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COG2124: CypX 
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Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]
Statistics
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PSSM-Id: 225035
View PSSM: COG2124
Aligned: 98 rows
Threshold Bit Score: 71.6909
Threshold Setting Gi: 13475115
Created: 7-Oct-2002
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
COG2124 is a member of the superfamily cl12078.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1E9X_A        1 MSAVALPRVSGGHDEHGHLEEFRt------dPIGLMQRVRDECGDVGTFQLAGKQ-----------VVLLSGSHANEFFF 63
gi 15614320   2 KSNDPIPKDSPLDHTMNLMREG---------YEFLSHRMERFQTDLFETRVMGQKvlc-----irgAEAVKLFYDPERFK 67
gi 9296939    1 -MNEQIPHDKSLDNSLTLLKEG---------YLFIKNRTERYNSDLFQARLLGKNfic-----mtgAEAAKVFYDTDRFQ 65
gi 15896573   2 LLKENTAKDKGIDSTLDLLKEG---------YLFIKNRADHYQSDLFETRLMGQRiic-----mtgEEAARIFYDSDKFK 67
gi 15807460   5 LHDLPEPASRPGSGHLQDWAARP--------LALIEEGATQALAAGQDLFRLRLGl---------pAVVGLSPAWNRRVL 67
gi 15827139     --------------------------------------------------------------------------------
gi 15598875   2 QQTIDCPIRRRLAHLPWANDGRAg-------VRHWLEMQRDPLAWLQKMHVAQPDlavar-mgpqrLWCLFHPQAVQELM 73
gi 19114700  29 ICFALLAVCIAYDQISYQMQKGHipgp-rfkIPFMGSFLDSMKPTFEKYNAKWQTgpls---cvsvFHKFVVIASERDLA 104
gi 1706693   48 IFATLICILLVWDQVAYQIKKGSiagpkfkfWPIIGPFLESLDPKFEEYKAKWASgpls---cvsiFHKFVVIASTRDLA 124
gi 17228856  10 DNSSSFPYLVTVLSVTTIAGTFAwrwwkqkkKYKSLQSLPSPPKHWLLGNLPQVLaavkqkklfqlFFDWSQQLGPMYVV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1E9X_A       64 RAG--------DDDLDQAKAYP-F----------MTPIFGEGv---VFDASPERRKE--MLHNAALRGEQMKGHAATIED 119
gi 15614320  68 RHRa-------TPKRIQKSLF-------------GENAIQT--------MDDKAHLHr-KQLFLSMMKPEDEQEL--ARL 116
gi 9296939   66 RQNa-------LPKRVQKSLF-------------GVNAIQG--------MDGSAHIHr-KMLFLSLMTPPHQKRL--AEL 114
gi 15896573  68 RQGa-------APKRVQETLL-------------GENAIQT--------LDGESHLHr-KKLFMLLTNQVQQKRL--AEL 116
gi 15807460  68 TDLn------tFVSAGSFSAVVp-------------YLAGG-----VILTDAPGHGArrRALNPGFGKGSVQQLRERMRQ 123
gi 15827139     --------------------------------------------------------------------------------
gi 15598875  74 VDRr------dDLQRWQPALCMlK------------QWNGRS----FMMREGAPAQArrKEVRPHLAPPPASEVRRLAAE 131
gi 19114700 105 RKIl------nSPSYVQPCVVDa-----------GKKILKHTn---WVFLDGRDHIEyrKGLNGLFTTRALASYLPAQEA 164
gi 1706693  125 RKIl------qSSKFVKPCVVDv-----------AVKILRPCn---WVFLDGKAHTDyrKSLNGLFTKQALAQYLPSLEQ 184
gi 17228856  90 WNGsspvvilsKPKVIEDTIVNgMrdgslirsarLRQAWNDIsgpiLIGETGNEWQWrrKVWNPEFSSSSLAKYLKIINQ 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1E9X_A      120 QVRRMIADw---GEa----GEIDLLDFFAELTIYTSSaCLIG---KKFRDQLDGRFAKLYhel-----ergTDplayvdP 184
gi 15614320 117 THETWRRVae-gWKk---sRPIVLFDEAKRVLCQVAC-EWAEvplKSTEIDRRAEDFHAMv----------DAf-----G 176
gi 9296939  115 MTEEWKAAvt-rWEk---aDEVVLFEEAKEILCRVAC-YWAGvplKETEVKERADDFIDMv----------DAf-----G 174
gi 15896573 117 TTEKWEASas-kWHt----KSIVLFNEANEILCQVAC-HWAGvplMESDIKNRAEDFSSMi----------DSf-----G 175
gi 15807460 124 ASSPVPTG------------RFNALAWADETVRRQLNaAYFAsefDDRLLAAFLAPLRRP-------------------- 171
gi 15827139     --------------------------------------------------------------------------------
gi 15598875 132 WGERVEEGr-----------eYDLDLEMAAFSVTLSGhALFDvdlQPSAYRIAKAVRLLSr------------------- 181
gi 19114700 165 VYNKYFKEfl-aHSkddyaQYMIPF---RDINVATSCrTFCGyyiSDDAIKHIADEYWKIt----------AAmelvnfP 230
gi 1706693  185 IMDKYMDKfv-rLSkennyEPQVFFHEMREILCALSLnSFCGnyiTEDQVRKIADDYYLVt----------AAlelvnfP 253
gi 17228856 170 ACVQVIDTlketALp----KEVEVDPLFVELTMRVISsLVLGipvDRKITTNEGPPLEVLkvyeamcvvgyRFlrqatgE 245
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1E9X_A      185 YLPIES-FRRRDEARNGLVALVADIMNGRIanp-------ptdKSDRDMLDVLIAVKAETGTP---------RFSADEIT 247
gi 15614320 177 AVGPr--HWRGRKGRRRTERWIQSIIHQVRtgs--------lqAREGSPLYKVSYHRELNGK-----------LLDERMA 235
gi 9296939  175 AVGPr--HWKGRRARPRAEEWIEVMIEDARagl--------lkTTSGTALHEMAFHTQEDGS-----------QLDSRMA 233
gi 15896573 176 AVGPr--HWKGKKARNTIEAWIKEIIENVRsgr--------irAEEGSPLHEIAFYIDVNGQ-----------QMPAEMA 234
gi 15807460 172 ---FPVpALPRPLLFRRVEQEIRRLAERRL-------------REGGDDLLSTLAPLPG---------------G--LLE 218
gi 15827139   1 -----------------------------------------------------MLYSADPSTGe--------QLDTDNVV 19
gi 15598875 182 ------vALLEMSTGLPLGHWFPSKLCPRK-------------RWALGQLREAVGEVAERSPR-----------PLADLR 231
gi 19114700 231 IVLPFTkVWYGIQSRKVVMRYFMKAAAESRknmeagnapacmmEEWIHEMIETRKYKSENKEGaekpsvlirEFSDEEIS 310
gi 1706693  254 IIIPYTkTWYGKKTADMAMKIFENCAQMAKdhiaaggkpvcvmDAWCKLMHDAKNSNDDDSRiy------hrEFTNKEIS 327
gi 17228856 246 KIWMKYlPTKNSQDYWASRRYLEEFLTPRVdlalqmreqstdfPQVSPLFRESMLVRIAAKEP---------KYNRQTLI 316
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1E9X_A      248 GMFISMMFAGHHTSSGTASWTLIELMRHRDa-------YAAVIDELDElygdgrsvsfhalrqiPQLENVLKETLRLHPP 320
gi 15614320 236 AIELINVLRPIVAIATFISFAAIALQEHPe--------WQERLKNGSN----------------EEFHMFVQEVRRYYPF 291
gi 9296939  234 AIELINVLRPIVAISYFLVFSALALHEHPk--------YKEWLRSGNS----------------REREMFVQEVRRYYPF 289
gi 15896573 235 AIELINILRPIVAISTFITFSALALYEHSe--------YREKLQSKDI----------------RYLEMFTQEVRRYYPF 290
gi 15807460 219 TRIS--LAAAHDTTTHALAYAVWELAKAPQ---------DQTPHTHS---------------------AVLKEVLRLYPP 266
gi 15827139  20 NQILTLLVSGSQTLANAIAFALHYLLSIHH----------DIAAQTRR-------------------EIYQNRSDRGIAN 70
gi 15598875 232 DELCTLLMASHQSTGVTLTWSLLLLAQRPEl-------LARLRAELAGvnwtairs-vadlrdcALLRAVLQECLRLYPP 303
gi 19114700 311 LTFLSFLFASQDATSSAMTWLFQLLADHPDvlqk-vreEQLRIRKGDIdvplsl----dlmekmTYTRAVVKECLRLRPP 385
gi 1706693  328 EAVFTFLFASQDASSSLACWLFQIVADRPDvlak-ireEQLAVRNNDMstelnl----dliekmKYTNMVIKETLRYRPP 402
gi 17228856 317 AESVEFLIAGTDTTAHTLSFAVGELSLNPRvfqkareiVDQAWQGQDNintes-------fkelAYISAILKETLRLYSI 389
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1E9X_A      321 LIIlMRVAKGEFEVQG---HRIHEGDLVAASPAISNRIPEDFPDPHDFVPARYEqprqedllnrwT-WIPFG-------- 388
gi 15614320 292 APL-IGAKVRKSFTWKg--VRFKKGRLVFLDMYGTNHDPKLWDEPDAFRPERFQer--------kDsLYDFIpqgggdpt 360
gi 9296939  290 GPF-LGALVKKDFVWNn--CEFKKGTSVLLDLYGTNHDPRLWDHPDEFRPERFAer--------eEnLFDMIpqggghae 358
gi 15896573 291 APF-VGARVRKDFLWNn--CEFKKEMLVLLDIYGTNHDSRIWQKPYEFIPDRFRsy--------kGnLFDFIpqgggdps 359
gi 15807460 267 GWMgSRRLSRAAEWQG---TEIPRGTLALYSPYLTGRDPTLWERPLDFRPERWEksp------paWaYLPFG-------- 329
gi 15827139  71 VSYcSAMSLNCDAYVVsstQLCGCGLVVPCYLRQARRDTTLGNGTSLFHKGQWV-----------IvLLTAPm------p 133
gi 15598875 304 AYGlAPRQVTADIEVFg--QRLKRGDVTMVSSWITQRDPRWFEAPLEFRPERFLepar----wprGaYFPFG-------- 369
gi 19114700 386 VLM-VPYRVKKAFPITp-dYTVPKDAMVIPTLYGALHDSKVYPEPETFNPDRWAp----------NgLAEQSpknwmvfg 453
gi 1706693  403 VLM-VPYVVKKNFPVSp-nYTAPKGAMLIPTLYPALHDPEVYENPDEFIPERWVe----------GsKASEAkknwlvfg 470
gi 17228856 390 ASGsTSLEAQRDTVIEg--KVIPSGTRISWSMLAAGRDPEVYANPEEFLPERWLdksk---etssLpMIDFG-------- 456
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|..
1E9X_A      389 AGRHRCVGAAFAIMQI-KAIFSVLLREYEFEMAQPpeSyRNDHSKMVVQLAQPACVRYRRRT 449
gi 15614320 361 KG-HRCPGEGITVEVM-KTTMDFLVNDIDYDVPDQdiS-YSLSRMPTRPESGYIMANIERKY 419
gi 9296939  359 KG-HRCPGEGITIEVM-KASLDFLVHQIEYDVPEQslH-YSLARMPSLPESGFVMSGIRRKS 417
gi 15896573 360 ST-HRCPGEGITLEIM-KTSLDFLSTKIDFTVPDQdlS-YSLSKIPTLPKSGFIIDNINLKL 418
gi 15807460 330 GGERTCLGVHLAQTLI--LDVLAELPPLQAHWGND-----EPHPGITLGPRGPLVVERR--- 381
gi 15827139 134 GGPMLTNSTPTESCRKfAGSCPVYL------------------------------------- 158
gi 15598875 370 LGDRACPGTAMAMIDL-AAALAYWVEHWDIMHDGD-----LAPRGWFSLRPQRARVRFRRRA 425
gi 19114700 454 NGPHVCLGQRYAVNHL-IACIGKASIMLDWKHKRTpdSdTQMIFATTFPQDMCYLKFSPFDA 514
gi 1706693  471 CGPHVCLGQTYVMITF-AALLGKFALYTDFHHTVTplSeKIKVFATIFPKDDLLLTFKKRDP 531
gi 17228856 457 SGPHRCLGEHLSMLEG-TMMLALLLRHFDWELVNGrsSlEQLQQNLLIYPSDKMPVRFRLRN 517
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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