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cd11359: AmyAc_SLC3A1 
Alpha amylase catalytic domain found in Solute Carrier family 3 member 1 proteins
SLC3A1, also called Neutral and basic amino acid transport protein rBAT or NBAT, plays a role in amino acid and cystine absorption. Mutations in the gene encoding SLC3A1 causes cystinuria, an autosomal recessive disorder characterized by the failure of proximal tubules to reabsorb filtered cystine and dibasic amino acids. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.
Links
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Statistics
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PSSM-Id: 200494
View PSSM: cd11359
Aligned: 11 rows
Threshold Bit Score: 741.483
Threshold Setting Gi: 340372185
Created: 4-Nov-2011
Updated: 17-Jan-2013
Structure
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Aligned Rows:
Hierarchy
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Display:
 
active sitecatalytic site
Feature 1:active site [active site]
Evidence:

cd11359 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd11359 is a member of the superfamily cl07893.
cd00551:AmyAc_familycd11313:AmyAc_arch_bac_AmyAcd11314:AmyAc_arch_bac_plant_AmyAcd11315:AmyAc_bac1_AmyAcd11316:AmyAc_bac2_AmyAcd11317:AmyAc_bac_euk_AmyAcd11318:AmyAc_bac_fung_AmyAcd11319:AmyAc_euk_AmyAcd11320:AmyAc_AmyMalt_CGTase_likecd11321:AmyAc_bac_euk_BEcd11322:AmyAc_Glg_BEcd11323:AmyAc_AGScd11324:AmyAc_Amylosucrasecd11325:AmyAc_GTHasecd11326:AmyAc_Glg_debranchcd11327:AmyAc_Glg_debranch_2cd11328:AmyAc_maltasecd11329:AmyAc_maltase-likecd11330:AmyAc_OligoGlucd11331:AmyAc_OligoGlu_likecd11332:AmyAc_OligoGlu_TScd11333:AmyAc_SI_OligoGlu_DGasecd11334:AmyAc_TreScd11335:AmyAc_MTase_Ncd11336:AmyAc_MTSasecd11337:AmyAc_CMD_likecd11338:AmyAc_CMDcd11339:AmyAc_bac_CMD_like_2cd11340:AmyAc_bac_CMD_like_3cd11341:AmyAc_Pullulanase_LD-likecd11343:AmyAc_Sucrose_phosphorylase-likecd11344:AmyAc_GlgE_likecd11345:AmyAc_SLC3A2cd11346:AmyAc_plant_IsoAcd11347:AmyAc_1cd11348:AmyAc_2cd11349:AmyAc_3cd11350:AmyAc_4cd11352:AmyAc_5cd11353:AmyAc_euk_bac_CMD_likecd11354:AmyAc_bac_CMD_likecd11355:AmyAc_Sucrose_phosphorylasecd11356:AmyAc_Sucrose_phosphorylase-like_1cd11359:AmyAc_SLC3A11563725451959970613403721852608184592607960012912357526747267411808798114823278822067949119841490315637254519599706134037218526081845926079600129123575267472674118087981148232788220679491198414903
cd11359 Sequence Cluster
cd11359 Sequence Cluster
Sub-family Hierarchy
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 cd11359 Branch
 Whole Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  #                   
gi 67472674  116 DWWQEGPMYQIYPRSFKDsnKDGNGDLKGIQDKLDYITA-LNIKTVWITSFYKSSLKDFRYGVEDFREVDPIFGTMEDFE 194
gi 156372545  17 RWWKNSVIYHIYPRSFQDsnGDGNGDLSGIRSRLDYLDY-LGVKIIYLSPIFKSPMVDNGYDVSDFMDVNPMFGTMEDFE 95
gi 195997061  88 QWWQTGIIYQIYPRSFQDsnGDGVGDLRGIMQRLDHLKF-IGVQTVWLSPVYKSPMKDFGYDVSDYYQIDPLFGNLRDFD 166
gi 340372185 124 TWYRKSVIYQCYPQSFQDsdGDGFGDLEGIRSRISYFKE-LGIRGVWLNPIYPSPKRDNGYDISNYTDIDPVYGNIEIFK 202
gi 260818459   3 HWWQRAVIYQIYPRSFQDsnGDGIGDLRGIERRVDYLEY-LGVEAVWLSPIFKSPMKDFGYDVSDFTDIDPIFGTMADFD 81
gi 260796001  53 PWWQDTVIYQIYPRSFKDsdGDGIGDIKGIHEKLGYLDD-LGVKTVWLSPIFPSPMKDFGYDVSDYTGIWETFGTMDDFQ 131
gi 291235752 104 PWWQTTVIYQLYPRSFMDsdGDGNGDLKGIEDNMEYFKE-LGVKAVWINPIYVSPKVDNGYDVSNYYEIDPMYGDMTDFD 182
gi 118087981 115 DWWQDGPIYQVYPRSFKDsnMDGNGDLKGIQEKLDHITH-LNIKTIWITSFYKSPLKDAGYGAEDFYDIDPMFGSMRDFE 193
gi 220679491  69 SWWQLSPIYQVYPRSFKDsnADGVGDLRGIKEKLSHFEY-LNIKAIWISPFYKSPMRDFGYDVEDFRDVDPLFGTMEDFD 147
gi 198414903 102 PFWQTSPIYQIYPKSYSDnnNDGVGDIAGIRSKLDYLKDdLGVNMIWLNPIYLSPQVDNGYDVMDYVTIDPMFGTMAEME 181
gi 148232788 118 DWWQRSPMYQVYPKSFKDsnNDGSGDLKGVQEKIDHFLY-LNIKNVWVAPFYKSSLKDFNYAVDDFMEVDPTFGTMADFE 196
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         #  #                                                   #       
gi 67472674  195 NLVAAIHDKGLKLIIDFIPNHTSDKHIWFQLSRTRt----gKYTDYYIWHDCtheng----ktipPNNWLSVYG---NSS 263
gi 156372545  96 SLLQDIHSRGMKLLLDFVPNHTSDQHDWFLESRSNrh---nPRREWYIWRDAasd-------gtpPNNWLSVFG---GSA 162
gi 195997061 167 AMLKAMGEKDIKLVMDFVPNHTSDLNQWFIDSVNRe----nGKDDWYMWADPkansvl-panesyPNNWISVFS---GSM 238
gi 340372185 203 RLLAELHENDIHLILDFVPNHTSDEHPWFKESKASkt---nSKRDWYVWADGvap-------gypPNNWLSVFG---NSS 269
gi 260818459  82 SLLKALHARDMKLILDFVPNHTSDQHHWFVWSSGSrde-snPYRDYYVWADGrdg--------gpPNNWVSVFG---GPA 149
gi 260796001 132 RLLDAMHERGMKLILDFVPNHTSDQHEWFNKSRESv----dPYTDYYVWKDCsddndgdgipdtpPTNWRSVFT---ESM 204
gi 291235752 183 RLLLSLKREGMKVIMDFIPNHSSDEHEWFNKSRQSkd---nDFKSHYIWADPknsd------gdcPNNWRSVWG---GSA 250
gi 118087981 194 DLLASIHDRGLKVIMDFIPNHTSDKHQWFQLSRNRt----gKYTDYYIWQDCvqaga----aisaPNNWVSVYG---NSS 262
gi 220679491 148 DLLTSMHDKGLKLIMDYIPNHTSDKHVWFQLSRNYt----ePYTDYYIWVNCtad--------khPNNWVSVFG---NST 212
gi 198414903 182 LLITDVHDRGMKIIMDFVPNHTSDKHAWFNASSNPshaqyeKYKDYYIWADStngg-----stgvPNNWQSVFSdtdPSA 256
gi 148232788 197 SMISAMHDKGLKLIIDLIPNHTSNKHKWFQLSRNRt----gKYADYYIWHDCmqtgg----lvvpPNNWVSFYG---NSA 265
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      #   #                               #                             
gi 67472674  264 WHFDEvRNQCYFHQFMKEQPDLNFRNPDVQEEIKEILRFWLTKGVDGFSLDAVKFLLEAKHLRDEIqvnktqipdtvtqy 343
gi 156372545 163 WSLDRkTNQYYLHQFFKEQPDLNFRNPDVVNATKEVLGFWLDKGVDGFRVDAVPHLLEDEEFRDEPvlasydtshpqyk- 241
gi 195997061 239 WNYNTkRSQFYLHQFLKEQPDLNYTNPEVVQASYDVISFWLNKGVDGFRIDAIKHVFENPLLPDEVrnpnfkpgeppys- 317
gi 340372185 270 WSYDEtTDQWYYHQFSSYQPDLNYSNPQVKQVMEDVLKFWLDLGVDGFRVDAVEFLLEDPQLQNETlnplfnesecsspp 349
gi 260818459 150 WTYVAsRDQWYLHQFLPEQPDLNFRCPDVRRHMENVLRFWLEKGVDGFRLDAVKHLVETADLSWHEppnpgyvsdpeetl 229
gi 260796001 205 WQRDEtRGQCYLHQFLVEQPDLNLRNTDVQDKLTDVIRTWLSRGVDGFRVDAIGHGLEEDSYSIDApeapcdpyftql-- 282
gi 291235752 251 WTYEErRNQYYLHQFDKSQPDLNWRNDEVKAEFDNILDFWLKKGVDGFRVSAVQLLLETDNYSLDEqpsgtndclgfend 330
gi 118087981 263 WQYDDvRKQCYFHQFGKEQPDLNFRNPAVQQEIHDVIKFWLGKGVDGFNFIAVKFLLEATHLRDEPqvnksqnpesitay 342
gi 220679491 213 WEYDEiRQQCYFHQFLKEQPDLNYRNPLVLQEMTDIIHFWLKKGVDGFRMDAVKHMLEATHLRDEPqvnpdqdpstvdte 292
gi 198414903 257 WEWNDkRKQFYYHAFYKEQPDLNLRNEAVLVELDAVLTYWMDQGVDGFRCDAVAFMLEATHLRDNPlvddtkppsytn-- 334
gi 148232788 266 WEYDDtRKQCYLHQFKKEQPDLDFNNPDVNEEILNIIKFWLEKGVDGFTINSAKFLLEAEHLRDEPqvnklqnpdtisny 345
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                   #                                    
gi 67472674  344 --selyhdftttqvgmHDIVRSFRQTMDQYste-pgRYRFMGTEAYa-eSIDRTVMYYGlpf---iqEADFPFNNYLSml 416
gi 156372545 242 ---dldhqftcnlddvHGIVRGWRQFCSMYr----nPYRLLIGEILc--GNETAMSYYGhh----kpEFNFPLNFSLIgl 308
gi 195997061 318 ---slihnettdypplHQLCKDWRKVIDKFst--sqKPRFAVGEAYn--PIREIMKYYGtn----gdEFHFPFNFFLLtl 386
gi 340372185 350 cydslvhnlttnypgiHELCRDWRKLVNGYsiq-drSEKILIGEIYd--NIETVMTYYGns----snEFTFPFNFFLLvn 422
gi 260818459 230 y-gsllhpcttnleetHAVIREWKALLDQYsk--kgSYRFMITEVYd--DDMRVLMTYNr-------EADMTFNFNLLgl 297
gi 260796001 283 ----hnytfeyepetlHGIIQGWRDSVLTEysnepeKYRFMVTEVYl--PPQGLTRYYGrdg---kvEADFPFNFQLIsg 353
gi 291235752 331 eyctlhhnltkeyegvHDIVKSWRSGEMNHyst-tgAYRFLTVEAYd--DVDVAVTYYGeseeegeeEANFPHHLNFLqi 407
gi 118087981 343 --selyhdytttqvgmHDIIRSFRQTMDQYsse-pgRYRFMGSDSDekeDIEATMMYYGttf---vqEADFPFNLHLInm 416
gi 220679491 293 --felyhdytytqaglHEILTDWRIQMDTYsre-pgRYRFMVMESYdyeEIDKTMRYYGtny---akESDFPFNFYLLdl 366
gi 198414903 335 ----vypdytqnqmgvHEIIARWRHVLDKFste-pgVYRFMETEVYd--DIDTVIRYYGtpy---vdEADFPMNFKLIdl 404
gi 148232788 346 --selfhdytttqvgmHDIIRNFRQTINKYsre-pgRYRFMGTESNdqaAVDKTMLYYGnsf---iqEADFPLNAYLFdl 419
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                ##                                      
gi 67472674  417 ---------dTVSGNSVYEVITSWMENmpeGKWPNWMIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMG 487
gi 156372545 309 --------kkGITALEISEKVVKYLNDvpkGKWPNWLLGNHDCKRVGTRMGQANLPAMTVLYLTLPGTAVMYYGDEIGLM 380
gi 195997061 387 ---------gDFTGTGVNKTVEDWMSHaprCGWPNWVVGNHDNNRISKRRGNAYVRAVNAINLLLPGTPTTYYGEEINMQ 457
gi 340372185 423 ---------sDWSGVRINCIVKSWLDRmpgGATANWVLGNHDNSRIATKAGLFRARALLLLLLTLPGTPVTYYGDEILMT 493
gi 260818459 298 g------sgaHAPGNHTRRLVESWMSNmtdGQWPNWVIGNHDNHRVATRVGPQYARAANMLLLLLPGTPFCYYGDEIGME 371
gi 260796001 354 eskygnlpdyELTGTKTHELVDSWLKEvpaRRWPNWVLGNHDNHRLPNRFNPEYSRAMVMMLMMLPGTPTTYYGEEIGMS 433
gi 291235752 408 gde---lsggTTSGKQIEELVLKWIDAvpeGRHPNFLLGNHDRSRIASRLGPDFARVCHVLLLTLPGTPTTYYGEEIGMV 484
gi 118087981 417 ---------kNLSGNSVFEAVNMWMKNmpeGKWPNWAVGSPNTARISSRFGSEYVRVINMLLLTLPGTPITYYGEEIGME 487
gi 220679491 367 --------pdNLSGNYAKSIVERWMSNmpkGKWPNWVVGNHDKPRIGSSAGKEYVRALNMLLLTLPGTPTTYYGEEIGMV 438
gi 198414903 405 q------kpaSWTGSNIESTVLQWMRKmpsSKWPNWVIGNHDNSRVSTRLGNKLASCAAFLTMTLSGTPGMYYGEEIGME 478
gi 148232788 420 n-------kaNIDGASIFSMVDLWMKAmpsGKWPNWMVGGPSSSRIASRVGRQYVNVMNMLLLTLPGTPTTYYGEELGME 492
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 67472674  488 NIVAANLNesy-----------diNTLRSKSPMQWDNSsNAGFSEAs-------nTWLPTNSDYht--vNVDVQKTQPRS 547
gi 156372545 381 DADISKGEin-------------dSRDPCRGIMQWENAeNYGFSQAk-------kLWLPGTDNNk---tNVEVQKLDETS 437
gi 195997061 458 HVDIDLSEakdpfalqnpdiyktvGRDPERTPMQWNRSaNAGFTNAgv------kPWLPVASDYqt--rNVAAQRADTHS 529
gi 340372185 494 DVYVPLDKrnd----------tfeGRDSERTPMQWNTSnHSGFTFPna------ePWLPLATNYsl--yNVEVEKDNSTS 555
gi 260818459 372 DARVSYNDtkdtfalnnpetyetkSRDPERTPMQWNRTeNSGFTDAgv------rPWLPLHDNYhr--lNVQTQRAHPRS 443
gi 260796001 434 DITPEVGKtqdp--------fcpdSGDPMRAPMQWSAEtNAGFSDNnetdqhgwtTWLPVNTDYqq-gvNVEEQQSATDS 504
gi 291235752 485 DLTGYEDKsk------------feKRDRARSPMQWSDEvGAGFSNSs-------dTWLRIGDDYke--vNVKALREQPDS 543
gi 118087981 488 NIASENVSeeyi--------nsdpVTSPEKSPMQWNGNlNAGFTKGn-------sSWIPVNSDYes--vNAEVQMTRFNS 550
gi 220679491 439 DVNISVIQdpagq------ydpskSRDPQRTPMQWNNElNAGFSESln------gTWLDIASDYrt--vNVEVQQDDTSS 504
gi 198414903 479 DLVMTNPAd---------------TRDPERTPMQWDITnNAGFCDNc-------tSWLPVNNNYlskgiNVEEQKTNSTS 536
gi 148232788 493 DGSPQVSTenpq--------eynpTEYPEKTPMQWDSSsNAGFSEAn-------rTWLSVNPDYea--vNVEAQKNEQYS 555
                        490       500
                 ....*....|....*....|..
Feature 1                              
gi 67472674  548 ALKLYQDLSLLHANELLLNRGW 569
gi 156372545 438 MLVLTRKILKLRNAEKAFHGLN 459
gi 195997061 530 DLWWYRSLANLRSSHDSFKYPG 551
gi 340372185 556 MLSLYKKLLQLHSTEAAFYEGE 577
gi 260818459 444 ILHLFRALVELRKEPTFLYGTI 465
gi 260796001 505 ALSMYKALIGMRGLSHLAIHRG 526
gi 291235752 544 IFNLYRELVALRNDNERVIPVG 565
gi 118087981 551 TLNLYRELTLLRNSELPIHRGW 572
gi 220679491 505 TISQYRALSLLRSSNVILSRGW 526
gi 198414903 537 MFNLYKQLINLRSDETFRQGYL 558
gi 148232788 556 TLNLYRELNHLRNNELPLHRGW 577

Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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