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pfam14099: Polysacc_lyase 
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Polysaccharide lyase
This family includes heparin lyase I, EC:4.2.2.7. Heparin lyase I depolymerizes heparin by cleaving the glycosidic linkage next to an iduronic acid moiety. The structure of heparin lyase I consists of a beta-jelly roll domain with a long, deep substrate-binding groove and an unusual thumb domain containing many basic residues extending from the main body of the enzyme. This family also includes glucuronan lyase, EC:4.2.2.14. The structure glucuronan lyase is a beta-jelly roll.
Statistics
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PSSM-Id: 258319
View PSSM: pfam14099
Aligned: 54 rows
Threshold Bit Score: 94.7713
Threshold Setting Gi: 255532724
Created: 31-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:

pfam14099 is a member of the superfamily cl16613.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ZZJ_A         2 RSFYNDGHLNGWDYVRKENQGTVSEV--------------------------SNVVFKGt-SALKmtqtYTPGYT----- 49
gi 123646872  35 QKIKWLEDVGTWSKNWRTHGWQSNAPwal--------------------rysKDIVRDGe-YSLRf--eKRKDDCgpkkn 91
gi 123512718  37 LSFGAERTFKVPGFTHPFRVTTERNQpggf-------------------tmvKDPLDQYn-AAKVfkfsINPGPCvrdd- 95
gi 152994528  18 QAQSVAQDINHGDFGPFMRSLNNTSYgyq---------------------viQDITDSAp-TKLIekfeVRPGDCywnkg 75
gi 254501168  55 eeDSYKCDMTAEEIPDDLSIKRLANCesa---------------------elIDFEMPGk-DLRAvkftISPDDKpi--- 109
gi 223938257 106 ptaDWMKPLETTWTLETPGK----PYsvq---------------------pvSDVQKNDq-DSLRf--eTRPGEVwi--- 154
gi 119713366  11 tNLQWKKSVAKGKKLTKFRet------------------------------vTSPA-LGe-KAWKitliPRDCGRdq--- 55
gi 119713280  19 YANKWHIKMKKQEKKDFAHYVLKAQSdnkmvfnlrniknsniykffdkfedrMGVAEKGveFNLKysfeGHKQDWsr--- 95
gi 400753792  21 paqadrvyeildntrietglshGQPYqfa---------------------mvSGFTRRGe-LAQRf--eIRHGDCgg--- 73
gi 241203487  24 TADPLPKGFERHKFNGSv----------------------------------RPEVKDG--VTRFeifdRQCSHVdygdg 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ZZJ_A        50 ----------G--------------------R-----------Y----HSEV--D-HNRGYQRGEEQFYGFAFrLSEDWQ 81
gi 123646872  92 kgdckrtsekW--------------------I-----------G----RSEIimD-YPKSMGETGNQWYSWSIyIPKESN 135
gi 123512718  96 -------ceqQ--------------------S-----------A----RATV--Q-QGRKTKQPKEAWYGWDMyFVPDFP 130
gi 152994528  76 w----ndckqD--------------------R-----------E----RSEL--SeQKKTTPAGSEAWYGWSMyFPDDYP 114
gi 254501168 110 ---------sS--------------------G-----------I----RAEL--R-DMYVAKNGEEVWYRISTlIPKTFP 142
gi 223938257 155 ---------nH--------------------R-----------FiptfRAEV--A-TEEYAPIHSVKWYAFSLqLPANFP 191
gi 119713366  56 ---------eGdysdctnngrdavvghgggdR-----------A----RSEY--S-AKP--RYNGEKWISVSIfIPKDFK 106
gi 119713280  96 ---------wG--------------------K-----------PghaqRFQImeP-YKETTKKNKTKWYRVGYfFPEDVK 134
gi 400753792  74 ---------tQ--------------------GwddcsndrgrvE----RKER--P-KNVFSETGEGIWYGYSIyIPADFD 117
gi 241203487  68 rg--endcrnG--------------------N-----------V----RSTI--R-YTRDMKVGESVEYKFDFrLDPTFA 107
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ZZJ_A        82 f---------------Q-P-QSYNIAQFIAN---RpgagcGgd-----------------dW---MPSTMIWI------- 114
gi 123646872 136 rp------------knI-D-GQIILGQFKTH---N-----KhlsktrkyvvggknkndsncT---EISLTIRL------- 183
gi 123512718 131 ig------------skQ-VrGHEIFVEFKDQ---DqcqlvAl------------------tT---NPHSNDQFlswsmek 173
gi 152994528 115 n---------------VfP-TKVALGQFHQA---N-----Sh------------------------PIWMFQN------- 139
gi 254501168 143 m--------------eA-D-HRLVLSQWHER---Lr---aGgh-----------------sL---RPNISHRL------- 173
gi 223938257 192 sipv---------kdsD-D-QWLCLAQWKFNeffN-----Gst-----------------hKagsRPGLHFGYrtr-std 237
gi 119713366 107 t---------------VeP-VSTSLFQIYEW---G-----Ntn----------------qqR---HPRMMLRV------- 136
gi 119713280 135 i---------------E-K-HTISLFDFKKL---Y-----Gkg-----------------eK---THDAALNI------- 162
gi 400753792 118 s--------------lG-R-ANTHLSQAKVE---G-----E--------------------G---MPLWQLTF------- 143
gi 241203487 108 ykgwqnnsangfypdgW-D-SHLRLASWE------------------------------------GPAIHNFI------- 142
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ZZJ_A       115 QNNQLYSRYVNGHyrqp---------ncgrNIV---TRPNLATVSA--GAWHRVVLQIKWAS-D-NTGYFKIWF------ 172
gi 123646872 184 NKDGLMSDRSGVTycnswh-----kdnislHKK---FYQKLVDIDDvrGKWHDIILHANWTD-N-DEGFFKIWV------ 247
gi 123512718 174 PSGKQMTQFGGDCid--------------lFDM---RVAPIRELA---GAWHRFELFVRWTR-E-GDGRFLMFL------ 225
gi 152994528 140 GRGGYHL---DDHis-------------gtKKN---YELIKESDLR--GRWHKIEVYARWEK-D-DSGVFQVWV------ 190
gi 254501168 174 WNGRFVVTLWSDDvierl-------gtiegDGQ---ILYSEPRIDQ--GVYHEYVYRVVWSP-E-DDGRINAWMrqcppl 239
gi 223938257 238 HKNRFEIEVLHANpd-------------arDGAdaeTVFKEKHFPL--GKWNDFVVQAKWSD-N-QDGFVNIWW------ 294
gi 119713366 137 KRGNLEPRYFAVNgmd------------sqGLI---YKHLKIDDMR--GKWTTIIFHTKMSK-DpDKGFIKMYV------ 192
gi 119713280 163 INNRFNWVFNSPNytshknetgeeylyfdtYFV---NLDDYFSPLK--GKWVNVLVNAKWA----EDGFLHLWI------ 227
gi 400753792 144 NDNPYILYSDDTY-----------------------CSLGSMAMWR--GGWNDVTVYAHYGEgG-EDAYFQLYR------ 191
gi 241203487 143 ----YMLKADTRNg---------------vNFL---ARQCQKPQDF--GKWATFSLKIRWAN-D-ESGWVTASC------ 190
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ZZJ_A       173 ----DG--AKVHEEYNvATTVD----Dd----------------S--VFQFRVGLYANSWHDDGH------Mtgtq--gf 216
gi 123646872 248 ----NS--ELKLDHKG-KTLSK----Vmtid----------gkkH--GPMFRFGVYSQKWTGTTI--------------- 289
gi 123512718 226 ----DG--KQVVDYQGvTCFSC----D-----------------K--LNYFLFGNYLCCTTGTKL------Vvp------ 264
gi 152994528 191 ----NG--EQKVDYQG-PTMDA----Di--------------------VYFKYGVYRSFLSRYKQakqlnaV-------- 231
gi 254501168 240 retcDGrwQDMIQFEG-TTGYS----Nd----------------KvdGYYFKYGLYTVSDFEVPF------Tafhkdyws 292
gi 223938257 295 ----NG--KQIVEYRG-PVGYE----Lt----------------T--GPEFKFGLYHSDSDQTlv--------------- 330
gi 119713366 193 ----DD--ELYNDYKG-RTGYG----G--------------------KFFNKFGIYHSWISRWND------E-------- 227
gi 119713280 228 ----DG--KLRSSYYG-DTL-G----Ga----------------S--SVRFKFGPYRHHMNQATN------Agv------ 265
gi 400753792 192 ----NG--VLLCERNR-PLMHPslwgRd----------------Q--QIGFKYGIYNSFVSRYLR------T-------- 232
gi 241203487 191 ----DN--KVIYAAEG-EATNQ----AphcwesnecepqsnrdpK--SFNFILGPVMMGWGNEWK------Tydhhtsqf 251
                        410
                 ....*....|....*....
2ZZJ_A       217 rqV---------WYDEVAV 226
gi 123646872 290 --A---------YYDSISR 297
gi 123512718 265 atV---------YYRYVSM 274
gi 152994528 232 --Ppq-----ivYYSNVKR 243
gi 254501168 293 gptaesiglsdpifk---- 307
gi 223938257 331 -----------aYFNQVKs 338
gi 119713366 228 --VhgeyptqvvYYDNlfr 244
gi 119713280 266 qiPdl-----kiKYSNVGK 279
gi 400753792 233 --Ndrlp-thviLYDEMla 248
gi 241203487 252 dvV---------QPDGIGI 261
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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