Conserved Protein Domain Family
PRK10473

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PRK10473: PRK10473 
MdtL family multidrug efflux MFS transporter
Statistics
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PSSM-Id: 182486
Aligned: 67 rows
Threshold Bit Score: 461.798
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
294140862   1 MFRYLLCSFALVLVYPLGIDLYLVGLPDIARDLNASQADLHLAFSIYLAGMASTMLLAGWLADRIGRKPIALMGAATFAI 80 
117922023   1 MFRYLLCCFGLVLMYPTGIDMYLVGLPQIANQLGATEAQLHIAFSVYLAGMATTMLFAGSLADRIGRKPITLFSALLFAL 80 
24375508    1 MFRYLLCSFGLVLMYPTGIDMYLVGLPQIASQLGASEAQLHIAFSVYLAGMATTMLFAGSLADRIGRKPITLFGALLFAL 80 
146313777   1 MARFLFCSFALVLLYPSGIDMYLVGLPHIARDLGASEAQLHIAFSAYLAGMASSMLFAGKIADKAGRQPVAITGAVIFAL 80 
152972624   1 MTRFLLCSFALVLLYPSGIDMYLVGLPRIAQDLGASEAQLHIAFSVYLAGMASAMLFAGRIADRSGRKPVAIVGAAIFVI 80 
238897219   1 MTRFLLCSFALVLLYPSGIDMYLVGLPRIAQDLGASEAQLHIAFSVYLAGMASAMLFAGRIADRSGRKPVAIVGAAIFVI 80 
206577597   1 MTRFLLCSFALVLLYPSGIDMYLVGLPRIAQDLGASEAQLHIAFSVYLAGMASAMLFAGRIADRSGRKPVAIVGAVIFVV 80 
197285120   1 MTKYVIFSFFLVLIYPLGVDLYLTGLTAIASDLNASEVTLHHAFSIYLMGMVSSMLIAGWCSDNLGRKPVILFGTLIFFL 80 
117617858   1 MGRYMLCCFLMITLYPVGIDLYLVALPNIGASLQASEAQLHTAFSLYLLGMAATVPLAGLLADRHGRRPVILSGAGLFML 80 
262396447   1 MSRFLLCSFALVLLYPTAIDLYLVGLPQIASDLNASESQLHIAFSIYLAGMATTMLFAGKIADSVGRKPVAVVGAMIFVL 80 
294140862  81 ASWYAASSVTVDYFLFARFGQGIGAGFCYVVTFAILRDTLDDDKRAKILTMINGITCIVPVLAPVIGHLILMGFEWPSLF 160
117922023  81 ASYFAARSQSSDLFLVARFVQGVGAGCCYVVAFAILRDALDDKRRAKVLSMVNGVTCIIPVIAPVIGHLIMLRFPWPSLF 160
24375508   81 ASYFAAGSQTSDLFLIARFAQGIGAGCCYVVAFAILRDVLDDKRRAKVLSMVNGVTCIIPVIAPVIGHLIMLKFPWPSLF 160
146313777  81 ASVLCSMAQDSTLFLSGRFIQGIGAGGCYVVAFAILRDTLSAQRRAKVLSMLNGITCIIPVLAPVVGYLIMLKLPWQSLF 160
152972624  81 ASLICAQVHTSSHFLIGRFIQGIAAGSCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKYPWQSLF 160
238897219  81 ASLLCAQAHTSSHFLIGRFIQGIGAGSCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKYPWQSLF 160
206577597  81 ASLLCAQAHASSHFLVGRFIQGIGAGSCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKYPWQSLF 160
197285120  81 ASLSAGLSITEKQFLISRFFQGSGSGFCYVVTFAILRDTLTEQQRAKVLSMINGITCIIPVLAPVLGFIILLYCEWSMMF 160
117617858  81 ASLLAGSADDTAQFLLARVGQGAGAGALYIMTFTVLRDVLPPARLAAVLSAINGVICVIPVLAPLLGYLILTGFPWPAIF 160
262396447  81 ASFLGGMAEQPNAFLIARFCQGIGAGSCYVVAFAILRDTLDDERRAKVLSMLNGITCIIPVIAPVIGHLIMLKFPWPSLF 160
294140862 161 ISMAIMATLIFQLCLLILKET---KPSHiETTHRNMNTSTQschrvnqahdhkanlaneatkkicdEPLGSRLFISRLIM 237
117922023 161 YTMAVMGLLVFGLCLFVLRET---YSKA-SFHSQTLPRVQT-------------------------ESFKQGFFISRVVI 211
24375508  161 YTMAAMGLLVFALCLLVLRET---HSKA-AFHTQALPGVQR-------------------------ESFKQGFFISRLVI 211
146313777 161 WTMAAMGALVFILSITVLKET---HPGS-HHSGHSATVQPA-------------------------EKLLNRFFISRLLV 211
152972624 161 YTMTGMGVMVAVLSVFILRET---RPT--APPQAALPQHDAg------------------------ESLLNRFFLSRLLI 211
238897219 161 YTMTGMGVMVAVLSVFILRET---RPT--APPQAASPQHDAg------------------------ESLLNRFFLSRLLI 211
206577597 161 YTMTGMGVMVGLLSVFILRET---RPTA-HPQTATPQHGGS-------------------------ESLLNRFFLSRILI 211
197285120 161 YLMGAYSLLVFIFCFLGIKETyhkKEIKiKKVNLSVIKPTT-------------------------ESFLTHYFLSRLLI 215
117617858 161 QAMALLGGMVLLINLLGLKES---LPL--HPESSSSASAARf------------------------ACLRAPQFLWMCAL 211
262396447 161 TTMAGMGILVSVLAIFVLKES---LPSQ-QGEEQTAPEIHQ-------------------------ETFFERFFISRLII 211
294140862 238 TSLAVTAILTYVNTSPMLLMEQMGYSTGKYSAAMAGLAVISMTSSFLAPKLLTHFGQQRIMLASQG-LYICSAVVFMAGY 316
117922023 212 TTLGVTTILSYVNVSPMLIMGQMGFDRGQYSNTMAMTALVSMLASFSTPFLLNQFKEKSLILFSQT-LFAAAALVFILTQ 290
24375508  212 TTLGVTTILSYVNVSPMLIMGQMGFDRGQYSNTMAMMALVSMLASFSTPFLLNRFKEKSLILFSQG-LFVAAALVFILTQ 290
146313777 212 TTLSVAVILTFVNVSPVLLMETMGFDRGEYSTVMALTAMVSMAVSFSTPFALNVFSQRSLMLTSQV-LFLAAGVILATAS 290
152972624 212 TTLSVTVILTYVNVSPVLMMEEMGFDRGTYSMAMALMAMISMAVSFSTPFVLSLFNPRTLMLTSQV-LFLAAGVTLSLAT 290
238897219 212 TTLSVTVILTYVNVSPVLMMEEMGFDRGTYSMAMALMAMISMAVSFSTPFVLSLFNPRTLMLTSQV-LFLAAGVTLSLAT 290
206577597 212 TTLSVTAILTYVNVSPVLMMEEMGFDRGTYSMAMALMAMISMAVSFSTPFALSLFTPRTLMLTSQV-LFLAAGLALSLAT 290
197285120 216 SCLGMAVILTYVNISPIVVMQQMNYSTGEYSILMTSLAMISMTISFLMPKILMKYRYKHILSVGLI-CFGIGIIFLFIGK 294
117617858 212 SSAGMTCILTYVSTSPMILMAQRGLATAEYARIMMIMAMISMITSFLAPWLLRRLHKHSLLALAHSgLGLALLLILASHL 291
262396447 212 TALGVTTILTFVNASPIVVMSMLGFDRGGYSSIMAGTATISMLISFSAPLALGIFKQRTLMMTSQV-LLACAAIVLSAAH 290
294140862 317 QFEldsrVNLLGISLICAGFSLGFGTAMSQALSPFSRRAGMASSVLGIFQIACSAAYITAMGWLGISTLNMLIFLLLTTG 396
117922023 291 LGWlgqlFNLLGFGLVCSGFAIGFGVTMSQALSPFVARAGVASSLLGIAQVCTSALYIWVMGLLEVSAINILLAILAVGA 370
24375508  291 LGGvshsFNLLGFAFVCSGFSIGFGVTMSQALSPFVARAGVASSLLGIAQVCTSALYIWVMGLLEVSAINILLLILSVGA 370
146313777 291 SHA----IMLGGITLICAGFSVGFGVAMSQALGPFSLRAGVASSALGIAQVCGSSLWIWLAAVIGLNALNMLIGILIGCS 366
152972624 291 RQA----VTLIGLGMICAGFSVGFGVAMSQALGPFTLRAGVASSVLGIAQVCGSSLWIWLAAIIGLSAMNMLIGILIACS 366
238897219 291 RQA----VTLIGLGMICAGFSVGFGVAMSQALGPFTLRAGVASSVLGIAQVCGSSLWIWLAAIIGLSAMNMLIGILIACS 366
206577597 291 RQT----LTLIGLGMICAGFSVGFGVAMSQALGPFTLRAGVASSVLGIAQVCGSSLWIWLAAIIGLSAMNMLIGILIACS 366
197285120 295 KSDm--rWFFITFALCGSGFALLFGIIMSQALSPFSQRAGVASSVLGISQLSFSSLYIWVMGWIEVSSINMLVVILFISC 372
117617858 292 ESSwglwLLLAGFAFTCIGFSASFGIAMGEALASCRHQIALASATLCLAQITVSAGYIWLMGWLGFTPSTLLACALLGAV 371
262396447 291 FHDgqshYYVFGLGLICAGFACGFGVAMSQALSPFSQQAGVASSLLGIAQVCSSAFYIWFMGFIGVSALNMLVFILVLGS 370
294140862 397 LTSIILLHVVPSDTAssdklthkvseLNSNDKVPASS 433
117922023 371 LISITLMLAVPKLSE-----------MVANEQIPESA 396
24375508  371 LVSITLMLAVPKMSE-----------MVVNEQIPESA 396
146313777 367 MLCILLLLAIQP--------------AAHYEEAPQQS 389
152972624 367 IVSLVLLLVVTPPRV-----------AQYDEEAAVES 392
238897219 367 IVSLVLLLVVTPPRV-----------AQYDEEAAVES 392
206577597 367 IVSLVLLLVVTPPRV-----------AQYDEEAAVES 392
197285120 373 IVGTLFLCFPR---------------FTEQKKVKYNV 394
117617858 372 LLYLLFRALGPAFDS-----------PAHGAPVMENP 397
262396447 371 VISLALILLIPKPVH-----------DTHYEEIPSAT 396
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