Conserved Protein Domain Family
DcpS
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pfam05652: DcpS (this model, PSSM-Id:283339 is obsolete and has been replaced by 461705)
Scavenger mRNA decapping enzyme (DcpS) N-terminal
This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the N-terminal domain of these proteins. DcpS is a scavenger pyrophosphatase that hydrolyzes the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway.
Links
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Statistics
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PSSM-Id: 283339
Aligned: 118 rows
Threshold Bit Score: 87.5474
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q2H304        10 ALVPRFKFERLLNQDQAGRRTSLVGAI----DD----QPALLILERAPF-------P------------SSPD------- 55  Chaetomium glob...
XP_002014145  15 YDISKFRLKRILQNNSVRKSIALLGTF----PDlsetDDAIVVFEKTAY-------Q------------ESDV------- 64  Drosophila pers...
XP_002073036  18 yeLKKFQLKRILNNNTVRKSIALLGTF----PDlssdNPAIVVFEKNAYresdvatD------------ESET------- 74  Drosophila will...
XP_002038476  15 YDLSKFQLKRILTNNSVRKSISLLGTF----PDlg-tDDAIVVFEKNAY-------R------------ESDV------- 63  Drosophila sech...
XP_001847826  70 fqLSQFELVRILSNNSTHKSVALLGHF----GDlsreQQAIVTLEKTAF-------T------------EGQL------- 119 southern house ...
XP_011066559  43 lnLSDFKVTRVLQNNCARKLICMEGTF----ENr--eGQAVVLLEQKSF-------S------------QDKV------- 90  Panamanian leaf...
XP_559218     11 YDLAHFRTVRVLNNNSTHKCVALLGRFsnlsPD----QQAIVVLEKRAA-------QhgesetekseqqPSSE------- 72  Anopheles gambi...
XP_001990602  22 YDLTKFCLKRILNNNSKFKSITLLGTF----PDlsetDAAIVVFEKNAY-------R------------ESDVatevpae 78  Drosophila grim...
XP_011146695  39 TDLSDFNVTRVLQNNCARKLICVEGTF----KDr--aDPAIVLLEQKSF-------P------------SDKV------- 86  Jerdon's jumpin...
XP_011267744  43 lnLSNFKVTKVLQNNCVRKSICIEGTF----EDr--eGSAIVLLEQKSF-------P------------HDKL------- 90  Florida carpent...

Q2H304        56 ------Y----L---------GSV------PTTLR---S---ITNL----GANDIYHWYLA--HsgadtttqdhhhpsSD 98  Chaetomium glob...
XP_002014145  65 ------StskeL---------PAK------PSYFSaelK---VDTE----FINNIYGSFQVvpS--------------PD 102 Drosophila pers...
XP_002073036  75 ------L----D---------KEA------PSYFS---KdlnVATQ----FINNIYGSYQVvpRq--------------E 108 Drosophila will...
XP_002038476  64 ------A----T---------ASSeespkkPSYFTadlK---VDTE----FINNIYGSFQVvpTr--------------n 103 Drosophila sech...
XP_001847826 120 ------Q----TttttgeserNSF------FTSKS---Q---LRTE----FINDVYGNFQClt--------------dPE 159 southern house ...
XP_011066559  91 ------V----Le--------KDF------FDGKT---T---FRKI----FTNDVYRNYNCfpT--------------EE 122 Panamanian leaf...
XP_559218     73 ------Q----G---------RTF------FTTSS---R---LHKE----FVNDVYGNFLCtvD--------------PE 103 Anopheles gambi...
XP_001990602  79 keseseK----K---------PSY------FSSDL---K---VRTD----FVNNIYASFQCvpTq--------------E 115 Drosophila grim...
XP_011146695  87 ----------------------SL------KKGFF---S---EKTIyqknCANDIYGNYDCfpA--------------EE 118 Jerdon's jumpin...
XP_011267744  91 ------V----Lek-----gyFDG------KTLFR---K------H----FTNDIYRNYDCfpT--------------EE 122 Florida carpent...

Q2H304        99 FADLKINLIWPCTEKHIKKYSKQ 121 Chaetomium globosum CBS 148.51
XP_002014145 103 LCGVKSTVIYPATDKHVEKYSic 125 Drosophila persimilis
XP_002073036 109 LCAVKSTVIYPATEKHIQKYSic 131 Drosophila willistoni
XP_002038476 104 LCSVKSTVIYPATEKHIEKYSvs 126 Drosophila sechellia
XP_001847826 160 INQLKVTIIYPASEKHIVKFAAQ 182 southern house mosquito
XP_011066559 123 NNGLHVTVIYPASQTHIDKYKRQ 145 Panamanian leafcutter ant
XP_559218    104 LNRLKVSIIYPASEKHIVKHTAQ 126 Anopheles gambiae str. PEST
XP_001990602 116 LCAVKSTVVYPATEKHIQKYSic 138 Drosophila grimshawi
XP_011146695 119 YNSLHATVIYPATRNQIEKYLKQ 141 Jerdon's jumping ant
XP_011267744 123 YNSIHTTVIYPATQNHIEKYKRQ 145 Florida carpenter ant
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