Conserved Protein Domain Family
Deltex_C

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cd09633: Deltex_C 
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Domain found at the C-terminus of deltex-like
The deltex family of proteins is involved in the regulation of Notch signaling, and therefore may play roles in cell-to-cell communications that regulate mechanisms determining cell fate. They have a central RING-type zinc finger domain and contain a C-terminal domain, described here, that is also found in other domain architectures. Deltex-1 (DTX1) contains a RING finger and two WWE domains, indicating that it may be an E3 ubiquitin ligase. Human deltex 3-like, which contains an additional N-terminal domain (presumably with ubiquitin ligase activity) is also described as E3 ubiquitin-protein ligase DTX3L, B-lymphoma- and BAL-associated protein (BBAP), or rhysin-2. DTX3L mediates monoubiquitination of K91 of histone H4 in response to DNA damage.
Links
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Source: Cdd
Taxonomy: Eukaryota
PubMed: 11 links
Protein: Representatives
Specific Protein
Related Protein
Related Structure
Architectures
Superfamily: cl15237
BioSystems: 368 links
Statistics
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PSSM-Id: 193607
View PSSM: cd09633
Aligned: 40 rows
Threshold Bit Score: 178.149
Threshold Setting Gi: 84994970
Created: 13-Apr-2011
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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putative dimer
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:
  • Structure:3PG6: the C-terminal domain of human deltex 3-like forms a homodimer, contacts at 4 A
    View structure with Cn3D

cd09633 is part of a hierarchy of related CD models.
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cd09633 is a member of the superfamily cl15237.
cd09633:Deltex_C6647604284994970221482181124408724198418191156368898187937042763480437077110115939196680678802413639721936787053409834615829648691088607705692221960134441183834731244169161244289341244291172991159531167883671680240183027548063234534981675348932608123053PG6 A118093857705710621183442786636487130425428334164391768663613245027941563855122912257916647604284994970221482181124408724198418191156368898187937042763480437077110115939196680678802413639721936787053409834615829648691088607705692221960134441183834731244169161244289341244291172991159531167883671680240183027548063234534981675348932608123053PG6 A11809385770571062118344278663648713042542833416439176866361324502794156385512291225791
cd09633 Sequence Cluster
cd09633 Sequence Cluster
Sub-family Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #####        #                       # # ###                  ### #    
3PG6_A        27 GNQP-EGSMVFTVS-------RDSLPGye------------sFGTIVITYSMKAGIQteehpnpGKRYPGIQRTAYLPDn 86
gi 116788367 313 GTQP-PGDMSIRYIpi---tsQQHWDGlqg---------ypgIDIIEITYTFPNGIQtaehpspGRRYYGTRRVAYLPKn 379
gi 323453498  13 GGQPdNGVMRDWVE-------DRALPGfr-----------fgSRTRVVEYDFDDGVQgdrhpnpGRPFSGTYRRCYLPTp 74
gi 302754806  69 GTQP-RGSMFVQTQs------DWSCAGfp------------lHGVITINYRFPNGIQgpehpnpGYHYKGTVRTAFLPDn 129
gi 168024018 273 GTQP-DGTMSVRIIragspefASGLEGfp------------gVDVIVIQYNFPSGIQgpehpspGCPYTGTRRVAYLPYt 339
gi 66476042  307 GNSP-PGKMRYIVYk------SGNIEIesy----------pnTNVIEIEYFIPSGIQnqrhpspNKLYTGTYKIAYLPFn 369
gi 221482181 336 GPSP-AGTMKWQID-------QTPSLGgy-----------sdSGTIYVEYDLPSGIQsarharpGSPFAGTRRSAYLPDt 396
gi 260812305  19 GNQP-EGSMKYEPIwpt--piFRPLPGfawfsramtlngykqTGTIIIDYAFGSGIQgsdhpnpGKPYTGTTRRAFLPYn 95
gi 167534893 379 GNQP-PGEMRVHLS-------QQPLPGfd------------sVGHYIIDYEFPPGLQgpehptpGAYFNGDRRRAYLPAt 438
gi 124408724  90 PPQP-PGTFTKQII-------NQSCSGye------------kTQTIEIVYDIPNGLQn------GIHYRGAKHTCYIPNt 143
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
Feature 1                                        #            ##       #                   
3PG6_A        87 kEGRKVLKLLYRAFDQKLIFTVGYSRvl---gVSDVITWNDIHHKTSRfggpemYGYPDPsYLKRVKEELKAKG 157
gi 116788367 380 kEGEEVLELLKTAWNRRLIFSVGTSVtt---gISDTVVWAGIHHKTQKyggssnYGYPDEtYFDRVKKELALVN 450
gi 323453498  75 -EGDAVFARLAVAFERRLVFNVGTSLtt---gRSDCVVWAGIHHKTQRtggaaeHGYPDAtYLDRVSDELAAAG 144
gi 302754806 130 eEGRDILRLLKIAWERKLVFTVGTSItt---gLSNCVIWNGIHHKTQYeg---tYGYPDAtYLSRVRQELAALG 197
gi 168024018 340 kEGEDVLNLLKIAWDRRLLFSVGTSItt---gRRDVVTWSGVHHKTSTwggptnFGYPDStYFARVKAELSEKG 410
gi 66476042  370 kKGLIMLDGLAKAFQLGHTFKVNSITnpstgsSMEIVQWGNIPHKISTcggpalHGFPDPnFFTTLINKLSSLG 443
gi 221482181 397 iEGREILSLLIHAFVKGHTFTVGTSLtt---gRSDVVVWNGIHHKTNRsggptgYGYPDAsYFDRVFTELEAKG 467
gi 260812305  96 sDGKKVLELLKQAFEQKLTFTIGTSStt---gHRDTVIWNDIHHKTSThggpsmHGYPDPgYLKRVTEELAAKG 166
gi 167534893 439 dKGLETLKRLKTAFERRLTFTIGLSLtlg-prAGERIIWNGIHHKTSLsg--gaFGFPDPtYFERVDEELRAFG 509
gi 124408724 144 kEGEELADLLKTAFDKGLVFTIGRSLqd---gHKYQVQFNDLHHKTSLng--gkYGYPDAtYINRMISELKQRL 212

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Conserved site includes 19 residues -Click on image for an interactive view with Cn3D