Conserved Protein Domain Family
Dynactin_p62

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pfam05502: Dynactin_p62 
Dynactin p62 family
Dynactin is a multi-subunit complex and a required cofactor for most, or all, of the cellular processes powered by the microtubule-based motor cytoplasmic dynein. p62 binds directly to the Arp1 subunit of dynactin.
Statistics
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PSSM-Id: 253226
View PSSM: pfam05502
Aligned: 11 rows
Threshold Bit Score: 431.262
Threshold Setting Gi: 74962747
Created: 29-Mar-2013
Updated: 4-Apr-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam05502 is a member of the superfamily cl20296.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74674328   68 PPEQLLYCEDCHQIKCPRCITEEIVCWYCPNCLFETPSSMVRSEGN----RCARNCFNCPICTAPLAVNTLEN------- 136
gi 121803996  69 PPEQLLYCEDCHQIKCPRCITEEIVCWYCPNCLFETPSSMVRSEGNrghsRCARNCFNCPICTAPLAVTTLEN------- 141
gi 74595540   70 PPEQLLYCEDCHQIKCPRCITEEILCWYCPSCLFETPSSLVRYEGN----RCGRNCFNCPSCTAPLAVTALQG------- 138
gi 74703687   47 PLESLYFCDECDQIRCNRCVTVDISSYYCPNCLFEVPGASVKAEKN----RCARNCFECPCCQHTLSVVASDPdsksvrg 122
gi 62900106   23 PLSQLYFCRYCSELRSLECVSHEVDSHYCPSCLENMPSAEAKLKKN----RCA-NCFDCPGCMHTLSTRATSIstq---- 93
gi 74962747   21 TLPDLVFCRYCFKIKCDDCSLGEVDNIFCPRCLEPSSVPEARLKKH----KCA-SCNDCPKCANVLSARTEN-------- 87
gi 121787333  88 PLEYLLYCEDCHQIRCPRCIAEEIVTYYCPNCLFEVPSSNLKSEGN----RCTRSCFQCPICIGPLAVTSVETkpdps-l 162
gi 74625054   57 PLEYLSFCEDCHQIRCPRCVAEEIVCYYCPNCLFEVPSSNIRSEGS----RCTRSCFQCPICIGPLAVNHVETppdpn-q 131
gi 134056695  57 PPEQLLYCEDCHQIKCPRCITEEIVCWYCPNCLFETPSSMVRSEGN----RCARNCFNCPICTAPLGVNTLENv------ 126
gi 121705626  68 PPEQLLYCEDCHQIKCPRCITEE------------TSSSAI---------RCARNCFNCPACTAPLAVTTLEN------- 119
gi 268552805  21 TLPDLFFCRHCFKIKCDDCSCREIDAIFCPRCLDTSSPPEARLKKH----KCT-SCNDCPNCANVLSARVEN-------- 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74674328  137 ----VAGSEGQQGPWVLSCAYCMWSSLDIGIKFDKPTNICTQLSK---------------------MTntttargrQMSK 191
gi 121803996 142 ----VTGGGSQQGPWVLSCGYCMWTTLDIGVKFDKPTNIRTQLSK---------------------MT--------DSSR 188
gi 74595540  139 ----DPPSGEQAGPWVLSCNYCMWTTLDIGIKFDKPTNIRAQLSK---------------------LTtep--sstTASR 191
gi 74703687  123 ldptDPAASQGEPPYFLACSVCRWDSKSVGLVFEKPTGLSLQLQRseenaadvlefdrlkdhfdpyLKaqt--qaaITSA 200
gi 62900106   94 -lpdDPAKTTMKKAYYLACGFCRWTSRDVGMA------------------------------------------------ 124
gi 74962747   88 ------------DNVYLVCQYCRWSSREANQ------------------------------------------------- 106
gi 121787333 163 laapDNAAAPHTGPYALTCSYCAWSSAEVGIQFEKPNGIHAQLAK---------------------LRngg--strLTAK 219
gi 74625054  132 llspDHASSSHSGSYVLSCSYCNWSSTEIGIKFDKPNSIHMQLAK---------------------LRngg--etrLTAK 188
gi 134056695 127 ----VTGGTSQQGPWVLSCGYCMWSTLDIGIKFDKPTNIRTQLSK---------------------MTe------iTPAR 175
gi 121705626 120 ----VTGGESQQGPWVLSCAYCMWTTLDIGIKFDKPTNIRTQLSK---------------------MTdpss-rgrQMSK 173
gi 268552805  88 ------------EKYYLHCHHCRWSTRDAK-------------------------------------------------- 105
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74674328  192 SVC------ELKSPLSTYSTIDDqfpap--gesrdGQSTPsgD------------QSAAPLTSDGRFSALKAFYKDQIAA 251
gi 121803996 189 GRQmsktfsDLKSPLSTYSSIDDqfpsp--semrgDDASPanE------------QSSGPLNPEARFQALKGFYKSQIAS 254
gi 74595540  192 SRGasrsfgDLKSPLSMYSSIDEqlpsa--gtnqpGEEQP--T------------NTHTPRTRDARFAALKAFYKDQMTA 255
gi 74703687  201 AVGsgsssrARSLPASTVSAAQAsssssaeastrsARATAarN------------AAAAALQSSKLVQDLPHLAHSKHAA 268
gi 62900106  125 ---------DKSVASGGWQEPEN--------------------------------------PHTQRMNKLIEYYQ-QLAQ 156
gi 74962747  107 ---------EDQENTKSWPTKEN--------------------------------------PLVNQLGEVTAYMK-RLEL 138
gi 121787333 220 ERK------ERRKDPSFRPQPAT--------------EGQgaP------------NETEVLDLETQFANLKAFYQDQLAN 267
gi 74625054  189 ERK------ERRKEQASQGGGGG------------SSTGQgeE------------DLDTLLDMETQFANLKSFYQNQLSD 238
gi 134056695 176 SRQmsrtfgDLKSPLSTYSSIDEhfppp--genkpEDSPL--D------------QPSAPLTPDARFHALKNFYKNQISA 239
gi 121705626 174 TVG------ELKSPLSIYSSVDD------------QFPTP--EesrdgqsttsneQPAAPLNFDARFSALKAFYKDQIAA 233
gi 268552805 106 --Q------DDRESNKSWPTKEN--------------------------------------PVTNHLNEVTAYMK-RMEV 138
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74674328  252 TSTSPTDPLGt-DFGP----GFASPG--ALNRIMSLYAASSRLSSLY-GsANKKPKSKPPV-MREALTASEGLKVa-tP- 320
gi 121803996 255 TSSLPNDPLA--DFGA----GFSSPG--ALNRIMSLYTSSSRLGNLY-GgTNKKPKSKPPV-MREALTTSEGLRVp-aP- 322
gi 74595540  256 TNTTGVDPG---DFAG----QFSSPN--TLQRFMVIYTQS-RLFTLY-G----------------TLTPSEGLFIpnrP- 307
gi 74703687  269 -NSARSAPIEpdELKTyralNPWQPVddGRSR-----SSGHAAASMG-VvAKREKHRRDYV-ARVQLGVNQPFAS----- 335
gi 62900106  157 KEKVERDRKKlaRRRNymplAFSDKY--GLGTRLQRPRAGASISTLA-GlSLKEGEDQKEIkIEPAQAVDEVEPL---P- 229
gi 74962747  139 IENAPKDLKKgkSGKAwtafHLKDKF--GFQQMV----------------DKRKKALAPEMnPVDAHAPTEAPTL----- 195
gi 121787333 268 PNSADTG------LSTlgdlGFSSPT--SLSRIMSIYTGGSL--------QDKKAKSRLGA-MREALDANEGLQLa--K- 327
gi 74625054  239 ANG--TGKVGgdPSAAlgnlGFDAPA--SLSRIMSLYTGSSSL-------HDKKSKSRPGT-MREALAPSEGLQLa--S- 303
gi 134056695 240 TSSSPTDPLGmdFGS-----GFSSPG--ALNRIMSLYTSSSRLSSLYgG-ANKKPKTKPPV-MREALTASEGLKIp-sP- 308
gi 121705626 234 TSTSPADPFg-aDFGP----GFASPG--ALNRIMSLYAASSRLNNLY-G-ANKKPKSKPPV-MREALTTSEGLKV---Pa 300
gi 268552805 139 IENAPKDLKKg-kGKAwsaiHLKDKF--GVQQMV----------------EKRRKAMVPEMnPLKAHDPTEAPTL----- 194
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74674328  321 -GAEDAIIQRISSev-----cGWDGLASIEQRMFQ-SPDV---------RFVEDLLPLPVLLRTKRSKRCKSCKHILVKP 384
gi 121803996 323 -DAENALIRRMASdd-----cGWDGMASIEQRTFQ-SPDA---------RFVEDLLPLPVLLRTKRSKRCKSCKHILVKP 386
gi 74595540  308 -ESEVAIIRRLASdd-----cGWDGVASIEQRTAQ--PQSfs------aRFVEDLLPLPTLLRTKRSKRCKSCKHILVKP 373
gi 74703687  336 ---LDAKISSLEQ--------RWSSVSIADQPVR-----------------AAELRPNRVSLKSKLSKRCPACRHIVIKP 387
gi 62900106  230 -EDYYTRPVNLTE------------VTTLQQRLLQpDFQP---------VCASQLYPRHKHLLIKRSLRCRKCEHNLSKP 287
gi 74962747  196 ----EDEIKERTD-----------DLRTLDQIIMQpLINI-----------SEPLLPVQVPLAGRVQVRCDECERTLIKR 249
gi 121787333 328 -LDESAAIEALRSe-------GHGSTASAAQLADQ-PPNLgeehlhgrgRFTSELRPIPYLLRTKRSKRCPVCRHIISKP 398
gi 74625054  304 -LDESSAITALQDfesttgldAYSSTASTTQLQSQ-APYLgasplhgltRFTSSLRPIPYLLRTKRSKRCPQCRHIISKP 381
gi 134056695 309 -DAEDTLIQRMSSpd-----cGWDGLASIEQRGFQ-SPDA---------RFVEDLLPLPVLLRTKRSKRCKSCKHILVKP 372
gi 121705626 301 pDTEETIIERMASed-----cGWDGVASIEQRMFQ-SPDA---------RFVEDLLPLPVLLRTKRSKRCKSCKHILVKP 365
gi 268552805 195 ----EEEIENRSN-----------VLRSLDQIIMQ--PLT---------NSNELLLPVKVPLQGRVMVRCDECERTLVKR 248
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74674328  385 ELKPQSTRFRIRLIALSYIPLPTLR-------------------------------PLA-----------LG-----PPt 417
gi 121803996 387 EFKPQSTRFRIRLIALSYIPLPTLK-------------------------------PLV-----------PS-----PFa 419
gi 74595540  374 EFKPQSVRYRIKLIAISYIPLPTLR-------------------------------PLV-----------LP-----PS- 405
gi 74703687  388 DIKAASNRFKIKLVALNFLPEIQIAladqqpyldalrfrstgvtgsnlmgaastssSLR-----------RR-----PQs 451
gi 62900106  288 EFNPTSIKFKIQLVAVNYIPEVRIM------------------------------------------------------- 312
gi 74962747  250 DFGVTTFKFKISSFARQFVPDIRMS------------------------------------------------------- 274
gi 121787333 399 EAKVQTTRFRIRLVAGSYIPSIAIR-------------------------------PLS-----------LS-----SGt 431
gi 74625054  382 ESKVTTTRFRIRLIAGNYIPTITIK-------------------------------QLI-----------IP-----GLt 414
gi 134056695 373 ELKPQSTRFRIRLIALSYIPLPTLR-------------------------------PLNpspspatttttTT-----VL- 415
gi 121705626 366 EFKPQSTRFRIRLIALSYIPLPTLK-------------------------------PLP-----------LGpatglPS- 402
gi 268552805 249 DFGVATYKFKISSFAREFIPDIRMS------------------------------------------------------- 273
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74674328  418 gl--------paITpsaSSSAPNLDALPPLKPFQLLLTLKNHMFDPVRVTLATPSVT-PGRVATK---VTILCPQFDIga 485
gi 121803996 420 gl--------psVT---SGAAPNLDALSPLKTVQLQLTLKNHMFDPVRVTLATPSVT-PGRVASK---VTILCPQFDIga 484
gi 74595540  406 ------------ASqplPPPPPDLNSLQPQKPIQLLLTLKNHMFDPVRITLATPSVT-PGRVASK---VTILCPQFDIga 469
gi 74703687  452 vlvsgadslgpaSSlfnASQDVDVNRLIAGQTYSYQIAVTNPLDDPVELDMSFVRFA-NASLSRG--------------- 515
gi 62900106  313 ----------------------SIPNLRYMKESQVLLTLTNPVENLTHVTLFECEEGdPDDINST---AKVVVPPKEL-- 365
gi 74962747  275 ---------------------RPVDDLKVGETSHVFLSITNLSSSAMDLTI-APQSG-NGFIQCSsdpIQLLLP------ 325
gi 121787333 432 -----------gTGtsaSGSAVPGALLEPLRPAHYLLTFKNPIFETIKVTLGAPAKT-PGRLASK---VTVLCPEFEIda 496
gi 74625054  415 p---------------pPMPNLPPDTIEPLKPAQFVLTFKNPIFESVRVTLATPATT-PGRFPAK---VTILCPQFEIds 475
gi 134056695 416 ------------PTpssSTTNPNLDALSPLRPIQLLLTLKNHMFDPVRVTLATPSVT-PGRVASK---VTILCPQFDI-- 477
gi 121705626 403 ------------TSsttSLGGPNLDALSPLKPIQLLLTLKNHMFDPVRVTLATPSVT-PGRVATK---VTILCPQFDIga 466
gi 268552805 274 ---------------------RPVKELKIGETAHVFLSVTNLSSSPLELTI-TPQSG-EGTIKCSnepIQLNLP------ 324
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74674328  486 nsdvwd--------------------------ealqgttTG-------------------------GDNR-SSRSGGMNL 513
gi 121803996 485 nsdvwd--------------------------ealqgstAP-------------------------GDAR-ASRSGTLGS 512
gi 74595540  470 nkdaw---------------------------sealepvAP-------------------------P------------- 484
gi 74703687  516 ---------------------------------------AA-------------------------AHPRtSSRVKGHLV 531
gi 62900106  366 ---------------------------------------VL-------------------------AGKDaAAEYDELAE 381
gi 74962747  326 -----------------------------------------------------------------------SSRASDTAA 334
gi 121787333 497 ntdvwdealnq---------------gggserdkrrrrgED-------------------------GAAAaAGSGSQSNI 536
gi 74625054  476 ntdvweealkdnnatssssqaqnlssstgpegsgpggrkRA-------------------------GTLRpGTAGGASLA 530
gi 134056695 478 ---------------------------------------GAnsdvwdealqgtsatttttaaagtgTDPR-GSRSGGLGV 517
gi 121705626 467 nsdvw---------------------------dealqgtAA-------------------------GDQR-SSRSGGFNL 493
gi 268552805 325 -----------------------------------------------------------------------SSKSIDSAA 333
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|...
gi 74674328  514 gYEKVAEAGKVWDKGRNWTTVVLEVVPGTLP-------GGSLGTRRRQSLGDD 559
gi 121803996 513 -TEKVAEAGKVWDKGRNWTTVVLEVVPGTLPg------GGATGRNRMKQHYDD 558
gi 74595540  485 -YERVAEAGKVWEKGRNWTTVVLEVVPGSLPglgarrsATGTGSNSDDDDDNA 536
gi 74703687  532 rPDALGLAGQVY---PSTTSISLNAFN------------------EVWELEDA 563
gi 62900106  382 pQDFQDDPDIIAFRKANKVGIFIKVTPQREE---------GEVTVCFKMKHDF 425
gi 74962747  335 pGVHADQSDVIVFRQHNRVGLRLDVIPTEMDls----sPCLNLLITYCQDGSF 383
gi 121787333 537 nHQNQLEVGKIWERGRNWVSIVVEVVPASLR--------LEEGDPPLAEDEDI 581
gi 74625054  531 gEELGPEVGKVWERGRNWTSIVIEVIPASLVq-----tAKRDGRGPIKEDEDV 578
gi 134056695 518 -YEKVAEAGKVWDKGRNWTTVVLEVVPGTLP-------GDSDPNQQLQPDEDV 562
gi 121705626 494 gSEKVAEAGKVWDKGRNWTTVVLEVVPGTLP-------GGTTGARKqrahdvd 539
gi 268552805 334 gGVHAEQSDVIVFRQHNRVGLRLDVVPTESDlt----sPILDLLLNYKQDGSF 382
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