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smart00242: MYSc 
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Myosin. Large ATPases.
ATPase; molecular motor. Muscle contraction consists of a cyclical interaction between myosin and actin. The core of the myosin structure is similar in fold to that of kinesin.
Statistics
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PSSM-Id: 197599
View PSSM: smart00242
Aligned: 62 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 13-Jul-2011
Updated: 18-Jul-2011
Structure
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Program:
Drawing:
Aligned Rows:

smart00242 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1W9J_A         81 NPIKFDGVEDMSELSYLN-----EPAVFHNLRVRYNQDL-IYTYSGLFLVAVNPFKRIp-IYTQEMVDIFKgrr------ 147
gi 2209250     94 SLIDPMTYGDIGMLPHTN-----IPCVLDFLKVRFMKNQ-IYTTADPLVVAINPFRDLg-NTTLDWIVRYRdtfd----- 161
gi 3132701    334 QPHEKIYVDDLAFLDSPT-----EEVVLENLEQRYRKGE-IYTFAGDVLLTLNPGKVLp-LYGDQTAVKYCerg------ 400
gi 157963     327 EKPEKMYPEDLAALENPV-----DENIIESLRHRILMGE-SYSFIGDILLSLNSNEIKq-EFPQEFHAKYRfks------ 393
gi 3642560    258 LERFELLQSDSTRIGGVS-----EEMESSTPIHGFYKEKtSKPSWLASLVILKPFKQPtkASNVLVFVNDFndkdsed-- 330
gi 2209254     22 VIPCCFSSLFCVCLPLRRvrdtvPRAEFGTRKSRFLRSI-IYTTAEPLLVAINPFKDLg-NTTDAWISTYRnask----- 94
gi 118354754   90 DSLQTLGYSDMVHMKYLN-----EAEIINNLRKRYQNNM-IFTYIGPTLVVMNPYKEIegVQDNQVIDKIKsdlgikfee 163
gi 1346638     70 KSVLDKSVDDLVQMDDIN-----EAMIVHNLRKRFKNDQ-IYTNIGTILISVNPFKRLp-LYTPTVMDQYMhkv------ 136
gi 119569114   35 EEDSKKDVEDNCSLMYLN-----EATLLHNIKVRYSKDR-IYTYVANILIAVNPYFDIpkIYSSEAIKSYQgks------ 102
gi 8214        53 CDGPQ-DHDDNCELMLLN-----EATFLDNLKTRYYKDK-IYTYVANILIAVNPYREIkeLYAPDTIKKYNgrs------ 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1W9J_A        148 -----------rneVAPHIFAISDVAYRSMLD-DRQNQSLLITGESGAGKTENTKKVIQYLASV---------------- 199
gi 2209250    162 -----------lskLAPHVFYTARRALDNLHA-VNKSQTIIVSGESGAGKTEATKQIMRYFAAA---------------- 213
gi 3132701    401 -----------rsdNPPHVFAVADRAYQQMLH-HKSPQAVILSGVSGSGKSFCTHQVIRHLAFL---------------- 452
gi 157963     394 -----------rseNQPHIFSVADIAYQDMLH-HKEPQHIVLSGESYSGKSTNARLLIKHLCYL---------------- 445
gi 3642560    331 -------qlswetsSTSGVNAVAKNALNKIFNmSSNAESIVFGGESGSGKSYNVFKAFKYLTSQ---------------- 387
gi 2209254     95 -----------pemLPPHVFKTARAALEDLEG-YKKNQSIIVSGESGAGKTEATKQIMRFFASA---------------- 146
gi 118354754  164 dfkmnnlstnqniiNTPHTYTVSGLAYKQMFS-NKKNQAIVISGESGAGKTENAKLSMQFLTSLssgsdkqndllnqlkt 242
gi 1346638    137 -----------pkeMPPHTYNIADDAYRAMID-NRMNQSILISGESGAGKTECTKQCLTYFAEL---------------- 188
gi 119569114  103 -----------lgtRPPHVFAIADKAFRDMKV-LKMSQSIIVSGESGAGKTENTKFVLRYLTES---------------- 154
gi 8214       120 -----------lgeLPPHVFAIADKAIRDMRV-YKLSQSIIVSGESGAGKTESTKYLLKYLCYS---------------- 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1W9J_A        200 --------AGrnq-anGSgvLEQQILQANPILEAFGNAKTTRNNNSSRFGKFIEIQFNSAG-FISGASIQSYLLEKSRVV 269
gi 2209250    214 --------KTgs--mdLR--IQNAIMAANPVLEAFGNAKTIRNNNSSRFGRFMQLDVGREG-GIKFGSVVAFLLEKSRVL 280
gi 3132701    453 --------GAqn---kEG--MREKLEYLCPLLDTLGNAYTSTNPNSSHFVKILEVTFTKTG-KITGAILFTFLLEARRLT 518
gi 157963     446 --------GDgnrgatGR--VESSIK----AILMLVNAGTPVNNDSTRCVLQYCLTFGKTG-KMSGAVFNMYMLEKLRVA 510
gi 3642560    388 --------PKs----kVS--TKHSSSI-EFVFKSFGCAKTLKNDEATRFGCSIDLLYKRNV-LTGLNLKYTVPLEVPRVI 451
gi 2209254    147 --------SSev---rTT--IQDTIMAGNPILEAFGNAKTIRNNNSSRFGRFMMLDVSSHR-GIQHGSISNFLLEKVRVV 212
gi 118354754  243 qtaknillEEfn---qFA--IEVKILACNPILEAFGNAKTVRNNNSSRFGKYVKIYIDKTSqKINGASIDSYLLEKSRIP 317
gi 1346638    189 --------AGs----tNG--VEQNILLANPILESFGNAKTLRN-NSSRFGKWVEIHFDQKG-SICGASTINHLLEKSRVV 252
gi 119569114  155 --------YGt----gQD--IDDRIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKS-SVVGGFVSHYLLEKSRIC 219
gi 8214       172 --------HDs----aGP--IETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKC-QMVGGYISHYLLEKSRIC 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1W9J_A        270 FQSETERNYHIFYQLLAGAT-AEEKKALHLAg---PESFNYLNQs-------------------------gCVDIK-GVS 319
gi 2209250    281 TQDEQERSYHIFYQMCKGAD-AAMKERFHILp---LSEYKYINPl--------------------------CLDAP-GID 329
gi 3132701    519 DIPKGERNFHVFYYFYEGLRsEGRLKEFGLE----EKNYRYLPE---------------------------LKSSN-SPE 566
gi 157963     511 TTDGTQHNFHIFYYFYDFINqQNQLKEYNLKa---DRNYRYLRVppevpp-----------------sklkyrRDD-PEG 569
gi 3642560    452 SQKPGERNFNIFYEVYHGLS-DEMKAKFGIk---gLQKFFYINQgns--------------------------seN-IQH 500
gi 2209254    213 SQEANERSYHIFYQLLKGAT-SEMRAKYHLRs---LKEYAYLNGkn-----------------------ggCYDVP-GID 264
gi 118354754  318 CPGKGERNYHIFYHMLKG---NQELSNLRLSqfknLSDFDYLKKs-------------------------dCFEVE-NIQ 368
gi 1346638    253 YQIKGERNFRIVATELVKAP-PRSRGGGGSSpa-rPESFKFLSQs-------------------------gCIDVE-GVD 304
gi 119569114  220 VQGKEERNYHIFYRLCAGAS-EDIREKLHLSs---PDNFRYLNRgctryfanketdkqilqnrkspeylkaGSMKDpLLD 295
gi 8214       237 TQSAEERNYHVFYMLLAGAP-QQLRDKLSLGk---PDDYRYLSgctqyfanakteql-ipgsqksknhqqkGPLKDpIID 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1W9J_A        320 DSEEFKItr---qAMDIVG-FSQEEQMSIFKIIAGILHLGNIKFEKGAG---EGA--V------LKDKTALNAASTVFGV 384
gi 2209250    330 DVAEFHEvc---eSFRSMN-LTEDEVASVWSIVSGVLLLGNVEVTATKDggiDDAaaIe-----GKNLEVFKKACGLLFL 400
gi 3132701    567 YVKGYQQfl---rALTSLA-FTEEEIFAIQKVLAAILLLGETEIQNSA-------------------------------- 610
gi 157963     570 NVERYREfe---nILRDID-FNHKQLETVRKVLAAILNIGNIRFRQNGKy--AEVenT----------DIVSRIAELLRV 633
gi 3642560    501 DVNRFKHle---sALHVLG-FSDDHCMSIYKIISTILHIGNIYFRTKRN---PNVe---------qDVVEIGNLAELKWI 564
gi 2209254    265 DKADFEEvl---qSLDAMQ-ITGSKRHSVFSILSGLLLIGNVSIEGKDAqgvPDAayIs-----PQSEEILEEACQLLSV 335
gi 118354754  369 DAKLYLEvk---kSFRQMN-FSNQEQEAIFSLISAILLLGNANLDSSKAs--DTQapTflnmslPTHHKEFKNASELLQV 442
gi 1346638    305 DVKEFEErvlchgQARVRVqFSEDDINNCMELISAILHLGNFEFVSGQG---KNVetSt-----VANREEVKIVATLLKV 376
gi 119569114  296 DHGDFIRmc---tAMKKIG-LDDEEKLDLFRVVAGVLHLGNIDFEEAG----STSggCnl---kNKSAQSLEYCAELLGL 364
gi 8214       312 DYQHFHNld---kALGRLG-LSDTEKLGIYSLVAAVLHLGNIAFEEIPD---DVRggCqv---sEASEQSLTITSGLLGV 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1W9J_A        385 NP--SVLEKALMEPRILAGRD-----LVAQHLNVEKSSSSRDALVKALYGRLFLWLVKKINNVLC-Qe---RKAYFIGVL 453
gi 2209250    401 DA--ERIREELTVKVSYAGNQ-----EIRGRWKQEDGDMLKSSLAKAMYDKLFMWIIAVLNRSIKpPg---GFKIFMGML 470
gi 3132701    611 -A--FKLLGAESSELE---------------NTLTQDVNARDVYARAMYLRLFSWIVAVVNRQLSfSrlvfGDVYSVTVI 672
gi 157963     634 DE--KKFMWSLTNFIMVKGGI-----AERRQYTTEEARDARDAVASTLYSRLVDFIINRINMNMSfPravfGDTNAIIIH 706
gi 3642560    565 AFllEVDFDQLVKFLLPTSED-------GSTIELNAALDNRDSFAMMIYEELFKWVLNRIGLQLKcS----LHTGVISIL 633
gi 2209254    336 DD--AALKKEILVKSTKVGPQ-----VIEGVRTKDEAKTSVLSLSKNVYDKLFDWLVRQLNSLIDaPd---GMPNFIGIL 405
gi 118354754  443 NP--KDLEESLVFKVRKVGTT-----VIKSPQTAEECLSMRDSLSKNLYDSLFNFLVWKLNQNLLpPqdllNKSLSIGLL 515
gi 1346638    377 DP--ATLEQNVTSKLMEIKGCd----PTRIPLTPVQATDATNALAKAIYSKLFDWLVKKINESMEpQk--gAKTTTIGVL 448
gi 119569114  365 DQ--DDLRVSLTTRVMLTTAGgtkgtVIKVPLKVEQANNARDALAKTVYSHLFDHVVNRVNQCFPfE----TSSYFIGVL 438
gi 8214       382 DQ--TELRTALVSRVMQSKGGgfkgtVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIPfQ----ASNFYIGVL 455
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1W9J_A        454 DIYGFEIFKVNSFEQLCINYTNEKLQQFFNHHMFKLEQEEYLKEKINWTFIDFg-lDSQATIDLIDGrQp-PGILALLDE 531
gi 2209250    471 DIFGFEVFKNNSLEQFFINITNEMLQKNFVDIVFDRESKLYRDEGVSSKELIFt--SNAEVIKILTA-Kn-NSVLAALED 546
gi 3132701    673 DSPGFENGLHNSLHQLCANVISDNLQNYIQQIIFFKELEEYGEEGVNVPFNLEggvDHRTLVNKLMD-Sg-QGLLTAISK 750
gi 157963     707 DMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFy--DNKTALDNLLT-Kp-DGLFYIIDD 782
gi 3642560    634 DHYGFEKYNNNGVEEFLINSVNERIENLFVKHCFHDQLIDYAKDGISVDYKVPnsiENGKTVELLFK-Kp-YGLLSLLTD 711
gi 2209254    406 DIFGFEVLEVNSLEQVLINITNEYLQKHFIDVVFDMETKLYQAEGVPTEALEYt--DNLALVGALCG-Kn-DSFFALLED 481
gi 118354754  516 DIFGFESFDINSFEQLCINFTNEKFQQLYVQYVFKSEEEDYKQEGILDVFSDLqyqENQLIIDTIEK-Kp-NGIMVLLDE 593
gi 1346638    449 DIFGFEIFDKNSFEQLCINFTNEKLQQHFNQYTFKLEEKLYQSEEVKYEHITFi--DNQPVLDLIEK-KqpQGLMLVLDE 525
gi 119569114  439 DIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHYv--DNQDCIDLIEA-Kl-VGILDILDE 514
gi 8214       456 DIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFt--DNQDIIELIEA-Ks-NGIFTLLDE 531
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1W9J_A        532 QSVFpNATDNTLITKLhs-hfSKKNAKYEE---------PRFSKTEFGVTHYAGQVMYEIQDWLEKNKDPLQQDLELCFK 601
gi 2209250    547 QCLApGGSDEKFLSTCkn-alKGTTKFKPA---------KVSPNINFLISHTVGDIQYNAEGFLFKNKDVLRAEIMEIVQ 616
gi 3132701    751 ATQYqRKGESGWMESLqeadsEELVEFSN-----------VNGKPIVSVKHIFRKVSYDATDLVKKNVEDKTRALTSTMQ 819
gi 157963     783 ASRS--CQDQNLIMDRv---sEKHSQFVKKh-----------tATEISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFR 846
gi 3642560    712 ECKFpKGTHETYLEHCnl-nhTDRSAYGKA---------RNKERLEFGVRHCIGTTWYNVTDFFARNKRIISLSAVQLMR 781
gi 2209254    482 ACLGiRSTDEGFCGTIlr-rlEPSGFFLES---------RRDKRLKFIIRHTIADIEYTCEGMLEKNKDFLRKEVMDVMK 551
gi 118354754  594 NCSLgSGTDDSFLNQItk-nhSKNQLVSFP----------KKDKYSFSLSHTAKQVVYDVRGFRDKNKDEVSTEVEKCLQ 662
gi 1346638    526 QISIpKSSDATFFIKAnqtqaARSTQLRGG----------EDSRTDFIIKHYAGDVIYDSTGMLEKNKDTLQKDLLVLSE 595
gi 119569114  515 ENRLpQPSDQHFTSAVhq-khKDHFRLTIPrksklavhrNIRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLIC 593
gi 8214       532 ESKLpKPSYSHFTAEVhk-swANHYRLGLPrssrlkahrTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQ 610
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1W9J_A        602 DSSDNVVTKLFndPNiasr-------------------------------akkGANFITVAAQYK---EQLASLMATLET 647
gi 2209250    617 QSKNPVVAQLF--AGivme-------------------------------kgkMAKGQLIGSQFL---SQLQSLMELINS 660
gi 3132701    820 RSCDPRIRAIF--SSenpspflssp-------------------rrssiqenmLLPERTVTDSLHs--ALSSVLNLASTE 876
gi 157963     847 SSLDESIMLMF--TNqltkagnltmpfeavqhkdeserksyalntlsagcisqVNNLRTLAANFRftcLTLLKMLSQNAN 924
gi 3642560    782 NSKNPIIGLLF--ESyggn--------------------------------tsdIIVSQAQFVLR----GAQDIADKINV 823
gi 2209254    552 ASTDPVTKALF--EGieie-------------------------------agkIGKGTLIASRFL---KNLEEMIGIVAQ 595
gi 118354754  663 SSKCPVIANLL--SYqgsqtqqnketqnlqnfg---nnlnfkkaeisnqmnssKKN----------------ELMIELNN 721
gi 1346638    596 SSKQKLMKLLF--PPseg---------------------------------dqKTSKVTLGGQFR---KQLDSLMTALNA 637
gi 119569114  594 ESRDKFIRELF--ESstnnnkd-------------------------tkqkagKLSFISVGNKFK---TQLNLLLDKLRS 643
gi 8214       611 ECDNPLLQTLF--PSgsst------------------------------svrgKLNFISVGSKFK---TQLGELMEKLEQ 655
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1W9J_A        648 TNPHFVRCIIPNNKQLPAKLEDKVVLDQLRCNGVLEGIRITRKGFPNRIIYADFVKRYY-LLAPNVPRdaedsqkAT--- 723
gi 2209250    661 TEPHFIRCIKPNDTKKPLDWVPSKMLIQLHALSVLEALQLRQLGYSYRRPFKEFLFQFKfIDLSASENpnldpkeAA--- 737
gi 3132701    877 DPPHLILCMRPQKKELINDYDSKSVQIQLHALNVLETILIRQFGFARRISFVDFLNRYQyLAFDFNENvel-tkeNC--- 952
gi 157963     925 LGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQfLAFDFDEPvem-tkdNC--- 1000
gi 3642560    824 SHVHFVRCIKSNNERQSTKFDIPLVNRQIKNLLLAELLSFRVKGYPVKISKTTFARQYRcLLPGDIAQcqn-ekeII--- 899
gi 2209254    596 TEAHFIRCLKPNEEKKPLGWNGSKVLNQLFSLSILEALQLRQVGYAYRRNFSEFCSHFRwLDLGLVNSdrd-rkeVA--- 671
gi 118354754  722 SDVHFIRCIKPNEEKKKNFFKYDYVYQQVQYLGILDSIKIRKVGYSYRMTYENFFLEYQeLGQKTKGLtlqkvqqQKldl 801
gi 1346638    638 TEPHYIRCIKPNSEKQADLFHGFMSLQQLRYAGVFEAVRIRQTGYPFRYSHENFLKRYGfLVKDIHKRygpnlkqNC--- 714
gi 119569114  644 TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKkYMPDKLARldp--rlFC--- 718
gi 8214       656 NGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKsVLPPELVSlpa--rtFC--- 730
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....*....
1W9J_A        724 ------DAV-----LKHLn-IDPEQYRFGITKIFFR-AGQLARIEEARE 759
gi 2209250    738 ------LRL-----LKSSk-LPSEEYQLGKTMVFLK-QTGAKELTQIQR 773
gi 3132701    953 ------RLL-----LLRL---KMDGWTLGKNKVFLK-YYSEEYLSRIYE 986
gi 157963    1001 ------RLL-----FLRL---KMEGWALGKTKVFLR-YYNDEFLARLYE 1034
gi 3642560    900 ------QDI-----LQGQgvKYEDDFKIGTEYVFLR-ERLAERYDGLQN 936
gi 2209254    672 ------HVL-----LEQSg-IPESSWVIGKTMVFVK-PDAAKELSILQR 707
gi 118354754  802 kqlittEIFektnlLQNKq-LPQKCVAFGKTKIFLK-NEeilpqefnen 848
gi 1346638    715 ------DLL-----LKSMkgDCXSKVQVGKTRVLYRaPEQR-GLELQRN 751
gi 119569114  719 ------KAL-----FKALg-LNENDYKFGLTKVFFR-PGKFAEFDQIMK 754
gi 8214       731 ------EAM-----FQSLn-LSAKDFKFGITKVFFR-PGKFVEFDRIMR 766
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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