2DWG


Conserved Protein Domain Family
RUN

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pfam02759: RUN (this model, PSSM-Id:251516 is obsolete and has been replaced by 460679)
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RUN domain
This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.
Statistics
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PSSM-Id: 251516
Aligned: 51 rows
Threshold Bit Score: 86.1413
Created: 28-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2DWG_A   46 QFFVVMEHCLKHGLKAK--------------------------------------------------------------- 62   house mouse
Q17FM5  615 TLAPTIKQVLEHGMKRPsflggpch------------------------------------------------------- 639  yellow fever mosquito
Q5RBJ4  563 TLCPALKALFEHGLKKPsllggach------------------------------------------------------- 587  Bornean orangutan
Q4S5H4  603 ALCPALKAIFQHGLKKPsilggpchpwlfieevgql-------------------------------------------- 638  spotted green puffe...
Q96C34  429 ELTVAVRDLLAHGLYASspgmslvmapiacllpa---------------------------------------------- 462  human
Q4TH27   39 ELAPALKDLLAHGLFSPsqtmslvlapiscllp----------------------------------------------- 71   spotted green puffe...
Q9W5C1  516 NFARTLQQLIQHGLRIPaesaasslmvpfmrclhpgppvvp--------------------------------------- 556  fruit fly
Q17Q22  446 QLAKTIQGLMQHGLRGItessgslvpfisgcfsgggyhsqgpsknsaeerfyrgdsrrkstggmtkaa-------ttppk 518  yellow fever mosquito
Q54LN3 1015 RLATAIANLVSHGFIVSptnmvgsifrnvingat---------------------------------------------- 1048 Dictyostelium disco...
Q7QH55  369 RLAKTIQRLMQHGLRSIsesashslvpfisgcfsttgsghsgtnhssmsgranesfyrsevrrkstgatttapkkqssyv 448  Anopheles gambiae s...
2DWG_A   63 ----------------------------------------------KTFLGQNKSFWGPLELV-----------EKL-VP 84   house mouse
Q17FM5  640 ---------------------------------------pwlfieeAATREVEKDFESVYSRLvlcktyrldedGKV-LT 679  yellow fever mosquito
Q5RBJ4  588 ---------------------------------------pwlfieeAAGREVERDFASVYSRLvlcktfrldedGKV-LT 627  Bornean orangutan
Q4S5H4  639 ---------------------------tlaqssritslivqlvssqAASREVERDFNSVYSRLvlcktyrldedGKV-LT 690  spotted green puffe...
Q96C34  463 ------------------------------fssapeamhpwelfvkYYHAKNGRAYVESPARKlsqsfalpvtgGTV-VT 511  human
Q4TH27   72 ------------------------------hqpapqalhpwdlfvkYYHSKNGRAFVESPARQlsqsfslpvggAAVtVT 121  spotted green puffe...
Q9W5C1  557 ----------------------pavggdsqflglgramhawelvlaYYRLKHGEEYNNTPARKlsqsfqldivdAQA-VT 613  fruit fly
Q17Q22  519 rnsssleeeepiemnlftqleededeeveycdgdesemhawellllYYNIKNGDRYNSAPARKlsesfnldlveGRP-QS 597  yellow fever mosquito
Q54LN3 1049 -----------------------------gsggggsgggnslssslGNIVTGKRHLWEFIENY-----------KKT-TQ 1087 Dictyostelium disco...
Q7QH55  449 eedtsnaavteenlfsqldddeeedmepqfdsnnkdemhvwelllvYYNIKNGDRYNSTPARKlsesfnldivdGRP-LS 527  Anopheles gambiae s...
2DWG_A   85 EaaEI-TASVKDLPGLKTP----------VGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEVNALMMEEEGA-IIA 152  house mouse
Q17FM5  680 PeeLL-YRCVQAVNQSHDAaha-----qmDVKLRSLICLGLNEQVLHLWMEVLCSCSEIVHKWYQPWSFIYSPGWV-QIK 752  yellow fever mosquito
Q5RBJ4  628 PeeLL-YRAVQSVNVTHDAvha-----qmDVKLRSLICVGLNEQVLHLWLEVLCSSLPTVEKWYQPWSFLRSPGWV-QIK 700  Bornean orangutan
Q4S5H4  691 PeeLL-YRAVQSVNMSHDLaha-----qmDIKFRSLVCVGLNEQVLHLWLEVLCSSVAAVEKWYHPWSFLRSPGWV-QIK 763  spotted green puffe...
Q96C34  512 PkqSL-LTAIHMVLTEHDPfkr-----saDSELKALVCMALNEQRLVSWVNLICKSGSLIEPHYQPWSYMAHTGFE-SAL 584  human
Q4TH27  122 PkqSL-LWAIHSVLKEHGRykr-----gpDTKFKALVCMALNEQRLVSWLNLLCKSGTLVD-HYQAWSYMAQTGFE-GAL 193  spotted green puffe...
Q9W5C1  614 AkqSL-LSAVGMILAMHRPykr-----snNAHFKAFVCAGLNSHLLVEWLNLILSCHELVDTYYSADSYVARTGFR-DSL 686  fruit fly
Q17Q22  598 NkqSL-LSAIGTIIALHSPykr-----syNSQFKAFICAALNAQKLTQWLHLIYQCKELVSSYYTSWSYVANTGFR-DAL 670  yellow fever mosquito
Q54LN3 1088 HgtIAgISLIQTINTINSFenissawkdpNIKFRTLICVGLNQHVLDQWFALLQTDTNGISHYFHPNAIINSLDHWrLFC 1167 Dictyostelium disco...
Q7QH55  528 NkqSL-LSAIGSIIALHSPykr-----syDSQFKAFVCAGLNAQKLTQWLYLIFQCKELVSSHYASWSYVANTGFR-DAL 600  Anopheles gambiae s...
2DWG_A  153 GLLVGLNVIDANFCMKG 169  house mouse
Q17FM5  753 CELRLLSQFAFNLNPDW 769  yellow fever mosquito
Q5RBJ4  701 CELRVLCCFAFSLSQDW 717  Bornean orangutan
Q4S5H4  764 CELRVLSKFAFSLSQDC 780  spotted green pufferfish
Q96C34  585 NLLSRLSSLKFSLPVDL 601  human
Q4TH27  194 RILGRTSHLKFSLPVDL 210  spotted green pufferfish
Q9W5C1  687 RSIDALSRFDFDLPVDL 703  fruit fly
Q17Q22  671 KTLDRLTQYRFDLPVDL 687  yellow fever mosquito
Q54LN3 1168 QCFAPILNLPFKLSLDY 1184 Dictyostelium discoideum AX4
Q7QH55  601 KTLDCLTQYRFDLPVDL 617  Anopheles gambiae str. PEST
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