Conserved Protein Domain Family
rasfadin_RA
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cd01784: rasfadin_RA (this model, PSSM-Id:176379 is obsolete and has been replaced by 340482)
Ubiquitin-like domain of Rasfadin
rasfadin_RA Rasfadin (RASSF2) belongs to a family of Ras effectors/tumor suppressors that includes RASSF1 and NORE1. RASSF2 binds directly to K-Ras in a GTP-dependent manner via its RA (RAS-associated) domain. RASSF2 promotes apoptosis and cell cycle arrest and is frequently down-regulated in lung tumor cell lines
Links
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Statistics
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PSSM-Id: 176379
Aligned: 5 rows
Threshold Bit Score: 164.679
Created: 2-Aug-2004
Updated: 17-Jan-2013
Structure
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Aligned Rows:
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Feature 1:putative Ras interaction site [polypeptide binding site]
Evidence:
  • Comment:interacts with the switch I and switch II regions of Ras
  • Citation:PMID 9628477
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     # #          ## ##   ##       #  ##                                             
1723118   177 NHKTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVVHTSGEKQKLKATDYPLIARILQGPCEQISK 256 human
BAB24062  178 DHETSIFTPTFGSETKVRANSIMRTEEVIKQLLQKFKIENSPRDFALYIIFGTGEQRKLKKTDVPLLQRLLQGPSKSNAR 257 house mouse
XP_417672 175 NHKTSVFTPAYGSITNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYIVHTSGEKQKLRATDYPLIARVLQGPCEQVSK 254 chicken
AAH70838  171 NHKTSVFTPTYGSVTNVRINSTMSTPQVLKLLLNKFKIENPASEFSLYMVHTSGEKRKLKETDYPLIARILHGPCEQVSK 250 African clawed frog
CAG09617  158 NHKTAVFTPAYGSVTNVRINSCMTTPQVLRVLLNKFKIENSPDDFAIYLVHTSGERVKLKRSDYPLVLRVMQGPCEQVCK 237 Tetraodon nigrovir...

Feature 1            
1723118   257 VFLMEKD 263 human
BAB24062  258 IFLMDKD 264 house mouse
XP_417672 255 VFLMEKD 261 chicken
AAH70838  251 VFLMEKD 257 African clawed frog
CAG09617  238 VFLMEED 244 Tetraodon nigroviridis

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