Conserved Protein Domain Family
Steroid_dh
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pfam02544: Steroid_dh (this model, PSSM-Id:217095 is obsolete and has been replaced by 460585)
3-oxo-5-alpha-steroid 4-dehydrogenase
This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.
Links
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Statistics
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PSSM-Id: 217095
Aligned: 10 rows
Threshold Bit Score: -1
Created: 21-Dec-2011
Updated: 16-Jan-2013
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q38944 111 NGFPITIAALAFT-FNLLNGYIQARWVSHYKDdy-----eDGNWFW-WRFVIGMVVFITGMYINITSDRTLV----RLKK 179 thale cress
P31213 105 RPYPAILILRGTA-FCTGNGVLQGYYLIYCAEy-------PDGWYTdIRFSLGVFLFILGMGINIHSDYILR----QLRK 172 human
P24008 110 KPTLLVTFVLAFL-FCTFNGYVQSRYLSQFAVy-------AEDWVThPCFLTGFALWLVGMVINIHSDHILR----NLRK 177 Norway rat
P18405 110 KPMPLLACTMAIM-FCTCNGYLQSRYLSHCAVy-------ADDWVTdPRFLIGFGLWLTGMLINIHSDHILR----NLRK 177 human
Q23431 103 NQSPVKIVIMAFG-FSVLNGFIQGTWNAFYQPe-------FDTLHPkFFVFLGAWLFVIGFITHCVSDLHLI----TLRN 170 Caenorhabditis elegans
Q19605  97 TKSPVAIVAAATF-FCAYNGFLQGYWNAFYQP--------EEPWTT--RKLVGSLMYCTGMYINHKSDTILR----ELRA 161 Caenorhabditis elegans
Q20344  97 TKSPLLIVAAAVA-FCTYNGTLQGVWNSYYQL--------EEELTY--RHLIGSILYFSGMFINHKSDNILM----TLRK 161 Caenorhabditis elegans
Q17428 189 DDISLTQWAGAVL-FWICN-------WKQHQL--------AEQIAN-----------------TRKGPRGLI-------- 227 Caenorhabditis elegans
O94511 146 ATMPLRNIFKNCAhYHLLSGLFLA--YFIYGPw------hANDYIKpNHLLFLIVGWAFAVLSNFRTHIILR----DLRP 213 Schizosaccharomyces p...
Q99190 154 ATMPIFNLFKNCFhYWVLSGLISFGYFGYGFPfgnaklfkYYSYLKlDDLSTLIGLFVLSELWNFYCHIKLRlwgdYQKK 233 Saccharomyces cerevis...

Q38944 180 ENRGGYVIPR-GGWFELVSCPNYFGEAIEWLGWAVMTWSWAGIGFFL---YTCSNLFPRARASHKWYIAKFkEEYPKTRK 255 thale cress
P31213 173 PGEISYRIPQ-GGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAF---FSLCFLGLRAFHHHRFYLKMF-EDYPKSRK 247 human
P24008 178 PGETGYKIPR-GGLFEYVSAANYFGELVEWCGFALASWSLQGVVFAL---FTLSTLLTRAKQHHQWYHEKF-EDYPKSRK 252 Norway rat
P18405 178 PGDTGYKIPR-GGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAF---FTFCFLSGRAKEHHEWYLRKF-EEYPKFRK 252 human
Q23431 171 DYLNSYSIPR-GHYFEYISCPNYFGECLQWIGYALAARSFPAIAFAF---FIVCNLAPRAMSHHKWYQKMFgEQYPRDRH 246 Caenorhabditis elegans
Q19605 162 DGGTGYKIPT-GFLYEYISCPNYAGEIMEWIGYSILAWNLPALAFAI---FTIANIGPRAVAHHKWYKETF-PGYPPNRR 236 Caenorhabditis elegans
Q20344 162 PGETGYKIPT-GFLYEYISCPNYFGEIMEWIGYAILGWNLPALAFAI---FTFANIGPRAIAHHNWYKEKF-PKYPPTRR 236 Caenorhabditis elegans
Q17428 228 -RNYAYGICF-GGWFNLVSCPHFLFEICIYLSLFLVIP--DAYVYRFiimFVCINQTFAALITHSWYHKTF-PKYPKSRK 302 Caenorhabditis elegans
O94511 214 AGSKKRVIPT-GYGFNLVSFPNYFFESLGWLFFALLTKSWASWIFLF---VGSAQMFVWAKKKHARYLKEF-PNYPRSRK 288 Schizosaccharomyces p...
Q99190 234 HGNAKIRVPLnQGIFNLFVAPNYTFEVWSWIWFTFVFK------FNL---FAVLFLTVSTAQMYAWAQKKN-KKYHTRRA 303 Saccharomyces cerevis...

Q38944 256 AVIPFVY 262 thale cress
P31213 248 ALIPFIF 254 human
P24008 253 ILIPFVL 259 Norway rat
P18405 253 IIIPFLF 259 human
Q23431 247 ALVPGVW 253 Caenorhabditis elegans
Q19605 237 ILIPRIF 243 Caenorhabditis elegans
Q20344 237 ALIPYIY 243 Caenorhabditis elegans
Q17428 303 ALIPYVL 309 Caenorhabditis elegans
O94511 289 IMIPFFL 295 Schizosaccharomyces pombe 972h-
Q99190 304 FLIPFVF 310 Saccharomyces cerevisiae S288c
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