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COG3239: DesA 
Fatty acid desaturase [Lipid metabolism]
Statistics
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PSSM-Id: 225779
View PSSM: COG3239
Aligned: 27 rows
Threshold Bit Score: 140.303
Threshold Setting Gi: 15600295
Created: 7-Oct-2002
Updated: 16-Jan-2013
Structure
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Aligned Rows:

COG3239 is classified as a model that may span more than one domain.
COG3239 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15842818   7 DVFAHLTDADIENLAAELDAIRRDVEES--RGERDARYIRRTIAAQRALEVSGRLLLAGSSRrlaWWTGALTLGVAK--I 82
gi 16127652   1 MSPGGLCDAPHMAVAPRVKPLDLFTPEE--WTRISARSSWRGIWMVAHAWGVILAAGALFVAfpnPLTYVLAVMLIGarQ 78
gi 15600295   1 ---------MAHYLSGRQRTLVRRLQDT--FQARSEWPTWLLVACLYGGWALLASQYERWG----WPVLAGLVPFAS--- 62
gi 17549005   1 ---MPTTRNADREAFLSYAPIRLTQEQKraLTRKRPVRFVIQFTALAALYAALASVGMLVDH---PALWVPIWIVLGamL 74
gi 17549250   1 ------------------MSTRARVGRPg-RVLSDRFADVPSLLFLAGVVANTALIACADTP----WLPALLTLPQAllL 57
gi 17229090  10 EIKNKLSNPE-----LRLKDIIKTLPKE--CFQQNRRKAWTQALLSVVMVGLGYWSLAIAP----WFLLPIAWIFTGtaL 78
gi 17230681   1 --MVQCQPSSLHSEKLVLLSSTIRDDKN--INKGIFIACFILFLWAISLILLLSIDTSIIHK----SLLGIAMLWQTflY 72
gi 13471288   1 ----------------MVDSMTGKSIKR---RNVPAIEWPTVVLAFFCYGTWLGTGFLLWP-----SYPILALALLGfiL 56
gi 13476454   1 --------------MDHRDIIASLAPEE--RSRLTAKSNAAGLVQLGAHWGAIAIIGSLIAAk--VPFWPLLMLPQGilI 62
gi 118451     9 TPTVTPSNPDRPIADLKLQDIIKTLPKE--CFEKKASKAWASVLITLGAIAVGYLGIIYLP----WYCLPITWIWTGtaL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15842818  83 IENMEIGHNVMHG----QWDWMNDPEIHSSTWEWDmsGSSKHWRYTHNFvHHKYTNILGMDdd---vgYGMLRVTRDQRW 155
gi 16127652  79 LGLAILMHEAAHGgl-hPKLKVNDWLGEWLCAAPVg-ASLASYRPYHLS-HHKYAQQAEDP--------DLVLSAPFPTT 147
gi 15600295  63 -LYMSLQHELIHGhp-tRWPRFNAMLGYLPLAVWY--P-YPLYRDSHLR-HHLDEQLTYPGld----pESRYVSLSEWPR 132
gi 17549005  75 GGLNLVGHECVHSsf-sGSRWLNRLAGSLFMATNF--LNFTLHRGYHLK-HHAHTMQEGDT-------QEEIGLYGYRSR 143
gi 17549250  58 GGCQEAKHLCVHGtf-lRNRRLNDTVGTVCAALFG--VNFVAYRSFHYQ-HHRATCTDADP-------EGGLYALSWRTR 126
gi 17229090  79 TGFFVIGHDCGHRsf-aKRRWVNDLVGHIFMMPLI--YPFHSWRIKHNH-HHKHTNKLDEDnawhpirPEVFASWGKTRQ 154
gi 17230681  73 TGLFITAHDAMHGvvypKNPRINNFIGKLTLILYGl-LPYKDLLKKHWL-HHGHPGTDLDP--------DYYNGHP---- 138
gi 13471288  57 ALQSSIMHEVLHGhp-tRSALINEAFVFLPIGLVW--P-FRRFKTLHLR-HHADERLTDPLdd----pESYYQALWQHDE 127
gi 13476454  63 VFLFTLLHETVHRta-fDTQWLNDFVARVCSLALA--LPADWFRYFHFA-HHRFTQDPEND-------PELAFPKPETLR 131
gi 118451    83 TGAFVVGHDCGHRsf-aKKRWVNDLVGHIAFAPLI--YPFHSWRLLHDH-HHLHTNKIEVDnawdpwsVEAFQASPAIVR 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15842818 156 KRYNIFNVVWNTILAIGFEWGVALQHLEIG-KIFKGRADREAAKTRLREFSAKAGrqvfkdYVAFPALTSLSPgatyrst 234
gi 16127652 148 RRSLRRKMIRDLTGQTFFKQRFGPLLGKMKgAKTTGQPKGAIFAGEIARQRPFLLwnl-giLVVLSALGLWWAw------ 220
gi 15600295 133 LGSWRRRWLCLDKTLLGRATLGPLLALAAMaRLEGSRLRRGEGAAWRLWGLHAVL------LGGLLAGLWRWAg------ 200
gi 17549005 144 AEYLKGLLSWSTIFNSFFYNEWKYSVLAFFgRRTAFFNTKTSDLAAVKTDFIVML------LWCAAVATFTWN------- 210
gi 17549250 127 -WIWLLAPIELPWVAFHINRIGWPMVPPGQ----RLRR--AAALAWMAAFAALIGl-----AACHAPRAVLFG------- 187
gi 17229090 155 S--AFKLFMRQRLWWVGSVGHWAVVHFDWR-KFKVKDQADVKLSVAVVVLFAAVA------FPTLIATTGIWGfvk---- 221
gi 17230681 139 ------QNFFLWYLHFMKSYWRWTQIFGLV------------MIFHGLKNLVHIP---------ENNLIIFW-------- 183
gi 13471288 128 LPPTMKFLLKINNTMVGRFFFGPWLSCIGFfIDDFKQMMAGDKAIRKAWLLHAIG------LAIVAPIVQFGFg------ 195
gi 13476454 132 QYLVHVSGIPLWWGHLKTLYANAVGGSQE--SYVPPK--GRPKVRAEACAMIAFY------A--VVLLLAVY-------- 191
gi 118451   159 ---LFYRAIRGPFWWTGSIFHWSLMHFKLS-NFAQRDRNKVKLSIAVVFLFAAIA------FPALIITTGVWGfvk---- 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15842818 235 ltanVVANVIRNVWSNAVIFCGHFpdgaekFTKTDMIGEPKGQWYLRQMLGSA-NFNAGPALRFMSGNLCHQIEHHLYPD 313
gi 16127652 221 ---pALWIVPMATWFPLVTR----------LRNIAEHALVAKDEPDPFRHARTtNANWIERALIAPYYVNFHAEHHMFMH 287
gi 15600295 201 ----IPPWLYLPAVAYPALG------------LS-MLRSFYEHRPAREPAQRSvLVDAGWPWRLLFLNNNLHLVHHDLPG 263
gi 17549005 211 -----APEIAVKTFLVPVCVFFPLi-----LYLISLPEHYKVDAGGNALENTR-TVRSSWLVRQIFWNINYHTAHHAFPY 279
gi 17549250 188 ----YAIPLALFAWFDFVLT-----------QAEHYQVDIAPAASVRAPAALThDIVLPLGLGWLTLHRTLHRVHHCHPG 252
gi 17229090 222 --fwFVPWLGYHFWMSTFTIVHHT------YPDVPFEAENKWHEAMAQLFGTI-HCDYPKWVEVLCHDINVHVPHHLSTA 292
gi 17230681 184 ----MIPSILSSVQLFYFGT------------FLPHKKLEGG--YTNPHCARS-IPLPLFWSFVTCYHFGYHKEHHEYPQ 244
gi 13471288 196 -----IPLWLYILAPVWLGQ-----------SLIAIRTFAEHQWSEHPEGRTV-IIERS-PLSFLFLNNNLHFVHHKTPT 257
gi 13476454 192 ----FRLSVLVYVWIIPALLGQPF------LRLYLLAEHGRCPFVANMLENTR-TTLTNWVVRKLAWNMPFHAEHHAYPG 260
gi 118451   225 --fwLMPWLVYHFWMSTFTIVHHT------IPEIRFRPAADWSAAEAQLNGTV-HCDYPRWVEVLCHDINVHIPHHLSVA 295
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15842818 314 LPSNRLHEISVRVREVCDRYD-LPYTTGSFLVQYGKTWRTLAKLSLPD-KYLRDNAddaPETRSERMFA 380
gi 16127652 288 TPCWNLPLAHRVLEKKGLTQG------MLTAPGYLSVLKAASSKPVAA--------------------- 329
gi 15600295 264 LPWYLLPRVYSASRRAYRRRS-----GDFHLPGYGRLWRRHGWRPVDA-PVHPEH-------------- 312
gi 17549005 280 VPFYNLPKAHKLLEKQVKYS-----EASYLGFHLKTFRDLRGAPAVER-ERA----------------- 325
gi 17549250 253 LRWFEAPRRLRADPSAAP--------MSYAAFVR--RWLSAGPRLWLRaDASPAAP---NPTDHPAHDA 308
gi 17229090 293 IPSYNLRLAYSSIQENWG--------DYLHDELR-FSWSLMKLITDEC-QLYQTDV---GYQPFKDYYA 348
gi 17230681 245 LPWWKLPEAHKISL------------------------------------------------------- 258
gi 13471288 258 VAWYRLPKLFRERRDEWLRMNnGYAYPNYFALIKAYAFKAKEPIVHPVlRRAPEHGrafKPRIRARNIN 326
gi 13476454 261 VPFHQLPQFHALIERHLK-----VVEPGYVSFHEKYVETLR---------------------------- 296
gi 118451   296 IPSYNLRLAHGSLKENWG--------PFLYERT--FNWQLMQQISGQC-HLYDPEH---GYRTFGSLKK 350
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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