Conserved Protein Domain Family
DHDPS

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cd00950: DHDPS 
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Dihydrodipicolinate synthase (DHDPS)
Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis. It catalyzes the aldol condensation of L-aspartate-beta- semialdehyde and pyruvate to dihydropicolinic acid via a Schiff base formation between pyruvate and a lysine residue. The functional enzyme is a homotetramer consisting of a dimer of dimers. DHDPS is member of dihydrodipicolinate synthase family that comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways.
BioAssay Targets and Results
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CID: 10367
AID: 321442
GI: 54040943
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Inhibition of Mycobacterium tuberculosis DHDPS at 20 mM
Target Name: Dihydrodipicolinate synthase
Chemical Name: Dipicolinic acid
CID: 5962
AID: 1811
GI: 73535730
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Experimentally measured binding affinity data derived from PDB
Chemical Name: L-lysine
CID: 25203457
AID: 388792
GI: 416876
IC50: 160µM
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Inhibition of Bacillus subtilis DHDPS
Target Name: Dihydrodipicolinate synthase
Chemical Name: CHEMBL451265
IC50: 160µM
Statistics
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PSSM-Id: 188637
View PSSM: cd00950
Aligned: 85 rows
Threshold Bit Score: 268.593
Threshold Setting Gi: 29122979
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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Display:

cd00950 is part of a hierarchy of related CD models.
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cd00950 is a member of the superfamily cl21457.
cd00344:FBP_aldolase_Icd00408:DHDPS-likecd00439:Transaldolasecd00452:KDPG_aldolasecd00502:DHQase_Icd00945:Aldolase_Class_Icd00948:FBP_aldolase_I_acd00949:FBP_aldolase_I_bactcd00950:DHDPScd00951:KDGDHcd00952:CHBPH_aldolasecd00953:KDG_aldolasecd00954:NALcd00955:Transaldolase_likecd00956:Transaldolase_FSAcd00957:Transaldolase_TalABcd00958:DhnAcd00959:DeoC17545384335948234878700626989358463123394876866248782699273824933993397529122979425206155011994211824172723613850340714547979201968291DHP A30172817145479665008653737196764344990333017283929654525145479694614152073004214547950462018891454795548849781463085103913408273818953993606324211617488587504882609930172809455316994168763026380230172844145479711454797224211619230240222837874348870663488653243017283123113740371546153752058714547946219034001454794846362615242116323449750330172864425216941O5K A2129042229346305488550962494088242116156014905242116146225237145479822339435832472136301728473999527046580277488330837531082455475902310032246198899250083524644632017545384335948234878700626989358463123394876866248782699273824933993397529122979425206155011994211824172723613850340714547979201968291DHP A30172817145479665008653737196764344990333017283929654525145479694614152073004214547950462018891454795548849781463085103913408273818953993606324211617488587504882609930172809455316994168763026380230172844145479711454797224211619230240222837874348870663488653243017283123113740371546153752058714547946219034001454794846362615242116323449750330172864425216941O5K A21290422293463054885509624940882421161560149052421161462252371454798223394358324721363017284739995270465802774883308375310824554759023100322461988992500835246446320
cd00950 Sequence Cluster
cd00950 Sequence Cluster
Sub-family Hierarchy
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 cd00950 Branch
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                  ##                                   
1DHP_A        2 FTGSIVAIVTPMDEkg-nVCRASLKKLIDYHVAsGTSAIVSVGTTGESATLNHDEHADVVMMTLDLad---grIPVIAGT 77
1O5K_A       14 FRGVGTAIVTPFKNg--eLDLESYERLVRYQLEnGVNALIVLGTTGESPTVNEDEREKLVSRTLEIvd---gkIPVIVGA 88
gi 118241    80 RLRLITAVKTPYLPdg-rFDLEAYDSLINMQIEgGAEGVIVGGTTGEGHLMSWDEHIMLIGHTVNCfg---srIKVIGNT 155
gi 7272361   47 SLRVITAVKTPYLPdg-rFDLEAYDSLINMQIEgGAEGVIVGGTTGEGHLMSWDEHIMLIGHTVNCfg---tkIKVVGNT 122
gi 27382493  22 LHGLWLPLVTPFRDg--kLDETSLRRLTRHYCGqAVDGFILGATSGEGMTLRDAELERLVAIVRDEmaagrrtLPICLGM 99
gi 29122979  15 FNGLYVPLVTPFTDdl-rLAPEALARLADEALSaGASGLVALGTTAEAATLTAEERETVIRVCSAAcra--hgAPLIVGV 91
gi 38503407  65 SLRVITAIKTPYLPdg-rFDLQAYDDLVNTQIEnGAEGVIVGGTTGEGQLMSWDEHIMLIGHTVNCfg---grIKVIGNT 140
gi 39933975  12 PRGLWLPLITPFRDg--eLDAASLRRLIAHYARaPLDGLILGATTGEGLTLDEAELERLVMLTADAlaasdrkLPVYLGL 89
gi 42520615   3 STFLWTACVTPFNCngdsIDYSSLQRLLTMQVK-AENGVVLLGSTGESLSLTDSEKRTLVEFVCKLkl----nTEIIIGV 77
gi 48768662  12 VDGLWLPMVTPLHHg--qVDFDGVQRLAAHYADaGVDGLIVLGTTGEGGLLTDVERLQVAAATLEAvq---gtVPVIAGV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #    #                  
1DHP_A       78 GANATaEAISLTQRFNDs-GIVGCLTVTPYYNRPSQEGLYQHFKAIAehtdLPQILYNVPSRTgCDLLPETVGRLAkv-k 155
1O5K_A       89 GTNSTeKTLKLVKQAEKl-GANGVLVVTPYYNKPTQEGLYQHYKYISertdLGIVVYNVPGRTgVNVLPETAARIAadlk 167
gi 118241   156 GSNSTrEAVHATEQGFAv-GMHAALHINPYYGKTSAEGMISHFEAVLp--mGPTIIYNVPSRSaQDIPPEVILAISgy-t 231
gi 7272361  123 GSNSTrEAIHATEQGFAv-GMHAALHINPYYGKTSVEGLISHFEAVLp--mGPTIIYNVPSRDwQDIPPPVIEAVSsy-t 198
gi 27382493 100 SGADTsRLKERLDETADw-PIDGYLIASPYYVRPSQRGLLAHFEALAdhaaWPLALYNIPYRCaVNITNQTMLRLAeh-p 177
gi 29122979  92 GTNDTaTAITALRELAArgDVAAALVPAPPYIRPGEAGTLAHFAALAehggLPLVVYDIPYRTgQTLGAGTITALGrl-p 170
gi 38503407 141 GSNSTrEAIHATEQGFAm-GMHGALHINPYYGKTSIEGMNAHFQTVLh--mGPTIIYNVPGRTcQDIPPQVIFKLSqn-p 216
gi 39933975  90 SGSDTrKLVKTLARTAHw-PIDGVLIACPYYTRPSQRGLVLHFEAAAdataRPILIYNIPYRTgVNLQNEAMLRLAer-a 167
gi 42520615  78 PGVNLyQTLEWLDFCKGm-PIHGYLMTTPIYAKPGIMGQTLWFEKLLekahVPVMFYNIPSRAgINLHAETVRNLSsh-e 155
gi 48768662  87 GGVAThAVCEQVRRLERl-DLAGYLVPPPYYLRVSDEGIAWHLRSVAshtaRPLMLYNVPKRTgCTISPDLTWRLAah-p 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #                           #  #                                           
1DHP_A      156 NIIGIKEAtgNLTRVNQIKelv---sddFVLLSGD-DASALDFMQLGGhGVISVTANVAARDMAQMCKlaaeghfaeARV 231
1O5K_A      168 NVVGIXEAnpDIDQIDRTVsltkqarsdFMVWSGN-DDRTFYLLCAGGdGVISVVSNVAPKQMVELCAeyfsgnlekSRE 246
gi 118241   232 NMAGVKECv-GHERVKHYAdk------gITIWSGNdDECHDSKWKHGAtGVISVTSNLVPGLMHSLMYkg------eNAT 298
gi 7272361  199 NMAGVKECv-GHERVKCYAdr------gISIWSGNdDECHESRWKYGAtGVISVASNLIPGLMHSLMYeg------eNAA 265
gi 27382493 178 NIVGLKDCgaSREQSIALLrdr---pdgFRVLTGE-DANYLEALTDGAdGGIVLSAHVETATFAAVYAelkrgnrdaAQA 253
gi 29122979 171 EVVGIKHAtgSIDPTTMELldsp--lpgFAVLGGD-DIVLSPLVAAGAhGGIVASANLRTADYAEMIAlwrrgsaapARA 247
gi 38503407 217 NMAGVKECv-GNNRVEEYTek------gIVVWSGNdDQCHDSRWDHGAtGVISVTSNLVPGLMRKLMFeg------rNSA 283
gi 39933975 168 NIVGVKDCcaDPAQTAELLrlr---ppgFAVLTGE-DALAFDALSRGCdGAILASAHLETEAFAAMMHrlqagdrlgGAT 243
gi 42520615 156 KFWAIKDSsgTVDTLAQYKkva----pnIEVFCGD-DNMISDMAAYGAaGLVSVASNVWPYVAHEYVKkcl----ngRNP 226
gi 48768662 165 QIVALKECdaAGMRALAGQd-------rLDVFCGD-DAAMLDHLLRGGaGIVPASAHIRPDLFVRLIQlartgreeaARA 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
Feature 1                                                              
1DHP_A      232 INQRLMPLHNKLFVEpNPIPVKWACKELGlvaTDTLRLPMtpITDSGRETVRAAL 286
1O5K_A      247 VHRKLRPLMKALFVEtNPIPVKAALNLMGf-iENELRLPLvpASEKTVELLRNVL 300
gi 118241   299 LNEKLSPLMKWLFCQpNPIALNTALAQLGv-aRPVFRLPYvpLPLEKRAEFVRIV 352
gi 7272361  266 LNDKLLPLMKWLFCQpNPIALNTALAQLGv-aRPVFRLPYvpLPLEKRVEFVRIV 319
gi 27382493 254 RWQEVAELTRLLFTEpSPAPAKHWLWRSGlidSPEVRLPMveVSSELAATIDREI 308
gi 29122979 248 LGADLARLSAALFTEpNPTVIKGVLHAQNripSPAVRMPLlaASADSVRRAAPLA 302
gi 38503407 284 LNAKLLPLMDWLFQEpNPIGVNTALAQLGv-aRPVFRLPYvpLPLSKRIEFVKLV 337
gi 39933975 244 EWQRLADLPKLLFAEpSPAPVKYALWRRGlidSPEVRLPMtpVSPTLAAAIDARM 298
gi 42520615 227 QADIWQQACEALFIAsNPIPTKALLHDIGlieHQTVRLPLstEDLPSVEKLRQVN 281
gi 48768662 237 LFRQLSPLIGMLFDEpNPAPVKAALALCGl-aRPEVRRPLmpASKSLVARLDAAI 290

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Conserved site includes 7 residues -Click on image for an interactive view with Cn3D