Conserved Protein Domain Family
Neur_chan_LBD

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pfam02931: Neur_chan_LBD 
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Neurotransmitter-gated ion-channel ligand binding domain
This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.
Statistics
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PSSM-Id: 251626
View PSSM: pfam02931
Aligned: 96 rows
Threshold Bit Score: 137.774
Threshold Setting Gi: 74962606
Created: 28-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam02931 is a member of the superfamily cl03788.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4AQ5_E         3 EGRLIEKLLGDYDKRIKPA-KTLDHvIDVTLKLTLTnLISLNEKEEALTTNVWIEIQWNDYRLSWNTSE--YEGIDLVRI 79
gi 74894632   34 IVRLAHDTYDD-LKTAPPSyDKLEP-ARIQVLLYVSsIDAVNEASMDFTVGILLHLRWTDTRIYHDKAHnlFLQSKLQSL 111
gi 143811394  48 FTRILDSLLDGYDNRLRPG--FGGPvTEVKTDIYVTsFGPVSDVEMEYTMDVFFRQTWIDKRLKYD------GPIEILRL 119
gi 120752     42 FTRILDRLLDGYDNRLRPG--LGERvTEVKTDIFVTsFGPVSDHDMEYTIDVFFRQSWKDERLKFK------GPMTVLRL 113
gi 13124728   71 ASRILNTILSNYDHKLRPG--IGEKpTVVTVEISVNsLGPLSILDMEYTIDIIFSQTWYDERLCYN------DTFESLVL 142
gi 462150     49 ATQILNSLLKNYDNKLRPD--IGIKpTFIDVDIYVNsIGPVSVIQMEYTIDIFFAQTWYDRRLRFN------STLKALTL 120
gi 13959689   47 VTLILNKLLREYDKKLRPD--IGIKpTVIDVDIYVNsIGPVSSINMEYQIDIFFAQTWTDSRLRFN------STMKILTL 118
gi 120782     64 ITQILNSLLQGYDNKLRPD--IGVRpTVIETDVYVNsIGPVDPINMEYTIDIIFAQTWFDSRLKFN------STMKVLML 135
gi 120785     65 VTLILNGLLEGYDNKLRPD--IGVKpTVIHTDMYVNsIGPVNAINMEYTIDIFFAQTWYDRRLKFN------STIKVLRL 136
gi 109933036  59 ISAILDSFSVSYDKRVRPN--YGGPpVEVGVTMYVLsISSVSEVLMDFTLDFYFRQFWTDPRLAYRKRP----GVETLSV 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4AQ5_E        80 PSE-----LLWLPDVVLENnv-dGQFEVa-YYANVLVYNDGSMYWLPPAIYRSTCPIAVTYFPFDWQNCSLVFRSQTYNA 152
gi 74894632  112 DFDsenikKVWVPDIFFPNekkgSFHDImtQNQMMRLYQGGTILYISRLSMTLSCPMDLINYPFDKQTCHILIMSFGYSD 191
gi 143811394 120 NNMmv--tKVWTPDTFFRNgkksVSHNMtaPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPK 197
gi 120752    114 NNLma--sKIWTPDTFFHNgkksVAHNMtmPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTR 191
gi 13124728  143 NGNvv--sQLWIPDTFFRNskrtHEHEItmPNQMVRIYKDGKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPE 220
gi 462150    121 NTNmv--sRIWIPDTFFRNskraDSHWIttPNQLLRIWNDGKVLYTLRLTIEAECLLQLQNFPMDTHSCPLVFSSYGYPR 198
gi 13959689  119 NSNmv--gLIWIPDTIFRNsktaEAHWIttPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPK 196
gi 120782    136 NSNmv--gKIWIPDTFFRNsrksDAHWIttPNRLLRIWSDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPK 213
gi 120785    137 NSNmv--gKIWIPDTFFRNskkaDAHWIttPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDAHSCPLEFSSYGYPR 214
gi 109933036 133 GSEfi--kNIWVPDTFFVNekqsYFHIAttSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGYTM 210
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
4AQ5_E       153 HEVNLQLsAeegev---vewiHIDPEDFTENGEWTIRHRPAKKnyNwQLTKDDIdfq-----eiiFFLIIQRKP 218
gi 74894632  192 QDLVLDW-Mnltta--ddltmNPDGKAIVVDSEVLLPQFEVKSviP-SFCNRRYhqkagnhsciqAEFHLARNI 261
gi 143811394 198 SEMIYTW-TkgpeksvevpkeSSSLVQYDLIGQTVSSE----TikS-ITGEYIVm---------tVYFHLRRKM 256
gi 120752    192 AEVVYEW-TreparsvvvaedGSRLNQYDLLGQTVDSG----IvqS-STGEYVVm---------tTHFHLKRKI 250
gi 13124728  221 NEMIYKW-Enfkle--ineknSWKLFQFDFTGVSNKTE----IitT-PVGDFMVm---------tIFFNVSRRF 277
gi 462150    199 EEIVYRW-Rrysie--vsdqrTWRLYQFDFTGLRNTSE----VlrT-GAGEYMVm---------tVSFDLSRRM 255
gi 13959689  197 EEMIYRW-Rknsve--aadqkSWRLYQFDFMGLRNTTE----IvtT-SAGDYVVm---------tIYFELSRRM 253
gi 120782    214 NEIEYKW-Kkpsve--vadpkYWRLYQFAFVGLRNSTE----IshT-ISGDYIIm---------tIFFDLSRRM 270
gi 120785    215 EEIIYQW-Krssve--vgdtrSWRLYQFSFTGLRNTTE----VvkT-TSGDYVVm---------sVYFNLSRRM 271
gi 109933036 211 RDIRYFW-Rdglss--vgmssEVELPQFRVLGHRQ-RA--TEInlT--TGNYSRl---------aCEIQFVRSM 267
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