2MOE


Conserved Protein Domain Family
MBD
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pfam01429: MBD (this model, PSSM-Id:279737 is obsolete and has been replaced by 396147)
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Methyl-CpG binding domain
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase.
Links
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Statistics
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PSSM-Id: 279737
Aligned: 14 rows
Threshold Bit Score: 55.0355
Created: 22-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2MOE_A    3 TECRKSVPCGWERVVKQRLFGkt--------------------aGRFDVYFISPQGLKFRSKSSLANYLHKNGe------ 56   human
Q9SGH2  262 SERHGVLEDGWRVEFRQPLNG-----------------------YQLCAVYCAPNGKTFSSIQEVACYLGLAIngnyscm 318  thale cress
Q5XEN5  114 KPGLPRTPRGFKRSLILRKDy-----------------------SKMDAYYITPTGKKLKSRNEIAAFIDANQd------ 164  thale cress
Q23590  327 AMLRLPLQLGWRRQTCVRSIAsa--------------------gVKGDVSYFAPCGKKLSTYSEVVRYLTKNSi------ 380  Caenorhabditis elegans
Q9UIF9  550 EEVRLPLQHGWRREVRIKK-Gsh--------------------rWQGETWYYGPCGKRMKQFPEVIKYLSRNVv------ 602  human
Q9UIF8  743 RELRIPLEYGWQRETRIRNFGg---------------------rLQGEVAYYAPCGKKLRQYPEVIKYLSRNGi------ 795  human
Q15047  598 NPLLVPLLYDFRRMTARRRVNrk---------------------mGFHVIYKTPCGLCLRTMQEIERYLFETGc------ 650  human
Q9Z2E2    5 WQDCPALGPGWKRRESFRKSGas--------------------fGRSDIYYQSPTGEKIRSKVELTRYLGPACd------ 58   house mouse
Q9VHB7   13 RVDCSVLPKGWQRDEV-RKSGssannnassnnnssatassnnnnNKVDVFYYSPTGKRAEGKPQDIAIPDFQ-------- 83   fruit fly
Q9VGA4  449 IVQDWRLPPGWIKHMYQRSnv----------------------lGKWDVILVSPSGKRFRSKSDLKLFLESQNl------ 500  fruit fly

2MOE_A   57 --------------------------------------TSLKPEDFDFTVLSK 71   human
Q9SGH2  319 daeirnensllqerlhtpkrrktsrwpnngfpeqkgssVSAQLRRFPFNGQTM 371  thale cress
Q5XEN5  165 -------------------------------------yKYALLGDFNFTVPKV 180  thale cress
Q23590  381 --------------------------------------HYITRDNFLFNTKLV 395  Caenorhabditis elegans
Q9UIF9  603 --------------------------------------HSVRREHFSFSPRMP 617  human
Q9UIF8  796 --------------------------------------MDISRDNFSFSAKIR 810  human
Q15047  651 --------------------------------------DFLFLEMFCLDPYVL 665  human
Q9Z2E2   59 ------------------------------------------LTLFDFRQGTL 69   house mouse
Q9VHB7   84 ---------------------------------------PGKMPHCALPSPSI 97   fruit fly
Q9VGA4  501 -------------------------------------vYNPDVYDFSIHRRRA 516  fruit fly
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