Conserved Protein Domain Family
GSH_Peroxidase

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cd00340: GSH_Peroxidase 
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Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per subunit, which is involved in catalysis. Different isoenzymes are known in mammals,which are involved in protection against reactive oxygen species, redox regulation of many metabolic processes, peroxinitrite scavenging, and modulation of inflammatory processes.
Statistics
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PSSM-Id: 238207
View PSSM: cd00340
Aligned: 141 rows
Threshold Bit Score: 151.129
Threshold Setting Gi: 28564459
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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Display:
 
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic residues [active site]
Evidence:
  • Comment:Selenocysteine forms part of the active triad. Upon reduction of hydroperoxides, the selenolate anion is oxidized to selenenic acid which is then regenerated by glutathione for another catalytic cycle. Because of its lower redox potential, selenocysteine is a better reductant than cysteine under physiological conditions.
  • Citation:PMID 9180378
  • Citation:PMID 6852035

cd00340 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00340 is a member of the superfamily cl00388.
cd00340:GSH_Peroxidasecd00570:GST_N_familycd01659:TRX_superfamilycd02066:GRX_familycd02947:TRX_familycd02948:TRX_NDPKcd02949:TRX_NTRcd02950:TxlAcd02951:SoxWcd02952:TRP14_likecd02953:DsbDgammacd02954:DIM1cd02955:SSP411cd02956:ybbNcd02957:Phd_likecd02958:UAScd02959:ERp19cd02960:AGRcd02961:PDI_a_familycd02962:TMX2cd02963:TRX_DnaJcd02964:TryX_like_familycd02965:HyaEcd02966:TlpA_like_familycd02967:mauDcd02968:SCOcd02969:PRX_like1cd02970:PRX_like2cd02971:PRX_familycd02972:DsbA_familycd02973:TRX_GRX_likecd02974:AhpF_NTD_Ncd02975:PfPDO_like_Ncd02976:NrdHcd02977:ArsC_familycd02978:KaiB_likecd02979:PHOX_Ccd02980:TRX_Fd_familycd02981:PDI_b_familycd02982:PDI_b'_familycd02983:P5_Ccd02984:TRX_PICOTcd02985:TRX_CDSP32cd02986:DLPcd02987:Phd_like_Phdcd02988:Phd_like_VIAFcd02989:Phd_like_TxnDC9cd02990:UAS_FAF1cd02991:UAS_ETEAcd02992:PDI_a_QSOXcd02993:PDI_a_APS_reductasecd02994:PDI_a_TMXcd02995:PDI_a_PDI_a'_Ccd02996:PDI_a_ERp44cd02997:PDI_a_PDIRcd02998:PDI_a_ERp38cd02999:PDI_a_ERp44_likecd03000:PDI_a_TMX3cd03001:PDI_a_P5cd03002:PDI_a_MPD1_likecd03003:PDI_a_ERdj5_Ncd03004:PDI_a_ERdj5_Ccd03005:PDI_a_ERp46cd03006:PDI_a_EFP1_Ncd03007:PDI_a_ERp29_Ncd03008:TryX_like_RdCVFcd03009:TryX_like_TryX_NRXcd03010:TlpA_like_DsbEcd03011:TlpA_like_ScsD_MtbDsbEcd03012:TlpA_like_DipZ_likecd03013:PRX5_likecd03014:PRX_Atyp2cyscd03015:PRX_Typ2cyscd03016:PRX_1cyscd03017:PRX_BCPcd03018:PRX_AhpE_likecd03019:DsbA_DsbAcd03020:DsbA_DsbC_DsbGcd03021:DsbA_GSTKcd03022:DsbA_HCCA_Isocd03023:DsbA_Com1_likecd03024:DsbA_FrnEcd03025:DsbA_FrnE_likecd03026:AhpF_NTD_Ccd03027:GRX_DEPcd03028:GRX_PICOT_likecd03029:GRX_hybridPRX5cd03030:GRX_SH3BGRcd03031:GRX_GRX_likecd03032:ArsC_Spxcd03033:ArsC_15kDcd03034:ArsC_ArsCcd03035:ArsC_Yffbcd03036:ArsC_likecd03037:GST_N_GRX2cd03038:GST_N_etherase_LigEcd03039:GST_N_Sigma_likecd03040:GST_N_mPGES2cd03041:GST_N_2GST_Ncd03042:GST_N_Zetacd03043:GST_N_1cd03044:GST_N_EF1Bgammacd03045:GST_N_Delta_Epsiloncd03046:GST_N_GTT1_likecd03047:GST_N_2cd03048:GST_N_Ure2p_likecd03049:GST_N_3cd03050:GST_N_Thetacd03051:GST_N_GTT2_likecd03052:GST_N_GDAP1cd03053:GST_N_Phicd03054:GST_N_Metaxincd03055:GST_N_Omegacd03056:GST_N_4cd03057:GST_N_Betacd03058:GST_N_Taucd03059:GST_N_SspAcd03060:GST_N_Omega_likecd03061:GST_N_CLICcd03062:TRX_Fd_Sucrasecd03063:TRX_Fd_FDH_betacd03064:TRX_Fd_NuoEcd03065:PDI_b_Calsequestrin_Ncd03066:PDI_b_Calsequestrin_middlecd03067:PDI_b_PDIR_Ncd03068:PDI_b_ERp72cd03069:PDI_b_ERp57cd03070:PDI_b_ERp44cd03071:PDI_b'_NRXcd03072:PDI_b'_ERp44cd03073:PDI_b'_ERp72_ERp57cd03074:PDI_b'_Calsequestrin_Ccd03075:GST_N_Mucd03076:GST_N_Picd03077:GST_N_Alphacd03078:GST_N_Metaxin1_likecd03079:GST_N_Metaxin2cd03080:GST_N_Metaxin_likecd03081:TRX_Fd_NuoE_FDH_gammacd03082:TRX_Fd_NuoE_W_FDH_betacd03083:TRX_Fd_NuoE_hoxFcd03418:GRX_GRXb_1_3_likecd03419:GRX_GRXh_1_2_like12958611552413862856445923508816488570193239455454659494121669131247482964861045383680330891121255292332851656225486217391272013814222268405349214781906860719171156708350356812995520810223507960885431148841055524335169015075161056789629631014001GP1 A44678374723024812167250755097670837596225488246554062838088428193436676752041151471598041750120763212336304631447648850705425219481559603529607432488360395402663867988103163304733823449257157722669633213247182833238199338646353752361262254692437486048862807289011063410241617427316475739405372980528199059229585675668029768182245487642872301413727379260580403072421370767931957293493796794098848853914133578515095533050254443680541605444384952657346435851585222622548723161174643561149653705503065313957563046097249572270061803310538566870395746575670785024373133425272357380459181446141362180550590280537587745379800468174625622546856479092675296003410509321230869341048603993668917055061419448423098025469072162265372824216998693962115894827265539641814457168053597492458425763622423097718569630385404101528377153488653706819427848862250543028615124438412958611552413862856445923508816488570193239455454659494121669131247482964861045383680330891121255292332851656225486217391272013814222268405349214781906860719171156708350356812995520810223507960885431148841055524335169015075161056789629631014001GP1 A446783747230248121672507550976708375962254882465540628380884281934366767520411514715980417501207632123363046314476488507054252194815596035296074324883603954026638679881031633047338234492571577226696332132471828332381993386463537523612622546924374860488628072890110634102416174273164757394053729805281990592295856756680297681822454876428723014137273792605804030724213707679319572934937967940988488539141335785150955330502544436805416054443849526573464358515852226225487231611746435611496537055030653139575630460972495722700618033105385668703957465756707850243731334252723573804591814461413621805505902805375877453798004681746256225468564790926752960034105093212308693410486039936689170550614194484230980254690721622653728242169986939621158948272655396418144571680535974924584257636224230977185696303854041015283771534886537068194278488622505430286151244384
cd00340 Sequence Cluster
cd00340 Sequence Cluster
Sub-family Hierarchy
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 cd00340 Branch
 Whole Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                         #                                        #    
1GP1_A       11 TVYAFSARPlagGEPFNLSSLrgKVLLIENVASLXGt---TVRDYTQMNDLQRRlgp---rgLVVLGFPCNQFgHQENAK 84
gi 12958611 120 SLYQFTATNi-dGDLINLNKYkgRPLIILNASSKANqlgtDMDHYEELKELYDKlkgs-kneLKILAFLCNQFdDSDKKD 197
gi 23508816  43 SIYDYEVKDl-sGSNVSMSKFknKVLIIFNSASKCGl---TKNHVEQFNKLHEKyna---rgLEILAFPTSQFlNQEFDN 115
gi 24655406   6 TIHALTVRDt-fGNPVQLDTFagHVLLIVNIASKCGl---TLSQYNGLRYLLEEyed---qgLRILNFPCNQFgGQMPES 78
gi 28193436   3 TIFDFEVLDa-dHKPYNLVQHkgSPLLIYNVASKCGy---TKGGYETATALYNKyks---qgFTVLVFPCNEFgGQEAGN 75
gi 28564459  46 SIYEFSALDi-dGNKVDFNKYrgHVTQIVNVACKCLl---TQEHYKKLSALYHKyse--skgLRIMAFPTNDFaKQEPWA 119
gi 32394554   6 LSDLQGLKDi-eGGAIDPSRFagKVVFAMNVASACGy---TKPGYELLKRLTDKfap---adFVAVAIPCNSFlWQESGS 78
gi 48857019 150 SFSTITFNDi-yGVQRSLGEWdgKVKIVVNVASNCGl---TKAHNKEFIELREKigt---daFEILAFPSRQFaNQEFAD 222
gi 54659494  18 SVYSYTLTTl-eGNLFPMESLkgKVVMVTNVASKCGy---TKSYYKQMVRIYSVfap---lgLEIIGLPSREFmGQEFED 90
gi 55241386  10 SIFEFTVTDl-nGNEVSLDRYqgSVCLIVNFSTKDAt---FEKVLSLLTPLLRKyhndtrkdLNVLFFPCFQFgSKESPD 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                  #    
1GP1_A       85 Ne--EILNCLKYvrpgggfepnfMLFEKCEVNGekahPLFAFLREVLPtpsddatalmtdpkfitwspvcrndVSWNFEK 162
gi 12958611 198 EtnvDFKEFITTdkk-----leaDLFTKVEVTGegaqPLWKWLYEQYCtdidv---------------tdckeINHDFTI 257
gi 23508816 116 Tk--DICTFNEKnki------kyNMFSPIEVNGdnthPLFKYLKKNCDsmhden--------------gtlksIGWNFGK 173
gi 24655406  79 Dg-qEMLDHLRRega-----nigHLFAKIDVKGaqadPLYKLLTRHQHd------------------------IEWNFVK 128
gi 28193436  76 Ee--EIKEFVCTkfk-----aefPIMAKINVNGenahPLYEYMKKTKPgila------------------tkaIKWNFTS 130
gi 28564459 120 Ep--EIKEFREAvrr-----hlrHVQQDQRERGqr-pPALEVPEGEAAgl---------------------plQRHQMEL 170
gi 32394554  79 Ae--DVKTFALArad------klLVTEKAAVNGnhphPIVALAKQAFPgr----------------------vMWNFDGR 128
gi 48857019 223 Ia--ETQQFCERvki------pfPVFTTSDVNGpetnPVFLYCKWNSDsfyhpvkn---------sksaklsdIGWNYGK 285
gi 54659494  91 Pk--EIRKFADShnv------kfPLMEICKVNGpdalEFVQKLKRETPelydek-------------sntlsaIKWNFSR 149
gi 55241386  86 E---IVQRFESStdss---gmigEIFTEIEVNGskapGLYKYLKAKKPgnc-------------------ggfINSNFTI 140
                       170       180
                ....*....|....*....|....*.
Feature 1                                 
1GP1_A      163 FLVGPDGVPVRRYSRrflTIDIEPDI 188
gi 12958611 258 FVVDKMGHYLGRFEYtkdLSSIERLI 283
gi 23508816 174 FLVDKNGEVVNYFSPktnPLDLEKII 199
gi 24655406 129 FLVDRKGNIHKRYGAelePVALTDDI 154
gi 28193436 131 FLIDRDGVPVERFSPgasVKDIEEKL 156
gi 28564459 171 HQVSGGQERTAREALw--THRLVRNN 194
gi 32394554 129 FVFDRNGVPVARFGNsakPEEIEAAI 154
gi 48857019 286 FLVDKDNGVYKYYGPrtkPLEMEEDI 311
gi 54659494 150 FLIDKNGKVVAFRGTrtePNELIPKI 175
gi 55241386 141 FLTDRQGVPVERLNAgihPYTLEDMV 166

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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D