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pfam06487: SAP18 
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Sin3 associated polypeptide p18 (SAP18)
This family consists of several eukaryotic Sin3 associated polypeptide p18 (SAP18) sequences. SAP18 is known to be a component of the Sin3-containing complex which is responsible for the repression of transcription via the modification of histone polypeptides. SAP18 is also present in the ASAP complex which is thought to be involved in the regulation of splicing during the execution of programmed cell death.
Statistics
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PSSM-Id: 253765
View PSSM: pfam06487
Aligned: 27 rows
Threshold Bit Score: 111.974
Threshold Setting Gi: 74951200
Created: 29-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:

pfam06487 is a member of the superfamily cl05809.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4A90_A        16 PEKPIDREKTCPLLLRVF-TT-NnGRHHRMDEFSR---GNVPs--------------SELQIYTWMDATLKELTSLVKE- 75
gi 74582877   19 A------VGPCPFLISVYhQF-Q-TKNHVLDIFE----DVIP----------------SIQVYGWLTMTLYELGVLIADq 70
gi 74882637  563 IIGIINREKTCPFLLRLFyKT-N-VEYTSVDDIDLn-mSGINn--------------NELQIYAWIDITMREIVTLVKD- 624
gi 74815275  604 KIGIINREKTCPFLLRLFyKV-D-KEY-NVDDMDIl-tKDNNs--------------NELQIYAWIDITMREIVTLVKD- 664
gi 124457677  30 K-----DKHQVPFLVRTH-WK-N-GQI-TLEDFN------KNq-------------tQEILLYLFLSSKLRDIVDQLKY- 80
gi 74683020   34 P-----KGPRTPHLIRMF-VT-K-GRHAPLADFDa---GLFPt-------------rDEFQVYAWQTSTPSELIKLLYPs 89
gi 74613890    9 PATPVTREP--PFIVRLY-YR-T-GAFHRMNEFTs--dSHLP---------------LYVEIPAWRSTTLDELSLDIANe 66
gi 154282329   8 APPKIDRQTTTPFHLKLF-YK-Q-HSFHNLSDFPI---PFPPstrnatttnhpptlpPHLQIYTWPSCSLRELAQLLTSc 81
gi 154291385   5 tlTKIDRNTTVPFHLKLF-YK-N-GSFPRIEEFNP---HGELp--------------LHVNISTWQSCTLRELSHLLAT- 63
gi 156094892 644 PGGLIDREKTCPFLLRLF-YKlD-DEYSNVEDVKLckkSGVQs--------------NELQIYGWLDITMREIVTLVKD- 706
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4A90_A        76 ----VYP---EARKKGTHFNFAIVFMDlK-----R--------PGYRVKEIGSTMS--GRK------------------- 114
gi 74582877   71 l-llNNE---ETRHSEWSLQIRTIFYDkY-----K--------DRPIARDLGTVCLhnp--------------------- 112
gi 74882637  625 ----FYE---EGRKRNAQWIFNRYSFEkK-----Q--------INFLSK-VHSIKH--NYK------------------- 662
gi 74815275  665 ----FYK---DSRQRNAQWVFKVFSYEkK-----K--------LTFLSK-VHSTIY--NYK------------------- 702
gi 124457677  81 ----QLN---GVYRRDIMFRVSNVYLDqH--------------GVQKKKDLGQVHSvkSGK------------------- 120
gi 74683020   90 ----FPA---PYRSPQTRFHFRHVYVDaS-----Pr-------GLYRFKDLTSFIGrdLQS------------------- 131
gi 74613890   67 qsphSLL---PHPAIGTRLVFRLIYVDaR-----Kd------sSRHVSKDLGSVVIgaGLP------------------- 113
gi 154282329  82 l--pSIL---PDPAIGTRLSFRLIYPDtR-----NqgivgeglGRYLSRDMGSVIV--GQSpvaerrektlpvngalklq 149
gi 154291385  64 ----ALPdilPDPAIGTRLSYRLIFPDsRpavsgP--------ARYVTKELGSVVI--GEG------------------- 110
gi 156094892 707 ----FYQ---ESRKRDAHWVFKVYSNErK-----E--------LTFLSR-VHSTKH--NYR------------------- 744
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
4A90_A       115 GT-----------------------DDSMTLQSQKFQIGDYLDIAI 137
gi 74582877  113 ----------------------klfQGNKLLKRTGIKCGDKIDVTI 136
gi 74882637  663 -------------------------EDNKTLLSLNYEIGDIILLSI 683
gi 74815275  703 -------------------------EDNKTLLSLNYEIGDIILLSI 723
gi 124457677 121 -------------------------EDDSDLKNHGFKIGDILMVEI 141
gi 74683020  132 GSnddsmdlded----relgrrgrkIEEKSLDDYGFVTGDFLSVSI 173
gi 74613890  114 GAnadaglp---------dddpcydDAHRTLADAKFMPGDFISCAI 150
gi 154282329 150 GE-----------------------EADKCLQDFRFVIGDYVDCAV 172
gi 154291385 111 GPgilpdeeessivgegimagslmgEPEKTLQDARFVIGDYVCCAI 156
gi 156094892 745 -------------------------EDNKTLLSLDYEIGDILLLSI 765
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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