Conserved Protein Domain Family
Fez1
?
pfam06818: Fez1 (this model, PSSM-Id:219189 is obsolete and has been replaced by 462015)
Fez1
This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. There is evidence that Fez1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth. Note that some family members contain more than one copy of this region.
Links
?
Statistics
?
PSSM-Id: 219189
Aligned: 8 rows
Threshold Bit Score: -1
Created: 22-Dec-2011
Updated: 16-Jan-2013
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
O42497   372 TKWEVCQKAAEISLLKQQLRESQAEVTQRAGEMLALRGHLKDLNAQLREREEAMLGLKDSYSTKTLELEKCEGELRRTLS 451 torafugu
Q4SL02   339 TKWEVCQKSGEISLLKQQLKEIQSELSQKAGDIVVLKAQLREARSEMQASQARFQEAQAALRTRSLELEVCENELQRRKS 418 spotted green puffe...
Q4RYH9   478 SKWEVCQKSGEISLLKQQLKEVQGELAQRVGEIVSLRGQLRETRGELTNTQVLLQEAHGTTRTRTLELEVCENELQRRKS 557 spotted green puffe...
Q9BRK4   439 TKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQELQRHRQ 518 human
Q6DIS8   446 TKWEVCQKSGEISLLKQQLKDSQAELAQKSNEILLLRAQVREARSDLQISEEQVQELQDTAHTKTLELEVCENELQRKKN 525 western clawed frog
A2AHG0   465 TKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFGSKQASLELSEGEL----- 539 house mouse
Q8C7U1   359 ARWEVCQKTAEISLLKQQLREAQAELAQKLAEIFSLKTQLRGSRAQAQAQDAELARLREAVHS----------------- 421 house mouse
AAI27607 377 TQWEVCQKSGEISLLKQQLKESQLEVNTKASEILSLKAQLKDTRGKLDGMELKTQDLESALRTKGLELEVCENELQRKKN 456 house mouse

O42497   452 EEALRQERQQREEAQWRDVQQRHDAA------------------------------------------------MQQD-- 481 torafugu
Q4SL02   419 EAELLREKLGRVEEELSRLRDALSNHsalvsgsgtlkgqcmnlsihqgravggrggpspcvyrdgeehhlvwggESDE-- 496 spotted green puffe...
Q4RYH9   558 EAELLREKAGRLEAELAHLKDALASQgpgnrq-------------------------------------cqvfpEDQEql 600 spotted green puffe...
Q9BRK4   519 EAEQLREKAGQLDAEAAGLREPPVPpatad---------------------------------------pfllaESDE-- 557 human
Q6DIS8   526 EAELLREKASKLDQEVAGLREAAVANlrhglclch------------------------------ekedpfllyESDE-- 573 western clawed frog
A2AHG0   540 PPACLKPALTPVD--LVEPQEALASC------------------------------------------------ESDE-- 567 house mouse
Q8C7U1   422 ----LQEQAPR--------EEAPGSC------------------------------------------------ETDD-- 439 house mouse
AAI27607 457 EAELLREKVNLLEQELMELRAQAALHpaplgp------------------------------------pgvgltFSED-- 498 house mouse

O42497   482 -VRMRQDAqgrpeiqlrheaqlrqeghhrhEAQLRELRRQLEQLQAALRLERQHRERQALNFDQERHTWQDEKERVLKYQ 560 torafugu
Q4SL02   497 -AKAQRQN----------------------AETVLGLRQQVDRLKAELIYERRTSEEHLSRFEDERRVWQEEKEKVIRYQ 553 spotted green puffe...
Q4RYH9   601 lARAQEPSg---------------------GEVLQNMSVKMDRMRAELSYEHQRAEQQMSSFEEERRIWQEEKDKVIRYQ 659 spotted green puffe...
Q9BRK4   558 -AKVQRAA----------------------AGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQ 614 human
Q6DIS8   574 -AKAQRQN----------------------ADNLQGLQQYVERLREALTSERRRYQEQADSFEDERRIWQEEKEKVIRYQ 630 western clawed frog
A2AHG0   568 -AKMRRQAgvaaaaslvs---vdgeveaggEGGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQ 643 house mouse
Q8C7U1   440 -CKSRGLLg---------------------EAGGSEAREGAEQLRAELLQERLRGQEQALRFEQERQTWQEEKERVLRYQ 497 house mouse
AAI27607 499 -IPA--------------------------------LQRELDRLRAELKEERQGHDQMSSGFQHERLVWKEEKEKVIQYQ 545 house mouse

O42497   561 AQLQLSYVETLQKNQALVKRMSS 583 torafugu
Q4SL02   554 KQLQQNYIQMYRRNRELERVMRE 576 spotted green pufferfish
Q4RYH9   660 KQLQQNYVQMYRRNRELEQLLQE 682 spotted green pufferfish
Q9BRK4   615 KQLQHNYIQMYRRNRQLEQELQQ 637 human
Q6DIS8   631 KQLQHNYIQMYQQNRELERDIKQ 653 western clawed frog
A2AHG0   644 KQLQLSYVEMYQRNQQLERRLRE 666 house mouse
Q8C7U1   498 REIQGSYMDMYRRNQALEHELRL 520 house mouse
AAI27607 546 RQLQQSYLAMYQRNQRLEKALQQ 568 house mouse
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap