2D8R,2JTG


Conserved Protein Domain Family
THAP
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pfam05485: THAP (this model, PSSM-Id:283206 is obsolete and has been replaced by 461662)
THAP domain
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.
Links
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Statistics
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PSSM-Id: 283206
Aligned: 466 rows
Threshold Bit Score: 35.4966
Created: 13-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2D8R_A        11 NCAAAGCATtynkh--------------inisFHRF---PLdpk-rrKEW-----VRLVRRk-nF--VpgkhtfLCSKHF 64  human
XP_003247525   3 RCVV--CRNcysntky----------trpdviYHAF---PKnee-rrKEW-----LKMYGIgrcY--Ewh---rICSDHF 56  pea aphid
EFZ16936      11 YCSIINCkkqlk----------------gnviFHKF---PKnke-lkKIW-----ISRcnitkn----vtkhmfVCSLHF 61  red fire ant
XP_011419521   9 MCVVAGCskrqs----------------dgvsVHVF---PKder-qrAAW-----VRFvkltradwsgpsqytvICSDHF 63  Pacific oyster
XP_011413654   9 myvVAGCskrqt----------------ddvsVHSF---PKdnr-qrAAW-----TRFvkltradwtgpsqytvICSEHF 63  Pacific oyster
XP_001641386   5 RCVAQDCENnhka-------------------gksLhlsPksg-pkkAEWirfvrLhsknfn------plgrfvVCSDHF 58  starlet sea ane...
XP_001618208   5 RCVVQDCENnhkt-------------------gksLrlsPksg-pkkAEW-----Irlhsknf----nplgrfvVCSDHF 55  starlet sea ane...
EGI62558      13 lCTINMCLStsdrnlinlptfaarktaenlinIHMF---PvdksdllKKW-----LDNIGIk-nW--IpnnsslLCSEHF 81  Panamanian leaf...
XP_003240653   9 aCIF--CLDspykn--------------pkisLHTF---PKdqs-krYLW-----LTACGLt-eE--DykpsrkLCSKHF 60  pea aphid
XP_001951674   4 RCCFf-CQTsalkv--------------pgliLHNF---PKdls-lrNIW-----LKRCGYt-eE--EffpynkLCSLHF 56  pea aphid

2D8R_A        65 e------------------aScfdltgqtRR-LK-MDAV--PTIFDF 89  human
XP_003247525  57 --------------------LeenykpgpRRiLN-KNTI--PQPYNK 80  pea aphid
EFZ16936      62 tkedyy-----------------piaipsQN-LTtRKEVftPNIFKK 90  red fire ant
XP_011419521  64 nddcyevrfsymkdfgipvnK--------C--LI-KGSV--PSIYPK 97  Pacific oyster
XP_011413654  64 neecyerqhfllkdfgittkK--------R--LV-PGSV--PSIYPK 97  Pacific oyster
XP_001641386  59 erecyhf----------------gegselKRyLI-KGSV--PTIWKP 86  starlet sea anemone
XP_001618208  56 erecyhf----------------gegselKRyLI-KGSV--PTIWKP 83  starlet sea anemone
EGI62558      82 eetcfrk-------------------igkylkLK-EGSV--PTIFKv 106 Panamanian leafcutter ant
XP_003240653  61 e-------------------KdcfktgtnLNiLL-PNSV--PTKINK 85  pea aphid
XP_001951674  57 d-------------------GnsykntklRKlLK-NNAI--PTKFKK 81  pea aphid
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