Conserved Protein Domain Family
NDUF_B7

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pfam05676: NDUF_B7 (this model, PSSM-Id:283359 is obsolete and has been replaced by 461710)
NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)
This family consists of several NADH-ubiquinone oxidoreductase B18 subunit proteins from different eukaryotic organizms. Oxidative phosphorylation is the well-characterized process in which ATP, the principal carrier of chemical energy of individual cells, is produced due to a mitochondrial proton gradient formed by the transfer of electrons from NADH and FADH2 to molecular oxygen. The oxidative phosphorylation (OXPHOS) system is located in the mitochondrial inner membrane and consists of five multi-subunit enzyme complexes and two small electron carriers: coenzyme Q10 and cytochrome C. At least 70 structural proteins involved in the formation of the whole OXPHOS system are encoded by nuclear genes, whereas 13 structural proteins are encoded by the mitochondrial genome. Deficiency of NADH ubiquinone oxidoreductase, the first enzyme complex of the mitochondrial respiratory chain, is one of the most frequent causes of human mitochondrial encephalomyopathies.
Statistics
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PSSM-Id: 283359
Aligned: 79 rows
Threshold Bit Score: 65.2654
Created: 13-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5KK26         6 TASQTEMEAARVPLGWRDQCSALLIPLNVC-R-HKELYM-P-WKCEDERHGYEKCQYDDYIRR 64  Cryptococcus neoformans
XP_784178     40 VASQEEMNMARVPMDKRDFCAHFYIAFLKC-R-RDNFPN-L-LNCRHAKHEYDHCEYEDFVIR 98  purple sea urchin
XP_002606019  44 VATQKEMADARVPMQLRDYCAHKYMAWMMC-R-RDHMPN-L-WACKHERHEWDQCEYDDWVHR 102 Florida lancelet
NP_001280287  39 IASLAEMESAKVPLDARDFCAHMLLNLRGC-I-RDNFPF-N-HHCHHEREEYYECQYHDYLDR 97  pea aphid
NP_492119     43 KATWEEMEQWKLKPAQRDYCAHHLISLMKC-Q-TQNAPF-AgHACDGERGAWDKCEYDDHIMR 102 Caenorhabditis elegans
EJW85795      40 KATWEEMDHWKLEFGDRDYCAHLLINLKKC-Q-RQYAPFsH-YYCTDDYHGWQNCEYEDHILR 99  Wuchereria bancrofti
XP_003372103  43 IATDEEMDAWQLEYRDRDYCAHFYINHRRC-L-DNNRPFaY-WNCKHERHELTKCEWEDMVMR 102 Trichinella spiralis
XP_002770433   9 LLSEEDLQKYKVPLRWRDRCAANFALYHIClK-RQSANS-S-VDCKHDKHVWEECENLDFIRR 68  Debaryomyces hansenii CBS767
XP_007372498   9 LLSQDDMQKYNVPLKWRDRCAAYYALYNTC-LvRERNSS-K-IDCKHDKHAWEECEFLDLQRR 68  Spathaspora passalidarum NRRL Y-...
XP_006689586   9 LLSDDDLQKYKVPLKWRDRCAFYFALYQTC-LiRQSANG-S-VDCGHDKHAWEECENLDLIRR 68  Candida tenuis ATCC 10573
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