954  Neurospora cr...
Q6BMF1        902 --E----------------------------------------------------------------------------- 902  Debaryomyces ...
XP_004200051  850 qmED-------------PKRHVEPHflvvn-----------------------------paseHT--------------- 872  Pichia farino...
EDK37276      720 --ETkienqlvdiftkkKGPGQPKGqaaiq-----------------------------rkrsPPpavaeatdededqed 768  Meyerozyma gu...
XP_003684661  844 --VS-------------ISREGSLIdedle-----------------------------etsiEE--------------- 864  Tetrapisispor...
EMG47527      912 --NK-------------ATVTRMSSppasq-----------------------------qqqqHP--------------- 932  Candida malto...
XP_011275006  815 --KD-------------HLQLEPLEqpep-------------------------------vraND--------------- 833  Wickerhamomyc...
XP_007376714  889 --V----------------------------------------------------------------------------- 889  Spathaspora p...
CCE44430      949 --E----------------------------------------------------------------------------- 949  Candida parap...
XP_001524316  967 --EE-------------EEEEEGG---------------------------------------DG--------------- 977  Lodderomyces ...

Q7RXS9        955 -------VLQSVG-DDGEG-----------------------------------EQGE-------------TPAERRRRE 978  Neurospora cr...
Q6BMF1        903 ------------E-TDEDEdq---------------------------------vlEE-------------TDIEKKRRL 923  Debaryomyces ...
XP_004200051  873 -------VSEPED-SDDDNeadtgaa---------------------smdsedeDLHE-------------TEVERKRRL 910  Pichia farino...
EDK37276      769 ydhdsedDDASVD-SEEDEi-----------------------------------LQE-------------SNVERQRRL 799  Meyerozyma gu...
XP_003684661  865 -------PDLQNF-DTQSYngsgyemsingeand-----hnhssddnddsyssgEESE-------------TSIQKIRRL 918  Tetrapisispor...
EMG47527      933 -------IV-----EASDEdle------------------------------nsDLSQdsevedddddeeeTEVEKRRRL 970  Candida malto...
XP_011275006  834 -------DSIHEEaDSDLEeitsgeeesdseevdsdedseesdddediaprpagFQEE-------------TAAERDRRL 893  Wickerhamomyc...
XP_007376714  890 --------DSEVD-SEEDSd-----------------------------------eHE-------------TEVEKRRRL 912  Spathaspora p...
CCE44430      950 ------------E-DEDESd-----------------------------------dEE-------------TEVEKQRRL 968  Candida parap...
XP_001524316  978 -------HGELMD-DEAESd-----------------------------------eEE-------------TSVERARRL 1001 Lodderomyces ...

Q7RXS9        979 AALGMFPG---AAE--DED 992  Neurospora crassa
Q6BMF1        924 AALGQMPTh-rRKE--DEE 939  Debaryomyces hansenii
XP_004200051  911 AALGHMPT---KRDvnDEE 926  Pichia farinosa CBS 7064
EDK37276      800 AALGRIPDk-rDRD--DEE 815  Meyerozyma guilliermondii ATCC 6260
XP_003684661  919 AALGAVED---NGSnnnek 934  Tetrapisispora phaffii CBS 4417
EMG47527      971 QALGKLPTtrrHED--DEE 987  Candida maltosa Xu316
XP_011275006  894 AAIGQVDA---PRD--ESD 907  Wickerhamomyces ciferrii
XP_007376714  913 QALGKLPVh-rHQD--DEE 928  Spathaspora passalidarum NRRL Y-27907
CCE44430      969 QALGKLPNrnrDQN--DEE 985  Candida parapsilosis
XP_001524316 1002 QALGRIPNrnrDED--DEE 1018 Lodderomyces elongisporus NRRL YB-4239
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