Conserved Protein Domain Family
Y_phosphatase

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pfam00102: Y_phosphatase 
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Protein-tyrosine phosphatase
Statistics
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PSSM-Id: 201002
View PSSM: pfam00102
Aligned: 119 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 21-Dec-2011
Updated: 5-Jan-2012
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam00102 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1L8K_A       42 NRNRNRYRDVSPYDHSRVKL----------QNA-----------------------E-ND--YINASLV----------- 74
gi 465663   150 NMHKIRAPDCPIPEEKLVKL------------------------------------TnGPesFICAAKIt---------- 183
gi 74966566 114 NPKKSRAPDWPIADNKLIKL------------------------------------ShAPgnFICAAKVd---------- 147
gi 74962827 158 HSSRNRHNDSKCYDHNRIIV------------------------------------QmCKddYINGSKIn---------- 191
gi 74958951 243 NKVRNREGCPKIYDENRVQLnr---------------------------------pGhEDvnYINASVItltdvcrrmac 289
gi 74958141 209 NSKYNQSEDFPALDSNLLKV---------------------------------------EkdYVNISRV----------- 238
gi 74958936 180 NLQMNQADNYPILDSTIVKN------------------------------------PaQPdsYVNMSSVi---------- 213
gi 74964442 164 NIDFSQSENVELYDTNRVKG------------------------------------GgEAdfFYHGSTL----------- 196
gi 74964562 237 YLTKARSKMVPCAEFSRVKLndglgrlddrNELrngmfsdeheflqeegytakstyGtTD--FIHANYV----------- 303
gi 74959922 432 NQEKCRNPRVHCRDSTRIALqf--------------------------------prGqYLgdFIHANRI----------- 468
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1L8K_A       75 --------DIEE-A---QRSYILTQGP----LP-NTC---CHFWLMVWQQK-TKAVVMLNRIVEK---------ESVKCA 124
gi 465663   184 ----------vPdF---NRTMILTQVP----DL-SSApdiADFWRMIHQES-IASVVIAVMPLE------------VTLQ 232
gi 74966566 148 ----------vPeF---NRTMIVTQIP----DV-TVSaniEDFWRMIFQEE-IVSIVIAVMPLE----------CSVTLQ 198
gi 74962827 192 -------------VphfTPSIYLVQLP-----KmDSVdavEEFWRVVFHEQ-CQTVHIIARPEEL---------TNPAID 243
gi 74958951 290 vpayvhlvVLYFvIfqfEHKLIVAQLPqmenE--SFV---EDFWYMIYQEQ-IHLVYLMVPDDKl---------KNTTTS 354
gi 74958141 239 -------------EiplGRNIYIGQVP----VK-DTE---ETFWKAVFDKR-IVSIDVIVGDEPI--------------- 281
gi 74958936 214 -------------VphcRYPILMAQMP-----KrGFE---EEFWRAAFNESvVIMYVLMGTEDEK--------------N 258
gi 74964442 197 --------TIPSvT---TKSTILAQLA----IV-DSPqslESFWIMVASQK-IQRLFILLGEEEL---------DKPTLS 250
gi 74964562 304 --------KGGP-L---LNTFICAQAP----LK-NTQ---EDFWRMVFQEK-CQFIVMLNSAVDSstlgpldsaNRNHCP 362
gi 74959922 469 --------SGKPlF----NEFIMTQAP----MK-NTV---DDFWRMVWQEE-VPYIVMLTSRKEP-----------ERCE 516
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1L8K_A      125 QYWPtddqEM--LFKETGFSVKLL---SED-VKsYYTVHLLQLENINSG---EtrTI-SHFHYT----TWP-DFGVP--E 187
gi 465663   233 QILPll-sGT--YSTYGKMFVNNKk-vESAvGMtEYCLE--IFPDGCSNs-----LLtTVYHLH----NWR--------Q 289
gi 74966566 199 QLFPll-sGT--FSNHGKMFLNNKk-vDSAvAMtAYTLE--VLPDGCSNs-----LLsTVYHLH----NWK--------Q 255
gi 74962827 244 KLFCqe-sGA--WLYANGFFVNTRk-vEKKeNAkADMFVVELLPEGCSNa-----VMcSVYLHT----YWK-PLFGP--D 307
gi 74958951 355 LFNDe--nGG--YQYTGKMFINNRr-aDVSgDPkEYTIEVLPEGNSDS-------VIcQVHHHA----PWK-HLQQP--P 415
gi 74958141 282 EFFPkk-aED--YKNYGQMWINNRk--VEYvSDdVFRFSIEVLPHGCSNs-----IIcNVTVIS----NWK-VDSVP--- 343
gi 74958936 259 DFFPtt-mGA--YVYYGAMFVNIRk--VEKmDEeRTRYTIEVLPNGFSNs-----VMmNVYVHT----GWE-ASGVPvrY 323
gi 74964442 251 EYFP----ED--FKEFKTIRVNNRktvPKTeEQaNTQLYYEVVPKDCAEa---------PFAMIeicdFWP-DAKIPtmG 314
gi 74964562 363 YYWPra-eNE--SLRFGSFHITCMk-vDSKaDP-LFTITKLKVQKVGGNlldA--EFdEELFLE----HWQwDWQ----- 426
gi 74959922 517 YYWPks-pSDpaVTVPGGLRIENF----GVyQApDPLFRVTHLRLIGPDr--------EERHVE----HWQgDVN----- 574
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1L8K_A      188 S-----PASFL----NFLFKVRESGsl--nPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDD---INIKQVLLNMRK 253
gi 465663   290 KrglevVTDLV----ATMEKVMKVN--------DNTVLMSMNGTGRAGTMLTLFTAMLQVQKgk---eVNAKETLASLRA 354
gi 74966566 256 KqglenVGELV----TTVEKVLKTN--------ENTVLMSMNGIGRAGTMLTLFTSMLSVQKsk---eVNPKEILIKLRG 320
gi 74962827 308 R-----FGAQI----RAAHQIAKNE-----NGNSPTVIASVNGSGRNAALLTLAVVEDQLTRgk---ePKISEIVRTIRE 370
gi 74958951 416 K-----TLPII----KMIHQFLSEKq----VQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIE---PNICEIMKNIKQ 479
gi 74958141 344 ------VKQAI----AIKEAFGLNSyllkaPADDNAMINSQHGAGRAGYFLALAVAVHTIDT--KvaePCIVDIVKSIRS 411
gi 74958936 324 An---tTRSVV----DVMNFVKTSS------GTEKMLVVSKNGCGRAGFFLSLGAAFCCLNDns---ePRIGEIVKAIRS 387
gi 74964442 315 ------YNRIA----ATAASVFESDi----DCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAge---aPNIKEIALSVRS 377
gi 74964562 427 ------YLGDVhwpfRVLRKARQLS--------TPTIVQCIDGCSKSGTLVSIETALMHFIRGSPitkSLILQSCVFVRL 492
gi 74959922 575 ------NSSNMysplNILRLLRNAS--------KPVVIHDHLGVSRAACLVAAEIAICSLLR-GPtykYPVQRAVQFLRQ 639
                       330       340
                ....*....|....*....|.
1L8K_A      254 YRMGLIQTPDQLRFSYMAIIE 274
gi 465663   355 ERCGIVDNIDQFGTVHRSMAC 375
gi 74966566 321 ERSGLVENADQFNTVHRAMAL 341
gi 74962827 371 QRPQSVDSYIQYVSLYMATNW 391
gi 74958951 480 QRPGGVESFAQYASIYAIVFD 500
gi 74958141 412 QRPRAVDSFCQYCSLYISLLY 432
gi 74958936 388 QRPNAVDSIKQYASIYLCFVY 408
gi 74964442 378 QRPAAIETLSQYMFTYVIALT 398
gi 74964562 493 QRRLSVSSVLLYLFIYRVILR 513
gi 74959922 640 RRPFSIETPMQYIFVHRLVAF 660
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