Conserved Protein Domain Family
DOCK-C2

?
pfam14429: DOCK-C2 
Click on image for an interactive view with Cn3D
C2 domain in Dock180 and Zizimin proteins
The Dock180/Dock1 and Zizimin proteins are atypical GTP/GDP exchange factors for the small GTPases Rac and Cdc42 and are implicated cell-migration and phagocytosis. Across all Dock180 proteins, two regions are conserved: C-terminus termed CZH2 or DHR2 (or the Dedicator of cytokinesis) whereas CZH1/DHR1 contain a new family of the C2 domain.
Statistics
?
PSSM-Id: 206595
View PSSM: pfam14429
Aligned: 48 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 23-Dec-2011
Updated: 5-Jan-2012
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam14429 is not assigned to any domain superfamily.
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3L4C_A         21 MPGDVRNDIYVTLVQGdf-----dKG--------------SKt-tA---------KNVEVTVSVYDEDGK-R-LEHVIfP 69
gi 296817857  610 aPTKPRSDIYVTLSRAni-----sRDallshpihgqvpvpQSt-gL---------RNIQLTLEVRDSSGA-R-VEKCIcP 672
gi 295674369  608 aPTKPRSDIYITINRAtisqdallSH--------------PIn-gQlpvpqmtglRNLQLTVEVRNAAGv-R-LEHCIyP 670
gi 123977007  318 PFLAPNHQVFVSLKSAn-----------------------iKs-nA---------RNILIKMTIRDTQHS-R-ELPLLcN 362
gi 154419939  596 PTTFYINKFFFGLRKVs------iKA--------------QRhvkA---------RNIFAKISLYAGPEN-T-PLKSIyS 644
gi 123448490  316 PDVTFRHQFTFRLDSIql-----kKL--------------PEglkA---------RNIFCVISVQESQITpR-LPYLIdP 366
gi 123479218  331 PFLSPIHQISVRLNSItl-----kDN--------------SNv-kH---------KNNQIMMSLRNSPNSsT-V-KGIyS 379
gi 123391946  343 PILSHTHKLVINLRAAkf-----sFP--------------PKv-sA---------RNIVVDVSYLYKG---Q-YLKCIrN 389
gi 123476875  344 PYRTFENKLFLNLKSArf-----kKP--------------RNhrmI---------RNAVIVIKILSDG---K-ELPLF-- 389
gi 123448598  580 lafqFRNQITFGLRDTs------fKP--------------PKgikA---------RNILARITMVPGKQNdKkPIKLLhS 630
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3L4C_A         70 GAGd-EAISEYKSVIYYQVKQPRWFETVKVAIPIEDVNRSHLRFTFRHRSSQDSKDKS-EKiFALAFVKLM-RyD--Gt- 143
gi 296817857  673 -SSnaTPVIAWRTTVT--ERLSGWNQTIRLSIPADKVPGSHLIMSIADA-------PE-FP-FALSWMPLW-D-Q--Qa- 735
gi 295674369  671 -SSngLGQTAWRTTVT--QRGSPWNQSIRLNIPADEVPGSHLIMSVADA-------PE-FP-FALSWMPLW-D-Q--Qa- 733
gi 123977007  363 PLSqdALDTAVYSHCVYHEKAPKFIDDFIVDLPFPVQQEAYLVFEIFHVHAKVSDKSD-TH-IGTGSFKLI-D-K--Gt- 435
gi 154419939  645 PFTg-KREAVVYTQCWYHNERAQFNEVFMAEIPYPLPQNLHFHVELFHGVAQESMLDS-QY-IGSADVPCY-D-E--Rg- 716
gi 123448490  367 MTk--QHVKSLTSTCTYHDKSPVFDDVFTADLPAKLPKNLYIFVYLYHAIVQNESDNDrQF-IAHAAFQIV-N-N--Gi- 438
gi 123479218  380 LFTasQLSYVAFSSIAYHNEKPNFNDTFTINLPLPIPPTLQLCFEVIHIHVKDNKDTF-SP-IGNGFVNLVkE-D--Gki 454
gi 123391946  390 RWEntKIVDHAVSRGLYHVTNPQFEDEFIIELPYPV--EGIVVFTFQRLSTKPNDEAC-FT-FGNSSFEIS-P-NhdNf- 462
gi 123476875  390 -----NGSEKYVSRVHYHEDHPNFHDEVIINLQLEMPPEPILEFSIYHASVKPGAATSlEL-CGKATYPLF-K-D--Gt- 458
gi 123448598  631 NId-dSYVDSVVTQTIYHNETPEFDDTFVADLPNPLPKELGFNIEFFHGVAQLSDVPM-MP-VGRCYAPIY-N-E--Kg- 702
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3L4C_A        144 tLRDGEHDLIVy-------------KAeak---klEDAATYLSLPSTK----AELe-------EKGHsatgksmqslgsc 196
gi 296817857  736 fIRDGPHSLLLh-------------AYdkstssleNGKGAYLSLPWSA----LGKnestkdeaVTGP------------- 785
gi 295674369  734 fIRDGPHSLLLyaydk-----stssIE--------NGRGAYLSLPWSA----LGKnestkdeaVTGP------------- 783
gi 123977007  436 iQTGRHIEIPItlngekdksskveiSI--------KNNSCYQSDNANMnkllNEKd-------LEKY------------- 487
gi 154419939  717 hFNPQLATVPIs-------------IK--------DQKA---------------Da-------ADEK------------- 740
gi 123448490  439 pVVSGPISAGVs-------------FG-------------------------MEDk-------PDKS------------- 460
gi 123479218  455 fLSGEKIEVPIn-------------ID--------GGY---------------------------DL------------- 473
gi 123391946  463 lIPDGEMNLGI-------------------------------SYGSNI----NPKe-------QPTK------------- 487
gi 123476875  459 vIADGDHTTYI----------------------------NYG-----P----DNPf-------DQID------------- 481
gi 123448598  703 iFENRKITLPIh-------------YE--------K--------TPSP----KELd-------PKNH------------- 729
                         250       260
                  ....*....|....*....|....
3L4C_A        197 tisKDSFQISTLVCSTKLTQNVDL 220
gi 296817857  786 ---VATLVVETDLCSTEYSQDQVM 806
gi 295674369  784 ---LATLSIETDLCSTEYSQDQVI 804
gi 123977007  488 ---IPLLSPELIITNLTSILNIFL 508
gi 154419939  741 ---KSTITFSTRIRSTFYSEDPNI 761
gi 123448490  461 ---LNVVNGDFRIFSTIFSGDPNL 481
gi 123479218  474 ---ISHLSISIFLRSTFVTdslqf 494
gi 123391946  488 ---DNCFTISTKLVSSLVTNQPTL 508
gi 123476875  482 ---SNAICFSTELFSSYYSSNPNI 502
gi 123448598  730 ---ATFFMVP---RSHFLAENVSL 747
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap
Click on image for an interactive view with Cn3D