Conserved Protein Domain Family
CHCH

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pfam06747: CHCH 
Click on image for an interactive view with Cn3D
CHCH domain
we have identified a conserved motif in the LOC118487 protein that we have called the CHCH motif. Alignment of this protein with related members showed the presence of three subgroups of proteins, which are called the S (Small), N (N-terminal extended) and C (C-terminal extended) subgroups. All three sub-groups of proteins have in common that they contain a predicted conserved [coiled coil 1]-[helix 1]-[coiled coil 2]-[helix 2] domain (CHCH domain). Within each helix of the CHCH domain, there are two cysteines present in a C-X9-C motif. The N-group contains an additional double helix domain, and each helix contains the C-X9-C motif. This family contains a number of characterized proteins: Cox19 protein - a nuclear gene of Saccharomyces cerevisiae, codes for an 11-kDa protein (Cox19p) required for expression of cytochrome oxidase. Because cox19 mutants are able to synthesize the mitochondrial and nuclear gene products of cytochrome oxidase, Cox19p probably functions post-translationally during assembly of the enzyme. Cox19p is present in the cytoplasm and mitochondria, where it exists as a soluble intermembrane protein. This dual location is similar to what was previously reported for Cox17p, a low molecular weight copper protein thought to be required for maturation of the CuA centre of subunit 2 of cytochrome oxidase. Cox19p have four conserved potential metal ligands, these are three cysteines and one histidine. Mrp10 - belongs to the class of yeast mitochondrial ribosomal proteins that are essential for translation. Eukaryotic NADH-ubiquinone oxidoreductase 19 kDa (NDUFA8) subunit. The CHCH domain was previously called DUF657.
Statistics
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PSSM-Id: 284221
View PSSM: pfam06747
Aligned: 50 rows
Threshold Bit Score: 30.3037
Threshold Setting Gi: 808356612
Created: 14-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam06747 is a member of the superfamily cl06008.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
2L0Y_A        68 CGEQFKSAFSCFHYSTE---EikGSDCVDQFRAMQE-CMQK 104
gi 75151446   79 CGSQFSEAFLCFLKSTA---EekGSDCVNPFVALQS-CINA 115
gi 74868006   61 CGVDFREAFSCFQNSTA---DpkGSDCYDAFTKMRD-CFQK 97
gi 74963706   72 CGYEFREAISCQKTSSDeemE--NGACGEQLMAFME-CAMR 109
gi 465879     66 CGFEFREAITCQKTNSDgeiE--QGACGKELMSFME-CVTR 103
gi 75156052   71 CQKEMDDYVGCMYYYTN---E--FDLCRKEQEAFEKvCPLK 106
gi 81897397   34 CAASHFAVQECMAQHQD------WRQCQPQVQAFRD-CMSA 67
gi 384872326  39 CYVENLALQLCHAETGD------WRQCFNEMALFRK-CWEK 72
gi 1171870    78 CAEPFTEYWTCIDYSGL---Ql-FRRCRKQQAQFDE-CVLD 113
gi 38048623   80 CHEEFTQYATCLDKSSG---TmaFSHCRKTQGVFDK-CIKd 116
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