Conserved Protein Domain Family
POLBc

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smart00486: POLBc 
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DNA polymerase type-B family
DNA polymerase alpha, delta, epsilon and zeta chain (eukaryota), DNA polymerases in archaea, DNA polymerase II in e. coli, mitochondrial DNA polymerases and and virus DNA polymerases
Statistics
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PSSM-Id: 214691
View PSSM: smart00486
Aligned: 97 rows
Threshold Bit Score: 48.2957
Threshold Setting Gi: 17558238
Created: 13-Jul-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

smart00486 is classified as a model that may span more than one domain.
smart00486 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1TGO_A        135 LKMLAFDIETLYHeg--------------eEFa------------EGPILMISYADEEGAR------------------- 169
gi 12248109     3 RSVYVCDFETTTDpe--------------dCR-------------LWAWGWMDIYNTDKWSygedi-------------- 41
gi 9629471    165 RLYVVYDIETYTYhskygk-----qlvpylLVfql--------fgEETLIDLAKAEAEMVGytaydgcfyilnkdpevvg 231
gi 163937699  361 VKEVFFDIESFSDetkhqipylicwsylgeLYyrtg------kncIKEFVEEILSYNVDIIlyawygsg----------y 424
gi 4870       365 TEEIFFDIESFTNeknfqipylicwsktngSIhkri-----gkncINDFVQYIINLKKNVIlyawfgsg----------y 429
gi 3702406    361 KITVCFDIEAYFDpdse---------ndqtHIpy---------lcCACFVYNDVIGNVIEFegrdcva------------ 410
gi 163932452  358 NITVCFDIESYFDpek------------esNQv------------NIPFICCASIIYNKVIgnivdf------------- 400
gi 118851       3 RKMYSCDFETTTKv-------------------------------EDCRVWAYGYMNIEDH------------------- 32
gi 22855149     3 RKMFSCDFETTTKl-------------------------------DDCRVWAYGYMEIGN-------------------- 31
gi 9630779    172 KLFLIYDIETFTLaetsgv-----llnpllLCfsifgddclinicKTEIAKIKSIQTKNSTyfwfskvknfis---tefr 243
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1TGO_A        170 -------VITWKNIDL-----------PYVDVVS-------TEKEMIKRFLKVVKEKDP------DVLITYNGDN---FD 215
gi 12248109    42 ---dsfmEWALNSNSD-------------IYFHN---------LKFDGSFILPWWLRNG------YVHTEEDRTNt-pKE 89
gi 9629471    232 qsfklfrSNLQDKVTNlawerfcednaLDPYSRIt-----aKQLQKLNKSQKLNKTAEPqf--yeIIIVGHNISG---FD 301
gi 163937699  425 dyqhvlpYMKSKCIKDkyii---knnmITYGELYy-----eNAIIYLKDPYLFILTSLD------KASKAFNVINkgeFP 490
gi 4870       430 dyqhvlpYFKKKCIKDkyii---knnmITYSELYf-----kHSKIILKDPFLFILTSLD------KAAKAFNVINkgsFP 495
gi 3702406    411 -qmieyiVDICSELKNk---------nIELIAHNg------GAYDFHYILSSMYKSSDI------KNILIRNNNF---IS 465
gi 163932452  401 -----egrdcvAQMIE--------------YVVD-------ICGELNISSVE---------------LIAHNGGG---YD 436
gi 118851      33 --------------SE--------------YKIG-------NSLDEFMAWVLKVQAD----------LYFHNLK----FD 63
gi 22855149    32 ---------------------------LDNYKIG-------NSLDEFMQWVMEIQAD----------LYFHNLK----FD 63
gi 9630779    244 klrnnilFALTDYFTKlilt---penrEILEDFAqtqnlesITNINLSEHTNLIMSLKVkpifieFYIIGHNIQS---FD 317
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1TGO_A        216 FAYLKKRSEK---LGVK--F---------ILGREGSEp--KIQRMGDRFAVE---------------------------- 251
gi 12248109    90 FTTTISGMGQw--YAVDvcIn--------TRGKNKNHvvfYDSLKKLPFKVEqiakg--------------------fgl 139
gi 9629471    302 EIVLASHILD---NVKDkdYfvmfnitrnFLPRAGKLlfnDITFSLPNPQYKkpsrgtfdrwqn-------gmldkqdlk 371
gi 163937699  491 HSIIHSWEDL---NKILpnWvkiq--krmIEYKDDNKlniYYKNIEIFENDRnynt----------------------il 543
gi 4870       496 HSLIKDWPDL---QKIYphWikt----qrKIIEFKHDnklNIKINTTLEEDNitnns--------------------tii 548
gi 3702406    466 FSFVHDDITF---NIKDsyS---------FLLCSLAN-----AAKAFLSGNHdfgkt---------------------df 507
gi 163932452  437 FHYILSSMYN---PAA--------------IKNILIR-----NNSFISFNFAhd-------------------------- 468
gi 118851      64 GAFIINWLERn------------------GFKWSADG----LPNTYNTIISRmg-------------------------- 95
gi 22855149    64 GAFIVNWLEH---HG---------------FKWSNEG----LPNTYNTIISKmg-------------------------- 95
gi 9630779    318 EILLATQILQdenLDITplFtve----rnFMPRQGRIlfnDITIKFPNPDYYvakeekknnkseilsqikegiphpesik 393
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1TGO_A        252 --VKGRIHFDLYPVIRRTIN---LPTYTLEA---------VYEAIFG----QPKEKVYAE---EIAQAWETg-------- 302
gi 12248109   140 pvLKGDIDYKKYRPVGYVMDdneIEYLKHDLl--------IVALALRs---MFDNDFTSMt--VGSDALNTy-------- 198
gi 9629471    372 wqGVKFMVRDTYLLTHTSLRn-aATAYQLPIskgccpyeaVNEYLMTgnyeQETNGYPTLkywNNADEYHQnkik----- 445
gi 163937699  544 enAIEYCKVDVLAMEKVWIKfkkLLEKNLNIt--------VSVKTFTl--sQLSMKIMESklpKYVKLYVPt-------- 605
gi 4870       549 ekAIEYCSIDVIAMKQVWQKfkkLVKENLQIs--------ISEKTFTl--sQLSMKIMEAsldRNIELYVPt-------- 610
gi 3702406    508 phHDVRSKADLEKVYRKWRSid-----------------nIIDIEIE----KEKLLISSH---NIINYETDgk------- 556
gi 163932452  469 -----gVKFSVKDSYSFL-----LCSLANAS---------KAFLNEe---tFKKTDFPHHd------------------- 507
gi 118851      96 ----qWYMIDICLGYKGKRK---IHTVIYDS---------LKKLPFP------VKKIAKD---FKLTVLKG--------- 141
gi 22855149    96 ----qWYMIDICFGYKGKRK---LHTVIYDS---------LKKLPFP------VKKIAKD---FQLPLLKG--------- 141
gi 9630779    394 nlYIKSMVRDTFQITHTSLKe-aAKAYNLKIhkgccpfkaINEYMSTnslsTDSDSFPSEkywSSKEEYNEqkeiwlekk 472
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1TGO_A        303 ----EGLERVARYSMEDAKVTYELGKE-------FFPMEAQLSRLVGQSLWDVSRSSTGNlVEWFL-----LRKAYERNE 366
gi 12248109   199 ----KEMLGVKQWEKYFPVLSLKVNSEi------rKAYKGGFTWVNPKYQGETVYGGMVFdVNSMY-------PAMMKNK 261
gi 9629471    446 -gpyDILKEALIYCIADVKVTSQLTRKliegyqsFCNDQIKLTCQFHIFQRPTISSNTHAlFKQIL-----YRAEKGQTE 519
gi 163937699  606 ----LEEYSKIRNAIYGGRVISKNGIYee-----nIVYADVVSLYPSAMKLLKHSYGKPKlVDYID-----FEKHGIYRV 671
gi 4870       611 ----SEEYQFIRNSIYGGRVAAKNGTYn-----eEIVYADVVSLYPSAMKLLEHSYGKPSkVFSIN-----FNKHGIYDV 676
gi 3702406    557 --skKLLDWSREYCCNDVIVLAKVWLEfk---iaVYEIFSAKVVDQSYTLAGMSFKLFESnLDPNId----LRHPKKEDY 627
gi 163932452  508 ---lKTADDLYKVYKEWSSVNTEINHV-------VEKEKLLITSEHIVNF--TKNDKSKTlIEWS--------KDYCRND 567
gi 118851     142 -----DIDYHKERPVGYEITPDEYAYIk-----nDIQIIAEALLIQFKQGLDRMTAGSDDlKGFKD-----IITTKKFKK 206
gi 22855149   142 -----DIDYHAERPVGHEITPEEYEYIk-----nDIEIIARALDIQFKQGLDRMTAGSDSlKGFKD-----ILSTKKFNK 206
gi 9630779    473 evkyDIVKELIDYCIKDVKITEELTKTllntfdtFIKEELNLKCNFNIFKRPTISSNSHAiFRQLHfkqngTKASTLPDI 552
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1TGO_A        367 LAPNKpd----------------------------------------------------eRELARRRESYAGG-YVKEPE 393
gi 12248109   262 LLPYGepvm--------------------------------------------------fkgEYKKNVEYPLYiQQVRCF 291
gi 9629471    520 HLPGLqapsekmydhirksvrggrcypsylgvyegpiyvydicgmyasalthpmpfgrteDPLTASISIKTFQdKLDSPA 599
gi 163937699  672 TLLNKhdq------------------------------------------------------epKNYLNFVPR-RINRKL 696
gi 4870       677 TLIHKsns------------------------------------------------------kpNHYLEFVPR-RIDKKL 701
gi 3702406    628 MNMKDsliggrci---------------------------------------svngiyenILCLDVKSLYPAAmAFYDQP 668
gi 163932452  568 VLVLSkvwlefknavedifncelvdqtmt-------laglsyklfqanmpfdvelrhpnkEDYFNMREALIGG-RCIS-V 638
gi 118851     207 VFPTLslg-----------------------------------------------------ldKEVRYAYRGGfTWLNDR 233
gi 22855149   207 VFPKLslp-----------------------------------------------------mdKEIRRAYRGGfTWLNDK 233
gi 9630779    553 VAPSDemysfirqsvrggrcypthlgifke-----kifvydicgmyasalthpmpygfpiGEKERNNEITKLNeKLKKTK 627
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1TGO_A        394 RG-LWENI-----VY-LDFRSLYPS------------IIITHNVSPDTLNREGCe------------------------- 429
gi 12248109   292 FElKKDKIp----CIqIKGNARFGQn----------eYLSTSGDEYVDLYVTNv-------------------------- 331
gi 9629471    600 KLsYFGESi----KPmIVYADCYPPplehvdvlpplcSRKSGRLCWTNEPLLGEvvttidlitlhnrgwkck-------- 667
gi 163937699  697 TWeWFKIHeg--wYHtYDLIIAKSEgf---------dIYCHEGFEYPEKDYIFNdfidtlys------------------ 747
gi 4870       702 IWsWFKEHrg--tYHtYDLLIAIQEgf---------eIICHSGIEYPNKGYIFNnfidklyt------------------ 752
gi 3702406    669 YGqFRRVQqrmteELgIYYVRVIPH------------TKINSNFFPVRYNNKITynnygstqyn---------------- 720
gi 163932452  639 NG-IYKD------VLcLDVKSLYPA------------SMAFYDQPYGSFKRVSSrpkdelgiyyvrvtpnrnnksnffpi 699
gi 118851     234 FK-EKEIGe----GMvFDVNSLYPA------------QMYSRLLPYGEPIVFEG-------------------------- 270
gi 22855149   234 YK-EKEIGe----GMvFDVNSLYPS------------QMYSRPLPYGAPIVFQG-------------------------- 270
gi 9630779    628 TKlSYFTDik-pmVVmIDAIPPPPEhldpl---pplcSRQSGKLCWTNEILKNEivtsidiitlhnr------------- 690
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1TGO_A        430 ---------------------------------------------------------------------E-YDVAPQvGH 439
gi 12248109   332 ---------------------------------------------------------------------DwELIKKHyDI 342
gi 9629471    668 ----------------------------------------------------iltseqlyavwpewkciTkEYVSINiAA 695
gi 163937699  748 --------------------------------------------------------------mkethtaCsCEEQPCpIR 765
gi 4870       753 --------------------------------------------------------------lkdihtnCkCKEQPCpIR 770
gi 3702406    721 ------------------------------------------------------------awytsvdidI-GISEGHdIQ 739
gi 163932452  700 rshnkitynnfeestyiawytnvdidiglseghnieyipfdsygnigyswskkgkifekyikdvlyklkI-KYEKQN--N 776
gi 118851     271 -----------------------------------------------------------------------KYVWDEdYP 279
gi 22855149   271 -----------------------------------------------------------------------KYEKDEqYP 279
gi 9630779    691 --------------------------------------------------------gwkvniiphklntVfPTWNTCcLE 714
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1TGO_A        440 KFCKDFP-----------------GFIPSLLGDLLEERQKVKKKMKATI------------------------------D 472
gi 12248109   343 FEEEFIGgf-------------mfKGFIGFFDEYIDRFMEIKNSPDSSA------------------------------E 379
gi 9629471    696 KEKADKDknmtq--------rsisKLLSNALYGSFATRLDNKKVVFANSmekgdmeriangkatitaqttvintclpkkD 767
gi 163937699  766 MVAKIALn---------------gGGYGKFVQKPIDKEIYIVKRDVVAG------------------------------- 799
gi 4870       771 MVAKIALn---------------gGGYGKFVQKPIDKEVYIVKRDVVAG------------------------------- 804
gi 3702406    740 YIPFDEEe----------------NIGYSWINKGKIFQQYIEDTLYKLK------------------------------- 772
gi 163932452  777 KVKRNVIkii------------mnSLWGKFAQKWVNFEYFIKSEDDIDF------------------------------- 813
gi 118851     280 LHIQHIR-------------------CEFELKEGYIPTIQIKRSRFYKGn------------------------------ 310
gi 22855149   280 LYIQRIR-------------------FEFELKEGYIPTIQIKKNPFFKGn------------------------------ 310
gi 9630779    715 YVTKNILakekatveknpvkraisKLLSNALYGSFATRESNDITIFENHiqenpkirnqll------nkqltidsittlP 788
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1TGO_A        473 PIE--KKLLDYRQRAIKILANSF--------YGYYGYAKA--RWYCKECA---ESVTAWGR----------------QYI 521
gi 12248109   380 QSLqaKLMLNSLYGKFATNPDITgkvpyldeNGVLKFRKG----ELKERD---PVYTPMGC----------------FIT 436
gi 9629471    768 TTSweRFFSNLPQTTALPVAPSTene--gndINPKSFIEGagHVTFKPIThltAACDDLIL----------------SII 829
gi 163937699  800 ECDklQENENGEICIGKRLVKRPl------fYNLDSENYDk-MIIEKEDEp--IYSTQCGI----------------SIL 854
gi 4870       805 ECEnlSQNENGEICIGKRIVKKPk------fFNLDGEDYDk-MIIERDDDp--IYSTQCGV----------------SIL 859
gi 3702406    773 -LKyeEEGNKVKRNVIKIIMNSLwg-----kFAQKWIDTNy-SIKAESDV---DFDEEEAY----------------KIW 826
gi 163932452  814 ESEeaYKIWDTDFMLIKKIKEST--------------------YSSKPIQ---NGV---------------------FTL 849
gi 118851     311 -----EYLKSSGGEIADLWVSNV--------DLELMKEH----YDLYNVE---YISGLKFK----------------ATT 354
gi 22855149   311 -----EYLKNSGAEPVELYLTNV--------DLELIQEH----YEMYNVE---YIDGFKFR----------------EKT 354
gi 9630779    789 TYNlpYVSIENLTFTLKNRTDSAernl-eldDELTSPFNSleFMDESPASqtsTSTAHVGTykpfnildvtsenltiYML 867
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1TGO_A        522 ETTIREIEEKf--------------------------------------------------------------------- 532
gi 12248109   437 AYARENILSNaqk------------------------------------------------------------------- 449
gi 9629471    830 EERSEWIENNryptqiasfvlawtrafts--------------------------------------------ewasflf 865
gi 163937699  855 SASRYRLYKLckq------------------------------------------------------------------- 867
gi 4870       860 SASRYRLYNLckk------------------------------------------------------------------- 872
gi 3702406    827 DTEYMLIKQHkeseysskpiqngvftl-----------------------------------------------swarhh 859
gi 163932452  850 SWARYHMKSIwdag------------------------------------------------------------------ 863
gi 118851     355 GLFKDFIDKWthikttsegaikqlaklmlnslygkfasnpdvtgkvpylkengalgfrlgeeetkdpvytpmgvfitawa 434
gi 22855149   355 GLFKEFIDKW---------------------------------------------------------------------- 364
gi 9630779    868 KSTNLHPTNKryptqlasfvlawtrafms--------------------------------------------ewreily 903
                         890       900
                  ....*....|....*....|....*....
1TGO_A        533 -----------GFKVLYADTDGFFATIPG 550
gi 12248109   450 ----------lypRFIYADTDSIHVEGLG 468
gi 9629471    866 eddwgsnienrSLKVVYGDTDSLFLTQHG 894
gi 163937699  868 ---------fenIDIIYSDTDSIFVKQKS 887
gi 4870       873 ---------fegLEIIYSDTDSIFVRKNT 892
gi 3702406    860 mkllwdastrpDTECIYSDTDSIFVRKEE 888
gi 163932452  864 --------akeGAECIYSDTDSIFVHKEH 884
gi 118851     435 ryttitaaqacFDRIIYCDTDSIHLTGTE 463
gi 22855149   365 ---------------TYVKTHEKGAKKQL 378
gi 9630779    904 sdedsipvqfkTIKSIYGDTDSLFLTEKG 932
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