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pfam12895: Apc3 
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Anaphase-promoting complex, cyclosome, subunit 3
Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.
Statistics
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PSSM-Id: 257383
View PSSM: pfam12895
Aligned: 111 rows
Threshold Bit Score: 41.103
Threshold Setting Gi: 74691126
Created: 29-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:

pfam12895 is classified as a model that may span more than one domain.
pfam12895 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3KAE_B        14 RYRDYETAIFLAACLLPCKPe------YRMlmSIVLYLNGEYTRALFHL--------------HKLNTcTSKY-----YE 68
gi 1709403    14 DNQNYDNSIFYSERLHAIEDsne--slYLL--AYSHFLNLDYNIVYDLLd-------------rVISHvPCTY-----LF 71
gi 74679433   14 SSYPPHTALFYARIWHTLAPttdsnhdSLHalALAFLQAAEPYSAIHLVrdhtgldnldldleIRFER-TDKVcggcaMI 92
gi 347840827  26 DNNLLKNALFFAERLHAYTPkgp-essYLL--SLCYLRLGDYASAFEVVks----------pnTRSGHlGCAY-----IY 87
gi 212532799  21 DNNLVKNALFLAGRLHAYEPrst-eaaYLL--ALCHLLSGQPKAAWEYSkv----------agSRGTHlGCSY-----VH 82
gi 189188614  20 DNGFTENALFLAGRLHALEPrnp-dasHLL--ALCSLRLGRYKAAYDEAra----------kgAHVQHlGCAY-----VF 81
gi 255935625  21 DNNLIRNALFLASRLHAYEPrsf-eaqFLL--ALCHLHNGEVKAAFECSqa----------sgSRGLHaGCAY-----VF 82
gi 213404832  14 DIQDYKNAIFFAERLYTMEGsld--nlCLL--AHTHLLQLNYAMTFQLLek----------haINPISc---Y-----TF 71
gi 170094074  26 DSDLTKTAVFHAERYYAMDPnnh-qarHLY--ATALLREGQTYSALYLVnn-----------aQDFQCtGCLE-----IK 86
gi 299754015  22 DNDLVKSAVFYAERFYSQDPknh-darHLY--ATALLAAKQTYSALHLVnv-----------sLDEQCtGCLE-----IK 82
                         90       100
                 ....*....|....*....|.
3KAE_B        69 -SLCYKKKKDYKKAIKSLESI 88
gi 1709403    72 -ARTSLILGRYKQGISAVEAC 91
gi 74679433   93 vARCCEKLGRYSEGQAVLARA 113
gi 347840827  88 -AQACLALGKLKEGILALEKn 107
gi 212532799  83 -AQACLDLGKYKEGISALDRS 102
gi 189188614  82 -AQTCLALGRHEQGAHALEKV 101
gi 255935625  83 -AQACLDLGKYLDGVTALERS 102
gi 213404832  72 -AKACLYLGKYKQGISALEMT 91
gi 170094074  87 -AKSCTALGRHRQAREALEAT 106
gi 299754015  83 -AKCCTVLGRFRQAREALDAT 102
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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