Conserved Protein Domain Family
BTB_2

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pfam02214: BTB_2 
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BTB/POZ domain
In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.
Statistics
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PSSM-Id: 251162
View PSSM: pfam02214
Aligned: 46 rows
Threshold Bit Score: 93.0122
Threshold Setting Gi: 74957051
Created: 28-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam02214 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2I2R_J        43 IVLNVSGRRFQTWRTTLERY-PDTLLGSTEK-------E---FFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYEC 111
gi 311033434  17 VNLNVGGFKQSVDQSTLLRF-PHTRLGKLLTchseeaiLelcDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELC 95
gi 24418468   19 IRINVGGFKRRLRSHTLLRF-PETRLGRLLLchsreaiLelcDDYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELC 97
gi 341940865  21 LRVNVGGVRRLLSARALARF-PGTRLGRLQAaaseeqaRrlcDDYDAAAHEFYFDRHPGFFLGLLHFYRTGHLHVLDELC 99
gi 74964546   28 VFVNVGGRRARLNSDIIIRRlATSRLAVFCEksh-verLtdcDAFFESTSEYYFERSPIIFEYVIDFYVTGKLHRPMDIC 106
gi 74895098  158 VILNVGGVKHEVLWRTLERMrPHTRLGKLRDctchealMelcDDYNLGENEFFFDRHPRSFSSILNFYRTGRLHLVEEMC 237
gi 24418479   65 IIINVGGIKYSLPWTTLDEF-PLTRLGQLKActnfddiLnvcDDYDVTCNEFFFDRNPGAFGTILTFLRAGKLRLLREMC 143
gi 24418469   59 VIINVGGIKYKVPWTTLENC-PLTRLGKLKScnnydeiMnicDDYDVSCNEFFFDRNPSAFRTIMTFLTAGKLRLLREMC 137
gi 74894095   72 VKLNVGGVVHEARWIILDKL-PNTRLGRLRHcssvstlMefiDDFDEEKEEMFFDRHPGAFTPVLNFYRTGKLHMPEDIC 150
gi 24418854   33 VRLNVGGLAHEVLWRTLDRL-PRTRLGKLRDcnthdslLevcDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMC 111
                         90       100
                 ....*....|....*....|.
2I2R_J       112 ISAYDDELAFYGILPEIIGDC 132
gi 311033434  96 VFSFCQEIEYWGINELFIDSC 116
gi 24418468   98 VFSFSQEIEYWGINEFFIDSC 118
gi 341940865 100 VFAFGQEADYWGLGENALATC 120
gi 74964546  107 PIRLRYELDYWRIPTPFMSPC 127
gi 74895098  238 VLSFSEDLEYWGVDELYLESC 258
gi 24418479  144 ALSFQEELLYWGIAEDHLDGC 164
gi 24418469  138 ALSFQEELVYWGIEEDHLEWC 158
gi 74894095  151 ALAFSQELEYWGIEDIYIESC 171
gi 24418854  112 ALSFSQELDYWGIDEIYLESC 132
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