Conserved Protein Domain Family
WASH-7_mid

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pfam14744: WASH-7_mid (this model, PSSM-Id:258881 is obsolete and has been replaced by 434177)
WASH complex subunit 7
This family is the central, conserved region of proteins that form subunit 7 of the WASH complex. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organizes actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament. WASH thus effectively nucleates actin on endosomes.
Statistics
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PSSM-Id: 258881
Aligned: 29 rows
Threshold Bit Score: 413.135
Created: 31-Mar-2013
Updated: 4-Apr-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
A0CZI0        641 YFYWCRE-LLPSFFQYIYQNPSQAKRFQFLLNAVSDCSIQLKDCMHLENP-DE-LFDSFRQYVVKEFYAQYLQPLARDIE 717  Paramecium te...
Q6UE81        644 FLFWCKD-ILPLAIKQFFENPSQSKRLIYLSQAISDTLPIVKATLHLQNP-LY-MYETFKEEVITTFKDEYLTPLTRQIE 720  Tetrahymena t...
EKG07420      619 FLYWHREtFYPLFFERMYQRPLRSNYLPYLLMAMHDCRTSILSSRHVEDA-HA-LLDAYISYIQKCIRNHLIKTLCIDIE 696  Trypanosoma c...
XP_002905324  799 FFYWSRE-LLHPFLSDLYNQPEQANRIQYVVGGFLDAIKLLRGAQHETDN-EL-YVNAYAEFIESVLEEEIVENLCKDVE 875  Phytophthora ...
XP_828666     651 FLYWQREvFFPTFIKRLYQKPLNSEYMPYTILAMHDCVPSILSSRHTKSA-RS-LLDAYTSYTWGCIREHLIEPLCVDIE 728  Trypanosoma b...
ACS87921      768 FLYFFREaLFPLFFKHCYESTRSAASLPYVVAALTDSRALILSARHVESPtET-LLADYICFLRDCLDHEVVQPLCAEIE 846  Leptomonas se...
XP_001565426  754 FLFFHREtLYPLFLRYCYEDTLVAVSLPQIVSAMGDCRLLIMSARHVRNPsET-LLRDYVEFVRDCVHHELVQPLCTEIE 832  Leishmania br...
EGB07736      569 CVYWSRE-LFQPMLDVLLDEPGGVKRLPLFVLAVSDVAPALRAAQHVDDA-ESsLVAGWTAFVFEALEAALVTPLCHRVE 646  Aureococcus a...
XP_003144562  148 FLFWHRS-FIAAYFSAIIENN--NSRPEFFFDAINDIETILGSDENEFD--IK-IKESVREELYELYEKLYLKKLCETVE 221  Loa loa
XP_001310610  604 WLFDSRE-LYDIFLHECQKNP---RRIVFLALSINDIGDLFK------DN-AD-LYGKCEKYFTKLLRDKFIQPCLSDLE 671  Trichomonas v...
A0CZI0        718 DYLRIQVHT-VLieKITALN--PFKQ---QV----K--DLKR--LLDIDYVLIFDSIVNLRTEINQILNETFYNINVLNM 783  Paramecium te...
Q6UE81        721 DFLRIQIHA-MLidKVVGKN--PFKD---EM----N--NIKK--LLELEQIQFFDVIIDIKKEIQNQLNEKFYNLNVLNM 786  Tetrahymena t...
EKG07420      697 NDLRLYTHS-VV--LGQPFR--KVDA---AG----RkcDVGC--FTLLPPLRFFYEWLHIASEVEHYLDAQFYNLNALMA 762  Trypanosoma c...
XP_002905324  876 NDLRLHVHSvHLd-HLDAPN--PKSA---DF----K--VLHY--YLDLRPIRLHGKALDLRQHVTHYLESTFYNLTTVAL 941  Phytophthora ...
XP_828666     729 NDLRLCTHS-VV--LGQPFR--QIGA---ST----RarDMAR--FTRLPPICLFSEWLHIATEVEKHLDEKFYNLNALMA 794  Trypanosoma b...
ACS87921      847 NQLRLRTHN-VV--LGQPYR--VLKP---SVdpagR--DLTR--FTLLPPFRLFHTWVHLAAQVEHYLSAQFYNLNALTP 914  Leptomonas se...
XP_001565426  833 NQLRLRTHD-AV--LGQPYRvlPLSA---DAv--eR--DLTR--YTLLQPFRFFDEWMHVAAQIEHYLSTQFYNLNALMP 900  Leishmania br...
EGB07736      647 NELRLRAHA-LG--QARGAG--ATRP---DA----P--SPGVvdALVLPPLRVLGRRLDVKRRLQRYLEKVFYDLTVVAL 712  Aureococcus a...
XP_003144562  222 TDLRLTFHS-HL--QLDDRT--PKDPihdTN----M--RLVH--LLQMPAVQLFDRLIDVKRYVEKYLESTFYNLTAVAL 288  Loa loa
XP_001310610  672 VELRFHAHQ-HL--AVSERN--PMKK---NY----S--QFDR--FLQTPPFKIMSRFFDMHYEASYYFTRVFYNETTVAP 735  Trichomonas v...
A0CZI0        784 YDQETYEQMRSLANSKFGLNLINVYLPTQTVDQGnFDVLNVLKNIQQFFTKYTYNLYQQQFVQVT--S--E--SKQVYSI 857  Paramecium te...
Q6UE81        787 HDMETYEQMRVLAKFYFDVNLINVYIPSQTIEQGqLDILQILRNIPTFVDTYTYNLHNQTFTQIT--T--E--SKLVQTI 860  Tetrahymena t...
EKG07420      763 NDWKTYEEMRNLALVRYGLRICDGYLPGSIVDQG-LDVLVITENIQVFVANYTYNMNEQLFVQRP--SttE--SKHLHTL 837  Trypanosoma c...
XP_002905324  942 HDWKTYGEMRNLANDKYGLSLADNHLPMGSLDQG-LDILQIMRNIQIFVARYNYNLNQQFFLERR--SdkG--SRHLNSI 1016 Phytophthora ...
XP_828666     795 NDWKTYEEIRNLALQRYGLRICDGYLPGSIVDQG-LDVLVITENIQVFVANYTYNMNEQLFVQRP--SttE--SKHLHTL 869  Trypanosoma b...
ACS87921      915 NDWRTYEEMRNLGRHSYHLNIADGHLPCCILDQG-LDVLVITENIHQFVAYYTYNLNEQVFIQRPslS--S--SKHLHTL 989  Leptomonas se...
XP_001565426  901 NDWKTYEEMRSLALRIYHLRIADSHLPSCILDQG-LDILVITENIQQFVVYYTYNLNEQVFIQRP--SltP--SKHLHTL 975  Leishmania br...
EGB07736      713 HDWSTYAEMKQLCLETYGVALRDNHLPMGSLDVG-LDVLRIMQNIDVFVSRFSYNLNQQNFVERR--P--DrgSKNIRTI 787  Aureococcus a...
XP_003144562  289 HDSNTYMTMGLLAKQKYNLILCQSRLPFQKLDQG-PDVLFVARNIDSFVENYDYNLNEQFFIEKD--S--K--SKQLTIL 361  Loa loa
XP_001310610  736 SVWETYTEMANILERLYGVSVVDCHIPGAMMQQE-IDVLEIMRNIPVFVACHNYDLNSQVFVQRA--E--D--SHYIAIV 808  Trichomonas v...
A0CZI0        858 SIQQIADSIRTHGIGILSTTVNSVYKFLQKKIQMFSQFLFDDLIQSPL----------KD-EL--D-GQYPYDRAEALYK 923  Paramecium te...
Q6UE81        861 GIQQISDSIRTHGLGILNTTVNSIFKYVAKKIEILSNLLYDELILQNLireekwfqenKM-QI--D-GYYPYERAKKLSS 936  Tetrahymena t...
EKG07420      838 HIRHIANSIRTHGTGIMNTTVNYVYKCLLKKLAILSQFLYDDHVKSRLikdakffiahKE-EL--N-GEYPLSRAENFIR 913  Trypanosoma c...
XP_002905324 1017 NIHSIASSIRTHGMGIMNTTVNFTYQFLTKKFDIFSQFLFDEYIKSYLqrekrwykkhRD-DKevD-NKYPFDRAFQFNK 1094 Phytophthora ...
XP_828666     870 HIRHIANSIRTHGTGIMNTTVNYVYKCLLKKLAILSQFLCDDHVKSRLlknakllhhkKE-ER--S-VEYTLAWAEKFIR 945  Trypanosoma b...
ACS87921      990 NTRHIANSIRTHGTGVMNTAVNYVYKCLLKKMAILSHFLQDDYVRSLLlkearvvrqrKQ-EH--QpIKYTTEQADQFIR 1066 Leptomonas se...
XP_001565426  976 STRHIANSIRTHGIGVMNTAVNHVYKYLLKKMVVLSHFLHDDYVRSHLlkdarvvrqrKEqQQ--S-VKYPVEQAEQLIR 1052 Leishmania br...
EGB07736      788 NIRSIAASLKQHGLGVLNTTVNYTYQFLATKFHVFNQFLYDDYIRSHLskerrwfrkhRE-SC--D-AMYPYDRAAKFAK 863  Aureococcus a...
XP_003144562  362 TAEHVANSIRTHGMGIMHTMINHAYQFLKKKFYTFSQLLYDDRIRNQLikderyfhenGE-KL--G-KMYPVSRAQRFNA 437  Loa loa
XP_001310610  809 GIPHIFASYRCHGIGIMNTTVDFTYRFLKTKFNTFSKFLFDDNVKSHLfnditwfeqhKE-EC--D-GQFPYERAEKLVT 884  Trichomonas v...
A0CZI0        924 EIKKMGTFDD---GTNYLDKFRTLITQIGNSLAFVRLLRSAALHVNSKCLEYVP-SQYNPTQLE 983  Paramecium tetraurelia
Q6UE81        937 TLKRLGVSKE---GNTYLDQFRIFITQIGNALGFIRLLRSASLNYCSKSIEFLPyQIDSEDSFL 997  Tetrahymena thermophila
EKG07420      914 EMHKLGVADD---GQTFLDKFRHLVSEIGNALGYMRMMRSGGLRAIADAAVFIP-FIDNVVRLE 973  Trypanosoma cruzi
XP_002905324 1095 DIRKLGVSDS---GKTFLDQFRMLITEIGNALGYVRMVRSAGMNYCSNAIKFVP-DLNHThfkf 1154 Phytophthora infestans T30-4
XP_828666     946 EMHKLGVADD---GQTFLSKFRHLVSEIGNALAYMRMMRSGGLRAVADSAAFVP-FVDADVSLE 1005 Trypanosoma brucei brucei str...
ACS87921     1067 EMDRLGVAAD---GSPFLEKARQLVSEVGNALGFMRMMRSGGLRAVAEGARFVPlplpnapeaa 1127 Leptomonas seymouri
XP_001565426 1053 EMDRLGVSHD---GVSFLEKARQLISEMGNALGFMRMMRSGGLRAVAEGARFVP-LPTTAVSng 1112 Leishmania braziliensis MHOM/...
EGB07736      864 DVRKLGVGDD---GRSFLDHFRVLITEIGNALGYVRMVRSAGAEFCADAARFVP-DFDDAAELa 923  Aureococcus anophagefferens
XP_003144562  438 AIRFLGVSDD---DL-YLDKLRILITEIGNVMGYVRLVRSGGIEASIQSLGFLP-NLDDVPSFE 496  Loa loa
XP_001310610  885 KFKRLSQNNNntsGLSALDKFRILITEIGNALGFVRMVRSGGTRYLNNAIGFVY-DEDSELSFK 947  Trichomonas vaginalis G3
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