Conserved Protein Domain Family
Mer2

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pfam09074: Mer2 
Mer2
Mer2 (Rec107) forms part of a complex that is required for meiotic double strand DNA break formation. Mer2 increases in abundance and is phosphorylated during the prophase phase of cell division. Blocking double strand break formation results in delayed dephosphorylation and dissociation of Mer2 from the chromosome.
Statistics
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PSSM-Id: 192203
View PSSM: pfam09074
Aligned: 6 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 22-Dec-2011
Updated: 5-Jan-2012
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam09074 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74608265   14 STDISSSIDADDLLHsg---------dsSLGEADKQIMEWAGKLELESIDLRE-KSEKLINTLTNMSQELmkvssqlv-- 81
gi 74695120   11 ERPTSATEPGSSPGR-------------QLDETDRQILEWAGKLELESVDLRE-KADALLGLLQQRCSEV---------- 66
gi 1170924    19 SEHSLMITETSSPFRsifshsgkvanagALEESDKQILEWAGKLELESMELRE-NSDKLIKVLNENSKTLckslnkf--- 94
gi 74600759   39 ASLQFASQPKDDKINekdtykenkrvctDVENADDKLITWAARLELESISLKEiVTGNLGHIFKQNYDFLkvaceei--- 115
gi 74951690  354 APFGASTTTKEDPLGag---------rgTDTVTEDKIIE-IFN-SLEKINKKE-PKEQIKDIINNLKKNLnltnyqln-- 419
gi 156848316  10 STDGMLSSPVGKTGCsg---------rdNVSEADKQILEWAGKLELETVDLKE-KASELTNVFNESNTKLlelvarlndh 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74608265   82 ---kqlencnHSKEEDIVDQVYKLDVNINNQLQDWKKSFSDQLKSINH--NSNLGQiknltecmanqeaniLgAIRHNST 156
gi 74695120   67 ----------AASQQGLETWKQTVGAELSAFKADVVQALEEQRKAVAGevRRAAGRa-------------rT-PPPDMER 122
gi 1170924    95 ---nqlleqdAATNGNVKTLIKDLASQIENQLDKVSTAMLSKGDEKKTksDSSYRQ---------------V-LVEEISR 155
gi 74600759  116 ---ttklsqmASQMEEMKKV--SSGCDIDERLIETVNALSEKVTTIEK-------------------------PCSSRDR 165
gi 74951690  420 ---elfnqceKRVNKEIEQLNYQMDNQLNNQIEQDMIKI----------------------------------DPIKVEP 462
gi 156848316  80 lgsieggdmkRSEADGFKSLIENLGATLKNGLKE---SLESSSKTSNGvmNKMMKQlqmvtdcvekhdsntV-TKSELTK 155
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74608265  157 ILKdecrDIIKSQElAGAPKLQRAVDYLHEIMHNMSCQTESMNELLLSIDKQLHNidlaLIKEKDQYK 224
gi 74695120  123 FAG----RIIKSFE-TRQQRWFKEFQATQDVLYNVTVQLDRATDVLGSVSRDLQA----LSARQAQTE 181
gi 1170924   156 YNS----KITRHVT-NKQHETEKSMRCTQEMLFNVGSQLEDVHKVLLSLSKDMHS----LQTRQTALE 214
gi 74600759  166 RNSiesiQTIISEKvDYSLTNNKLIKAIIKSVEKMSHNLEKK-------DRPLQD------NTCDSNK 220
gi 74951690  463 IDVedpfDIIMKPE-------------------NMENSLLVKKYYSITKSQQLK-----LKNRCEDYI 506
gi 156848316 156 FLGdnnkQLLQEFD-ARFDEIMKSVDTTQDLVINCGKQLESIFGVMVSVSTEIKN----LSDRQTTLE 218
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