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pfam11561: Saw1 
Single strand annealing-weakened 1
This family of yeast proteins is involved in single-strand-annealing, or SSA. SSA entails multiple steps: end resection and ssDNA formation; annealing of complementary ssDNAs; removal of 3' single-stranded non-homologous tails; gap fill-in synthesis; and ligation. Saw1 in combination with Slx4 catalyses the 3' non-homologous tail removal during recombination. Saw1 interacts physically with Rad1/Rad10, Msh2/Msh3, and Rad52 proteins, and works by targeting Rad1/Rad10 to Rad52-coated recombination intermediates.
Statistics
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PSSM-Id: 256505
View PSSM: pfam11561
Aligned: 9 rows
Threshold Bit Score: 79.5218
Threshold Setting Gi: 74626000
Created: 29-Mar-2013
Updated: 4-Apr-2013
Structure
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Aligned Rows:

pfam11561 is a member of the superfamily cl13076.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74610054    1 MVQNIAYIKVAKDSILPVRVHINRRQILS------TATEESKVQaplLSNNTIVCLKSPLTKIYLSNTDLKNLVTEMEDD 74
gi 731270      1 MAPSIATVKIARDMVLPLRIFVNRKQILQtndktsNKSNATIFEaplLSNNSIICLKSPNTRIYLSQQDKKNLCDEIKED 80
gi 74694029    1 MSPTHALLQLQPGYVMPVRVFINRREVLN------NAASCSLFEapiLSNSAIVRLKSPSVRVHLSEDDKQSLLAELRDD 74
gi 74626000    1 MCSVEKIVRLRHNLLCHVRIHFKTKEDL----------------------------------------DIRAFLFSLQRE 40
gi 74603016    1 MPATTSFIRVTPDKSIPVRIFVNRSKLLE---------NASVIS---VNEKSIVKLQKINI-LKLSNGDINSLIGTIRRE 67
gi 74590821    1 MPPQVTFVKIADNLSIPIKIFVKKSATTKls---tSSSSSKSIE---INSKYLININYQPYHIQLSKNQLNSIINKLKPK 74
gi 156837066   1 MTLSIARIKISDNIILPLRVFINRKQLLY------NITNEPIIQaplLSNNSIVCLKSPNTRIFVSNNDLESLCDEIRDD 74
gi 190345195   1 -mPTLTYVSVGPHDAFPIRVFVHRRKLLA-------STKSSVVA---VNQRSILHLSRINI-IRLSNADLDSLVSNIRHS 68
gi 150951499   1 MPPQITFVKVSSR-VLPVKVFL--------------------------------------VNVQLNEVLLSVLLKAPLRE 41
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74610054   75 IILILYELsspamkqnifskirvgqvydfdedtlkKFPQSIQ-G-S----LKESNLTSLKRVGKMKYKLTYRKNWDVDIF 148
gi 731270     81 LLLIVYELaspeiissvlskirvghstdfqinvlpKLFAGAD-T-Dn---AVTSHIQSVTRLAKFKYKLHYKHKWELDIF 155
gi 74694029   75 LLYIIYELgspgaeetlrkfk--iggladfrdivrAAEQGDR-P-EqpipGLDLHTMTFERLDKQRFPLHFEHNWVVNII 150
gi 74626000   41 LHAVAF------------------------------LNQGS---------IRTLYEKRVVDITSESVQSHAIIETARNFA 81
gi 74603016   68 LVDVLTNKpi-----------------------gkLLEENTlr-----nnRIVIDINTHEWKCYMNVSVYFLVNLRLNIG 119
gi 74590821   75 ILPILI------------------------------YNNHDQ-P-ItnieTQQLIINDEEDTLKIIIPQQTILNVRARLR 122
gi 156837066  75 ILLIIYELtsqevmnqtigklrvgynldfkksvinRFFKDDD-T-Gd--yYIDSNILMVTRVSKLKYKFRFKKNWEVDIF 150
gi 190345195  69 LMDVLLNS---------------------------EINHSSSkT-T----QVTFVLDKTDWKCYVKVPVHIMLQLRFYLN 116
gi 150951499  42 LVE----------------------------------NRDDT-WvK----LRQTTSDDKKLKFRLEVPVHLIVRLRLELD 82
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74610054  149 ISNINKLETIRTY--LIFkdqyp--------qwneYPCLQKQQSLLVMGQKLS----E----STNQDPIILQEEEELNl- 209
gi 731270    156 INSIKKIANLRHY--LMF-----------------QTLTLNGFSLNAGPKTLLarkiE----KQPQVPNLLIENGDAD-- 210
gi 74694029  151 LNDIRKLAVWRRL--LLCdia-----------pigVPAAAAPAPMPAGAPYVLlrerR----GRVSPQGMLQEDAPEGv- 212
gi 74626000   82 LPN----------------------------------------------------------------------------- 84
gi 74603016  120 RLTKDDIEHISKR-----------------------KGSNFSVSLLVKTSSFSf-------------------------- 150
gi 74590821  123 LINYENFITNSGSgnGNGngqvnvseseitslwkkIGNSEHNNNLKMLTVKKDf-------------------------- 176
gi 156837066 151 INNIKKLSDLRDY--LLFrhnpnq------msspsIPINSVKKVLIMEPDDYLn--iE----TGKDQTMILQEDENDSgi 216
gi 190345195 117 SLTNRDQEYLEQk---------------------nIHFSKCDTELLTRETKYL----F---------------------- 149
gi 150951499  83 KLTIDDIEFVNSG--KFKlen-----------ilkEKNSRADNSLLLMTKRNV----FnnrsFSEEPTILVEEDESLGls 145
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 74610054  210 ------NYEQSAEDQpnnEKPEIAFTYEPQL---SLIQCLDLYIL 245
gi 731270    211 ------ALDTPVEED---IKPVIEFMYKPVI---NLGEIIDVHVL 243
gi 74694029  213 ------PREGDLNVE---QKPVLDYRYKSVT---NLGPGIEIHVL 245
gi 74626000   85 ------TAEEEENMD---RKPELQLSFKGSM----TSKIIHIYVQ 116
gi 74603016  151 -------------EE---EKKLTKYKIRKSSlvsGFHDGLDLYVY 179
gi 74590821  177 ------KFPKDSEKE---DTKDVKFKLKQNYiidNLKDCIKVYIN 212
gi 156837066 217 -----iDQQSSQDDD---SKPIIHYRYKPTL---NLAELIDIHVL 250
gi 190345195 150 ------KQDPDDDNElvsEKKESQYSIGSKRi--IIPKGISIYVY 186
gi 150951499 146 egseveKENTDKHSD---DKKSVSYKVNGLRmfnNTQNCMKLYMI 187
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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