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cd00058: FGF 
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Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate embryogenesis, and has neurotrophic activities. FGFs have a high affinity for heparan sulfate proteoglycans and require heparan sulfate to activate one of four cell surface FGF receptors. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active. FGFs have internal pseudo-threefold symmetry (beta-trefoil topology).
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Statistics
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PSSM-Id: 238015
View PSSM: cd00058
Aligned: 31 rows
Threshold Bit Score: 100.766
Threshold Setting Gi: 7494587
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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heparin bindingreceptor
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:heparin binding site (glycine box) [chemical binding site]
Evidence:
  • Comment:binding site for anionic heparin sulfate contains conserved positively charged residues
  • Citation:PMID 1849658
  • Structure:1BFC; basic fibroblast growth factor with bound heparin
    View structure with Cn3D
  • Citation:PMID 1702556
  • Comment:motif has been described as glycine-box in the literature
  • Comment:9843417

cd00058 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00058 is a member of the superfamily cl00060.
cd00058:FGF24944557494587249446515320682116967830061209634259200699309631123730054813626688111321966015144136266951RML  1BFC  1CVS A1QQK A13626689601514113459951G82 D2494456199128221IJT A1345996398019013637763249445724944612126446624944557494587249446515320682116967830061209634259200699309631123730054813626688111321966015144136266951RML  1BFC  1CVS A1QQK A13626689601514113459951G82 D2494456199128221IJT A13459963980190136377632494457249446121264466
cd00058 Sequence Cluster
cd00058 Sequence Cluster
Sub-family Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1QQK_A       13 RRLFCRt-QWYLRIDKRGKVKGTQEMrnSYNIMEIRTVA-VGIVAIKGVeSEYYLAMNKEGKLYAKK-----ECNEDCNF 85
1BFC         22 KRLYCKngGFFLRIHPDGRVDGVREKsdPHIKLQLQAEE-RGVVSIKGVsANRYLAMKEDGRLLASK-----SVTDECFF 95
gi 2494465   31 VQVLIH--NRYLAVRSDGTVGGTTYAssLDTVLQRIAIA-HGRILLRNAvSCMYVCLDRCGAMYASA-----ALSSDCIL 102
gi 1169678   30 GQLFIN--RQFLAVNPDGAVYGTIESdnVDTIFKRVAVD-RNRIVIQNAiTCVYLCMDRCGQLYGSK-----TLSKDCFM 101
gi 15320682  31 VQVFVH--NRYLAVRLNGTVEGTEDAfdVDTMLQRVSFR-DGRILLRNAiTCMHVCLDRCGVMYSTN-----AMSYDCFL 102
gi 3006120   29 IQMFVK--NQYIAVDGNGDVMGCRDRtaSRTVFYRISIS-HNLLSLVNSvSCRYVCINACGYVYTLAmngagGISQDCLL 105
gi 9634259   35 VHIFLN--HYFLQMNADGVVDGALTDasNQTIWHRIARP-DGMMLLRSSiYCTYLCVNECGYGYSAL-----LPNGECLW 106
gi 9631123   25 VQIGIN--RQLLTCFANGTVGGSTDEraDGTAWRRWAAK-PREVLIRSAaTCAFVCLDDCGFLYTAAe----APNKECLF 97
gi 20069930  36 VQIFIN--HHLLRMNLDGIVNGTQTGesSETVWHRISQS-DGILLRSSL-YCNYACINECGYGYSAL-----IPNNECLW 106
gi 2494455   54 YQLYSRtsGKHVQILDNKKINAMAEDgdVHAKLIVETDTfGSRVRIKGAaTGFYICMNKKGKLIGKSn----GKGKDCVF 129
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                                   ##    #   #          #        
1QQK_A       86 KELILENHYNTYASakwthsggemFVALNQKGLPVKGKKtkk-----eqKTAHFLPMA 138
1BFC         96 FERLESNNYNTYRSrky----tswYVALKRTGQYKLGSKtgp-----gqKAILFLPMS 144
gi 2494465  103 NEVMLENNYDVMFKiyng---kktYVALDNTGNPRRVQLprqrp-lrmmNVYTFIMRI 156
gi 1169678  102 REFLEKNNYNTYYKvydr---kltYVALKNDGTPRKLQIsksr---klgKLSVYAMAL 153
gi 15320682 103 KENYTENNYSVMYKiykr---krtYVALNNRGRARRVQLpmrr---tlrKMSQYALLL 154
gi 3006120  106 REHMTESYYNWYYRednd---trsFLALNKYGRTKRVRIksddvlhnniNSINVITGQ 160
gi 9634259  107 SEIYDDFNNRFIVKrfen--nrtaYLALNAAGKLKRVVLlkkeklmdafEQTHVFIKN 162
gi 9631123   98 VEELSENHYSYLYRvhdr---sriYLALGANGKSRRVVApvd-----epLADHGNPTS 147
gi 20069930 107 TEQYDEHNYRFINKkfgn---rtaYLSINLEGKLKRTVLlrketlgnkfEQSHVTLKD 161
gi 2494455  130 TEIVLENNYTALQNaky----egwYMAFTRKGRPRKGSKtrq-----hqREVHFMKRL 178

Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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Click on image for an interactive view with Cn3D
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D