Conserved Protein Domain Family
outer_YhbN_LptA

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TIGR03002: outer_YhbN_LptA 
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lipopolysaccharide transport periplasmic protein LptA
Members of this protein family include LptA (previously called YhbN). It was shown to be an essential protein in E. coli, implicated in cell envelope integrity, and to play a role in the delivery of LPS to the outer leaflet of the outer membrane. It works with LptB (formerly yhbG), a homolog of ABC transporter ATP-binding proteins, encoded by an adjacent gene. Numerous homologs in other Proteobacteria are found in a conserved location near lipopolysaccharide inner core biosynthesis genes. This family is related to organic solvent tolerance protein (OstA), though distantly. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other]
Statistics
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PSSM-Id: 274384
View PSSM: TIGR03002
Aligned: 39 rows
Threshold Bit Score: 105.769
Threshold Setting Gi: 499660952
Created: 8-Oct-2014
Updated: 11-Oct-2014
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

TIGR03002 is classified as a model that may span more than one domain.
TIGR03002 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2R19_A         1 AVTGDTDQPIHIESDQQSLDMQ-GNVVTFTGNVIVTQGTIKINADKVVVtRp-GGe-----Q-GKEVIDGYG---KPATF 69
gi 492179387  29 ALSSDQFKPYHVRSIEVIYRRP-DHITLYHGDVYATQGTTWISGDKVIVyHn-PTt-----N-RIVRLKAIG---HPAHY 97
gi 499533743  23 ALPFDKEKMVQVVSDSADLNQK-NHQGVYIGNVEFVQGSTNLRAEKAITqGd-AK------N-QLTLAIAEGskdKQAHY 93
gi 499689662  25 etnANESLPIEIKADSLVSQDQ-KGQSVYSGRVIITQGTTVIHGDKVTIfHp--N------R-KVIKAIVIG---QPATF 91
gi 499718321  26 dLLNGSDEPVRIKAGRWERDGQ-KGIDTYIGNVVITQGKSSIEADKVVLyT--DD------K-GISRFQATG---KPAHL 92
gi 501531080  35 AEQGLGKGPIQISADALHGENKpQQQAVYTGNVVMTQGDVVVHADKLTVdA--IA------G-KVHQATAVG---SPVTF 102
gi 499428704  11 CMCMNAADTLEVSAKVFQSDLK-NGLTELSGEVLVVKGEDKLWADKVVIeTn-KK------N-KPQKYTATG---N-VRF 77
gi 499501045  22 STAFAKDAPIYIEANHMTSTEN-TNTVFFEGDVDAKQDDVRIRSNKMTVfYs-KAskgeksQ-QVKKIICTG---N---- 91
gi 490647090  25 pkggrqgQPITIKSNELSTDSR-HNTATFTGKVIARQGDLTIYADKLVVhYkaDG------G-DLDRVEASG---N---- 89
gi 499660952  26 SATAGKAQPLEITSQKLEADGT-LKKVVFVGKVVARQDGLTIRSSKLIVaYg-QS------GtRVSSIEAIG---DVV-- 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2R19_A        70 YQMQDNGK-P-V-EGHASQMHYELAKDFVVLTGNAYLQQVD--SNIKGDKITYLVKEQKMQAFSD--KGK-----RVTTV 137
gi 492179387  98 STMPDNQK-A-RlYAQAETILYFPAKAQVLLIKNARVTQKQ--NILTGPHIWYDIKKQTVISTVP--NGKg----NTTVV 167
gi 499533743  94 WTTTAPDKpP-F-HAYADTIKYYPLKHLIELIGNARIEQGP--NSLSAAKISYDTQEQHVLSHSD--EKT-----RTTII 162
gi 499689662  92 KRFLPEEK-NwI-DGRADTITYHAERRTVLLEGHAFVNQEGk-NSISGPEILYNLNDKTLSAKGN--KTEk---kRITVI 163
gi 499718321  93 VQFDAEKQtE-T-HAYAESMDYDRSQSKVVMRNHARILQDN--SSVEGEEIIYFTDKRLVTAKGAssGNQt---eQVEII 165
gi 501531080 103 TMSAAQ-----R-HGYGDTLVYKPGKGEIVLTGNAHLWQKK--NEISGQQVTYFLQTQQTAVTAA--PGK-----RVQSI 167
gi 499428704  78 YAKMPN-K-E-M-RGKAKKAVYNVIKDEYQLIDSAMLEEIGkkNIIRGNMIVFNPQSQEAFVKGS--SQKp---gMMTFI 148
gi 499501045  92 -TEVTRG--E-W-LGTGQRMVYTTKDKKIVLTGNAKAWQNQ--NMVSGETITYFLDQKRSEVVGT--PQKnkkpsRVNMT 162
gi 490647090  90 -VRIVQGD---R-LATARDGVYQSAEQKIVLTGDPKVFQGE--NTVSGKVITYFVDEEKSIVTGG--Pd-----tRVEAV 155
gi 499660952  93 VQKDD------R-TATAGRGLYNVAEGTVVLTETPRVQQGD--NSVEGDEIVFYLEEDRSIVKSQ--SGs-----RVRAI 156

                 ....
2R19_A       138 LVPS 141
gi 492179387 168 IEPQ 171
gi 499533743 163 IYPE 166
gi 499689662 164 FEPE 167
gi 499718321 166 YHPp 169
gi 501531080 168 FYPa 171
gi 499428704 149 MEDK 152
gi 499501045 163 IIQN 166
gi 490647090 156 ITPK 159
gi 499660952 157 LTPg 160
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