Conserved Protein Domain Family
WD40

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cl02567: WD40 Superfamily 
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WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Links
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Taxonomy: root
PubMed: 7 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl02567
PSSM Id: 207648
Name: WD40
Created: 8-Feb-2008
Updated: 13-Jan-2012
Superfamily
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Curated CD Hierarchy
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cd00200:WD40
CD Hierarchy
Imported CD
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