1BP1,1BP1


Conserved Protein Domain Family
BPI
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cd00264: BPI 
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BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative bacteria.; Apolar pockets on the concave surface bind a molecule of phosphatidylcholine, primarily by interacting with their acyl chains; this suggests that the pockets may also bind the acyl chains of lipopolysaccharide.
Links
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Statistics
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PSSM-Id: 238164
Aligned: 31 rows
Threshold Bit Score: 80.8936
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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apolar bindingBPI
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:apolar binding pocket
Evidence:
  • Comment:formed mainly by alpha helices and the beta sheet beneath them
  • Comment:binds acyl chains of phosphatidylcholine
  • Comment:may also bind acyl chains of lipopolysaccharide
  • Citation:PMID 9188532
  • Structure:BPI1, binds phosphatidylcholine
    - View structure with Cn3D
  • Structure:BPI2, binds phosphatidylcholine
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #    #  #   #  #                                                           
1BP1        4 GVVVRISQKGLDYASQQGTAAlqkelkRIKipdysdsfkik----------hlgkghysfySMDIrEFQLPSSQISMVpn 73  human
1BP1      253 MVYLGLSDYFFNTAGLVYQEAgvl-kmTLRddmipkeskfrlttkffgtflpevakkfpnmKIQIhVSASTPPHLSVQp- 330 human
115110     30 GIVARITQKGLDYACQQGVLTlqkeleKITipnfsgnfkik----------ylgkgqysffSMVIqGFNLPNSQIRPLpd 99  Bos taurus
AAG42844   31 GVVVRISQKGLDYASQQGTAAlqkelkRIKipdysdsfkik----------hlgkghysfySMDIrEFQLPSSQISMVpn 100 human
AAH04795   29 GVVARITDKGLAYAAKEGLVAlqrelyKITlpdfsgdfkik----------avgrgqyefhSLEIqNCELRGSSLKLLpg 98  house mouse
AAH19847   21 GCKIRVTSKALELVKQEGLRFleqeleTITipdlrgke---------------ghfyynisEVKVtELQLTSSELDFQpq 85  Homo sapiens
116119     27 GIVCRITKPALLVLNHETAKViqtafqRASypditgekamm----------llgqvkyglhNIQIsHLSIASSQVELVea 96  human
AAL60017   66 HISIIVSETGLEFAKDYLIKKvitttlPLQlpdienkvkip----------ligkvrmglsNIQIdAVHVQSSKMETRk- 134 thale cress
NP_563724  28 FTSVLVSQNGLDFVKNLLVNKaiasiiPLQiprieksmkip----------flggidvvvsNLTIyELDVASSYVKLGe- 96  thale cress
XP_066207  21 GALLRLGMDIMNREVQSAMDEshi-leKMAaeagkkqpg--------------mkpikgitNLKVkDVQLPVITLNFVp- 84  human

Feature 1       #                                                 # #          #              
1BP1       74 vGLKFSIsnANIKISGkwkaqkrf------lkmsgnfDLSIEg---MSISADLKLGSnptsgkPTITCSSCSSHInsvhv 144 human
1BP1      331 tGLTFYPa-VDVQAFAvlpns------------alasLFLIG----MHTTGSMEVSAes--nrLVGELKLDRLLLelkhs 391 human
115110    100 kGLDLSIrdASIKIRGkwkarknf------iklggnfDLSVEg---ISILAGLNLGYdpasghSTVTCSSCSSGIntvri 170 Bos taurus
AAG42844  101 vGLKFSIsnANIKISGkwkaqkrf------lkmsgnfDLSIEg---MSISADLKLGSnptsgkPTITCSSCSSHInsvhv 171 human
AAH04795   99 qGLSLAIsdSSIGVRGkwkvrksf------lklhgsfDLDVKg---VTISVDLLLGMdps-grPTVSASGCSSRIcdldv 168 house mouse
AAH19847   86 qELMLQItnASLGLRFrrqllywf------fydggyiNASAEg---VSIRTGLELSRdpa-grMKVSNVSCQASVsrmha 155 Homo sapiens
116119     97 kSIDVSIqnVSVVFKGtlkygytt-----awwlgidqSIDFEidsaIDLQINTQLTCds--grVRTDAPDCYLSFhklll 169 human
AAL60017  135 dGIILSVlgATANLSMdwsytyrasf--feisdhgdaSVEVKg---MNVRITATLVNdn--gsLKIASRENDCTVknidi 207 thale cress
NP_563724  97 tGVVIVAsgTTCNLSMnwhysystwlppieisdqgiaSVQVQg---MEIGLSLGLKSde--ggLKLSLSECGCHVediti 171 thale cress
XP_066207  85 -GVGIFQc-VSTGMTVtgksf-----------mggnmEIIVA----LNITATNRLLRdeetglPVFKSEGCEVILvnvkt 147 human

Feature 1                                       #   #   #                                 #   
1BP1      145 hiskskvg-wliqlfhkkiesaLRNKMNSQVCEKVTNSVSSKLQPyfqtlpvmtkidsvaGINYglvapPATTAETLDVQ 223 human
1BP1      392 ni-------------gpfpvelLQDIMNYIVPILVLPRVNEKLQKgfpl-------ptpaRVQLyn-vvLQPHQNFLLFG 450 human
115110    171 hisgsslg-wliqlfrkrieslLQKSMTRKICEVVTSTVSSKLQPyfqtlpvttkldkvaGVDYslvapPRATANNLDWL 249 Bos taurus
AAG42844  172 hiskskvg-wliqlfhkkiesaLRNKMNSQVCEKVTNSVSSKLQPyfqtlpvmtkidsvaGINYglvapPATTAETLDVQ 250 human
AAH04795  169 hisgnvgw--llnlfhnqieskLQKVLENKVCEMIQKSVTSDLQPylqtlpvtaeidnvlGIDYslvaaPQAKAQVLDVM 246 house mouse
AAH19847  156 afggtfkk--vydflstfitsgMRFLLNQQICPVLYHAGTVLLNSlldtvpvrssvdelvGIDYslmkdPVASTSNLDMD 233 Homo sapiens
116119    170 hlqgerepgwikqlftnfisftLKLVLKGQICKEINVISNIMADFvqtraas-ilsdgdiGVDIsltgdPVITASYLESH 248 human
AAL60017  208 hinggas---wlyqgvvdafqkMIISTVEKTVSTKIVEKMKKLDSflqslpkqrkiddsaAVNLtftgnPVLGNSSVEVD 284 thale cress
NP_563724 172 eleggas---wfyqgmvnafkdQIGSSVESTIAKKLTEGVSDLDSflqslpkeipvddnaDLNVtftsdPILRNSSITFE 248 thale cress
XP_066207 148 nlpsnml----pkmvnkfldstLHKVLPGLMCPAIDAVLVYVNRKwtnlsdp-mpvgqmgTVKYvlmsaPATTASYIQLD 222 human

Feature 1         
1BP1      224 MKGE 227 human
1BP1      451 ADVV 454 human
115110    250 LKGE 253 Bos taurus
AAG42844  251 MKGE 254 human
AAH04795  247 FKGE 250 house mouse
AAH19847  234 FRGA 237 Homo sapiens
116119    249 HKGH 252 human
AAL60017  285 INGL 288 thale cress
NP_563724 249 IDGL 252 thale cress
XP_066207 223 FSPV 226 human

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