Conserved Protein Domain Family
RNA_Cyclase_Class_I
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cd00875: RNA_Cyclase_Class_I 
RNA 3' phosphate cyclase domain (class I) This subfamily of cyclase-like proteins are encoded in eukaryotic genomes. They lack a conserved catalytic histidine residue required for cyclase activity, so probably do not function as cyclases. They are believed to play a role in ribosomal RNA processing and assembly.
Links
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Statistics
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PSSM-Id: 238447
Aligned: 15 rows
Threshold Bit Score: 399.764
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative active
Feature 1:putative active site [active site]
Evidence:
  • Comment:These residues are observed to form a charged pocket in related proteins for which structure is known. It is believed to be the site of RNA binding.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  #                  #  # #     ##                                   
Q09870      3 TGQLKRFKGCEYLTHRLVLATLSGTPIRVEGIYPDEADPGVKDYQVSFLRLLEKLTNGSVIEISYT-GTSFIYRPGNII- 80  fission yeast
Q9C578      1 MVMMKKMKGSQSFRQRLLLSTLSSTPISIDEIRADETIPGLRPHEVNLLRLLEIVTDDAVVDINET-GTRLKYKPGTIVg 79  thale cress
AAR88594    3 RDKARRLSGSRHFRQRVVLATLTSTAITIDDIRSGGAAPGLRPHEVSLLHLLHKISDHHSLDLNET-GTKLRYKPGVIVg 81  Japanese rice
P56175      7 EGNCLIYRGSNFLKQRLILACLSGKPVKISQIRSEDETAPGLREYEISLIRLLDKITNGTKIELNPaGTSVMFSPGLLH- 85  fruit fly
Q9Y2P8      4 QAHSLSYAGCNFLRQRLVLSTLSGRPVKIRKIRARDDNPGLRDFEASFIRLLDKITNGSRIEINQT-GTTLYYQPGLLY- 81  human
AAH45026    4 KGNCLRYEGCNFFRQRIVLSTLSGRPVKIQGIRVKDESPGIRDFEASFIRLMDKITNGTRIEINET-GTSLYYQPGLLS- 81  African clawed frog
CAE76484    6 TDFIRFTGHRAFTHRIVLSTLTGRPVHISKIRSSSATHPGLAPHEVSFLRLIEAITNGSVIDVSYS-GTTITYQPGLITg 84  Neurospora crassa
XP_405611   6 QPPIKLTGHKNFVYRLVFSTLTGRTIHISQIRPSSPTNPGLASHEISFLRLLEAVTNGSQMEISYT-GTIIVYKPGLITg 84  Aspergillus nidula...
XP_381278   6 PEFLKFSGHRSFTQRLVLSTLTGRPIHIAKIRSSSPTNPGLAPHEISFLRLLEAVTNGSSMQISYT-GTTITYHPGLITg 84  Gibberella zeae PH-1
XP_314471  18 EKGCLIYEGSNFLKQRLLLSTLSGKSIEVREIRPHHETNPGLQEYETNLLQLLDKITNGTITRVDRdGCSFVYQPGLLY- 96  Anopheles gambiae ...

Feature 1                                   #                                                 
Q09870     81 ---------GGRVVHDCPTTK---GIGYFLEPILILCLF------AKTPTSLTLTGVTSSNEDIGVDVLRTSVLPSLQKR 142 fission yeast
Q9C578     80 ---------GKNLVHSCSLSR---SIGYYLEPLLLLGLF------GKKPLSIRLKGITNDPRDASVDTFRSTTLNIIKRF 141 thale cress
AAR88594   82 ---------GRDLEHDCGVHR---GIGYFLEPLILLGLF------ARAPISIRLKGITNDTKDPSVDTFRMVTLHMLKQF 143 Japanese rice
P56175     86 ---------GGQLNHDCCVQR---GIGYYLDALIALGPF------CKSPLQCTLRGVTNSKDSPSVDHIKGAALSLLKRF 147 fruit fly
Q9Y2P8     82 ---------GGSVEHDCSVLR---GIGYYLESLLCLAPF------MKHPLKIVLRGVTNDQVDPSVDVLKATALPLLKQF 143 human
AAH45026   82 ---------GGTLEHDCNILR---SIGYYLESLFCLAPF------MKHPLKITLRGVTNDQVDPSVDTLKATAIPLLKRF 143 African clawed frog
CAE76484   85 tvagvnagaVGDVVEHTLPANntrGITYFLLPLALLAPFskahmnVRFTGPGVITSATHLTGDISVDSFRTAVLPLYGMF 164 Neurospora crassa
XP_405611  85 tasgvgassGSVIRHEIPAGCt-rGVSYFLIPLCLLAPFska-piKVLFTGPGVITSSTPTGDMSVDSVRTAILPLFNQF 162 Aspergillus nidula...
XP_381278  85 tiagfgasdGDVINHNISVNNt-rGVTYFLMPLCLLAPFska-hmNVRFTGPGVITSSTETGDISVDSFRTAILPLFGLY 162 Gibberella zeae PH-1
XP_314471  97 ---------GGVIHHDCSTER---GIGYYLDVLVALGPF------CKKPLDVTLTGVTNSKESPSVDHIKASALPALKRF 158 Anopheles gambiae ...

Feature 1                                                                                     
Q09870    143 FQVGDELELRILKRGSAPGGGGEVNFL------CPVIKESLPpirlsefgrvFRIRGIAsstrvspAFANRLVESARGVL 216 fission yeast
Q9C578    142 GVPAEDLELKIEARGVAPNGGGEVLLT------VPNIKTLSAvhwve-egmvKKIRGTTfstrvtsDFEHSMRFAARGIF 214 thale cress
AAR88594  144 GVPLEGLELKIESRGAPPLGGGEVFLR------VPNIKSTLKaanwadegmvKRIRGVSfstrvspQIENRIIYAARGIF 217 Japanese rice
P56175    148 LLVDEGLELKVVRRGVAPLGGGEIIFR------CPVRKSLRAiqfqs-qgmvKRIRGTVyackvspAMANRTVEAAKGCM 220 fruit fly
Q9Y2P8    144 GIDGESFELKIVRRGMPPGGGGEVVFS------CPVRKVLKPiqltd-pgkiKRIRGMAysvrvspQMANRIVDSARSIL 216 human
AAH45026  144 GIDGEHFELKVLKRGMPPGGGGEVIFS------CPVRKLLRPvqltd-pgkiKRIRGVAysvrvspQIGNRIVDAARGVL 216 African clawed frog
CAE76484  165 GIPPARIELRVLSRSCSGPGGRGGGGVvelrfaSQVRLPKTLhlnrr-pgriRRIRGVAyctgvsaSHNNRMITAARGVL 243 Neurospora crassa
XP_405611 163 GIFNNIELRVLRRSNLGPNGRGGGGEVqlv-fgHQVRLPKTLhlmn--agriKRVRGVAysvgvsaSNNARMIDTCRGVL 239 Aspergillus nidula...
XP_381278 163 GIPPARIELRVLQRSCAGPGGKGGGGCvelrfaSQVRLPKTLhlnrs-pgriKRIRGVAyctgvsaSNNARMIHSAREVL 241 Gibberella zeae PH-1
XP_314471 159 LIVDEGLELKVLKRGIMPGGGGEITFR------CPVRKSLKAiqctk-qtmvKRIRGTAycckvspAMANRAVEHAKGVM 231 Anopheles gambiae ...

Feature 1                                                                                     
Q09870    217 NP------FIPDVFIYTDVrrgd----------ecgnSPGYSITLVAETnkg---------csYAAEHCGEAGET----- 266 fission yeast
Q9C578    215 NN------LLPDVHIFQDHraga----------qagkSPGYGISLAAETttgcfisadttvscERPDETGELDVEkke-- 276 thale cress
AAR88594  218 NR------FIPDVHIFTDHrsgs----------aggrSAGYGVSVVAETttgcll---sadatVSYPNVDEMNEEsenle 278 Japanese rice
P56175    221 LK------FLPDVYIYTDQnkgk----------msgnSPGFGICLIAETtdg---------vcFAADCCSNTREEsedt- 274 fruit fly
Q9Y2P8    217 NK------FIPDIYIYTDHmkgv----------nsgkSPGFGLSLVAETtsg---------tfLSAELASNPQGQgaa-- 269 human
AAH45026  217 NR------FLPDIYIHTDHlkga----------nsgkSPGFGLSLVAETteg---------cfLSAELASNPQGEgst-- 269 African clawed frog
CAE76484  244 NQ------LVSDVHVAAQYdpaplvgd--ksgakkkiGIGFGLSLVAESsad--------gvlYSADVVAPPEGGv---- 303 Neurospora crassa
XP_405611 240 NPlvpdtyIFSDVSSAPLVpapernn----psakkkiGLGFGLSLVAESstg---------clFSADVACPPSGGq---- 302 Aspergillus nidula...
XP_381278 242 NP------LVPDIHIAAQYdqaplvptgdkagskrrlGIGFGLSLVAESsav--------gvlYSADVVVPAQGGv---- 303 Gibberella zeae PH-1
XP_314471 232 LN------FLPDVYINTDQhkgk----------rsgnSPGYGINLVAETtdg---------tmFSAEAICKTMDEqqgn- 285 Anopheles gambiae ...

Feature 1                                   #                         #                       
Q09870    267 ---PEDVGSFCAKKLLEVIESGGCVDPYTQPSTLTGMLLSs-eDVNTIVVGQLGITSqlVVFLRDvKALFNC-----EYR 337 fission yeast
Q9C578    277 rspAEDTGVEVASWLLQEIEKGGVVDSTHQGLLFLLCALSeqdVSKVRVGTLSPYAV--ETLRNI-KEFLGV-----KFA 348 thale cress
AAR88594  279 ltsPEDLGVQVASMLLEEVAQGGVVDSAHQGLLFILCALSppdVSKVRVGQLTPYAI--ETLRNI-RDFLDV-----KFI 350 Japanese rice
P56175    275 psiPENLGKEVALRLLDEIYRGGCVDSSYQWLAALYIALGq-kHVSKFLTGALSNYT--VHFLQHlRDFFSI-----TFK 346 fruit fly
Q9Y2P8    270 -vlPEDLGRNCARLLLEEIYRGGCVDSTNQSLALLLMTLGq-rDVSKVLLGPLSPYT--IEFLRHlKSFFQI-----MFK 340 human
AAH45026  270 -vlPEDLGRNCAMLLLEEIYRGGCVDSVNQSLVLLLMTLGq-qDVSKVLLGPLSPYT--IQFLRHlRSYFQI-----MFK 340 African clawed frog
CAE76484  304 --vPEDIGARCAYQLLEVIAQGGCVSNVSAPTLLTLMAMGsedVGRLRLGREVLAREetIGLARDlKKFGAAsw--gIRD 379 Neurospora crassa
XP_405611 303 --pPEDIGKQCAYQLLETISKGGCVAPAAFPIMIGLMTMGsedVGRIQVGRDIIGDEssIQLARD-LMKFGApgwglRDA 379 Aspergillus nidula...
XP_381278 304 --vPEDIGKQCAYQLLENISQGGCATQVSAKTMLILMAMGsedVGRLRIGREVLGNEemVILARDlRTFGASsw-glRDV 380 Gibberella zeae PH-1
XP_314471 286 psiPEDLGREAGMKLLDEVFRGGCVDSAFQWLVVLYMALAq-kDVSKFLIGPLSQYT--IHFLQHlREFFAI-----TFK 357 Anopheles gambiae ...

Feature 1        
Q09870    338 FKE 340 fission yeast
Q9C578    349 IKP 351 thale cress
AAR88594  351 IKP 353 Japanese rice
P56175    347 LEN 349 fruit fly
Q9Y2P8    341 IET 343 human
AAH45026  341 MES 343 African clawed frog
CAE76484  380 VDD 382 Neurospora crassa
XP_405611 380 GDE 382 Aspergillus nidulans FGSC A4
XP_381278 381 GDD 383 Gibberella zeae PH-1
XP_314471 358 LEN 360 Anopheles gambiae str. PEST

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