Conserved Protein Domain Family
tRNA_Me_trans
?
cd01998: tRNA_Me_trans (this model, PSSM-Id:238956 is obsolete and has been replaced by 467502)
tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs. This family of enzyme only presents in bacteria and eukaryote. The archaeal counterpart of this enzyme performs same function, but is completely unrelated in sequence.
Links
?
Statistics
?
PSSM-Id: 238956
Aligned: 85 rows
Threshold Bit Score: 223.938
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
Ligand Binding
Feature 1:Ligand Binding Site [chemical binding site]
Evidence:
  • Comment:Adenosine nucleotide binding site predicted by similar proteins
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1         ### ####                  # #                                               
Q9RTK1     21 RVLCAMSGGVDSSVTASLLKEQGyq-vIGAMMRFWpddkr--------------tdtfdSCCs-----------pDAAYE 74  Deinococcus radiod...
EAK96007   60 HIIVAMSSGVDSSVCAALYKDYPn--vHGLYMANWsq--------------------saTCTe------------RDWKD 105 Candida albicans S...
EAK81273   86 RVVVALSGGVDSSVTAALLAQADfd-lEAVFMRNWneldesgrm-------qpgsggasGCTw-----------qRDWQD 146 Ustilago maydis 521
XP_456180  31 NIVVGMSGGVDSSVCAALFAAYPn--vHGVYMQNWgkdqsl------------trpeedPCYe------------KEWKD 84  Kluyveromyces lact...
NP_984774  28 NIIVAMSGGVDSSVCAALYAHFPk--vRGLYMQNWsqtsgsg----------pvkgkaePCYe------------QDWKD 83  Eremothecium gossypii
Q12093     28 NVIVAMSSGVDSSVAAALFAGEFpn-tRGVYMQNWsesqsl------------ddpgkePCYe------------RDWRD 82  baker's yeast
XP_458677  49 EIIVAMSSGVDSSVCAALYAEKYkn-vRGIYMANWsq--------------------taKCTe------------SDWND 95  Debaryomyces hanse...
XP_448291  28 NVVIAMSGGVDSSVAAALFAHYPk--aTGVYMQNWsesqal------------esiaeePCYe------------KDWKD 81  Candida glabrata C...
CAG78664   38 HVYVAMSAGVDSSVTAALMAERYkgrvTGVFMRNWsp--------------------dsKCAe------------ADWND 85  Yarrowia lipolytic...
EAL17598   11 HVTVGMSGGVDSATTLRILREFPih-lDVVFMRNWdpllsesppesslspspislaypsGSTsnreqnlspcqweRDWND 89  Cryptococcus neofo...

Feature 1                                                                                     
Q9RTK1     75 ARRVAEQVGVPfy---lLDYREPFQRHIVGPFLEEYARGRTPNPCVNCNTKVKFDelvkk-------akmlGCRYVATGH 144 Deinococcus radiod...
EAK96007  106 VQRVCQDLGISsc--erVNFEHEYWQDVFMPMIEKYEKGLTPNPDIGCNKFVKFGklidylh--kkydgtgKDWWLVTGH 181 Candida albicans S...
EAK81273  147 VQSVCRHLGNIpv--kmIDLSKEYWTQVFEPALQDWQQGTTPNPDVSCNKEIKFGalmdrli--rtgdhggSKSWLATGH 222 Ustilago maydis 521
XP_456180  85 AEKVAKHLNIPve---fVNFEKDYWLNVFAPMLEQYSMGYTPNPDIGCNQFVKFGklmdhl----dvkfgkNNYWLVMGH 157 Kluyveromyces lact...
NP_984774  84 IEKVGAYLNIPve---rVNFERDYWLDVFEPMLQRYQQGYTPNPDIGCNRFVKFGalrehl----dkeygrGNYWLVTGH 156 Eremothecium gossypii
Q12093     83 VNRVAKHLNIRvd---kVNFEQDYWIDVFEPMLRGYSEGSTPNPDIGCNKFVKFGklrewl----dekygtGNYWLVTGH 155 baker's yeast
XP_458677  96 VKKICNDLNIPce---rVNFEKEYWNEVFQPMVQMYEKGLTPNPDVGCNKYVKFGkmiehlt---kkflnnQKWWLVTGH 169 Debaryomyces hanse...
XP_448291  82 VAKLGDFLGVPve---kVNFESDYWIDVFEPMLQEYDQGRTPNPDIGCNKFVKFGklksyl----dqkyghDNYHLVTGH 154 Candida glabrata C...
CAG78664   86 VQQVCAHIDIPav---nLSLEKEYWLEVFEPMLERYRQGLTPNPDVSCNRYIKFGslkhrlkdrhensgmeGDWWLATGH 162 Yarrowia lipolytic...
EAL17598   90 VLKVATQVGIPkdsiklVDLSKEYWSRVFEPAVGVWERGGTPNPDVDCNREIKFGallda-------lpkkDRHFLATGH 162 Cryptococcus neofo...

Feature 1                                                                                     
Q9RTK1    145 YVKrvdna----qgeveFHRGDDPRKDQTYFLWGTPRDALPYILFPVGELEKPQVrEIAAERgll-taqKPESQNICFVP 219 Deinococcus radiod...
EAK96007  182 YARimkhne---tgeyhLLRGLSQRKDQSYYLSSIPQSSLSKILLPIGHYIKPQIrELAHDQfklhtatKPDSQGLCFVN 258 Candida albicans S...
EAK81273  223 YAHvawqqqg-drtrpmLMRAKDRSKDQTYYLSSVGEDKLAHAHFPLAHLLKTQVrELAKKFqlp-taeRRESMGICFIG 300 Ustilago maydis 521
XP_456180 158 YARilrrdsgpersephLMRGLYQQKDQSYYLSQVSVPSLNQMILPIGHLTKPEVrEMAKEVdlh-tatKPDSQGICFVN 236 Kluyveromyces lact...
NP_984774 157 YARilspqt---rrethLLRSHYAPKDQSYYLSQVGREALADLLMPMGFLTKPEVrQWAAELhlp-natKPDSQGICFVN 232 Eremothecium gossypii
Q12093    156 YARvmqemn--gkglfhLLRSIYRPKDQSYYLSQINSTVLSSLLLPIGHLTKPEVrDLAKYAglp-taeKPDSQGICFVN 232 baker's yeast
XP_458677 170 YARimkcqt---sneynLLRGYYKSKDQSYYLANIPKRVLLQVLMPIGHLTKPNVrELAKGYnlh-takKPDSQGLCFVS 245 Debaryomyces hanse...
XP_448291 155 YSRvlqhle---skeyhLLRGYYPQKDQSYYLSQINGGILPRLVLPMGHLTKPEVrDMARELqlp-tanKRDSQGICFVN 230 Candida glabrata C...
CAG78664  163 YARvmtde----sgtpgLFRPKHLAKDQSYYLSSVNSDSLRNVMFPLSDYLKPEIrEMAHAYklh-vasKPDSQGLCFVS 237 Yarrowia lipolytic...
EAL17598  163 YGRvahapllshpgpsrLLRAVDQSKDQTYYLSQMTEQQLSRAILPLGSLLKTDVrRLAEHWglp-nakKEESMGVCFIG 241 Cryptococcus neofo...

Feature 1                                                                                     
Q9RTK1    220 GKV------------QDFVAEHLPQA-QGYIREIAt----GEVVGEHLGTQFYTLGQKKGLGly------qsHRVRHVVH 276 Deinococcus radiod...
EAK96007  259 PQQsn---------fREFLNDYIPEN-PGDIITED-----GKVWGQHKGLWHATIGQKSSVCmpqa--dpqyQGIWFVSD 321 Candida albicans S...
EAK81273  301 TRGsnggavsntqgfSTFLNGYIPSA-PGDMVDES-----GRVVSKHCGLHTLTVGQGARIRg--------aTSKYYVAK 366 Ustilago maydis 521
XP_456180 237 NSQhg--------kfKNFLKEYLPME-LGNIITIDeltgkKTVWGKHPGIWSYTIGQKIGISlpqg--dpryQGAWYVSE 305 Kluyveromyces lact...
NP_984774 233 NSQhg--------rfQNFLQEYLPSS-VGHIVTVEeesgtRRIWGQHRGIWSYTIGQRVGISlpqg--dpkyQGAWYVSH 301 Eremothecium gossypii
Q12093    233 NSQhg--------kfKNFLKHYLPSS-PGDIITVDpqsgaKTTWGRHDGLWSYTIGQKVGISmpqa--dpnyQGTWFVSE 301 baker's yeast
XP_458677 246 QDEnn---------fRNFLNEYIAPN-PGNIITED-----GKIWGQHQGLWHATIGQKLGISmpqg--dpryKGIWFISE 308 Debaryomyces hanse...
XP_448291 231 NSQhk--------kfNKFLEHYLTNK-PGNVITVEpt-geKTVWGTHKGLWSYTLGQKIGDGislpqadpryTGAWYVSE 300 Candida glabrata C...
CAG78664  238 QDQrk---------fRDFLSDYISTT-PGNVITEE-----GEVVGQHNGLWNATVGQKSGIClpqg--npkyRGSWFVKE 300 Yarrowia lipolytic...
EAL17598  242 ERGk----------fGDFISQYTSPPeSGYLVNLS-----GERLAEHKGLWYYTIGQRARVAn--------qLKPMFVAK 298 Cryptococcus neofo...

Feature 1                                                                                     
Q9RTK1    277 LDPDSNTVWVGD-----YDDCLWTGLKATDANYLLdlae---------lpteLEVQVRYRt----APVKAHVLHADAe-- 336 Deinococcus radiod...
EAK96007  322 KNYEKNQIIIVKgh--dNPKLFKQTVELTQLEWLHpkek---------vlclQSLQFQYHslsksIPVTRIIESQDR--- 387 Candida albicans S...
EAK81273  367 KDIPNNKIVVVQgk--dHPMLLCTRLYVRDIEWIWrepppelk-ydgvgrvtLLAQVRHRq----VESECVVSRFKQgk- 438 Ustilago maydis 521
XP_456180 306 KNKRTREIVIVRgk--dNNNLFKDVVTVKHFKILSknplskeelneainketLHMQFRSLq----TPVKVTSVEWINsn- 378 Kluyveromyces lact...
NP_984774 302 KDPKTNTIEIVKgr--dNRALYKDTLSVSDFESLVppedlastleaamtngeLYMQFRSLq----QAVKVTRLQLQDs-- 373 Eremothecium gossypii
Q12093    302 KLRDTNEILIVRgr--dNPALYSDTMRIENFSSLGpredtin---afqntgaLTLQFRSLq----VPVQIKSCKLNRsad 372 baker's yeast
XP_458677 309 KRYDTNELVIVKgn--nNDRLFKKGLKVKEWSWLMddisais---ekceegnLSVQYRSLq----EPEIINSIKILQs-- 377 Debaryomyces hanse...
XP_448291 301 KIPATNEIVIVRgr--eNPQLYRDKLRIQDFEYLGepqtirkaitealqrgeLRARYRSLm----EPEPLISINTDAd-- 372 Candida glabrata C...
CAG78664  301 KNIDTNELVIVKgg--nHPSLFSSNIKAKYFSWLGtkpad-------lsgmnLTIQFRSLm----EPVAITNLAIEGe-- 365 Yarrowia lipolytic...
EAL17598  299 KGVGEKGTDILVvpgsdHPMLLCKSVHTSDFHWIHrtfprel---lvkepekVGIQVRHRm----NPVGGRIVIGGNvk- 370 Cryptococcus neofo...

Feature 1                                        
Q9RTK1    337 --gFELEFAEPQFAVAPGQSAVLYAgsRLLGGGLI 369 Deinococcus radiodurans
EAK96007  388 ---LTVELETPVRALAPGQAGVLYKgnQVLGGGMI 419 Candida albicans SC5314
EAK81273  439 -ngYVVQFTEPVLAVAPGQVLGLWRgnWCLGSAVI 472 Ustilago maydis 521
XP_456180 379 --eFSLKLERKERAMAPGQYCCLYVneRVIGSGII 411 Kluyveromyces lactis NRRL Y-1140
NP_984774 374 --gFELQLATAQRAMAPGQYCCLYHndRVLGSGTV 406 Eremothecium gossypii
Q12093    373 nldITIHLASKQRAITPGQSCCLYIddRVLGSGPI 407 baker's yeast
XP_458677 378 --dVDIELVKKARAMAPGQNIVLYEgnRVLGSGIL 410 Debaryomyces hansenii CBS767
XP_448291 373 --eFHLQFQRPQRAMAPGQFCCLLSqnRILGSGPI 405 Candida glabrata CBS138
CAG78664  366 --dIAIRTAVPVRAVSPGQNLVLYHedRVLGCGVI 398 Yarrowia lipolytica CLIB99
EAL17598  371 --dVTVEFNDPIVGVSPGQVVAIWHdgWCLGSGVI 403 Cryptococcus neoformans var. neoformans B-3501A

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap