Conserved Protein Domain Family
PH_Phafin2-like

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cd01218: PH_Phafin2-like (this model, PSSM-Id:241253 is obsolete and has been replaced by 269927)
Phafin2 (also called EAPF, FLJ13187, ZFYVE18 or PLEKHF2) Pleckstrin Homology (PH) domain
Phafin2 is differentially expressed in the liver cancer cell and regulates the structure and function of the endosomes through Rab5-dependent processes. Phafin2 modulates the cell's response to extracellular stimulation by modulating the receptor density on the cell surface. Phafin2 contains a PH domain and a FYVE domain. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.
Statistics
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PSSM-Id: 241253
Aligned: 26 rows
Threshold Bit Score: 168.587
Created: 4-Feb-2003
Updated: 1-Feb-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAF45637        7 NSEANTRRIASVENCFGSSGVp-LAMQGRVLVGEGVLTKMCRKRPKSRQFFLFNDILVYGNIVIg--------------- 70   fruit fly
AAH53138        7 FTIQNRERIQAVESSFGRTGKm-LQKPGRFLVGEGCLQKLCRRGPQPRVFYLFNDILVYGSIMLh--------------- 70   zebrafish
EFW45491        9 NSQANIDRIQAVEACFGSSGKm-LQKAGRVLIGEGILTKMCRKKLKPRQFYLFNDCIVYGSIIIp--------------- 72   Capsaspora ow...
XP_002108025    1 MDPINENQIKQVDEYFKGSGAqtLLKEGRILLGQGSLTKMCRKGPQRRQFFLFNDILVYASIKVp--------------- 65   Trichoplax ad...
CAX69329        8 DPKQNVERIFEVEKLFGFPPNk-LVTTNRVLVGEGVLTKICRRKPKLRHFFLFNDILIYGRIVVn--------------- 71   Schistosoma j...
XP_001743423    3 TSQANSLRIIKVEKCFGANGKp-LRKPGRVLKGEGVLNKVCRKVVKPRIFFLFNDILVYGSIAQe--------------- 66   Monosiga brev...
XP_003384904   30 QSSFNIEKITDIQNHFTRGEV--LLVPGRLFIREGSLWKICRKGPKKRQFFLFNDILVYGSILSr--------------- 92   Amphimedon qu...
XP_651719     208 VAAERRRRLFLIEGRISGFSGk-LVEPHRCFIKEGMLMKVCRKTIKPRYFYLFNDILIYGIGDS---------------- 270  Entamoeba his...
XP_629755     217 REKQNSEKILTIQKRFTGQCPp-LLAPLRTFIREGSLTKVCRKDHKKRWFILFSDALVYGNRIDtav------------- 282  Dictyostelium...
EFA79388      343 RKHENKLKVQKIQNELVGGPR--IITDSRVFVREGSMMKVCRKVPKSRWFFMFSDILIYTSVSTtpnssgstvvgpyvnn 420  Polysphondyli...
AAF45637       71 ---kKKYNKQHIMPLEEVSLESIADNqt-----------------yRNGWYIRTT-TKSFVVFAATSTEKQEWMAHINKC 129  fruit fly
AAH53138       71 ---gRWNNKQNIIPLEEVQQEDLEDGma-----------------mANQWLIRTP-RKSFYVSAESPEEKIAWMGHIEQY 129  zebrafish
EFW45491       73 ---rKKLTRQRLIPLAHMFLRPIADTesa---------------amKHGWYILSK-GKSFQVFTATEQEKREWMAHICKC 133  Capsaspora ow...
XP_002108025   66 ---hKKYVKQRIIPLEYAGLTSTDNTae-----------------lKHGWTINSI-GKSFVVYADSERDKAKWMDQINEC 124  Trichoplax ad...
CAX69329       72 ---rKVLRNPQFIDLADSSVKNVVDNgi-----------------yRNGFSILSP-RKSFTVYASTSEEKIQWMVHLKKC 130  Schistosoma j...
XP_001743423   67 ---qQRYTKQTILNLEGMQFRSLDDTpk-----------------lKHAWVISTP-SKSFTVCAASPREKAQWLDHLTKA 125  Monosiga brev...
XP_003384904   93 ----GLYSNQHILPISSMTVSSKCHYmpqveletvgegggkeeldpDNAFQINHA-DKSFHVFALTKADKTNWIANLTKQ 167  Amphimedon qu...
XP_651719     271 ----NNMVISQVVDVANIVVKNVEES--------------------VNGFELFTN-KKSFVVYAIDQNEKQEWMDEINKA 325  Entamoeba his...
XP_629755     283 --gnPIYKFHRLLPLSNTKIANLDDTk------------------hKNSFQLIHP-IKSFTLIADTEQEKSSWMNSFSDA 341  Dictyostelium...
EFA79388      421 rdapTSYTFHRMMNLNDIKIKDLKDKen-----------------qKNAFQIISStEKSFTVYTETPKEKNNWLEDFKLL 483  Polysphondyli...
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