1IFY


Conserved Protein Domain Family
UBA1_Rad23

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cd14377: UBA1_Rad23 
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UBA1 domain of Rad23 proteins found in metazoa
The family includes mammalian orthologs of yeast nucleotide excision repair (NER) proteins, Rad23p (in Saccharomyces cerevisiae) and Rhp23p (in Schizosaccharomyces pombe). Rad23 proteins play dual roles in DNA repair as well as in proteosomal degradation. They have affinity for both the proteasome and ubiquitinylated proteins and participate in translocating polyubiquitinated proteins to the proteasome. Rad23 proteins carry a ubiquitin-like (UBL) and two ubiquitin-associated (UBA) domains, as well as a xeroderma pigmentosum group C (XPC) protein-binding domain. UBL domain is responsible for the binding to proteasome. UBA domains are important for binding of ubiquitin (Ub) or multi-ubiquitinated substrates which suggests Rad23 proteins might be involved in certain pathways of ubiquitin metabolism. Both UBL domain and XPC-binding domain are necessary for efficient NER function of Rad23 proteins. This model corresponds to the UBA1 domain.
Statistics
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PSSM-Id: 270560
Aligned: 11 rows
Threshold Bit Score: 77.0542
Created: 20-Mar-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1IFY_A         7 EYETMLTEIMSMGYeRERVVAALRASYNNPHRAVEYLLTG 46  human
ELU07000     173 SYEQTVQEMMSMGFaRDMVVRALRASFNNPDRAVEYLLSG 212 Capitella sp. I Grassle & Grassle, 1976
XP_001625753 161 EYEGLVTEIMNMGFeRDQVVRALQASFNNPDRAVEYLTTG 200 starlet sea anemone
P54727       189 SYENMVTEIMSMGYeREQVIAALRASFNNPDRAVEYLLMG 228 human
XP_002731773 158 AYENVVAELMNMGYeRDPVVRALRAAFNNPDRAVDYLLSG 197 Saccoglossus kowalevskii
XP_001176797 221 EYQNMVTELMSLGFpRDKVIRAMQASYNNPNRAAEYLVVG 260 purple urchin
CCD82179     139 NFERVVKELMSMGFeRSLVIQAMRAGFNNPDRAFEYLSSG 178 Schistosoma mansoni
XP_002131525 145 AYNELVTSIMAMGFeRERVVAALNASFCNPDRAVEYLMSG 184 Ciona intestinalis
XP_003385903 160 DYERTVNDMVGMGFmRNDVVRALQASYNNPTRAMEYLCGE 199 Amphimedon queenslandica
XP_002114015 157 SIEQIVSEIVSMGFpRDQVLLALRASFNNPHRAVEYLTTG 196 Trichoplax adhaerens
XP_002606011 137 AYETMVTSMMSMGFeRDQVVAALRASFNNPDRAVEYLLTG 176 Florida lancelet
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