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TIGR03002: outer_YhbN_LptA 
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lipopolysaccharide transport periplasmic protein LptA
Members of this protein family include LptA (previously called YhbN). It was shown to be an essential protein in E. coli, implicated in cell envelope integrity, and to play a role in the delivery of LPS to the outer leaflet of the outer membrane. It works with LptB (formerly yhbG), a homolog of ABC transporter ATP-binding proteins, encoded by an adjacent gene. Numerous homologs in other Proteobacteria are found in a conserved location near lipopolysaccharide inner core biosynthesis genes. This family is related to organic solvent tolerance protein (OstA), though distantly [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other].
Statistics
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PSSM-Id: 234083
View PSSM: TIGR03002
Aligned: 39 rows
Threshold Bit Score: 105.769
Threshold Setting Gi: 77919536
Created: 11-Sep-2012
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:

TIGR03002 is classified as a model that may span more than one domain.
TIGR03002 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2R19_A         1 AVTGDTDQPIHIESDQQSLDMQ-GNVVTFTGNVIVTQGTIKINADKVVVtRp-GGe-----Q-GKEVIDGYG---KPATF 69
gi 154707186  29 ALSSDQFKPYHVRSIEVIYRRP-DHITLYHGDVYATQGTTWISGDKVIVyHn-PTt-----N-RIVRLKAIG---HPAHY 97
gi 54293812   23 ALPFDKEKMVQVVSDSADLNQK-NHQGVYIGNVEFVQGSTNLRAEKAITqGd-AK------N-QLTLAIAEGskdKQAHY 93
gi 78485318   25 etnANESLPIEIKADSLVSQDQ-KGQSVYSGRVIITQGTTVIHGDKVTIfHp--N------R-KVIKAIVIG---QPATF 91
gi 83647981   26 dLLNGSDEPVRIKAGRWERDGQ-KGIDTYIGNVVITQGKSSIEADKVVLyT--DD------K-GISRFQATG---KPAHL 92
gi 198284715  35 AEQGLGKGPIQISADALHGENKpQQQAVYTGNVVMTQGDVVVHADKLTVdA--IA------G-KVHQATAVG---SPVTF 102
gi 32266827   11 CMCMNAADTLEVSAKVFQSDLK-NGLTELSGEVLVVKGEDKLWADKVVIeTn-KK------N-KPQKYTATG---N-VRF 77
gi 51244292   22 STAFAKDAPIYIEANHMTSTEN-TNTVFFEGDVDAKQDDVRIRSNKMTVfYs-KAskgeksQ-QVKKIICTG---N---- 91
gi 78222495   25 pkggrqgQPITIKSNELSTDSR-HNTATFTGKVIARQGDLTIYADKLVVhYkaDG------G-DLDRVEASG---N---- 89
gi 77919536   26 SATAGKAQPLEITSQKLEADGT-LKKVVFVGKVVARQDGLTIRSSKLIVaYg-QS------GtRVSSIEAIG---DVV-- 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2R19_A        70 YQMQDNGK-P-V-EGHASQMHYELAKDFVVLTGNAYLQQVD--SNIKGDKITYLVKEQKMQAFSD--KGK-----RVTTV 137
gi 154707186  98 STMPDNQK-A-RlYAQAETILYFPAKAQVLLIKNARVTQKQ--NILTGPHIWYDIKKQTVISTVP--NGKg----NTTVV 167
gi 54293812   94 WTTTAPDKpP-F-HAYADTIKYYPLKHLIELIGNARIEQGP--NSLSAAKISYDTQEQHVLSHSD--EKT-----RTTII 162
gi 78485318   92 KRFLPEEK-NwI-DGRADTITYHAERRTVLLEGHAFVNQEGk-NSISGPEILYNLNDKTLSAKGN--KTEk---kRITVI 163
gi 83647981   93 VQFDAEKQtE-T-HAYAESMDYDRSQSKVVMRNHARILQDN--SSVEGEEIIYFTDKRLVTAKGAssGNQt---eQVEII 165
gi 198284715 103 TMSAAQ-----R-HGYGDTLVYKPGKGEIVLTGNAHLWQKK--NEISGQQVTYFLQTQQTAVTAA--PGK-----RVQSI 167
gi 32266827   78 YAKMPN-K-E-M-RGKAKKAVYNVIKDEYQLIDSAMLEEIGkkNIIRGNMIVFNPQSQEAFVKGS--SQKp---gMMTFI 148
gi 51244292   92 -TEVTRG--E-W-LGTGQRMVYTTKDKKIVLTGNAKAWQNQ--NMVSGETITYFLDQKRSEVVGT--PQKnkkpsRVNMT 162
gi 78222495   90 -VRIVQGD---R-LATARDGVYQSAEQKIVLTGDPKVFQGE--NTVSGKVITYFVDEEKSIVTGG--Pd-----tRVEAV 155
gi 77919536   93 VQKDD------R-TATAGRGLYNVAEGTVVLTETPRVQQGD--NSVEGDEIVFYLEEDRSIVKSQ--SGs-----RVRAI 156

                 ....
2R19_A       138 LVPS 141
gi 154707186 168 IEPQ 171
gi 54293812  163 IYPE 166
gi 78485318  164 FEPE 167
gi 83647981  166 YHPp 169
gi 198284715 168 FYPa 171
gi 32266827  149 MEDK 152
gi 51244292  163 IIQN 166
gi 78222495  156 ITPK 159
gi 77919536  157 LTPg 160
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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