Conserved Protein Domain Family
ABCG_White

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cd03234: ABCG_White 
White pigment protein homolog of ABCG transporter subfamily
The White subfamily represents ABC transporters homologous to the Drosophila white gene, which acts as a dimeric importer for eye pigment precursors. The eye pigmentation of Drosophila is developed from the synthesis and deposition in the cells of red pigments, which are synthesized from guanine, and brown pigments, which are synthesized from tryptophan. The pigment precursors are encoded by the white, brown, and scarlet genes, respectively. Evidence from genetic and biochemical studies suggest that the White and Brown proteins function as heterodimers to import guanine, while the White and Scarlet proteins function to import tryptophan. However, a recent study also suggests that White may be involved in the transport of a metabolite, such as 3-hydroxykynurenine, across intracellular membranes. Mammalian ABC transporters belonging to the White subfamily (ABCG1, ABCG5, and ABCG8) have been shown to be involved in the regulation of lipid-trafficking mechanisms in macrophages, hepatocytes, and intestinal mucosa cells. ABCG1 (ABC8), the human homolog of the Drosophila white gene is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. It is possible that human ABCG1 forms heterodimers with several heterologous partners.
Links
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Statistics
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PSSM-Id: 213201
View PSSM: cd03234
Aligned: 13 rows
Threshold Bit Score: 284.549
Threshold Setting Gi: 115140
Created: 12-Dec-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
Hierarchy
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Display:
  next features
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:Walker A, Walker B, Q-loop, D-loop, and H-loop form the nucleotide binding site

cd03234 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd03234 is a member of the superfamily cl21455.
cd00267:ABC_ATPasecd03213:ABCG_EPDRcd03214:ABC_Iron-Siderophores_B12_Hemincd03215:ABC_Carb_Monos_IIcd03216:ABC_Carb_Monos_Icd03217:ABC_FeS_Assemblycd03218:ABC_YhbGcd03219:ABC_Mj1267_LivG_branchedcd03220:ABC_KpsT_Wztcd03221:ABCF_EF-3cd03222:ABC_RNaseL_inhibitorcd03223:ABCD_peroxisomal_ALDPcd03224:ABC_TM1139_LivF_branchedcd03225:ABC_cobalt_CbiO_domain1cd03226:ABC_cobalt_CbiO_domain2cd03227:ABC_Class2cd03228:ABCC_MRP_Likecd03229:ABC_Class3cd03230:ABC_DR_subfamily_Acd03231:ABC_CcmA_heme_exportercd03232:ABCG_PDR_domain2cd03233:ABCG_PDR_domain1cd03234:ABCG_Whitecd03235:ABC_Metallic_Cationscd03236:ABC_RNaseL_inhibitor_domain1cd03237:ABC_RNaseL_inhibitor_domain2cd03238:ABC_UvrAcd03239:ABC_SMC_headcd03240:ABC_Rad50cd03241:ABC_RecNcd03242:ABC_RecFcd03243:ABC_MutS_homologscd03244:ABCC_MRP_domain2cd03245:ABCC_bacteriocin_exporterscd03246:ABCC_Protease_Secretioncd03247:ABCC_cytochrome_bdcd03248:ABCC_TAPcd03249:ABC_MTABC3_MDL1_MDL2cd03250:ABCC_MRP_domain1cd03251:ABCC_MsbAcd03252:ABCC_Hemolysincd03253:ABCC_ATM1_transportercd03254:ABCC_Glucan_exporter_likecd03255:ABC_MJ0796_LolCDE_FtsEcd03256:ABC_PhnC_transportercd03257:ABC_NikE_OppD_transporterscd03258:ABC_MetN_methionine_transportercd03259:ABC_Carb_Solutes_likecd03260:ABC_PstB_phosphate_transportercd03261:ABC_Org_Solvent_Resistantcd03262:ABC_HisP_GlnQcd03263:ABC_subfamily_Acd03264:ABC_drug_resistance_likecd03265:ABC_DrrAcd03266:ABC_NatA_sodium_exportercd03267:ABC_NatA_likecd03268:ABC_BcrA_bacitracin_resistcd03269:ABC_putative_ATPasecd03270:ABC_UvrA_Icd03271:ABC_UvrA_IIcd03272:ABC_SMC3_eukcd03273:ABC_SMC2_eukcd03274:ABC_SMC4_eukcd03275:ABC_SMC1_eukcd03276:ABC_SMC6_eukcd03277:ABC_SMC5_eukcd03278:ABC_SMC_barmotincd03279:ABC_sbcCDcd03280:ABC_MutS2cd03281:ABC_MSH5_eukcd03282:ABC_MSH4_eukcd03283:ABC_MutS-likecd03284:ABC_MutS1cd03285:ABC_MSH2_eukcd03286:ABC_MSH6_eukcd03287:ABC_MSH3_eukcd03288:ABCC_SUR2cd03289:ABCC_CFTR2cd03290:ABCC_SUR1_Ncd03291:ABCC_CFTR1cd03292:ABC_FtsE_transportercd03293:ABC_NrtD_SsuB_transporterscd03294:ABC_Pro_Gly_Betainecd03295:ABC_OpuCA_Osmoprotectioncd03296:ABC_CysA_sulfate_importercd03297:ABC_ModC_molybdenum_transportercd03298:ABC_ThiQ_thiamine_transportercd03299:ABC_ModC_likecd03300:ABC_PotA_Ncd03301:ABC_MalK_Ncd03369:ABCC_NFT1191733371907476219074934115140502551245025512417432916507404254721822333860121472182245074042128571871191733371907476219074934115140502551245025512417432916507404254721822333860121472182245074042128571871
cd03234 Sequence Cluster
cd03234 Sequence Cluster
Sub-family Hierarchy
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 cd03234 Branch
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                         ## ###                         
gi 17432916   59 ASQVPWFEQLAQFkmpwtspscqnscelGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVItgrghg-----gkiksGQIW 133
gi 33860121   50 NRVGPWWNIKSCQqkw---------drkILKDVSLYIESGQTMCILGSSGSGKTTLLDAIsgrlrr-----tgtleGEVF 115
gi 47218224    3 ERVGPWWDLPSCRkrw---------trqILNDVSFHVESGQIMGILGNSGSGKTTLLDAIagrign-----agtllGDVF 68
gi 50740421   42 VNVGPWWKVPLYHtkw---------trqILKDVSFHVEGGQIMGILGNSGSGKTTLLDAIsgrled-----kdsffGEVY 107
gi 19173337   19 RRILRFGNVSLKApnknkdl--kgkyvdLISGTSGEIVSGRLTAVMGGSGSSKTSFLNLLmgkves-----daltsGVIT 91
gi 19074762   15 SYKLELEDVTLEAvnedlss--snkyvkLINGVSVTFESGKLSAIMGPSGSGKTTLINSIvgmvqe-----gsmtyGRIL 87
gi 19074934    3 QHTLQLEGVTLDVpnqnlss--nekyarLINGLTADFKSGNVYAFMGTSGSGKTTTLETIaglvps-----gsrtgGRIL 75
gi 47218223   47 EFKVPWGVNGSKQk--------------AISNLSLRVRSGQMLALIGSSGCGKTSLLDIItcrdeg-----gemtsGQIL 107
gi 50740425  170 QLLLPWNSGPDSHv-------------sIIQNLNLKVHSGQMLAIIGSTAGGKTSLLDVItcrdhg-----gkiksGHIM 231
gi 115140     31 QSNYSFWNECRKKre-----------lrILQDASGHMKTGDLIAILGGSGAGKTTLLAAIsqrlr-------gnltGDVV 92
gi 28571871   15 IFHTTEVDGGGCFngag-------nsalVLKGVNLTVHSGEVMAILGSKGSGKRALLDVIsrrad-------gatrGQVL 80
gi 50255124  798 NLSLMWKRRGRGPlkdr--------ekiILNDLSLDFPAGEVSAILGPSGAGKSTLLQLIagrqlnpgplshytisGTLL 869
gi 50255124  108 RWVPSLFKVFAKRkekdeeepgkpkkkwILQDVNCECQNGEVLAILGGSGSGKTTLLNAIanrvsg-----lptanGEVA 182
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                     #                                                  
gi 17432916  134 INGqpsspq----------lvrkcVAHVRQHNqll-pnLTVRETLAFIAQMRlprtfsqaqrdkrvedvia-------el 195
gi 33860121  116 VNGcelrrd----------qfqdcVSYLLQSDvfl-ssLTVRETLRYTAMLAlrsssadfydkkveavlt--------el 176
gi 47218224   69 INGrkikra----------ksqdcFSYVLQSDnll-syLTVEETLTYTAQLAlqrhsaeairkkswpss----------- 126
gi 50740421  108 VNGqqlkke----------qfrdcFSYVPQNDall-sfLTIEESLTYTALLAlqkcsnnfikkkvdavma--------el 168
gi 19173337   92 FDGeqrkiy----------kwlesTSYLEQFDifa-sgLTVEESITYSLIFRgreikdssipsmvddi------------ 148
gi 19074762   88 FREeerdpk----------twlfhVAYLSQDDcta-pyITVYEYIYFCVNCRttrkqrggrsteevvde----------- 145
gi 19074934   76 VDGqernpd----------efpyeFAYGDQLGyii-deLTVEEFVYYYVVSSlpeeskervrekmdev------------ 132
gi 47218223  108 INGrpnkah----------lvkksIAHVRQDDrll-phLTVREAWPFSNPNPnpnpnpnpnlapetpffrpqvddviael 176
gi 50740425  232 INNkpstpq----------lvkkcIAHVRQDDrll-phLTVRETLLFIARLRlpacfsdsqrqkrvedvia-------el 293
gi 115140     93 LNGmamerh----------qmtriSSFLPQFEinv-ktFTAYEHLYFMSHFKmhrrttkaekrqrvad------------ 149
gi 28571871   81 LNGsplska----------lfqqrCGYVTQSCtfv-pgLTVAQTLHYTPTILsgylksskvrqvla-------------- 135
gi 50255124  870 FANkpvsr-----------ttqsnVAFVEQDDdwhlpsLTVRETLTYAAILRlpvkmpkkqkvaraetvlr-------ml 931
gi 50255124  183 YFSvephagvrrgiklekgqmkkrIGFVRQQDflv-ecLTVRETLTYAAKLRlpnhlsdeaisfiveqtid-------el 254
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                       ##                               
gi 17432916  196 rlrqcadtrvgnmyvrGLSGGERRRVSIGVQLLWNP------GILILDEPTSGLDSFTAHNLVKTLSRLakg-------- 261
gi 33860121  177 slshvadqmignynfgGISSGERRRVSIAAQLLQDP------KVMMLDEPTTGLDCMTANHIVLLLVELarr-------- 242
gi 47218224  127 asshvahtviggrffpGISGGERRRVSIASQLLQDP------RVILLDEPTTGLDSMTANQIVVLLAQLarr-------- 192
gi 50740421  169 slshiankiigsqiyvGISGGERRRVSIAAQLLQDP------KVMLLDEPTTGLDCLTANQIVSLLVELahr-------- 234
gi 19173337  149 -igelglarlrgslvsSISGGERRRVMLAAELVVEP------EVVFLDEPTSGLDSRLALDTVRILKKYaesr------- 214
gi 19074762  146 vmkrlhieslrdvvmtAVSGGERKRVMIAIEFAVVP------DVLILDEPTTGLDSHLAFELIQMVKQYaven------- 212
gi 19074934  133 lenllnighirhnkmkNISGGEQKRANLARTFTKMLllegelKVVLLDEPTSELDAGLALKLGEFLRDYarrs------- 205
gi 47218223  177 rlrqcahtrvgndyvrGVSGGERRRVSIAVQLLWNP------GILILDEPTSGLDSFTAHNLVITLSRLarg-------- 242
gi 50740425  294 rlrqcantrvgneylrGISGGERRRVSIAVQLLWNP------GILILDEPTSGLDSFTSHNLVITLSRLarg-------- 359
gi 115140    150 lllavglrdaahtriqQLSGGERKRLSLAEELITDP------IFLFCDEPTTGLDSFSAYSVIKTLRHLctrrriakhsl 223
gi 28571871  136 ---dlalsqvahkrveYLNISEARRLAIGIQLVRDP------VMLLLDEPTHGLDPLSAYLLISILSNTakkt------- 199
gi 50255124  932 glkdcadlpiggallkGISGGEKRRLSLAVQMINDP------AVLVVDEPTSGLDASIALGVMHVLRDIaat-------- 997
gi 50255124  255 glrdaadtvvggplrkGISGGEKRRLSIGCALVTLP------SVLILDEPTSGLDAFTSYLLLLTLSQLarr-------- 320
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                           #            
gi 17432916  262 -----------------------------------------------------------nrlVLISLHQPRSDIFRLFDL 282
gi 33860121  243 -----------------------------------------------------------nriVIVTIHQPRSELFHHFDK 263
gi 47218224  193 -----------------------------------------------------------nriVIVTIHQPRSELFRVFSR 213
gi 50740421  235 -----------------------------------------------------------driVIITIHQPRSELFRLFDK 255
gi 19173337  215 -----------------------------------------------------------nkiVLMTVHQPGSSMFSLFDD 235
gi 19074762  213 -----------------------------------------------------------nkiVITTIHQPGPGLFDMFDS 233
gi 19074934  206 -----------------------------------------------------------nsiVLVTVHQPGAELYNTFDN 226
gi 47218223  243 -----------------------------------------------------------nrlILLSVHQPRSDIFQLFDL 263
gi 50740425  360 -----------------------------------------------------------nrlVLLSLHQPRSDIFQLFDL 380
gi 115140    224 nqvygedsfetpsgessasgsgsksiemevvaeshesllqtmrelpalgvlsnspngthkkaAICSIHQPTSDIFELFTH 303
gi 28571871  200 -----------------------------------------------------------gcgILLSLEKPRSDVFPFLDR 220
gi 50255124  998 -----------------------------------------------------------grtVIATIHQPRSDIWKLTDN 1018
gi 50255124  321 -----------------------------------------------------------grtIILSIHAPRSDAFEIFDR 341
                        330
                 ....*....|....
Feature 1                      
gi 17432916  283 VLLMTs-GTPIYLG 295
gi 33860121  264 IAILTy-GELVFCG 276
gi 47218224  214 IAIMSr-GELAFCG 226
gi 50740421  256 IAIMSf-GEMVFCG 268
gi 19173337  236 IIFLDr-GKIVYAG 248
gi 19074762  234 LLFLHe-GSVVYSG 246
gi 19074934  227 LLFMNn-GEKLYLG 239
gi 47218223  264 VVLLSs-GSAVYCG 276
gi 50740425  381 VLLMTs-GVTIYSG 393
gi 115140    304 IILMDg-GRIVYQG 316
gi 28571871  221 ALFLCl-GGVVYSG 233
gi 50255124 1019 VTLLAkgGTIAYTG 1032
gi 50255124  342 IALLSk-GEIVYSG 354

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