Conserved Protein Domain Family
PLAT_LOX

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cd01753: PLAT_LOX 
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PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.
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Statistics
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PSSM-Id: 238851
View PSSM: cd01753
Aligned: 15 rows
Threshold Bit Score: 151.692
Threshold Setting Gi: 51467646
Created: 13-Sep-2004
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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Display:
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cd01753 is part of a hierarchy of related CD models.
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cd01753 is a member of the superfamily cl00011.
cd00113:PLATcd01751:PLAT_LH2cd01752:PLAT_polycystincd01753:PLAT_LOXcd01754:PLAT_plant_stresscd01755:PLAT_lipasecd01756:PLAT_repeatcd01757:PLAT_RAB6IP1cd01758:PLAT_LPLcd01759:PLAT_PLcd02899:PLAT_SR1LOX  403169375146764617088601223021512640745020576978493683709134105453712230234517035062792380347219951507942811LOX  40316937514676461708860122302151264074502057697849368370913410545371223023451703506279238034721995150794281
cd01753 Sequence Cluster
cd01753 Sequence Cluster
Sub-family Hierarchy
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 cd01753 Branch
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1LOX          1 GVYRVCVSTGASIYAGs---kNKVELWLVGQHGEVELGSCLRpt------rNKEEEFKVNVSKyLGSLLFVRLRKKHFlk 71
gi 12230215   2 AEFRVRVSTGEAFGAGt---wDKVSVSIVGTRGESPPLPLDNlgke--ftaGAEEDFQVTLPEdVGRVLLLRVHKAPPvl 76
gi 12230234   2 ATYKVRVATGTDLLSGt---rDSISLTIVGTQGESHKQLLNHfgrd--fatGAVGQYTVQCPQdLGELIIIRLHKERYaf 76
gi 27923803   2 AVYRLCVTTGPYLRAGt---lDNISVTLVGTCGESPKQRLDRmgrd--fapGSVQKYKVRCTAeLGELLLLRVHKERYaf 76
gi 40316937   2 GLYRIRVSTGASLYAGs---nNQVQLWLVGQHGEAALGKRLWpa------rGKETELKVEVPEyLGPLLFVKLRKRHLlk 72
gi 41054537   1 MEYKVTVATGTSEYSGt---nNYVYVTLIGEKGKSERTLLDNpgld--fcrGAVDDYIVKSDTdLGPLILVRLEKHKYfi 75
gi 47219951   2 VRYHVTVSTADVVAATt---fNNVFIKLVGEDGESERRLLVSlkgaaafikGAVSKFAVHCSEsLGKLVLVELDKQQLpl 78
gi 50794281  43 AAYKVKVATGDVLEAGt---rNSIYITLVGTRGESPQKAMSYkf-----lpGKVKERTVKCEQdLGPLVLVRLTKTRLfl 114
gi 51467646  24 KERNVFEQDWSLLRPGvhrglTLCQLQQLGAAVAPRWLSLLCl--------PREVEFKVQVPEhLGPLLFGKLRKRHLll 95
gi 51703506  18 STYKLEVETGKDLLAAt---mDSISIVLIGSRGESQKQKLDHwgkd--flpGARDRYEVKSKEdLGEILVVRLYKESFgs 92
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
1LOX         72 e-------daWFCNWISVQALgaaeDKYWFPCYRWVVG-DGVQSLPVG 111
gi 12230215  77 pllgplapdaWFCRWFQLTPPr--gGHLLFPCYQWLEG-AGTLVLQEG 121
gi 12230234  77 fp-----kdpWYCNYVQICAPn--gRIYHFPAYQWMDG-YETLALREA 116
gi 27923803  77 fr-----kdsWYCSRICVTEPd--gSVSHFPCYQWIEG-YCTVELRPG 116
gi 40316937  73 d-------daWFCNWISVQGPga-gDEVRFPCYRWVEG-NGVLSLPEG 111
gi 41054537  76 e-------dnWFCRYVKVSVPge-rCCYTFPCYRWLVGdGVFVELREG 115
gi 47219951  79 fp-----edsWFPSKVEVTSPe--gDTYHFPIYRWIDD-TKVHRFREG 118
gi 50794281 115 e-------daWFCKEVHVTAPn--gTTYHFPCHQWLEG-ITTQEFREG 152
gi 51467646  96 d-------asWFCNWISVQGPgs-gEEVKFPCYLWVEG-NGVLSVPEG 134
gi 51703506  93 fp-----esaWFCNSIKVTCPs--gEIYEFPFHLWISG-YGTFEIPQG 132
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