NCBI CDD Logo
?
pfam11759: KRTAP 
Keratin-associated matrix
The major structural proteins of mammalian hair are the hair keratin intermediate filaments (KIFs) and the keratin-associated proteins (KRTAPs). In the hair cortex, hair keratins are embedded in an inter-filamentous matrix consisting of KRTAPs which are essential for the formation of a rigid and resistant hair shaft as a result of disulfide bonds between cysteine residues. There are essentially three groups of KRTAPs, viz: the high-sulfur (HS) and ultra-high-sulfur (UHS) KRTAPs (cysteine content: 16-30 and >30 mol%, respectively) and the high-glycine/tyrosine (HGT: 35-60 mol% glycine and tyrosine) KRTAPs.
Statistics
?
PSSM-Id: 256601
View PSSM: pfam11759
Aligned: 22 rows
Threshold Bit Score: 23.9573
Threshold Setting Gi: 123781217
Created: 29-Mar-2013
Updated: 4-Apr-2013
Structure
?
Aligned Rows:

pfam11759 is a member of the superfamily cl15662.
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81867751    1 MSyy--sGY-SGGLGYGYg------sSFG-GLG-----CGCNsirrlgc--gsgyggFGYGSgyggfggfgygsgyggyg 63
gi 218526494   2 CCny-ygNS-CGGCGYGSr------yGYGcGYGsg-ygCGYG---------------SGYGCgy---------------- 41
gi 75043939    1 MSggffnEGiYPGYYWGS---------WGyPLGys-vgCGYG-------------------------------------- 32
gi 296434554   1 MCcnyyrNC-CGGCGYGSg------wSSGcGYGcg-ygCGYGsg-----------crYGSGYg----------------- 44
gi 296434555   1 MSfd--nNY-HGGQGYAK----------G-GLGcs-ygCGLS-------------------------------------- 27
gi 88909181    1 MCgsyygNY-YGDHGYGCcgyeglgyGYG-SLRcg-ysSC-----------------CGYG------------------- 41
gi 81879972    1 MCgy-ygNY-YGGRGYGCcgcgglgyGYG-GLGcg-ygSYYGcgyr--------glgCGYGYg----------------- 51
gi 88909169    1 MC-----------YGYGC--------GCGsFCRlg-ygCGYE-------------------------------------- 22
gi 88909174    1 MIyy--sNY-YGGYGYG-------------GLGcg-ygCGYR-------------------------------------- 25
gi 77157601    8 MCgsyyrNY-NGGHGYGCc-------GYG-GLGcgyggCGYGccgyrglgfgyggldCGYGGl----------------- 61
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 81867751   64 ygsgyggfGGFGY----GSGYG-GF--GYGSgyggfggfGYGSGYGGY 104
gi 218526494  42 -------gSGYGCg--yGSGYGcGYgsGYGC--------GYGSGYGCG 72
gi 75043939   33 --------STYSP-----VGYGfGY--GYGG--------FRPFDYRRY 57
gi 296434554  45 --------TGCGY----GCGYGsGC--GYGCgysssccgYRPLCYRRC 78
gi 296434555  28 -----------------------GY--GYAC--------YCPWCYERS 42
gi 88909181   42 --------HGYGSrffcGCGYGcGS--GY------------------Y 61
gi 81879972   52 --------CGYGSrslyGCGYGcGS--GYGS------------GFGYY 77
gi 88909169   23 -----------GCr--yGCGHR-GC--GDGC--------CCPSCYRRY 46
gi 88909174   26 ---------GYGCg--yG-GYG-GY--GNGY--------YCPSCYGRY 50
gi 77157601   62 -------gCGYGSf--cGCGYR-GLdcGYGC------------GYGYV 87
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap